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Aliases for KCNG3 Gene

Aliases for KCNG3 Gene

  • Potassium Voltage-Gated Channel Modifier Subfamily G Member 3 2 3 5
  • Potassium Voltage-Gated Channel, Subfamily G, Member 3 2 3
  • Voltage-Gated Potassium Channel Subunit Kv10.1 3 4
  • Voltage-Gated Potassium Channel Subunit Kv6.3 3 4
  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 3 3
  • Potassium Voltage-Gated Channel Subfamily G Member 3 3
  • Voltage-Gated Potassium Channel Subunit Kv6.4 3
  • Voltage-Gated Potassium Channel Kv10.1 3
  • Voltage-Gated Potassium Channel 6.3 3
  • KV10.1 3
  • KV6.3 3

External Ids for KCNG3 Gene

Previous GeneCards Identifiers for KCNG3 Gene

  • GC02M042659
  • GC02M042837
  • GC02M042643
  • GC02M042580
  • GC02M042523
  • GC02M042669
  • GC02M042403

Summaries for KCNG3 Gene

Entrez Gene Summary for KCNG3 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG3 Gene

KCNG3 (Potassium Voltage-Gated Channel Modifier Subfamily G Member 3) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. Gene Ontology (GO) annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNG1.

UniProtKB/Swiss-Prot for KCNG3 Gene

  • Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).

Tocris Summary for KCNG3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNG3 Gene

Additional gene information for KCNG3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNG3 Gene

Genomics for KCNG3 Gene

GeneHancer (GH) Regulatory Elements for KCNG3 Gene

Promoters and enhancers for KCNG3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I042492 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 -0.3 -336 3.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZNF48 ZNF213 ZNF143 RUNX3 KCNG3 MTA3 HAAO COX7A2L
GH02I042566 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.2 -74.4 -74407 4.3 PKNOX1 RB1 SIN3A DMAP1 ZNF48 RFX5 ZNF335 ZNF366 ZNF143 ATF7 MTA3 KCNG3 HAAO GC02P042587 GC02M042525
GH02I042663 Enhancer 1.1 Ensembl ENCODE 11.9 -169.5 -169468 0.9 MLX ARID4B SIN3A ZNF2 IRF4 ZNF48 TCF12 ARID2 ZNF143 RUNX3 KCNG3 MTA3 COX7A2L GC02P042660 ENSG00000226523
GH02I042544 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 -52.2 -52228 3.6 ZFP64 NEUROD1 MAX E2F1 CTBP1 GATA3 POLR2A ZBTB20 TCF7L2 EGR2 MTA3 KCNG3 OXER1 HAAO EML4 GC02M042525 GC02P042587
GH02I042751 Enhancer 1 Ensembl ENCODE 10.2 -260.0 -260003 4.6 HDGF BMI1 BATF IRF4 ATF7 BCLAF1 IKZF2 RUNX3 CBFB JUNB HAAO MTA3 KCNG3 OXER1 RNU6-137P GC02P042660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCNG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNG3 gene promoter:

Genomic Locations for KCNG3 Gene

Genomic Locations for KCNG3 Gene
chr2:42,442,017-42,494,097
(GRCh38/hg38)
Size:
52,081 bases
Orientation:
Minus strand
chr2:42,669,157-42,721,237
(GRCh37/hg19)

Genomic View for KCNG3 Gene

Genes around KCNG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNG3 Gene

Proteins for KCNG3 Gene

  • Protein details for KCNG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAE7-KCNG3_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily G member 3
    Protein Accession:
    Q8TAE7
    Secondary Accessions:
    • Q53SC1

    Protein attributes for KCNG3 Gene

    Size:
    436 amino acids
    Molecular mass:
    49593 Da
    Quaternary structure:
    • Heterotetramer with KCNB1 (PubMed:11852086, PubMed:12060745, PubMed:19074135). Does not form homomultimers (PubMed:12060745).

    Alternative splice isoforms for KCNG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNG3 Gene

Post-translational modifications for KCNG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNG3 Gene

Domains & Families for KCNG3 Gene

Gene Families for KCNG3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAE7

UniProtKB/Swiss-Prot:

KCNG3_HUMAN :
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily.
Domain:
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily.
genes like me logo Genes that share domains with KCNG3: view

Function for KCNG3 Gene

Molecular function for KCNG3 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).

Phenotypes From GWAS Catalog for KCNG3 Gene

Gene Ontology (GO) - Molecular Function for KCNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005251 delayed rectifier potassium channel activity IDA 19074135
GO:0005267 potassium channel activity IEA --
GO:0005515 protein binding IPI 11852086
genes like me logo Genes that share ontologies with KCNG3: view
genes like me logo Genes that share phenotypes with KCNG3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNG3

miRNA for KCNG3 Gene

miRTarBase miRNAs that target KCNG3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNG3 Gene

Localization for KCNG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG3 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135). Remains intracellular in the absence of KCNB1 (PubMed:12060745). {ECO:0000269 PubMed:12060745, ECO:0000269 PubMed:19074135}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNG3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA 12060745
GO:0005886 plasma membrane TAS --
GO:0008076 colocalizes_with voltage-gated potassium channel complex IDA 19074135
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KCNG3: view

Pathways & Interactions for KCNG3 Gene

genes like me logo Genes that share pathways with KCNG3: view

Pathways by source for KCNG3 Gene

1 Qiagen pathway for KCNG3 Gene

Gene Ontology (GO) - Biological Process for KCNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNG3: view

No data available for SIGNOR curated interactions for KCNG3 Gene

Drugs & Compounds for KCNG3 Gene

(4) Drugs for KCNG3 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KCNG3 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for KCNG3 Gene

Compound Action Cas Number
Chromanol 293B IKs blocker. Also blocks ICFTR 163163-23-3
Flupirtine maleate KV7 channel activator 75507-68-5
Kaliotoxin KV and KCa blocker 145199-73-1
MaxiPost Potassium channel modulator; exerts subtype-specific effects 187523-35-9
genes like me logo Genes that share compounds with KCNG3: view

Transcripts for KCNG3 Gene

mRNA/cDNA for KCNG3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNG3 Gene

Potassium voltage-gated channel, subfamily G, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:
SP2: -

Relevant External Links for KCNG3 Gene

GeneLoc Exon Structure for
KCNG3
ECgene alternative splicing isoforms for
KCNG3

Expression for KCNG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNG3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.7), Brain - Putamen (basal ganglia) (x4.7), Brain - Caudate (basal ganglia) (x4.5), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for KCNG3 Gene

This gene is overexpressed in Pancreatic juice (55.6) and Platelet (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNG3 Gene



Protein tissue co-expression partners for KCNG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNG3 Gene:

KCNG3

SOURCE GeneReport for Unigene cluster for KCNG3 Gene:

Hs.352633

mRNA Expression by UniProt/SwissProt for KCNG3 Gene:

Q8TAE7-KCNG3_HUMAN
Tissue specificity: Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed:11852086, PubMed:12060745).

Evidence on tissue expression from TISSUES for KCNG3 Gene

  • Blood(5)
  • Nervous system(4.1)
  • Heart(2.9)
genes like me logo Genes that share expression patterns with KCNG3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNG3 Gene

Orthologs for KCNG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNG3 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia KCNG3 34
  • 98 (a)
OneToOne
LOC525901 33
  • 95.47 (n)
dog
(Canis familiaris)
Mammalia KCNG3 33 34
  • 95.95 (n)
mouse
(Mus musculus)
Mammalia Kcng3 33 16 34
  • 93.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNG3 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcng3 33
  • 92.69 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNG3 34
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNG3 33 34
  • 82.83 (n)
lizard
(Anolis carolinensis)
Reptilia KCNG3 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcng3 33
  • 75.72 (n)
zebrafish
(Danio rerio)
Actinopterygii kcng3 33 34
  • 68.82 (n)
Species where no ortholog for KCNG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNG3 Gene

ENSEMBL:
Gene Tree for KCNG3 (if available)
TreeFam:
Gene Tree for KCNG3 (if available)

Paralogs for KCNG3 Gene

Paralogs for KCNG3 Gene

(17) SIMAP similar genes for KCNG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNG3: view

Variants for KCNG3 Gene

Sequence variations from dbSNP and Humsavar for KCNG3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000078288 -- 42,463,776(-) A/G intron_variant
rs1000115702 -- 42,451,472(-) C/A intron_variant
rs1000149556 -- 42,459,691(-) T/C intron_variant
rs1000222898 -- 42,459,120(-) C/A intron_variant
rs1000248141 -- 42,491,897(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNG3 Gene

Variant ID Type Subtype PubMed ID
dgv1118e212 CNV loss 25503493
esv23097 CNV loss 19812545
esv2671664 CNV deletion 23128226
esv3555600 CNV deletion 23714750
esv3583762 CNV loss 25503493
esv3583763 CNV loss 25503493
esv3590503 CNV loss 21293372
nsv524679 CNV loss 19592680
nsv581643 CNV gain 21841781
nsv953773 CNV deletion 24416366
nsv961769 CNV duplication 23825009

Variation tolerance for KCNG3 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNG3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNG3 Gene

Disorders for KCNG3 Gene

Additional Disease Information for KCNG3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KCNG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNG3 Gene

Publications for KCNG3 Gene

  1. Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. (PMID: 11852086) Sano Y … Furuichi K (FEBS letters 2002) 2 3 4 58
  2. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. (PMID: 19074135) Mederos Y Schnitzler M … Preisig-Müller R (The Journal of biological chemistry 2009) 3 4 58
  3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman GA … Wang X (Pharmacological reviews 2005) 2 3 58
  4. Modification of Kv2.1 K+ currents by the silent Kv10 subunits. (PMID: 15046870) Vega-Saenz de Miera EC (Brain research. Molecular brain research 2004) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for KCNG3 Gene

Sources for KCNG3 Gene

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