Aliases for KBTBD6 Gene

Aliases for KBTBD6 Gene

  • Kelch Repeat And BTB Domain Containing 6 2 3 5
  • Kelch Repeat And BTB Domain-Containing Protein 6 3 4
  • Kelch Repeat And BTB (POZ) Domain Containing 6 2 3
  • DKFZp547E1912 2
  • KBTBD6 5

External Ids for KBTBD6 Gene

Previous GeneCards Identifiers for KBTBD6 Gene

  • GC13M039501
  • GC13M040599
  • GC13M041701
  • GC13M022501

Summaries for KBTBD6 Gene

GeneCards Summary for KBTBD6 Gene

KBTBD6 (Kelch Repeat And BTB Domain Containing 6) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is KBTBD7.

Additional gene information for KBTBD6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KBTBD6 Gene

Genomics for KBTBD6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KBTBD6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KBTBD6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KBTBD6

Top Transcription factor binding sites by QIAGEN in the KBTBD6 gene promoter:
  • AhR
  • c-Myc
  • CREB
  • deltaCREB
  • LCR-F1
  • Max1
  • Pax-5
  • Pax-6
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KBTBD6 Gene

Genomic Locations for KBTBD6 Gene
chr13:41,127,569-41,132,802
(GRCh38/hg38)
Size:
5,234 bases
Orientation:
Minus strand
chr13:41,701,705-41,706,936
(GRCh37/hg19)
Size:
5,232 bases
Orientation:
Minus strand

Genomic View for KBTBD6 Gene

Genes around KBTBD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KBTBD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KBTBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KBTBD6 Gene

Proteins for KBTBD6 Gene

  • Protein details for KBTBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V97-KBTB6_HUMAN
    Recommended name:
    Kelch repeat and BTB domain-containing protein 6
    Protein Accession:
    Q86V97
    Secondary Accessions:
    • Q5T6Y8
    • Q8N8L0
    • Q8NDM5
    • Q96MP6

    Protein attributes for KBTBD6 Gene

    Size:
    674 amino acids
    Molecular mass:
    76138 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KBTBD6 Gene

neXtProt entry for KBTBD6 Gene

Post-translational modifications for KBTBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KBTBD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KBTBD6 Gene

Domains & Families for KBTBD6 Gene

Gene Families for KBTBD6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KBTBD6 Gene

InterPro:
Blocks:
  • BTB/POZ domain
  • BTB/Kelch-associated
ProtoNet:

Suggested Antigen Peptide Sequences for KBTBD6 Gene

GenScript: Design optimal peptide antigens:
  • Kelch repeat and BTB domain-containing protein 6 (KBTB6_HUMAN)
genes like me logo Genes that share domains with KBTBD6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KBTBD6 Gene

Function for KBTBD6 Gene

Phenotypes From GWAS Catalog for KBTBD6 Gene

Gene Ontology (GO) - Molecular Function for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with KBTBD6: view
genes like me logo Genes that share phenotypes with KBTBD6: view

Animal Model Products

CRISPR Products

miRNA for KBTBD6 Gene

miRTarBase miRNAs that target KBTBD6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KBTBD6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KBTBD6 Gene

Localization for KBTBD6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KBTBD6 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KBTBD6 Gene

Pathways & Interactions for KBTBD6 Gene

genes like me logo Genes that share pathways with KBTBD6: view

Gene Ontology (GO) - Biological Process for KBTBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with KBTBD6: view

No data available for SIGNOR curated interactions for KBTBD6 Gene

Drugs & Compounds for KBTBD6 Gene

No Compound Related Data Available

Transcripts for KBTBD6 Gene

mRNA/cDNA for KBTBD6 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KBTBD6

Alternative Splicing Database (ASD) splice patterns (SP) for KBTBD6 Gene

No ASD Table

Relevant External Links for KBTBD6 Gene

GeneLoc Exon Structure for
KBTBD6

Expression for KBTBD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KBTBD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for KBTBD6 Gene

This gene is overexpressed in Urinary Bladder (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KBTBD6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KBTBD6

SOURCE GeneReport for Unigene cluster for KBTBD6 Gene:

Hs.534040

Evidence on tissue expression from TISSUES for KBTBD6 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with KBTBD6: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KBTBD6 Gene

Orthologs for KBTBD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KBTBD6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KBTBD6 30 31
  • 99.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KBTBD6 30 31
  • 86.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KBTBD6 30 31
  • 85.86 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zbtbd6 30 31
  • 82.74 (n)
OneToOne
Kbtbd6 17
Rat
(Rattus norvegicus)
Mammalia Kbtbd6 30
  • 82.53 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 71 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 70 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii kbtbd7 31
  • 49 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for KBTBD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KBTBD6 Gene

ENSEMBL:
Gene Tree for KBTBD6 (if available)
TreeFam:
Gene Tree for KBTBD6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KBTBD6: view image

Paralogs for KBTBD6 Gene

(6) SIMAP similar genes for KBTBD6 Gene using alignment to 3 proteins:

  • KBTB6_HUMAN
  • F5GZN7_HUMAN
  • L8ECN4_HUMAN
genes like me logo Genes that share paralogs with KBTBD6: view

Variants for KBTBD6 Gene

Additional dbSNP identifiers (rs#s) for KBTBD6 Gene

Structural Variations from Database of Genomic Variants (DGV) for KBTBD6 Gene

Variant ID Type Subtype PubMed ID
esv2747299 CNV deletion 23290073
nsv832587 CNV gain 17160897
nsv974084 CNV duplication 23825009

Variation tolerance for KBTBD6 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KBTBD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KBTBD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KBTBD6 Gene

Disorders for KBTBD6 Gene

No disorders were found for KBTBD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KBTBD6 Gene

Publications for KBTBD6 Gene

  1. CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. (PMID: 25684205) Genau HM … Behrends C (Molecular cell 2015) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Dimerization quality control ensures neuronal development and survival. (PMID: 30190310) Mena EL … Rape M (Science (New York, N.Y.) 2018) 3
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3

Products for KBTBD6 Gene

Sources for KBTBD6 Gene