Aliases for KCNAB1 Gene
- Potassium Voltage-Gated Channel Subfamily A Member Regulatory Beta Subunit 1 2 3 5
- Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Beta Member 1 2 3
- Voltage-Gated Potassium Channel Subunit Beta-1 3 4
- K(+) Channel Subunit Beta-1 3 4
- K+ Channel Beta1a Chain 2 3
- KCNA1B 3 4
- Potassium Channel, Voltage Gated Subfamily A Regulatory Beta Subunit 1 3
- Potassium Channel Shaker Chain Beta 1a 3
External Ids for KCNAB1 Gene
Previous GeneCards Identifiers for KCNAB1 Gene
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]
GeneCards Summary for KCNAB1 Gene
KCNAB1 (Potassium Voltage-Gated Channel Subfamily A Member Regulatory Beta Subunit 1) is a Protein Coding gene. Diseases associated with KCNAB1 include Episodic Ataxia, Type 1 and Episodic Ataxia. Among its related pathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include voltage-gated potassium channel activity and NADPH binding. An important paralog of this gene is KCNAB2.
UniProtKB/Swiss-Prot Summary for KCNAB1 Gene
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.