Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - ... See more...

Aliases for KCNA3 Gene

Aliases for KCNA3 Gene

  • Potassium Voltage-Gated Channel Subfamily A Member 3 2 3 4 5
  • HPCN3 2 3 4
  • HLK3 2 3 4
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.3 3 4
  • Voltage-Gated K(+) Channel HuKIII 3 4
  • HGK5 3 4
  • MK3 2 3
  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 3 3
  • Voltage-Gated Potassium Channel Protein Kv1.3 3
  • Type N Potassium Channel 3
  • Potassium Channel 3 3
  • Potassium Channel 2
  • HUKIII 3
  • KV1.3 3
  • KCNA3 5
  • Kv1.3 2
  • PCN3 3

External Ids for KCNA3 Gene

Previous GeneCards Identifiers for KCNA3 Gene

  • GC01M111630
  • GC01M110080
  • GC01M110316
  • GC01M110513
  • GC01M110926
  • GC01M111015
  • GC01M111214
  • GC01M109085

Summaries for KCNA3 Gene

Entrez Gene Summary for KCNA3 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA3 Gene

KCNA3 (Potassium Voltage-Gated Channel Subfamily A Member 3) is a Protein Coding gene. Diseases associated with KCNA3 include Alzheimer Disease 17. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNA2.

UniProtKB/Swiss-Prot Summary for KCNA3 Gene

  • Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Tocris Summary for KCNA3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNA3 Gene

Additional gene information for KCNA3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNA3 Gene

Genomics for KCNA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCNA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNA3

Top Transcription factor binding sites by QIAGEN in the KCNA3 gene promoter:
  • c-Ets-1
  • E47
  • FOXO4
  • GATA-1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT5B

Genomic Locations for KCNA3 Gene

Genomic Locations for KCNA3 Gene
chr1:110,653,560-110,674,940
(GRCh38/hg38)
Size:
21,381 bases
Orientation:
Minus strand
chr1:111,214,310-111,217,655
(GRCh37/hg19)
Size:
3,346 bases
Orientation:
Minus strand

Genomic View for KCNA3 Gene

Genes around KCNA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA3 Gene

Proteins for KCNA3 Gene

  • Protein details for KCNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22001-KCNA3_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 3
    Protein Accession:
    P22001
    Secondary Accessions:
    • Q5VWN2

    Protein attributes for KCNA3 Gene

    Size:
    575 amino acids
    Molecular mass:
    63842 Da
    Quaternary structure:
    • Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
    SequenceCaution:
    • Sequence=AAA36425.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA36425.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAB88073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCNA3 Gene

neXtProt entry for KCNA3 Gene

Post-translational modifications for KCNA3 Gene

  • N-glycosylation promotes the cell surface expression.
  • Glycosylation at Asn279
  • Ubiquitination at Lys120 and Lys526
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA3 Gene

Domains & Families for KCNA3 Gene

Gene Families for KCNA3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for KCNA3 Gene

InterPro:
Blocks:
  • BTB/POZ domain
  • Potassium channel signature
  • Skaker voltage-gated K+ channel family signature
  • Kv1.3 voltage-gated K+ channel signature
ProtoNet:

Suggested Antigen Peptide Sequences for KCNA3 Gene

GenScript: Design optimal peptide antigens:
  • Voltage-gated potassium channel subunit Kv1.3 (KCNA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22001

UniProtKB/Swiss-Prot:

KCNA3_HUMAN :
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
genes like me logo Genes that share domains with KCNA3: view

Function for KCNA3 Gene

Molecular function for KCNA3 Gene

UniProtKB/Swiss-Prot Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
GENATLAS Biochemistry:
potassium voltage-gated channel,Drosophila shaker-related subfamily,member 3,T cell (mouse Kv1.3 homolog)

Phenotypes From GWAS Catalog for KCNA3 Gene

Gene Ontology (GO) - Molecular Function for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005244 voltage-gated ion channel activity TAS 1373731
GO:0005249 voltage-gated potassium channel activity IBA 21873635
GO:0005251 delayed rectifier potassium channel activity IEA,IBA 21873635
GO:0005267 potassium channel activity IEA --
genes like me logo Genes that share ontologies with KCNA3: view
genes like me logo Genes that share phenotypes with KCNA3: view

Animal Models for KCNA3 Gene

MGI Knock Outs for KCNA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNA3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCNA3 Gene

Localization for KCNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNA3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0008076 voltage-gated potassium channel complex TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with KCNA3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNA3 Gene

Pathways & Interactions for KCNA3 Gene

genes like me logo Genes that share pathways with KCNA3: view

Pathways by source for KCNA3 Gene

1 Qiagen pathway for KCNA3 Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway

SIGNOR curated interactions for KCNA3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 1373731
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNA3: view

Drugs & Compounds for KCNA3 Gene

(14) Drugs for KCNA3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Potassium Approved, Experimental Pharma 0
4-Aminopyridine Approved Pharma Pore Blocker, Inhibitor, Antagonist, Target, antagonist potassium channel-blocking agent 60
Clofazimine Approved, Investigational Pharma Target, antagonist Tuberculosis drug 41
Enflurane Approved, Investigational, Vet_approved Pharma Target, inhibitor, activator 2
Promethazine Approved, Investigational Pharma Target, inducer 470

(2) Additional Compounds for KCNA3 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
noxiustoxin
Inhibitor
Kaliotoxin
145199-73-1

(4) Tocris Compounds for KCNA3 Gene

Compound Action Cas Number
Chromanol 293B IKs blocker. Also blocks ICFTR 163163-23-3
Flupirtine maleate KV7 channel activator 75507-68-5
Kaliotoxin KV and KCa blocker 145199-73-1
MaxiPost Potassium channel modulator; exerts subtype-specific effects 187523-35-9

(2) ApexBio Compounds for KCNA3 Gene

Compound Action Cas Number
ADWX 1 Kv1.3 channel blocker,potent and selective
Psora 4 Kv1.3 blocker 724709-68-6
genes like me logo Genes that share compounds with KCNA3: view

Drug Products

Transcripts for KCNA3 Gene

mRNA/cDNA for KCNA3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA3

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA3 Gene

No ASD Table

Relevant External Links for KCNA3 Gene

GeneLoc Exon Structure for
KCNA3

Expression for KCNA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNA3 Gene

mRNA differential expression in normal tissues according to GTEx for KCNA3 Gene

This gene is overexpressed in Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for KCNA3 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KCNA3 Gene



Protein tissue co-expression partners for KCNA3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNA3

SOURCE GeneReport for Unigene cluster for KCNA3 Gene:

Hs.169948

Evidence on tissue expression from TISSUES for KCNA3 Gene

  • Nervous system(4.6)
  • Blood(4.6)
  • Muscle(4.4)
  • Intestine(2.8)
  • Spleen(2.2)
  • Lymph node(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with KCNA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNA3 Gene

Orthologs for KCNA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KCNA3 30 31
  • 99.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KCNA3 30 31
  • 92.12 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KCNA3 30 31
  • 91.05 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kcna3 30
  • 90.31 (n)
Oppossum
(Monodelphis domestica)
Mammalia KCNA3 31
  • 90 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Kcna3 30 17 31
  • 89.74 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KCNA3 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CKV1.1 31
  • 84 (a)
OneToOne
KCNA3 30
  • 76.26 (n)
Lizard
(Anolis carolinensis)
Reptilia KCNA3 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kcna1 30
  • 75.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia kcna3b-A-prov 30
Zebrafish
(Danio rerio)
Actinopterygii KCNA3 (2 of 2) 31
  • 86 (a)
OneToMany
KCNA3 (1 of 2) 31
  • 86 (a)
OneToMany
LOC100330283 30
  • 73.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000254 30
  • 61.83 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Sh 30 32
  • 60.57 (n)
Worm
(Caenorhabditis elegans)
Secernentea shk-1 30
  • 53.35 (n)
Y55F3C.3 32
  • 30 (a)
Species where no ortholog for KCNA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KCNA3 Gene

ENSEMBL:
Gene Tree for KCNA3 (if available)
TreeFam:
Gene Tree for KCNA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNA3: view image

Paralogs for KCNA3 Gene

(19) SIMAP similar genes for KCNA3 Gene using alignment to 1 proteins:

  • KCNA3_HUMAN
genes like me logo Genes that share paralogs with KCNA3: view

Variants for KCNA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNA3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
726014 Benign: not provided 110,673,184(-) G/A SYNONYMOUS_VARIANT
733876 Benign: not provided 110,674,144(-) C/A SYNONYMOUS_VARIANT
rs1553187844 Uncertain Significance: not provided 110,674,409(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for KCNA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNA3 Gene

Variant ID Type Subtype PubMed ID
nsv1122384 CNV deletion 24896259

Variation tolerance for KCNA3 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNA3 Gene

Human Gene Mutation Database (HGMD)
KCNA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNA3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNA3 Gene

Disorders for KCNA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNA3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alzheimer disease 17
  • ad17
- elite association - COSMIC cancer census association via MalaCards
Search KCNA3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KCNA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KCNA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNA3 Gene

Publications for KCNA3 Gene

  1. A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. (PMID: 16317062) Tschritter O … Fritsche A (The Journal of clinical endocrinology and metabolism 2006) 3 23 41
  2. Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PMID: 7829094) Folander K … Swanson R (Genomics 1994) 3 4 23
  3. Crystallization and preliminary X-ray diffraction studies of the tetramerization domain derived from the human potassium channel Kv1.3. (PMID: 19574640) Winklmeier A … Kremer W (Acta crystallographica. Section F, Structural biology and crystallization communications 2009) 3 23
  4. Effect of genetic variation in Kv1.3 on olfactory function. (PMID: 19489042) Guthoff M … Fritsche A (Diabetes/metabolism research and reviews 2009) 3 41
  5. Methyl-beta-cyclodextrin reversibly alters the gating of lipid rafts-associated Kv1.3 channels in Jurkat T lymphocytes. (PMID: 17242956) Pottosin II … Dobrovinskaya OR (Pflugers Archiv : European journal of physiology 2007) 3 23

Products for KCNA3 Gene

Sources for KCNA3 Gene