Aliases for KCNE1 Gene
- Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1 2 3 5
- Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 1 2 3
- IKs Producing Slow Voltage-Gated Potassium Channel Subunit Beta Mink 3 4
- Potassium Voltage-Gated Channel, Isk-Related Family, Member 1 2 3
- Potassium Voltage-Gated Channel Subfamily E Member 1 3 4
- Delayed Rectifier Potassium Channel Subunit IsK 3 4
- Minimal Potassium Channel 3 4
- Long QT Syndrome 5 2 3
- JLNS2 2 3
- LQT5 2 3
External Ids for KCNE1 Gene
Previous GeneCards Identifiers for KCNE1 Gene
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNE1 Gene
KCNE1 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1) is a Protein Coding gene. Diseases associated with KCNE1 include Jervell And Lange-Nielsen Syndrome 2 and Long Qt Syndrome 5. Among its related pathways are Cardiac conduction and Phase 0 - rapid depolarisation. Gene Ontology (GO) annotations related to this gene include voltage-gated potassium channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNE1B.
UniProtKB/Swiss-Prot Summary for KCNE1 Gene
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.