Aliases for KCNIP1 Gene
External Ids for KCNIP1 Gene
Previous GeneCards Identifiers for KCNIP1 Gene
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
GeneCards Summary for KCNIP1 Gene
KCNIP1 (Potassium Voltage-Gated Channel Interacting Protein 1) is a Protein Coding gene. Diseases associated with KCNIP1 include Hypertension, Diastolic and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Cardiac conduction. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein N-terminus binding. An important paralog of this gene is KCNIP4.
UniProtKB/Swiss-Prot Summary for KCNIP1 Gene
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.