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Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
KCNA5 (Potassium Voltage-Gated Channel Subfamily A Member 5) is a Protein Coding gene. Diseases associated with KCNA5 include Atrial Fibrillation, Familial, 7 and Familial Atrial Fibrillation. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ion channel activity. An important paralog of this gene is KCNA2.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005216 | ion channel activity | IEA | -- |
GO:0005244 | voltage-gated ion channel activity | IEA | -- |
GO:0005249 | voltage-gated potassium channel activity | IBA | 21873635 |
GO:0005251 | delayed rectifier potassium channel activity | IEA,IMP | 19343045 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005794 | Golgi apparatus | IEA,HDA | 16780588 |
GO:0005886 | plasma membrane | IDA,TAS | -- |
GO:0005887 | integral component of plasma membrane | IEA,IDA | 12130714 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Potassium Channels | ||
2 | Antiarrhythmic Pathway, Pharmacodynamics | ||
3 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Dopamine-DARPP32 Feedback onto cAMP Pathway
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4 | Transmission across Chemical Synapses |
.62
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEA | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0006813 | potassium ion transport | IDA | 8576199 |
GO:0007219 | Notch signaling pathway | IEA | -- |
GO:0009612 | response to mechanical stimulus | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bupivacaine | Approved, Investigational | Pharma | Pore Blocker, blocker | 2037 | ||
Flecainide | Approved, Withdrawn | Pharma | Pore Blocker, blocker | 50 | ||
Nifedipine | Approved | Pharma | Channel blocker, Gating inhibitor, Antagonist, Pore Blocker, Agonist, Activator, blocker | 148 | ||
Propafenone | Approved | Pharma | Pore Blocker, blocker | 37 | ||
Quinidine | Approved, Investigational | Pharma | Pore Blocker, Inhibitor, Inhibition, blocker | 57 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Kaliotoxin |
|
145199-73-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
Chromanol 293B | IKs blocker. Also blocks ICFTR | 163163-23-3 |
Flupirtine maleate | KV7 channel activator | 75507-68-5 |
Kaliotoxin | KV and KCa blocker | 145199-73-1 |
MaxiPost | Potassium channel modulator; exerts subtype-specific effects | 187523-35-9 |
Compound | Action | Cas Number |
---|---|---|
Gliquidone | 33342-05-1 | |
Tolbutamide | CAMP inhibitor | 64-77-7 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KCNA5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KCNA5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KCNA5 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Mouse (Mus musculus) |
Mammalia | Kcna5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Kcna5 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | KCNA5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | KCNA5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | KCNA5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kcna5 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100004160 30 |
|
||
CABZ01083827.1 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Sh 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | Y55F3C.3 32 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
469582 | Benign: Atrial fibrillation, familial, 7 | 5,045,296(+) | TG/CA | MISSENSE_VARIANT | |
638821 | Uncertain Significance: Atrial fibrillation, familial, 7 | 5,044,853(+) | G/A | MISSENSE_VARIANT | |
640925 | Uncertain Significance: Atrial fibrillation, familial, 7 | 5,044,335(+) | G/T | MISSENSE_VARIANT | |
648351 | Uncertain Significance: Atrial fibrillation, familial, 7 | 5,045,849(+) | G/T | MISSENSE_VARIANT | |
653091 | Uncertain Significance: Atrial fibrillation, familial, 7 | 5,044,377(+) | C/G | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
atrial fibrillation, familial, 7 |
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familial atrial fibrillation |
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atrial fibrillation |
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insulinoma |
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pulmonary hypertension |
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