Aliases for KCNA5 Gene
- Potassium Voltage-Gated Channel Subfamily A Member 5 2 3 4 5
- Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 2 3
- Voltage-Gated Potassium Channel Subunit Kv1.5 3 4
- Voltage-Gated Potassium Channel HK2 3 4
- HPCN1 3 4
- Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 5 3
- Voltage-Gated Potassium Channel Protein Kv1.5 3
- Insulinoma And Islet Potassium Channel 3
External Ids for KCNA5 Gene
Previous GeneCards Identifiers for KCNA5 Gene
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
GeneCards Summary for KCNA5 Gene
KCNA5 (Potassium Voltage-Gated Channel Subfamily A Member 5) is a Protein Coding gene. Diseases associated with KCNA5 include Atrial Fibrillation, Familial, 7 and Familial Atrial Fibrillation. Among its related pathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Antiarrhythmic Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ion channel activity. An important paralog of this gene is KCNA3.
UniProtKB/Swiss-Prot for KCNA5 Gene
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.