Aliases for KCNE4 Gene
Aliases for KCNE4 Gene
- Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4 2 3 5
- Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 4 2 3
- Potassium Voltage-Gated Channel, Isk-Related Family, Member 4 2 3
- Minimum Potassium Ion Channel-Related Peptide 3 3 4
- Potassium Channel Subunit Beta MiRP3 3 4
- Cardiac Voltage-Gated Potassium Channel Accessory Subunit 4 3
External Ids for KCNE4 Gene
- HGNC: 6244
- Entrez Gene: 23704
- Ensembl: ENSG00000152049
- OMIM: 607775
- UniProtKB: Q8WWG9
Previous GeneCards Identifiers for KCNE4 Gene
- GC02P221939
- GC02P222637
- GC02P223880
- GC02P224119
- GC02P223742
- GC02P223625
- GC02P215768
Summaries for KCNE4 Gene
-
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNE4 Gene
KCNE4 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4) is a Protein Coding gene. Diseases associated with KCNE4 include Hypokalemic Periodic Paralysis, Type 1. Among its related pathways are Cardiac conduction and Phase 0 - rapid depolarisation. Gene Ontology (GO) annotations related to this gene include voltage-gated potassium channel activity.
UniProtKB/Swiss-Prot for KCNE4 Gene
-
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.
-
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.
Additional gene information for KCNE4 Gene
- Monarch Initiative
- Search for KCNE4 at DataMed
- Search for KCNE4 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNE4 Gene
Genomics for KCNE4 Gene
GeneHancer (GH) Regulatory Elements for KCNE4 Gene
Promoters and enhancers for KCNE4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KCNE4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KCNE4 gene promoter:
-
- GR-alpha
- GR
- E2F-5
- E2F-4
- E2F-3a
- E2F-2
- E2F-1
- E2F
- Nkx3-1 v4
- GR-beta
Regulatory Element Products
Genomic Locations for KCNE4 Gene
Genomic Locations for KCNE4 Gene
- chr2:223,051,814-223,198,399
- (GRCh38/hg38)
- Size:
- 146,586 bases
- Orientation:
- Plus strand
- chr2:223,916,532-224,063,117
- (GRCh37/hg19)
- Size:
- 146,586 bases
- Orientation:
- Plus strand
Genomic View for KCNE4 Gene
Genes around KCNE4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.1 by Entrez Gene
- 2q36.1 by HGNC
- 2q36.1 by Ensembl
KCNE4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNE4 Gene
Proteins for KCNE4 Gene
-
Protein details for KCNE4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWG9-KCNE4_HUMAN
- Recommended name:
- Potassium voltage-gated channel subfamily E member 4
- Protein Accession:
- Q8WWG9
- B7Z275
- Q53SM4
- Q96CC4
Protein attributes for KCNE4 Gene
- Size:
- 221 amino acids
- Molecular mass:
- 23806 Da
- Quaternary structure:
-
- Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.
- SequenceCaution:
-
- Sequence=AAH14429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL49979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Post-translational modifications for KCNE4 Gene
Other Protein References for KCNE4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KCNE4
- Novus Biologicals Antibodies for KCNE4
- Invitrogen Antibodies for KCNE4
- GeneTex Kcne4 Antibody for KCNE4
Protein Products
-
OriGene Purified Proteins for KCNE4
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNE4
- Origene Custom Protein Services for KCNE4
- antibodies-online: Search results for 5 available KCNE4 Proteins ranked by validation data
- Compare Top KCNE4 Proteins
-
Quality Products:
- Search GeneTex for Proteins for KCNE4
-
Abcam proteins for KCNE4
Assay Products
No data available for DME Specific Peptides for KCNE4 Gene
Domains & Families for KCNE4 Gene
Gene Families for KCNE4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for KCNE4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KCNE4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WWG9- Family:
-
- Belongs to the potassium channel KCNE family.
Function for KCNE4 Gene
Molecular function for KCNE4 Gene
- UniProtKB/Swiss-Prot Function:
- Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.
Phenotypes From GWAS Catalog for KCNE4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005249 | voltage-gated potassium channel activity | IEA | -- |
| GO:0005267 | potassium channel activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 19687231 |
| GO:0044325 | ion channel binding | IPI | 19687231 |
Phenotypes for KCNE4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for KCNE4
- Cyagen custom Knockout/knockin (KOKI) mouse models for KCNE4
-
CRISPR Products
-
OriGene CRISPR knockouts for KCNE4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNE4
- genomics-online: gRNA clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
- Applied Biological Materials CRISPR for KCNE4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNE4
miRNA for KCNE4 Gene
- miRTarBase miRNAs that target KCNE4
-
- hsa-mir-6776-5p (MIRT628854)
- hsa-mir-6514-3p (MIRT628855)
- hsa-mir-7977 (MIRT628856)
- hsa-mir-143-5p (MIRT628857)
- hsa-mir-24-3p (MIRT628858)
- hsa-mir-4284 (MIRT628859)
- hsa-mir-4743-5p (MIRT628860)
- hsa-mir-6847-3p (MIRT628861)
- hsa-mir-6811-3p (MIRT628862)
- hsa-mir-214-5p (MIRT628863)
- hsa-mir-6499-3p (MIRT628864)
- hsa-mir-5693 (MIRT628865)
- hsa-mir-3677-5p (MIRT628866)
- hsa-mir-4796-3p (MIRT628867)
- hsa-mir-548t-5p (MIRT628868)
- hsa-mir-548az-5p (MIRT628869)
- hsa-mir-4668-5p (MIRT670795)
- hsa-mir-4743-3p (MIRT681714)
- hsa-mir-6888-3p (MIRT681715)
- hsa-mir-550a-3p (MIRT681716)
- hsa-mir-200c-5p (MIRT681717)
- hsa-mir-196a-3p (MIRT681718)
- hsa-mir-661 (MIRT681719)
- hsa-mir-302a-5p (MIRT681720)
- hsa-mir-3120-5p (MIRT681721)
- hsa-mir-6860 (MIRT681722)
- hsa-mir-612 (MIRT681723)
- hsa-mir-5189-5p (MIRT681724)
- hsa-mir-3187-5p (MIRT681725)
- hsa-mir-1285-3p (MIRT681726)
- hsa-mir-939-3p (MIRT681727)
- hsa-mir-4778-5p (MIRT681728)
- hsa-mir-3689d (MIRT767073)
- hsa-mir-377-5p (MIRT767414)
- hsa-mir-4459 (MIRT769288)
- hsa-mir-455-3p (MIRT770344)
- hsa-mir-548c-3p (MIRT774315)
- hsa-mir-6086 (MIRT775545)
- hsa-mir-6134 (MIRT775947)
- hsa-mir-6516-5p (MIRT777142)
- hsa-mir-665 (MIRT777565)
- hsa-mir-6807-5p (MIRT779582)
- hsa-mir-6825-3p (MIRT779887)
- hsa-mir-6840-3p (MIRT780140)
- hsa-mir-6851-5p (MIRT780411)
- hsa-mir-6880-5p (MIRT780834)
- hsa-mir-7847-3p (MIRT782150)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KCNE4
- Browse OriGene Inhibitory RNA Products For KCNE4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNE4
- genomics-online: shRNA clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KCNE4
- VectorBuilder custom plasmid, inducible vectors for KCNE4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNE4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNE4
- Applied Biological Materials Clones for KCNE4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KCNE4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNE4 Gene
Localization for KCNE4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNE4 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| nucleus | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Microtubules (2)
- Nuclear bodies (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016324 | apical plasma membrane | IEA | -- |
Pathways & Interactions for KCNE4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cardiac conduction | ||
| 2 | Antiarrhythmic Pathway, Pharmacodynamics | ||
| 3 | Dopamine-DARPP32 Feedback onto cAMP Pathway | ||
| 4 | Phase 0 - rapid depolarisation | ||
Pathways by source for KCNE4 Gene
4 Reactome pathways for KCNE4 Gene
1 PharmGKB pathway for KCNE4 Gene
1 Qiagen pathway for KCNE4 Gene
Interacting Proteins for KCNE4 Gene
GPS-Prot Interaction Network for KCNE4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | IEA | -- |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
| GO:0071805 | potassium ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for KCNE4 Gene
Drugs & Compounds for KCNE4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Chromanol 293B | Pharma | Antagonist, Pore Blocker | IKs blocker. Also blocks ICFTR | 0 | ||
| Flupirtine maleate | Pharma | KV7 channel activator | 0 | |||
| Kaliotoxin | Pharma | KV and KCa blocker | 0 | |||
| MaxiPost | Pharma | Potassium channel modulator; exerts subtype-specific effects | 0 |
(4) Tocris Compounds for KCNE4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Chromanol 293B | IKs blocker. Also blocks ICFTR | 163163-23-3 |
| Flupirtine maleate | KV7 channel activator | 75507-68-5 |
| Kaliotoxin | KV and KCa blocker | 145199-73-1 |
| MaxiPost | Potassium channel modulator; exerts subtype-specific effects | 187523-35-9 |
Drug Products
Transcripts for KCNE4 Gene
mRNA/cDNA for KCNE4 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (50) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000281830 3291 bps (uc002vnl.7)
- ENST00000488477 908 bps (uc061tbx.1)
Unigene Clusters for KCNE4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNE4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNE4
- genomics-online: gRNA clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
- Applied Biological Materials CRISPR for KCNE4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNE4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KCNE4
- Browse OriGene Inhibitory RNA Products For KCNE4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNE4
- genomics-online: shRNA clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KCNE4
- VectorBuilder custom plasmid, inducible vectors for KCNE4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNE4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNE4
- Applied Biological Materials Clones for KCNE4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KCNE4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for KCNE4 Gene
This gene is overexpressed in Artery - Tibial (x4.4).
NURSA nuclear receptor signaling pathways regulating expression of KCNE4 Gene:
KCNE4SOURCE GeneReport for Unigene cluster for KCNE4 Gene:
Hs.348522mRNA Expression by UniProt/SwissProt for KCNE4 Gene:
Q8WWG9-KCNE4_HUMAN
Tissue specificity:
Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.
Evidence on tissue expression from TISSUES for KCNE4 Gene
- Heart(4.3)
- Nervous system(4.2)
- Kidney(4.1)
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for KCNE4
-
OriGene qPCR primer pairs for KCNE4
- genomics-online: primer clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNE4 Gene
Orthologs for KCNE4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNE4 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KCNE4 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Kcne4 33 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNE4 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Kcne4 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNE4 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNE4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KCNE4 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KCNE4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcne4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kcne4 34 33 |
|
OneToOne |
- Species where no ortholog for KCNE4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for KCNE4 Gene
- ENSEMBL:
- Gene Tree for KCNE4 (if available)
- TreeFam:
- Gene Tree for KCNE4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KCNE4: view image
Paralogs for KCNE4 Gene
(1) SIMAP similar genes for KCNE4 Gene using alignment to 3 proteins:
- KCNE4_HUMAN
- A5H1P5_HUMAN
- Q2N1I0_HUMAN
No data available for Paralogs for KCNE4 Gene
Variants for KCNE4 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000635482 | -- | 223,050,156(+) | T/G | upstream_transcript_variant | |
| rs1000677361 | -- | 223,055,934(+) | T/A | downstream_transcript_variant | |
| rs1001869033 | -- | 223,055,892(+) | T/A | downstream_transcript_variant | |
| rs1002253333 | -- | 223,054,124(+) | T/C | 3_prime_UTR_variant | |
| rs1002387602 | -- | 223,055,834(+) | G/T | downstream_transcript_variant |
Residual Variation Intolerance Score:
47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.05;
21.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KCNE4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCNE4 Gene
Disorders for KCNE4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypokalemic periodic paralysis, type 1 |
|
|
Search KCNE4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KCNE4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNE4 Gene
Publications for KCNE4 Gene
- Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits. (PMID: 19687231) Vanoye CG … George AL (The Journal of general physiology 2009) 3 4 22 58
- Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka DC … Mohlke KL (Obesity (Silver Spring, Md.) 2011) 3 44 58
- Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting. (PMID: 20533308) Roura-Ferrer M … Felipe A (Journal of cellular physiology 2010) 3 4 58
- Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Treviño LR … Relling MV (Nature genetics 2009) 3 44 58
- KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating. (PMID: 19773357) Solé L … Felipe A (Journal of cell science 2009) 3 22 58
Products for KCNE4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for KCNE4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for KCNE4
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNE4
- Origene Custom Protein Services for KCNE4
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KCNE4
- Browse OriGene Inhibitory RNA Products For KCNE4
- OriGene qPCR primer pairs and template standards for KCNE4
- OriGene qPCR primer pairs for KCNE4
- OriGene CRISPR knockouts for KCNE4
- OriGene ORF clones in human for KCNE4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KCNE4
- GenScript: Next-day shipping of latest version cDNA ORF clones for KCNE4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for KCNE4
- GenScript Custom Assay Services for KCNE4
- GenScript Custom overexpressing Cell Line Services for KCNE4
- Browse GenScript CRISPR for KCNE4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for KCNE4
- Sino Biological Human cDNA Clone for KCNE4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for KCNE4
- Novus Biologicals lysates and proteins for KCNE4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for KCNE4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for KCNE4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for KCNE4
- Cyagen custom Knockout/knockin (KOKI) mouse models for KCNE4
- VectorBuilder custom plasmid, inducible vectors for KCNE4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNE4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 44 available KCNE4 Antibodies ranked by validation data
- Compare Top KCNE4 Antibodies
- antibodies-online: Search results for available KCNE4 related products ranked by validation data
- antibodies-online: Search results for 5 available KCNE4 Proteins ranked by validation data
- Compare Top KCNE4 Proteins
- Quality Products:
- GeneTex Kcne4 Antibody for KCNE4
- Search GeneTex for Proteins for KCNE4
- Horizon Cell Lines for KCNE4
- genomics-online: cdna clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
- orf clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
- genomics-online: gRNA clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
- genomics-online: primer clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
- genomics-online: shRNA clones - Search results for 95 available KCNE4 gene related products
- Overview of 95 available KCNE4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNE4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNE4
- GeneCopoeia miRNA 3'UTR Target clone products for KCNE4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNE4
Sources for KCNE4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt