Free for academic non-profit institutions. Other users need a Commercial license
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - ... See more...
Aliases for KCNA3 Gene
Aliases for KCNA3 Gene
- Potassium Voltage-Gated Channel Subfamily A Member 3 2 3 4 5
- Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 2 3
- Voltage-Gated Potassium Channel Subunit Kv1.3 3 4
- Voltage-Gated K(+) Channel HuKIII 3 4
- HPCN3 3 4
- HGK5 3 4
- HLK3 3 4
- Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 3 3
External Ids for KCNA3 Gene
- HGNC: 6221
- Entrez Gene: 3738
- Ensembl: ENSG00000177272
- OMIM: 176263
- UniProtKB: P22001
Previous GeneCards Identifiers for KCNA3 Gene
- GC01M111630
- GC01M110080
- GC01M110316
- GC01M110513
- GC01M110926
- GC01M111015
- GC01M111214
- GC01M109085
Summaries for KCNA3 Gene
-
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNA3 Gene
KCNA3 (Potassium Voltage-Gated Channel Subfamily A Member 3) is a Protein Coding gene. Diseases associated with KCNA3 include Lymph Node Cancer and Autoimmune Pancreatitis. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. Gene Ontology (GO) annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNA2.
UniProtKB/Swiss-Prot Summary for KCNA3 Gene
-
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
-
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNA3 Gene
Genomics for KCNA3 Gene
GeneHancer (GH) Regulatory Elements for KCNA3 Gene
Promoters and enhancers for KCNA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KCNA3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KCNA3 gene promoter:
-
- c-Ets-1
- E47
- FOXO4
- GATA-1
- Nkx2-5
- POU2F1
- POU2F1a
- PPAR-gamma1
- PPAR-gamma2
- STAT5B
Genomic Locations for KCNA3 Gene
Genomic Locations for KCNA3 Gene
- chr1:110,653,560-110,675,033
- (GRCh38/hg38)
- Size:
- 21,474 bases
- Orientation:
- Minus strand
- chr1:111,214,310-111,217,655
- (GRCh37/hg19)
- Size:
- 3,346 bases
- Orientation:
- Minus strand
Genomic View for KCNA3 Gene
Genes around KCNA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
KCNA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNA3 Gene
Proteins for KCNA3 Gene
-
Protein details for KCNA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22001-KCNA3_HUMAN
- Recommended name:
- Potassium voltage-gated channel subfamily A member 3
- Protein Accession:
- P22001
- Q5VWN2
Protein attributes for KCNA3 Gene
- Size:
- 575 amino acids
- Molecular mass:
- 63842 Da
- Quaternary structure:
-
- Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
- SequenceCaution:
-
- Sequence=AAA36425.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA36425.1; Type=Frameshift; Positions=42; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAB88073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Protein Expression for KCNA3 Gene
Post-translational modifications for KCNA3 Gene
Other Protein References for KCNA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-KCNA3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for KCNA3
- Novus Biologicals Antibodies for KCNA3
-
Abcam antibodies for KCNA3
- Invitrogen Antibodies for KCNA3 (AFLGC-KCNA3)
-
Boster Bio Antibodies for KCNA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for KCNA3
Protein Products
- Atlas Antibodies PrEST Antigen KCNA3
- Creative Biomart Recombinant Human KCNA3
-
OriGene Purified Proteins for KCNA3
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNA3
- Origene Custom Protein Services for KCNA3
- antibodies-online: Show 5 available KCNA3 Proteins ranked by validation data
- Compare Top KCNA3 Proteins
-
Quality Products:
-
Abcam proteins for KCNA3
No data available for DME Specific Peptides for KCNA3 Gene
Domains & Families for KCNA3 Gene
Gene Families for KCNA3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted membrane proteins
- Transporters
- Voltage-gated ion channels
Protein Domains for KCNA3 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KCNA3 Gene
- GenScript: Design optimal peptide antigens:
-
- Voltage-gated potassium channel subunit Kv1.3 (KCNA3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P22001UniProtKB/Swiss-Prot:
KCNA3_HUMAN :- The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
- Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
- Domain:
-
- The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
- The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
- Family:
-
- Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
Function for KCNA3 Gene
Molecular function for KCNA3 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
- GENATLAS Biochemistry:
- potassium voltage-gated channel,Drosophila shaker-related subfamily,member 3,T cell (mouse Kv1.3 homolog)
Phenotypes From GWAS Catalog for KCNA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005244 | voltage-gated ion channel activity | TAS | 1373731 |
| GO:0005249 | voltage-gated potassium channel activity | IBA | 21873635 |
| GO:0005251 | delayed rectifier potassium channel activity | IBA,IEA | 21873635 |
| GO:0005267 | potassium channel activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 18818304 |
Phenotypes for KCNA3 Gene
- MGI mutant phenotypes for KCNA3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KCNA3:
Animal Model Products
-
Taconic Biosciences Mouse Models for KCNA3
CRISPR Products
-
OriGene CRISPR knockouts for KCNA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNA3
- genomics-online: gRNA clones - Search for available KCNA3 gRNA products
- Overview of 99 available KCNA3 gene related products
- Applied Biological Materials (abm): CRISPR Clones for KCNA3 - Select products 50% OFF >
- * KCNA3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KCNA3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNA3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KCNA3
- Browse OriGene Inhibitory RNA Products For KCNA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA3
- genomics-online: shRNA clones - Search for available KCNA3 shRNA products
- Overview of 99 available KCNA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KCNA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNA3
- genomics-online: cdna clones - Search for available KCNA3 CDNA products
- Overview of 99 available KCNA3 gene related products
- orf clones - Search for available KCNA3 ORF products
- Overview of 99 available KCNA3 gene related products
- Applied Biological Materials (abm): Clones for KCNA3 - Select products 50% OFF >
- * KCNA3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KCNA3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for KCNA3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCNA3 Gene
Localization for KCNA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNA3 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0008076 | voltage-gated potassium channel complex | IBA,TAS | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNA3 Gene
Pathways & Interactions for KCNA3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Potassium Channels | ||
| 2 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Dopamine-DARPP32 Feedback onto cAMP Pathway
-
|
|
| 3 | Transmission across Chemical Synapses |
.62
|
|
| 4 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway | ||
Pathways by source for KCNA3 Gene
1 BioSystems pathway for KCNA3 Gene
3 Reactome pathways for KCNA3 Gene
1 Qiagen pathway for KCNA3 Gene
- Dopamine-DARPP32 Feedback onto cAMP Pathway
Interacting Proteins for KCNA3 Gene
Selected Interacting proteins:
P22001-KCNA3_HUMAN
ENSP00000358784
for KCNA3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for KCNA3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | TAS | 1373731 |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
| GO:0051260 | protein homooligomerization | IEA | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
Drugs & Compounds for KCNA3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Potassium | Approved, Experimental | Pharma | 0 | |||
| 4-Aminopyridine | Approved | Pharma | Pore Blocker, Inhibitor, Antagonist, Target, antagonist | potassium channel-blocking agent | 58 | |
| tetraethylammonium | Experimental, Investigational | Pharma | Inhibitor, Pore Blocker, Antagonist, Inhibition | 1 | ||
| Charybdotoxin | Pharma | Pore Blocker, Inhibitor, Inhibition, blocker | 0 | |||
| correolide | Pharma | Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| noxiustoxin |
|
Inhibitor |
|
|
(4) Tocris Compounds for KCNA3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Chromanol 293B | IKs blocker. Also blocks ICFTR | 163163-23-3 |
| Flupirtine maleate | KV7 channel activator | 75507-68-5 |
| Kaliotoxin | KV and KCa blocker | 145199-73-1 |
| MaxiPost | Potassium channel modulator; exerts subtype-specific effects | 187523-35-9 |
(3) ApexBio Compounds for KCNA3 Gene
Drug Products
- Atlas Antibodies PrEST Antigen KCNA3
- Creative Biomart Recombinant Human KCNA3
- ApexBio compounds for KCNA3
Transcripts for KCNA3 Gene
mRNA/cDNA for KCNA3 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369769 2476 bps (ENST00000369769.3)
CRISPR Products
-
OriGene CRISPR knockouts for KCNA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNA3
- genomics-online: gRNA clones - Search for available KCNA3 gRNA products
- Overview of 99 available KCNA3 gene related products
- Applied Biological Materials (abm): CRISPR Clones for KCNA3 - Select products 50% OFF >
- * KCNA3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KCNA3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNA3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KCNA3
- Browse OriGene Inhibitory RNA Products For KCNA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA3
- genomics-online: shRNA clones - Search for available KCNA3 shRNA products
- Overview of 99 available KCNA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KCNA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNA3
- genomics-online: cdna clones - Search for available KCNA3 CDNA products
- Overview of 99 available KCNA3 gene related products
- orf clones - Search for available KCNA3 ORF products
- Overview of 99 available KCNA3 gene related products
- Applied Biological Materials (abm): Clones for KCNA3 - Select products 50% OFF >
- * KCNA3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KCNA3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for KCNA3 Gene
mRNA differential expression in normal tissues according to GTEx for KCNA3 Gene
This gene is overexpressed in Whole Blood (x8.3).
This gene is overexpressed in Frontal cortex (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KCNA3 Gene
NURSA nuclear receptor signaling pathways regulating expression of KCNA3 Gene:
KCNA3SOURCE GeneReport for Unigene cluster for KCNA3 Gene:
Hs.169948Evidence on tissue expression from TISSUES for KCNA3 Gene
- Nervous system(4.6)
- Blood(4.5)
- Muscle(4.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for KCNA3
-
OriGene qPCR primer pairs and template standards for KCNA3
- genomics-online: primer clones - Search for available KCNA3 Primer products
- Overview of 99 available KCNA3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNA3 Gene
Orthologs for KCNA3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNA3 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KCNA3 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KCNA3 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Kcna3 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNA3 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Kcna3 17 33 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNA3 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CKV1.1 33 |
|
OneToOne | |
| KCNA3 32 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | KCNA3 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcna1 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | kcna3b-A-prov 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | KCNA3 (2 of 2) 33 |
|
OneToMany | |
| KCNA3 (1 of 2) 33 |
|
OneToMany | |||
| LOC100330283 32 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000254 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Sh 34 32 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | shk-1 32 |
|
||
| Y55F3C.3 34 |
|
|
- Species where no ortholog for KCNA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for KCNA3 Gene
- ENSEMBL:
- Gene Tree for KCNA3 (if available)
- TreeFam:
- Gene Tree for KCNA3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KCNA3: view image
Paralogs for KCNA3 Gene
Paralogs for KCNA3 Gene
(19) SIMAP similar genes for KCNA3 Gene using alignment to 1 proteins:
- KCNA3_HUMAN
Variants for KCNA3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1553187844 | uncertain-significance, not provided | 110,674,409(-) | T/C | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant | |
| rs1000190886 | -- | 110,662,037(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000230859 | -- | 110,675,666(-) | G/A | upstream_transcript_variant | |
| rs1000324636 | -- | 110,668,094(-) | C/A/G/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000512882 | -- | 110,663,300(-) | T/C | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1122384 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.70;
46.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KCNA3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNA3 Gene
Disorders for KCNA3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymph node cancer |
|
|
| autoimmune pancreatitis |
|
|
Search KCNA3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KCNA3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNA3 Gene
Publications for KCNA3 Gene
- A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. (PMID: 16317062) Tschritter O … Fritsche A (The Journal of clinical endocrinology and metabolism 2006) 3 23 43 56
- Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PMID: 7829094) Folander K … Swanson R (Genomics 1994) 3 4 23 56
- Effect of genetic variation in Kv1.3 on olfactory function. (PMID: 19489042) Guthoff M … Fritsche A (Diabetes/metabolism research and reviews 2009) 3 43 56
- Crystallization and preliminary X-ray diffraction studies of the tetramerization domain derived from the human potassium channel Kv1.3. (PMID: 19574640) Winklmeier A … Kremer W (Acta crystallographica. Section F, Structural biology and crystallization communications 2009) 3 23 56
- Methyl-beta-cyclodextrin reversibly alters the gating of lipid rafts-associated Kv1.3 channels in Jurkat T lymphocytes. (PMID: 17242956) Pottosin II … Dobrovinskaya OR (Pflugers Archiv : European journal of physiology 2007) 3 23 56
ExternalLinks
Products for KCNA3 Gene
- Custom Antibody ServicesOriGene Antibodies for KCNA3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for KCNA3
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNA3
- Origene Custom Protein Services for KCNA3
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KCNA3
- Browse OriGene Inhibitory RNA Products For KCNA3
- OriGene qPCR primer pairs for KCNA3
- OriGene qPCR primer pairs and template standards for KCNA3
- OriGene CRISPR knockouts for KCNA3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KCNA3
- Sino Biological Human cDNA Clone for KCNA3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for KCNA3
- Novus Biologicals proteins and lysates for KCNA3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for KCNA3
- Abcam proteins for KCNA3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for KCNA3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for KCNA3 (AFLGC-KCNA3)
- ApexBio compounds for KCNA3
- antibodies-online: Show 33 available KCNA3 Antibodies ranked by validation data
- Compare Top KCNA3 Antibodies
- antibodies-online: Search results for available KCNA3 related products ranked by validation data
- antibodies-online: Show 5 available KCNA3 Proteins ranked by validation data
- Compare Top KCNA3 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for KCNA3
- Search Santa Cruz Biotechnology (SCBT) for KCNA3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KCNA3
- Horizon Cell Lines for KCNA3
- genomics-online: cdna clones - Search for available KCNA3 CDNA products
- Overview of 99 available KCNA3 gene related products
- orf clones - Search for available KCNA3 ORF products
- Overview of 99 available KCNA3 gene related products
- genomics-online: gRNA clones - Search for available KCNA3 gRNA products
- Overview of 99 available KCNA3 gene related products
- genomics-online: primer clones - Search for available KCNA3 Primer products
- Overview of 99 available KCNA3 gene related products
- genomics-online: shRNA clones - Search for available KCNA3 shRNA products
- Overview of 99 available KCNA3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNA3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KCNA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA3
- Boster Bio Antibodies for KCNA3
- Browse Boster Bio ELISA Kits
Sources for KCNA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource