Free for academic non-profit institutions. Other users need a Commercial license
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - ... See more...
Aliases for KCNA7 Gene
Aliases for KCNA7 Gene
External Ids for KCNA7 Gene
- HGNC: 6226
- Entrez Gene: 3743
- Ensembl: ENSG00000104848
- OMIM: 176268
- UniProtKB: Q96RP8
Previous GeneCards Identifiers for KCNA7 Gene
- GC19M050228
- GC19M049938
- GC19M054246
- GC19M054262
- GC19M049570
- GC19M045947
Summaries for KCNA7 Gene
-
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNA7 Gene
KCNA7 (Potassium Voltage-Gated Channel Subfamily A Member 7) is a Protein Coding gene. Diseases associated with KCNA7 include Progressive Familial Heart Block and Photosensitive Epilepsy. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNA6.
UniProtKB/Swiss-Prot Summary for KCNA7 Gene
-
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).
-
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.
Additional gene information for KCNA7 Gene
- HGNC(6226)
- Entrez Gene(3743)
- Ensembl(ENSG00000104848)
- OMIM(176268)
- UniProtKB(Q96RP8)
- Open Targets Platform(ENSG00000104848)
- Search for KCNA7 at DataMed
- Search for KCNA7 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNA7 Gene
Genomics for KCNA7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KCNA7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KCNA7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNA7
- Top Transcription factor binding sites by QIAGEN in the KCNA7 gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- Evi-1
- NF-Y
- NF-YA
- NF-YB
- p53
- SREBP-1a
Genomic Locations for KCNA7 Gene
Genomic Locations for KCNA7 Gene
- chr19:49,067,418-49,072,941
- (GRCh38/hg38)
- Size:
- 5,524 bases
- Orientation:
- Minus strand
- chr19:49,570,675-49,576,198
- (GRCh37/hg19)
- Size:
- 5,524 bases
- Orientation:
- Minus strand
Genomic View for KCNA7 Gene
Genes around KCNA7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
KCNA7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNA7 Gene
Proteins for KCNA7 Gene
-
Protein details for KCNA7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RP8-KCNA7_HUMAN
- Recommended name:
- Potassium voltage-gated channel subfamily A member 7
- Protein Accession:
- Q96RP8
- A1KYX7
- Q9BYS4
Protein attributes for KCNA7 Gene
- Size:
- 456 amino acids
- Molecular mass:
- 50559 Da
- Quaternary structure:
-
- Heterotetramer of potassium channel proteins.
Post-translational modifications for KCNA7 Gene
Other Protein References for KCNA7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences KCNA7 / Kv1.7 Antibody
- Creative Diagnostics Anti-KCNA7 (C-terminal) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for KCNA7
- Novus Biologicals Antibodies for KCNA7
- Invitrogen Antibodies for KCNA7 (AFLGC-KCNA7)
Protein Products
-
OriGene Purified Proteins for KCNA7
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNA7
- Origene Custom Protein Services for KCNA7
- Novus Biologicals lysates for KCNA7
No data available for DME Specific Peptides for KCNA7 Gene
Domains & Families for KCNA7 Gene
Gene Families for KCNA7 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted membrane proteins
- Voltage-gated ion channels
Protein Domains for KCNA7 Gene
- InterPro:
- Blocks:
-
- BTB/POZ domain
- Potassium channel signature
- Skaker voltage-gated K+ channel family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for KCNA7 Gene
- GenScript: Design optimal peptide antigens:
-
- Potassium voltage-gated channel, shaker-related subfamily, member 7 (B2RU13_HUMAN)
- Voltage-gated potassium channel subunit Kv1.7 (KCNA7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96RP8UniProtKB/Swiss-Prot:
KCNA7_HUMAN :- The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
- Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.
- Domain:
-
- The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
- The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
- Family:
-
- Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.
Function for KCNA7 Gene
Molecular function for KCNA7 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).
- GENATLAS Biochemistry:
- potassium voltage-gated channel,Drosophila shaker-related subfamily,member 7 (mouse Kv1.7 homolog),expressed in heart,skeletal muscle and pancreatic islet cells
Phenotypes From GWAS Catalog for KCNA7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005249 | voltage-gated potassium channel activity | IBA | 21873635 |
| GO:0005251 | delayed rectifier potassium channel activity | IBA | 21873635 |
| GO:0005267 | potassium channel activity | IEA | -- |
Phenotypes for KCNA7 Gene
- GenomeRNAi human phenotypes for KCNA7:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased viability in colon lineage
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
Animal Model Products
-
Taconic Biosciences Mouse Models for KCNA7
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KCNA7 - Select products 50% OFF >
- * KCNA7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KCNA7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNA7
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNA7
miRNA for KCNA7 Gene
- miRTarBase miRNAs that target KCNA7
-
- hsa-miR-6855-5p (MIRT519403)
- hsa-miR-3170 (MIRT519404)
- hsa-miR-6807-5p (MIRT519405)
- hsa-miR-7151-3p (MIRT519406)
- hsa-miR-5095 (MIRT519407)
- hsa-miR-193b-5p (MIRT519408)
- hsa-miR-5589-5p (MIRT519409)
- hsa-miR-4731-5p (MIRT519410)
- hsa-miR-627-3p (MIRT519411)
- hsa-miR-7155-5p (MIRT519412)
- hsa-miR-1292-3p (MIRT519413)
- hsa-miR-512-3p (MIRT519414)
- hsa-miR-4438 (MIRT519415)
- hsa-miR-520e (MIRT519416)
- hsa-miR-520d-3p (MIRT519417)
- hsa-miR-520c-3p (MIRT519418)
- hsa-miR-520b (MIRT519419)
- hsa-miR-520a-3p (MIRT519420)
- hsa-miR-373-3p (MIRT519421)
- hsa-miR-372-3p (MIRT519422)
- hsa-miR-302e (MIRT519423)
- hsa-miR-302d-3p (MIRT519424)
- hsa-miR-302c-3p (MIRT519425)
- hsa-miR-302b-3p (MIRT519426)
- hsa-miR-302a-3p (MIRT519427)
- hsa-miR-93-5p (MIRT519428)
- hsa-miR-526b-3p (MIRT519429)
- hsa-miR-519d-3p (MIRT519430)
- hsa-miR-20b-5p (MIRT519431)
- hsa-miR-20a-5p (MIRT519432)
- hsa-miR-17-5p (MIRT519433)
- hsa-miR-106b-5p (MIRT519434)
- hsa-miR-106a-5p (MIRT519435)
- hsa-miR-520h (MIRT540920)
- hsa-miR-520g-3p (MIRT540921)
- hsa-miR-5698 (MIRT686053)
- hsa-miR-744-3p (MIRT686054)
- hsa-miR-642a-5p (MIRT686055)
- hsa-miR-4423-5p (MIRT686056)
- hsa-miR-6501-5p (MIRT686057)
- hsa-miR-143-5p (MIRT686058)
- hsa-miR-4430 (MIRT686059)
- hsa-miR-3652 (MIRT686060)
- hsa-miR-122-5p (MIRT686061)
- hsa-miR-504-3p (MIRT686062)
- hsa-miR-3135b (MIRT686063)
- hsa-miR-6499-3p (MIRT686064)
- hsa-miR-367-5p (MIRT686065)
- hsa-miR-1267 (MIRT686066)
- hsa-miR-4469 (MIRT686067)
- hsa-miR-2276-5p (MIRT686068)
- hsa-miR-6892-3p (MIRT686069)
- hsa-miR-2681-3p (MIRT686070)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KCNA7
- Browse OriGene Inhibitory RNA Products For KCNA7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA7
Clone Products
- Applied Biological Materials (abm): Clones for KCNA7 - Select products 50% OFF >
- * KCNA7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for KCNA7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNA7
Cell Line Products
-
Horizon Cell Lines for KCNA7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNA7 Gene
Localization for KCNA7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNA7 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008076 | voltage-gated potassium channel complex | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNA7 Gene
Pathways & Interactions for KCNA7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Potassium Channels | ||
| 2 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Dopamine-DARPP32 Feedback onto cAMP Pathway
-
|
|
| 3 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for KCNA7 Gene
3 Reactome pathways for KCNA7 Gene
1 Qiagen pathway for KCNA7 Gene
- Dopamine-DARPP32 Feedback onto cAMP Pathway
Interacting Proteins for KCNA7 Gene
GPS-Prot Interaction Network for KCNA7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | IEA | -- |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
| GO:0051260 | protein homooligomerization | IEA | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for KCNA7 Gene
Drugs & Compounds for KCNA7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Amiodarone | Approved, Investigational | Pharma | Pore Blocker, blocker | 138 | ||
| Flecainide | Approved, Withdrawn | Pharma | Pore Blocker, blocker | 50 | ||
| Quinidine | Approved, Investigational | Pharma | Pore Blocker, Inhibitor, Inhibition, blocker | 57 | ||
| Verapamil | Approved | Pharma | Channel blocker, Pore Blocker, Inhibitor, Inhibition, blocker | 134 | ||
| 4-Aminopyridine | Approved | Pharma | Pore Blocker, Inhibitor, Antagonist, Target, antagonist | potassium channel-blocking agent | 60 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Kaliotoxin |
|
145199-73-1 |
|
|
(4) Tocris Compounds for KCNA7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Chromanol 293B | IKs blocker. Also blocks ICFTR | 163163-23-3 |
| Flupirtine maleate | KV7 channel activator | 75507-68-5 |
| Kaliotoxin | KV and KCa blocker | 145199-73-1 |
| MaxiPost | Potassium channel modulator; exerts subtype-specific effects | 187523-35-9 |
Transcripts for KCNA7 Gene
mRNA/cDNA for KCNA7 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000221444 4372 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KCNA7 - Select products 50% OFF >
- * KCNA7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KCNA7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNA7
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNA7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KCNA7
- Browse OriGene Inhibitory RNA Products For KCNA7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA7
Clone Products
- Applied Biological Materials (abm): Clones for KCNA7 - Select products 50% OFF >
- * KCNA7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for KCNA7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNA7
Relevant External Links for KCNA7 Gene
- GeneLoc Exon Structure for
- KCNA7
Expression for KCNA7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for KCNA7 Gene
This gene is overexpressed in Muscle - Skeletal (x46.6).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNA7
SOURCE GeneReport for Unigene cluster for KCNA7 Gene:
Hs.306973mRNA Expression by UniProt/SwissProt for KCNA7 Gene:
Q96RP8-KCNA7_HUMAN
Tissue specificity:
Highly expressed in skeletal muscle, heart and kidney.
Evidence on tissue expression from TISSUES for KCNA7 Gene
- Muscle(4.5)
- Heart(4.3)
Primer Products
-
OriGene qPCR primer pairs for KCNA7
-
OriGene qPCR primer pairs and template standards for KCNA7
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNA7 Gene
Orthologs for KCNA7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KCNA7 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KCNA7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KCNA7 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Kcna7 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Kcna7 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | KCNA7 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | KCNA7 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | KCNA7 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Sh 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | Y55F3C.3 32 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for KCNA7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for KCNA7 Gene
- ENSEMBL:
- Gene Tree for KCNA7 (if available)
- TreeFam:
- Gene Tree for KCNA7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KCNA7: view image
Paralogs for KCNA7 Gene
Paralogs for KCNA7 Gene
(19) SIMAP similar genes for KCNA7 Gene using alignment to 2 proteins:
- KCNA7_HUMAN
- B2RU13_HUMAN
Variants for KCNA7 Gene
Residual Variation Intolerance Score:
15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.93;
97.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KCNA7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KCNA7
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNA7 Gene
Disorders for KCNA7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| progressive familial heart block |
|
|
| photosensitive epilepsy |
|
|
Search KCNA7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KCNA7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNA7 Gene
Publications for KCNA7 Gene
- Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). (PMID: 11896454) Bardien-Kruger S … Corfield V (European journal of human genetics : EJHG 2002) 3 4 23
- Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. (PMID: 11368907) Kashuba VI … Zabarovsky ER (Gene 2001) 3 4 23
- International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman GA … Wang X (Pharmacological reviews 2005) 2 3
- [Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China]. (PMID: 15639836) Ding Q … Guo L (Yi chuan = Hereditas 2003) 3 41
- Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. (PMID: 9488722) Kalman K … Chandy KG (The Journal of biological chemistry 1998) 3 23
ExternalLinks
Products for KCNA7 Gene
- Custom Antibody ServicesOriGene Antibodies for KCNA7
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for KCNA7
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNA7
- Origene Custom Protein Services for KCNA7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KCNA7
- Browse OriGene Inhibitory RNA Products For KCNA7
- OriGene qPCR primer pairs for KCNA7
- OriGene qPCR primer pairs and template standards for KCNA7
- OriGene CRISPR knockouts for KCNA7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KCNA7
- Sino Biological Human cDNA Clone for KCNA7
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for KCNA7
- Novus Biologicals lysates for KCNA7
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for KCNA7
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for KCNA7 (AFLGC-KCNA7)
- VectorBuilder Custom and pre-made DNA vectors for KCNA7 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for KCNA7 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for KCNA7 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for KCNA7 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for KCNA7
- antibodies-online: Show 6 available KCNA7 Antibodies ranked by validation data
- Compare Top KCNA7 Antibodies
- antibodies-online: Search results for available KCNA7 related products ranked by validation data
- antibodies-online: Search results for available KCNA7 related products ranked by validation data
- Horizon Cell Lines for KCNA7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNA7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNA7
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KCNA7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA7
Sources for KCNA7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB