Aliases for KCNH5 Gene
External Ids for KCNH5 Gene
Previous GeneCards Identifiers for KCNH5 Gene
This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for KCNH5 Gene
KCNH5 (Potassium Voltage-Gated Channel Subfamily H Member 5) is a Protein Coding gene. Among its related pathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Potassium Channels. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and ion channel activity. An important paralog of this gene is KCNH1.
UniProtKB/Swiss-Prot for KCNH5 Gene
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.