Aliases for KCNE2 Gene
- Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 2 2 3 5
- Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 2 2 3
- Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 2 3
- Potassium Voltage-Gated Channel Subfamily E Member 2 3 4
- Minimum Potassium Ion Channel-Related Peptide 1 3 4
- Potassium Channel Subunit Beta MiRP1 3 4
- Cardiac Voltage-Gated Potassium Channel Accessory Subunit 2 3
External Ids for KCNE2 Gene
Previous GeneCards Identifiers for KCNE2 Gene
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNE2 Gene
KCNE2 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 2) is a Protein Coding gene. Diseases associated with KCNE2 include Long Qt Syndrome 6 and Atrial Fibrillation, Familial, 4. Among its related pathways are Salivary secretion and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNE1.
UniProtKB/Swiss-Prot Summary for KCNE2 Gene
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.