Aliases for KCNE4 Gene
- Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4 2 3 5
- Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 4 2 3
- Potassium Voltage-Gated Channel, Isk-Related Family, Member 4 2 3
- Potassium Voltage-Gated Channel Subfamily E Member 4 3 4
- Minimum Potassium Ion Channel-Related Peptide 3 3 4
- Potassium Channel Subunit Beta MiRP3 3 4
External Ids for KCNE4 Gene
Previous GeneCards Identifiers for KCNE4 Gene
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNE4 Gene
KCNE4 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4) is a Protein Coding gene. Diseases associated with KCNE4 include Cataract 31, Multiple Types and Deafness, Autosomal Recessive 98. Among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Dopamine-DARPP32 Feedback onto cAMP Pathway. Gene Ontology (GO) annotations related to this gene include voltage-gated potassium channel activity.
UniProtKB/Swiss-Prot Summary for KCNE4 Gene
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.