Free for academic non-profit institutions. Other users need a Commercial license
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]
KCNA7 (Potassium Voltage-Gated Channel Subfamily A Member 7) is a Protein Coding gene. Diseases associated with KCNA7 include Progressive Familial Heart Block and Photosensitive Epilepsy. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA6.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005216 | ion channel activity | IEA | -- |
GO:0005244 | voltage-gated ion channel activity | IEA | -- |
GO:0005249 | voltage-gated potassium channel activity | IBA | 21873635 |
GO:0005251 | delayed rectifier potassium channel activity | IBA | 21873635 |
GO:0005267 | potassium channel activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0008076 | voltage-gated potassium channel complex | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Potassium Channels | ||
2 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Dopamine-DARPP32 Feedback onto cAMP Pathway
-
|
|
3 | Transmission across Chemical Synapses |
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006813 | potassium ion transport | IEA | -- |
GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
GO:0051260 | protein homooligomerization | IEA | -- |
GO:0055085 | transmembrane transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Amiodarone | Approved, Investigational | Pharma | Pore Blocker, blocker | 138 | ||
Flecainide | Approved, Withdrawn | Pharma | Pore Blocker, blocker | 50 | ||
Quinidine | Approved, Investigational | Pharma | Pore Blocker, Inhibitor, Inhibition, blocker | 57 | ||
Verapamil | Approved | Pharma | Channel blocker, Pore Blocker, Inhibitor, Inhibition, blocker | 134 | ||
4-Aminopyridine | Approved | Pharma | Pore Blocker, Inhibitor, Antagonist, Target, antagonist | potassium channel-blocking agent | 60 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Kaliotoxin |
|
145199-73-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
Chromanol 293B | IKs blocker. Also blocks ICFTR | 163163-23-3 |
Flupirtine maleate | KV7 channel activator | 75507-68-5 |
Kaliotoxin | KV and KCa blocker | 145199-73-1 |
MaxiPost | Potassium channel modulator; exerts subtype-specific effects | 187523-35-9 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KCNA7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KCNA7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KCNA7 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Kcna7 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Kcna7 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | KCNA7 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | KCNA7 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | KCNA7 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Sh 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | Y55F3C.3 32 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
progressive familial heart block |
|
|
photosensitive epilepsy |
|
|