Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of... See more...

Aliases for KCNG2 Gene

Aliases for KCNG2 Gene

  • Potassium Voltage-Gated Channel Modifier Subfamily G Member 2 2 3 5
  • KCNF2 2 3 4
  • Potassium Voltage-Gated Channel, Subfamily G, Member 2 2 3
  • Potassium Voltage-Gated Channel Subfamily G Member 2 3 4
  • Voltage-Gated Potassium Channel Subunit Kv6.2 3 4
  • Cardiac Potassium Channel Subunit 3 4
  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 2 3
  • KV6.2 3
  • KCNG2 5
  • Kv6.2 2

External Ids for KCNG2 Gene

Previous GeneCards Identifiers for KCNG2 Gene

  • GC18P077138
  • GC18P077677
  • GC18P077358
  • GC18P075722
  • GC18P075724
  • GC18P074246
  • GC18P079863

Summaries for KCNG2 Gene

Entrez Gene Summary for KCNG2 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG2 Gene

KCNG2 (Potassium Voltage-Gated Channel Modifier Subfamily G Member 2) is a Protein Coding gene. Among its related pathways are Integration of energy metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNG1.

UniProtKB/Swiss-Prot Summary for KCNG2 Gene

  • Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

Tocris Summary for KCNG2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNG2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNG2 Gene

Genomics for KCNG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCNG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J079796 Enhancer 0.7 ENCODE 600.7 -0.7 -703 1.1 ZSCAN4 SCRT2 ZNF792 CTCF KLF9 RAD21 ZBTB10 ZNF23 ZBTB26 MYNN KCNG2 RBFADN ADNP2 ATP9B ENSG00000267127 ENSG00000267780 LOC105376875
GH18J079797 Promoter 0.7 EPDnew 600.7 0.0 -28 0.1 ZSCAN4 SCRT2 CTCF RAD21 ZBTB26 ZFHX2 EGR1 EZH2 GLIS2 KCNG2 ENSG00000267780 LOC105376875
GH18J079392 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.8 -397.8 -397797 14.4 SP1 PRDM10 ZNF629 RFX1 KDM1A POLR2A BACH1 LARP7 ZIC2 PATZ1 NFATC1 CTDP1 LOC107985163 MN297545 lnc-PQLC1-16 ATP9B ADNP2 RBFA PARD6G ENSG00000267287
GH18J079790 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 5.5 -6.3 -6306 2.6 GATAD2A TFE3 NFKBIZ RCOR2 RXRB IRF2 SP1 CEBPA SOX13 CEBPB ENSG00000267780 KCNG2 RBFADN CTDP1 SLC66A2 ENSG00000266924 LOC105376875
GH18J079819 Enhancer 0.6 ENCODE 10.1 +22.4 22442 0.9 RELA EED RUNX3 BCL11A IKZF1 SPI1 MAX POLR2A BHLHE40 MYC piR-41229 SLC66A2 HSBP1L1 KCNG2 lnc-KCNG2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNG2

Top Transcription factor binding sites by QIAGEN in the KCNG2 gene promoter:
  • AhR
  • AP-2gamma
  • Arnt
  • ATF
  • c-Myc
  • En-1
  • GATA-1
  • GATA-2
  • Max
  • POU2F1a

Genomic Locations for KCNG2 Gene

Genomic Locations for KCNG2 Gene
chr18:79,797,963-79,903,512
(GRCh38/hg38)
Size:
105,550 bases
Orientation:
Plus strand
chr18:77,623,668-77,660,184
(GRCh37/hg19)
Size:
36,517 bases
Orientation:
Plus strand

Genomic View for KCNG2 Gene

Genes around KCNG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNG2 Gene

Proteins for KCNG2 Gene

  • Protein details for KCNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ96-KCNG2_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily G member 2
    Protein Accession:
    Q9UJ96

    Protein attributes for KCNG2 Gene

    Size:
    466 amino acids
    Molecular mass:
    51240 Da
    Quaternary structure:
    • Heterodimer with KCNB1. Does not form homomultimers.
    Miscellaneous:
    • Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.

neXtProt entry for KCNG2 Gene

Post-translational modifications for KCNG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNG2 Gene

No data available for DME Specific Peptides for KCNG2 Gene

Domains & Families for KCNG2 Gene

Gene Families for KCNG2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Voltage-gated ion channels

Protein Domains for KCNG2 Gene

InterPro:
Blocks:
  • BTB/POZ domain
  • Potassium channel signature
  • Kv6 potassium channel alpha subunit signature
ProtoNet:

Suggested Antigen Peptide Sequences for KCNG2 Gene

GenScript: Design optimal peptide antigens:
  • Voltage-gated potassium channel subunit Kv6.2 (KCNG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJ96

UniProtKB/Swiss-Prot:

KCNG2_HUMAN :
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.
genes like me logo Genes that share domains with KCNG2: view

Function for KCNG2 Gene

Molecular function for KCNG2 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
GENATLAS Biochemistry:
potassium voltage-gated channel,subfamily G,member 2,rat Kv6.2 homolog,preferentially expressed in myocard

Phenotypes From GWAS Catalog for KCNG2 Gene

Gene Ontology (GO) - Molecular Function for KCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IBA 21873635
GO:0005251 delayed rectifier potassium channel activity TAS 10551266
GO:0005267 potassium channel activity IEA --
genes like me logo Genes that share ontologies with KCNG2: view
genes like me logo Genes that share phenotypes with KCNG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNG2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNG2 Gene

Localization for KCNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNG2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with KCNG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNG2 Gene

Pathways & Interactions for KCNG2 Gene

genes like me logo Genes that share pathways with KCNG2: view

Pathways by source for KCNG2 Gene

1 Qiagen pathway for KCNG2 Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway

Gene Ontology (GO) - Biological Process for KCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 10551266
GO:0008016 regulation of heart contraction TAS 10551266
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0050796 regulation of insulin secretion TAS --
genes like me logo Genes that share ontologies with KCNG2: view

No data available for SIGNOR curated interactions for KCNG2 Gene

Drugs & Compounds for KCNG2 Gene

(5) Drugs for KCNG2 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Enflurane Approved, Investigational, Vet_approved Pharma Target, inhibitor, activator 2
Promethazine Approved, Investigational Pharma Target, inducer 470
Chromanol 293B Pharma Pore Blocker, Antagonist IKs blocker. Also blocks ICFTR 0
Flupirtine maleate Pharma KV7 channel activator 0
MaxiPost Pharma Potassium channel modulator; exerts subtype-specific effects 0

(1) Additional Compounds for KCNG2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Kaliotoxin
145199-73-1

(4) Tocris Compounds for KCNG2 Gene

Compound Action Cas Number
Chromanol 293B IKs blocker. Also blocks ICFTR 163163-23-3
Flupirtine maleate KV7 channel activator 75507-68-5
Kaliotoxin KV and KCa blocker 145199-73-1
MaxiPost Potassium channel modulator; exerts subtype-specific effects 187523-35-9
genes like me logo Genes that share compounds with KCNG2: view

Transcripts for KCNG2 Gene

mRNA/cDNA for KCNG2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNG2

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG2 Gene

No ASD Table

Relevant External Links for KCNG2 Gene

GeneLoc Exon Structure for
KCNG2

Expression for KCNG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNG2 Gene

This gene is overexpressed in Brain - Hippocampus (x8.0) and Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for KCNG2 Gene

This gene is overexpressed in Pancreatic juice (48.3) and Platelet (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNG2 Gene



Protein tissue co-expression partners for KCNG2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNG2

SOURCE GeneReport for Unigene cluster for KCNG2 Gene:

Hs.247905

mRNA Expression by UniProt/SwissProt for KCNG2 Gene:

Q9UJ96-KCNG2_HUMAN
Tissue specificity: Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.
genes like me logo Genes that share expression patterns with KCNG2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNG2 Gene

Orthologs for KCNG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KCNG2 30 31
  • 98.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KCNG2 30 31
  • 91.83 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Kcng2 30 17 31
  • 88.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kcng2 30
  • 88.56 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 70 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 65 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia KCNG2 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KCNG2 31
  • 57 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 57 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CABZ01045232.1 31
  • 52 (a)
ManyToMany
Species where no ortholog for KCNG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KCNG2 Gene

ENSEMBL:
Gene Tree for KCNG2 (if available)
TreeFam:
Gene Tree for KCNG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNG2: view image

Paralogs for KCNG2 Gene

(13) SIMAP similar genes for KCNG2 Gene using alignment to 1 proteins:

  • KCNG2_HUMAN
genes like me logo Genes that share paralogs with KCNG2: view

Variants for KCNG2 Gene

Additional dbSNP identifiers (rs#s) for KCNG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNG2 Gene

Variant ID Type Subtype PubMed ID
dgv1662n106 CNV duplication 24896259
dgv1663n106 CNV deletion 24896259
dgv1955e59 CNV duplication 20981092
dgv6119n54 CNV loss 21841781
dgv6120n54 CNV loss 21841781
dgv6121n54 CNV loss 21841781
dgv6122n54 CNV loss 21841781
dgv6123n54 CNV loss 21841781
dgv6124n54 CNV loss 21841781
dgv6125n54 CNV gain+loss 21841781
dgv6126n54 CNV gain 21841781
dgv6127n54 CNV gain 21841781
dgv6128n54 CNV loss 21841781
dgv6129n54 CNV gain 21841781
esv1002151 CNV deletion 20482838
esv1026680 CNV deletion 17803354
esv1438403 CNV insertion 17803354
esv2118355 CNV deletion 18987734
esv23843 CNV gain 19812545
esv23902 CNV loss 19812545
esv2487517 CNV deletion 19546169
esv2656366 CNV loss 23635498
esv2666043 CNV deletion 23128226
esv2672923 CNV deletion 23128226
esv2674523 CNV deletion 23128226
esv29216 CNV gain 19812545
esv3106012 CNV deletion 24192839
esv3555797 CNV deletion 23714750
esv3555798 CNV deletion 23714750
esv3643326 CNV loss 21293372
esv3643327 CNV loss 21293372
esv4697 CNV loss 18987735
esv9261 CNV loss 19470904
nsv1061450 CNV gain 25217958
nsv1065902 CNV gain 25217958
nsv1071478 CNV deletion 25765185
nsv1072287 CNV deletion 25765185
nsv1078431 CNV duplication 25765185
nsv1125379 CNV deletion 24896259
nsv1125385 CNV deletion 24896259
nsv1130723 CNV deletion 24896259
nsv1146364 CNV insertion 26484159
nsv1146954 CNV deletion 26484159
nsv1147284 CNV deletion 26484159
nsv1148079 CNV duplication 26484159
nsv1149460 CNV deletion 26484159
nsv130639 CNV deletion 16902084
nsv130646 CNV deletion 16902084
nsv130913 CNV deletion 16902084
nsv131019 CNV deletion 16902084
nsv428359 CNV gain 18775914
nsv469607 CNV loss 16826518
nsv470437 CNV loss 18288195
nsv509710 CNV insertion 20534489
nsv519406 CNV gain 19592680
nsv520750 CNV loss 19592680
nsv525694 CNV loss 19592680
nsv577916 CNV loss 21841781
nsv577917 CNV loss 21841781
nsv577918 CNV loss 21841781
nsv577919 CNV loss 21841781
nsv577920 CNV gain 21841781
nsv577923 CNV gain 21841781
nsv577929 CNV gain+loss 21841781
nsv577936 CNV gain 21841781
nsv577953 CNV loss 21841781
nsv577956 CNV loss 21841781
nsv821139 CNV deletion 20802225
nsv953929 CNV deletion 24416366
nsv953930 CNV deletion 24416366

Variation tolerance for KCNG2 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.53; 91.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNG2 Gene

Disorders for KCNG2 Gene

No disorders were found for KCNG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNG2 Gene

Publications for KCNG2 Gene

  1. Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel. (PMID: 10551266) Zhu XR … Pongs O (Receptors & channels 1999) 2 3 4 23
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman GA … Wang X (Pharmacological reviews 2005) 2 3
  3. Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways. (PMID: 24143882) Gelernter J … Farrer LA (Biological psychiatry 2014) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3

Products for KCNG2 Gene

Sources for KCNG2 Gene