Aliases for KCNH3 Gene
External Ids for KCNH3 Gene
Previous GeneCards Identifiers for KCNH3 Gene
The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
GeneCards Summary for KCNH3 Gene
KCNH3 (Potassium Voltage-Gated Channel Subfamily H Member 3) is a Protein Coding gene. Diseases associated with KCNH3 include Background Diabetic Retinopathy. Among its related pathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Potassium Channels. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNH4.
UniProtKB/Swiss-Prot for KCNH3 Gene
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.