Aliases for KCNE3 Gene
- Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 3 2 3 5
- Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 3 2 3
- Potassium Voltage-Gated Channel, Isk-Related Family, Member 3 2 3
- Potassium Voltage-Gated Channel Subfamily E Member 3 3 4
- Minimum Potassium Ion Channel-Related Peptide 2 3 4
- Potassium Channel Subunit Beta MiRP2 3 4
External Ids for KCNE3 Gene
Previous GeneCards Identifiers for KCNE3 Gene
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNE3 Gene
KCNE3 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 3) is a Protein Coding gene. Diseases associated with KCNE3 include Brugada Syndrome 6 and Brugada Syndrome. Among its related pathways are Cardiac conduction and Dopamine-DARPP32 Feedback onto cAMP Pathway. Gene Ontology (GO) annotations related to this gene include voltage-gated potassium channel activity and potassium channel regulator activity. An important paralog of this gene is KCNE5.
UniProtKB/Swiss-Prot Summary for KCNE3 Gene
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.