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This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 chann... See more...
Aliases for KCNIP2 Gene
Aliases for KCNIP2 Gene
- Potassium Voltage-Gated Channel Interacting Protein 2 2 3 5
- Kv Channel-Interacting Protein 2 2 3 4
- KCHIP2 2 3 4
- Cardiac Voltage-Gated Potassium Channel Modulatory Subunit 3 4
- A-Type Potassium Channel Modulatory Protein 2 3 4
- Potassium Channel-Interacting Protein 2 3 4
- Kv Channel Interacting Protein 2 3
- KCNIP2 5
- KChIP2 4
External Ids for KCNIP2 Gene
- HGNC: 15522
- Entrez Gene: 30819
- Ensembl: ENSG00000120049
- OMIM: 604661
- UniProtKB: Q9NS61
Previous GeneCards Identifiers for KCNIP2 Gene
- GC10M102478
- GC10M102819
- GC10M103716
- GC10M103250
- GC10M103575
- GC10M097216
Summaries for KCNIP2 Gene
-
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNIP2 Gene
KCNIP2 (Potassium Voltage-Gated Channel Interacting Protein 2) is a Protein Coding gene. Diseases associated with KCNIP2 include Spinocerebellar Ataxia Type 19/22 and Brugada Syndrome. Among its related pathways are Cardiac conduction and Antiarrhythmic Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein N-terminus binding. An important paralog of this gene is KCNIP4.
UniProtKB/Swiss-Prot Summary for KCNIP2 Gene
-
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).
-
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.
Additional gene information for KCNIP2 Gene
- HGNC(15522)
- Entrez Gene(30819)
- Ensembl(ENSG00000120049)
- OMIM(604661)
- UniProtKB(Q9NS61)
- Open Targets Platform(ENSG00000120049)
- Search for KCNIP2 at DataMed
- Search for KCNIP2 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNIP2 Gene
Genomics for KCNIP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KCNIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KCNIP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNIP2
- Top Transcription factor binding sites by QIAGEN in the KCNIP2 gene promoter:
-
- NRSF form 1
- Sp1
Genomic Locations for KCNIP2 Gene
Genomic Locations for KCNIP2 Gene
- chr10:101,825,971-101,843,920
- (GRCh38/hg38)
- Size:
- 17,950 bases
- Orientation:
- Minus strand
- chr10:103,585,731-103,603,677
- (GRCh37/hg19)
- Size:
- 17,947 bases
- Orientation:
- Minus strand
Genomic View for KCNIP2 Gene
Genes around KCNIP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.32 by HGNC
- 10q24.32 by Entrez Gene
- 10q24.32 by Ensembl
KCNIP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNIP2 Gene
Proteins for KCNIP2 Gene
-
Protein details for KCNIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NS61-KCIP2_HUMAN
- Recommended name:
- Kv channel-interacting protein 2
- Protein Accession:
- Q9NS61
- A6NJE5
- A8MQ75
- Q3YAC6
- Q3YAC8
- Q3YAC9
- Q7Z6F1
- Q96K86
- Q96T41
- Q96T42
- Q96T43
- Q96T44
- Q9H0N4
- Q9HD10
- Q9HD11
- Q9NS60
- Q9NY10
- Q9NZI1
Protein attributes for KCNIP2 Gene
- Size:
- 270 amino acids
- Molecular mass:
- 30907 Da
- Quaternary structure:
-
- Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits (PubMed:14623880, PubMed:14980201). Interacts with KCND2 (PubMed:10676964, PubMed:14623880, PubMed:14980201). Isoform 1 and isoform 3 interact with KCND3 isoform 1. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. At least isoform 2 and isoform 3 can self-associate to form homodimers and homotetramers. Isoform 3 interacts with KCNIP1 in a calcium-dependent manner.
Protein Expression for KCNIP2 Gene
Post-translational modifications for KCNIP2 Gene
- Palmitoylated. Palmitoylation enhances association with the plasma membrane.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for KCNIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents KChIP2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for KCNIP2
- Novus Biologicals Antibodies for KCNIP2
-
Abcam antibodies for KCNIP2
- Invitrogen Antibodies for KCNIP2 (AFLGC-KCNIP2)
-
Boster Bio Antibodies for KCNIP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for KCNIP2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNIP2
- Origene Custom Protein Services for KCNIP2
- antibodies-online: Show 8 available KCNIP2 Proteins ranked by validation data
- Compare Top KCNIP2 Proteins
-
Quality Products:
-
Abcam proteins for KCNIP2
No data available for DME Specific Peptides for KCNIP2 Gene
Domains & Families for KCNIP2 Gene
Gene Families for KCNIP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transporters
Protein Domains for KCNIP2 Gene
- InterPro:
- Blocks:
-
- Recoverin family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for KCNIP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Kv channel interacting protein 2 (A6QL43_HUMAN)
- cDNA FLJ37349 fis, clone BRAMY2021746, highly similar to Kv channel-interacting protein 2 (B3KSZ5_HUMAN)
- Potassium channel-interacting protein 2 (KCIP2_HUMAN)
- Kv channel interacting protein 2 transcript variant 9 (Q09MK0_HUMAN)
- Potassium channel interacting protein 2 (Q3YAC6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NS61- Family:
-
- Belongs to the recoverin family.
Function for KCNIP2 Gene
Molecular function for KCNIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).
Phenotypes From GWAS Catalog for KCNIP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005250 | contributes_to A-type (transient outward) potassium channel activity | TAS | 26016905 |
| GO:0005267 | potassium channel activity | IEA | -- |
| GO:0005509 | calcium ion binding | TAS | 11287421 |
| GO:0005515 | protein binding | IPI | 14623880 |
Phenotypes for KCNIP2 Gene
- MGI mutant phenotypes for KCNIP2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KCNIP2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased shRNA abundance
- Increased Nanog expression
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
Animal Models for KCNIP2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KCNIP2 - Select products 50% OFF >
- * KCNIP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KCNIP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNIP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNIP2
miRNA for KCNIP2 Gene
- miRTarBase miRNAs that target KCNIP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KCNIP2
- Browse OriGene Inhibitory RNA Products For KCNIP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNIP2
Clone Products
- Applied Biological Materials (abm): Clones for KCNIP2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223165
- MG223584
- MG224400
- MR223165
- MR223165L3
- MR223165L4
- MR223584
- MR223584L3
- MR223584L4
- MR224400
- MR224400L3
- MR224400L4
- MR228616
- RC203823
- RC203823L3
- RC203823L4
- RC211485
- RC211485L3
- RC211485L4
- RC212555
- RC212555L3
- RC212555L4
- RC212601
- RC212601L3
- RC212601L4
- RC213131
- RC213131L1
- RC213131L2
- RC213131L3
- RC213131L4
- RC213178
- RC213178L3
- RC213178L4
- RC219876
- RC219876L3
- RC219876L4
- RG203823
- RG211485
- RG212555
- RG212601
- RG213131
- RG213178
- RG219876
- RR200343
- RR200343L3
- RR200343L4
- RR200344
- RR200344L3
- RR200344L4
- RR200345
- RR200345L3
- RR200345L4
- MR223165L3V
- MR223165L4V
- MR223584L3V
- MR223584L4V
- MR224400L3V
- MR224400L4V
- RC203823L3V
- RC203823L4V
- RC211485L3V
- RC211485L4V
- RC212555L3V
- RC212555L4V
- RC212601L3V
- RC212601L4V
- RC213131L1V
- RC213131L2V
- RC213131L3V
- RC213131L4V
- RC213178L3V
- RC213178L4V
- RC219876L3V
- RC219876L4V
- RR200343L3V
- RR200343L4V
- RR200344L3V
- RR200344L4V
- RR200345L3V
- RR200345L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KCNIP2
- Addgene plasmids for KCNIP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNIP2
Cell Line Products
-
Horizon Cell Lines for KCNIP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNIP2 Gene
Localization for KCNIP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNIP2 Gene
- [Isoform 1]: Cell membrane. Lipid-anchor. Note=Detected on lipid rafts (By similarity). {ECO:0000250 UniProtKB:Q9JM59}.
- [Isoform 2]: Cell membrane. Lipid-anchor.
- [Isoform 6]: Cell membrane. Lipid-anchor.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 3 |
| cytosol | 3 |
| endoplasmic reticulum | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 11287421 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008076 | voltage-gated potassium channel complex | NAS | 11287421 |
| GO:0016020 | membrane | IEA | -- |
| GO:0034705 | potassium channel complex | TAS | 26016905 |
Pathways & Interactions for KCNIP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cardiac conduction | ||
| 2 | Antiarrhythmic Pathway, Pharmacodynamics | ||
Pathways by source for KCNIP2 Gene
3 Reactome pathways for KCNIP2 Gene
1 PharmGKB pathway for KCNIP2 Gene
Interacting Proteins for KCNIP2 Gene
Selected Interacting proteins:
Q9NS61-KCIP2_HUMAN
ENSP00000420040
for KCNIP2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KCNIP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005513 | detection of calcium ion | TAS | 10676964 |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | TAS | 11287421 |
| GO:0006936 | muscle contraction | NAS | 11287421 |
| GO:0007165 | signal transduction | TAS | 10676964 |
No data available for SIGNOR curated interactions for KCNIP2 Gene
Drugs & Compounds for KCNIP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Potassium | Approved, Experimental | Pharma | 0 | |||
| Calcium | Nutra | 6556 | ||||
| Chromanol 293B | Pharma | Pore Blocker, Antagonist | IKs blocker. Also blocks ICFTR | 0 | ||
| Flupirtine maleate | Pharma | KV7 channel activator | 0 | |||
| MaxiPost | Pharma | Potassium channel modulator; exerts subtype-specific effects | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Kaliotoxin |
|
145199-73-1 |
|
|
(4) Tocris Compounds for KCNIP2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Chromanol 293B | IKs blocker. Also blocks ICFTR | 163163-23-3 |
| Flupirtine maleate | KV7 channel activator | 75507-68-5 |
| Kaliotoxin | KV and KCa blocker | 145199-73-1 |
| MaxiPost | Potassium channel modulator; exerts subtype-specific effects | 187523-35-9 |
Transcripts for KCNIP2 Gene
mRNA/cDNA for KCNIP2 Gene
- 8 REFSEQ mRNAs :
- 32 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000239117 555 nts (view in UCSC)
- ENST00000343195 663 nts (view in UCSC)
- ENST00000348850 2089 nts (view in UCSC)
- ENST00000353068 684 nts (view in UCSC)
- ENST00000355657 2617 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KCNIP2 - Select products 50% OFF >
- * KCNIP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KCNIP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNIP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNIP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KCNIP2
- Browse OriGene Inhibitory RNA Products For KCNIP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNIP2
Clone Products
- Applied Biological Materials (abm): Clones for KCNIP2 - Select products 50% OFF >
- * KCNIP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223165
- MG223584
- MG224400
- MR223165
- MR223165L3
- MR223165L4
- MR223584
- MR223584L3
- MR223584L4
- MR224400
- MR224400L3
- MR224400L4
- MR228616
- RC203823
- RC203823L3
- RC203823L4
- RC211485
- RC211485L3
- RC211485L4
- RC212555
- RC212555L3
- RC212555L4
- RC212601
- RC212601L3
- RC212601L4
- RC213131
- RC213131L1
- RC213131L2
- RC213131L3
- RC213131L4
- RC213178
- RC213178L3
- RC213178L4
- RC219876
- RC219876L3
- RC219876L4
- RG203823
- RG211485
- RG212555
- RG212601
- RG213131
- RG213178
- RG219876
- RR200343
- RR200343L3
- RR200343L4
- RR200344
- RR200344L3
- RR200344L4
- RR200345
- RR200345L3
- RR200345L4
- MR223165L3V
- MR223165L4V
- MR223584L3V
- MR223584L4V
- MR224400L3V
- MR224400L4V
- RC203823L3V
- RC203823L4V
- RC211485L3V
- RC211485L4V
- RC212555L3V
- RC212555L4V
- RC212601L3V
- RC212601L4V
- RC213131L1V
- RC213131L2V
- RC213131L3V
- RC213131L4V
- RC213178L3V
- RC213178L4V
- RC219876L3V
- RC219876L4V
- RR200343L3V
- RR200343L4V
- RR200344L3V
- RR200344L4V
- RR200345L3V
- RR200345L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KCNIP2
- Addgene plasmids for KCNIP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNIP2
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP12: |
Relevant External Links for KCNIP2 Gene
- GeneLoc Exon Structure for
- KCNIP2
Expression for KCNIP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
- Neural Tube (Nervous System)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for KCNIP2 Gene
This gene is overexpressed in Heart - Atrial Appendage (x7.3), Brain - Nucleus accumbens (basal ganglia) (x6.5), Heart - Left Ventricle (x6.5), Brain - Putamen (basal ganglia) (x6.0), and Brain - Caudate (basal ganglia) (x5.1).
This gene is overexpressed in Retina (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNIP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNIP2
SOURCE GeneReport for Unigene cluster for KCNIP2 Gene:
Hs.97044mRNA Expression by UniProt/SwissProt for KCNIP2 Gene:
Q9NS61-KCIP2_HUMAN
Tissue specificity:
Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
Evidence on tissue expression from TISSUES for KCNIP2 Gene
- Nervous system(4.9)
- Heart(4.7)
- Muscle(4.7)
- Kidney(4.3)
Primer Products
-
OriGene qPCR primer pairs for KCNIP2
-
OriGene qPCR primer pairs and template standards for KCNIP2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNIP2 Gene
Orthologs for KCNIP2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KCNIP2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KCNIP2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KCHIP2 31 |
|
OneToOne | |
| KCNIP2 30 |
|
||||
| Mouse (Mus musculus) |
Mammalia | Kcnip2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC100911951 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | KCNIP2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | KCNIP2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | KCNIP2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | KCNIP2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kcnip2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100003947 30 |
|
||
| kcnip2 31 |
|
OneToMany | |||
| KCNIP2 (1 of 2) 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5890 31 32 |
|
ManyToMany | |
| CG42683 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | ncs-7 31 |
|
ManyToMany | |
| ncs-4 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FRQ1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for KCNIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for KCNIP2 Gene
- ENSEMBL:
- Gene Tree for KCNIP2 (if available)
- TreeFam:
- Gene Tree for KCNIP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KCNIP2: view image
Paralogs for KCNIP2 Gene
Paralogs for KCNIP2 Gene
(15) SIMAP similar genes for KCNIP2 Gene using alignment to 4 proteins:
- KCIP2_HUMAN
- A6NFF4_HUMAN
- A6QL43_HUMAN
- Q09MK0_HUMAN
Variants for KCNIP2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1126267 | CNV | deletion | 24896259 |
| nsv951004 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.67;
14.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KCNIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KCNIP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNIP2 Gene
Disorders for KCNIP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia type 19/22 |
|
|
| brugada syndrome |
|
|
| cardiomyopathy, dilated, 1e |
|
|
| myasthenic syndrome, congenital, 5 |
|
|
| short qt syndrome |
|
|
Search KCNIP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KCNIP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNIP2 Gene
Publications for KCNIP2 Gene
- Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. (PMID: 16112838) Pruunsild P … Timmusk T (Genomics 2005) 3 4 23
- Modulation of Kv4.3 current by accessory subunits. (PMID: 12297301) Deschênes I … Tomaselli GF (FEBS letters 2002) 3 4 23
- Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. (PMID: 11263977) Ohya S … Imaizumi Y (Biochemical and biophysical research communications 2001) 3 4 23
- Modulation of A-type potassium channels by a family of calcium sensors. (PMID: 10676964) An WF … Rhodes KJ (Nature 2000) 2 3 4
- [Atrial myocytes KChIP2 mRNA expression in rheumatic heart disease patients with atrial fibrillation]. (PMID: 19927631) Tan XQ … Zeng XR (Zhonghua xin xue guan bing za zhi 2009) 3 23
ExternalLinks
Products for KCNIP2 Gene
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- RR200345L3V
- RR200345L4V
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- Invitrogen Antibodies for KCNIP2 (AFLGC-KCNIP2)
- VectorBuilder Custom and pre-made DNA vectors for KCNIP2 (ie. gene expression, shRNA knockdown, CRISPR)
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- Boster Bio Antibodies for KCNIP2
- Browse Boster Bio ELISA Kits
Sources for KCNIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB