Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - ... See more...

Aliases for KCNA10 Gene

Aliases for KCNA10 Gene

  • Potassium Voltage-Gated Channel Subfamily A Member 10 2 3 4 5
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 10 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.8 3 4
  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 10 3
  • Cyclic GMP Gated Potassium Channel 3
  • Kv1.8 3
  • Kcn1 3

External Ids for KCNA10 Gene

Previous GeneCards Identifiers for KCNA10 Gene

  • GC01M111476
  • GC01M109926
  • GC01M110161
  • GC01M110358
  • GC01M110772
  • GC01M110861
  • GC01M111059
  • GC01M108931

Summaries for KCNA10 Gene

Entrez Gene Summary for KCNA10 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA10 Gene

KCNA10 (Potassium Voltage-Gated Channel Subfamily A Member 10) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. Gene Ontology (GO) annotations related to this gene include ion channel activity and intracellular cyclic nucleotide activated cation channel activity. An important paralog of this gene is KCNA2.

UniProtKB/Swiss-Prot Summary for KCNA10 Gene

  • Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.

Gene Wiki entry for KCNA10 Gene

Additional gene information for KCNA10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNA10 Gene

Genomics for KCNA10 Gene

GeneHancer (GH) Regulatory Elements for KCNA10 Gene

Promoters and enhancers for KCNA10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J110523 Promoter 0.3 Ensembl 750.6 -1.8 -1826 0.4 KCNA10 lnc-PROK1-4 piR-57133-029 KCNA2
GH01J110630 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -116.8 -116825 10.8 ZNF24 SP1 CTCF ETV6 RELA RAD21 IKZF1 REST PRDM10 TRIM22 CD53 KCNA3 KCNA2 KCNA10 LINC02586 LRIF1 RBM15 lnc-KCNA2-1 lnc-PROK1-4
GH01J110421 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.1 +90.9 90874 19.8 RBPJ SMARCE1 CTBP1 MYC CC2D1A HLF L3MBTL2 MAX RAD21 DACH1 RF00017-291 PROK1 LAMTOR5-AS1 SLC16A4 RBM15 RBM15-AS1 KCNC4 LINC02586 LAMTOR5 CD53
GH01J110618 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.9 -100.5 -100499 1.5 CTCF MYC L3MBTL2 MAX RAD21 TEAD4 NFIB MLLT1 SP7 POLR2A KCNA3 KCNA10 CD53 KCNA2 RBM15 piR-48759-019 lnc-PROK1-4
GH01J110476 Enhancer 1 Ensembl ENCODE 11.2 +41.8 41774 4 CTCF SMARCE1 ZNF133 TEAD4 ZKSCAN8 MAFK CBFA2T2 SP7 ZSCAN21 PRDM1 ENSG00000258634 ENSG00000273373 STRIP1 PROK1 KCNA10 KCNC4 LINC02586 UBE2FP3 ENSG00000260948 CYMP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNA10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNA10 gene promoter:
  • ATF6
  • ER-alpha
  • p300
  • POU2F1
  • POU2F1a
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • Zic3
  • ZID

Genomic Locations for KCNA10 Gene

Genomic Locations for KCNA10 Gene
chr1:110,517,217-110,519,175
(GRCh38/hg38)
Size:
1,959 bases
Orientation:
Minus strand
chr1:111,059,839-111,061,797
(GRCh37/hg19)
Size:
1,959 bases
Orientation:
Minus strand

Genomic View for KCNA10 Gene

Genes around KCNA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA10 Gene

Proteins for KCNA10 Gene

  • Protein details for KCNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16322-KCA10_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 10
    Protein Accession:
    Q16322

    Protein attributes for KCNA10 Gene

    Size:
    511 amino acids
    Molecular mass:
    57785 Da
    Quaternary structure:
    • Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.

neXtProt entry for KCNA10 Gene

Post-translational modifications for KCNA10 Gene

  • Glycosylation at Asn256, Asn334, and Asn498
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA10 Gene

Domains & Families for KCNA10 Gene

Gene Families for KCNA10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNA10 Gene

GenScript: Design optimal peptide antigens:
  • Voltage-gated potassium channel subunit Kv1.8 (KCA10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16322

UniProtKB/Swiss-Prot:

KCA10_HUMAN :
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
genes like me logo Genes that share domains with KCNA10: view

Function for KCNA10 Gene

Molecular function for KCNA10 Gene

UniProtKB/Swiss-Prot Function:
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.
GENATLAS Biochemistry:
potassium voltage-gated channel,cGMP activated,Drosophila shaker-related subfamily,member 10

Phenotypes From GWAS Catalog for KCNA10 Gene

Gene Ontology (GO) - Molecular Function for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005221 intracellular cyclic nucleotide activated cation channel activity TAS 9177773
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IBA 21873635
GO:0005251 delayed rectifier potassium channel activity IBA 21873635
GO:0005267 potassium channel activity IEA --
genes like me logo Genes that share ontologies with KCNA10: view
genes like me logo Genes that share phenotypes with KCNA10: view

Animal Models for KCNA10 Gene

MGI Knock Outs for KCNA10:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNA10

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCNA10 Gene

Localization for KCNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNA10 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with KCNA10: view

Pathways & Interactions for KCNA10 Gene

PathCards logo

SuperPathways for KCNA10 Gene

genes like me logo Genes that share pathways with KCNA10: view

Pathways by source for KCNA10 Gene

1 Qiagen pathway for KCNA10 Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway

Gene Ontology (GO) - Biological Process for KCNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 9177773
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNA10: view

No data available for SIGNOR curated interactions for KCNA10 Gene

Drugs & Compounds for KCNA10 Gene

(9) Drugs for KCNA10 Gene - From: DrugBank, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-Aminopyridine Approved Pharma Pore Blocker, Inhibitor, Antagonist, Target, antagonist potassium channel-blocking agent 58
Ketoconazole Approved, Investigational Pharma Pore Blocker, inhibitor Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 192
Pimozide Approved Pharma Antagonist, Pore Blocker, antagonist 12
Verapamil Approved Pharma Channel blocker, Pore Blocker, Inhibition, Inhibitor, blocker 145
tetraethylammonium Experimental, Investigational Pharma Inhibitor, Pore Blocker, Antagonist, Inhibition 1
genes like me logo Genes that share compounds with KCNA10: view

Transcripts for KCNA10 Gene

mRNA/cDNA for KCNA10 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNA10

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA10 Gene

No ASD Table

Relevant External Links for KCNA10 Gene

GeneLoc Exon Structure for
KCNA10
ECgene alternative splicing isoforms for
KCNA10

Expression for KCNA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNA10 Gene

This gene is overexpressed in Testis (x22.3) and Lung (x6.6).

NURSA nuclear receptor signaling pathways regulating expression of KCNA10 Gene:

KCNA10

SOURCE GeneReport for Unigene cluster for KCNA10 Gene:

Hs.248140

mRNA Expression by UniProt/SwissProt for KCNA10 Gene:

Q16322-KCA10_HUMAN
Tissue specificity: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells.

Evidence on tissue expression from TISSUES for KCNA10 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with KCNA10: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNA10 Gene

Orthologs for KCNA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNA10 33 32
  • 99.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KCNA10 33 32
  • 91.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KCNA10 33 32
  • 90.31 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNA10 33
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna10 17 33 32
  • 88.78 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911265 32
  • 88.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA10 33
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNA10 33 32
  • 76.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNA10 33
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcna10 32
  • 68.55 (n)
zebrafish
(Danio rerio)
Actinopterygii KCNA10 (2 of 2) 33
  • 71 (a)
OneToMany
LOC100329515 32
  • 67.79 (n)
KCNA10 (1 of 2) 33
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sh 33 34
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y48A6B.6 34
  • 35 (a)
Y55F3C.3 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 56 (a)
ManyToMany
-- 33
  • 53 (a)
ManyToMany
Species where no ortholog for KCNA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA10 Gene

ENSEMBL:
Gene Tree for KCNA10 (if available)
TreeFam:
Gene Tree for KCNA10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNA10: view image

Paralogs for KCNA10 Gene

(22) SIMAP similar genes for KCNA10 Gene using alignment to 1 proteins:

  • KCA10_HUMAN
genes like me logo Genes that share paralogs with KCNA10: view

Variants for KCNA10 Gene

Sequence variations from dbSNP and Humsavar for KCNA10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs755748044 A colorectal cancer sample 110,518,189(-) C/G/T coding_sequence_variant, missense_variant
rs1001793431 -- 110,520,962(-) T/G upstream_transcript_variant
rs1002396549 -- 110,519,465(-) C/G upstream_transcript_variant
rs1002743758 -- 110,518,494(-) C/G coding_sequence_variant, missense_variant
rs1002774806 -- 110,518,670(-) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNA10 Gene

Variant ID Type Subtype PubMed ID
nsv1006346 CNV gain 25217958
nsv547498 CNV loss 21841781

Variation tolerance for KCNA10 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNA10 Gene

Disorders for KCNA10 Gene

Additional Disease Information for KCNA10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KCNA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNA10 Gene

Publications for KCNA10 Gene

  1. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. (PMID: 12444201) Yao X … Desir GV (Journal of the American Society of Nephrology : JASN 2002) 3 4 23 56
  2. KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. (PMID: 10836990) Lang R … Desir GV (American journal of physiology. Renal physiology 2000) 3 4 23 56
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman GA … Wang X (Pharmacological reviews 2005) 2 3 56
  5. Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. (PMID: 12060596) Tian S … Desir GV (American journal of physiology. Renal physiology 2002) 3 4 56

Products for KCNA10 Gene

Sources for KCNA10 Gene