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This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
KAT8 (Lysine Acetyltransferase 8) is a Protein Coding gene. Diseases associated with KAT8 include Capgras Syndrome and Gummatous Syphilis. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include enzyme binding and histone acetyltransferase activity. An important paralog of this gene is KAT5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004402 | histone acetyltransferase activity | IBA,IDA | 11742995 |
GO:0005515 | protein binding | IPI | 11965546 |
GO:0008134 | transcription factor binding | IDA | 11742995 |
GO:0016407 | acetyltransferase activity | IDA | 11742995 |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000123 | histone acetyltransferase complex | IBA,IDA | 20018852 |
GO:0000776 | kinetochore | IEA | -- |
GO:0000790 | nuclear chromatin | IBA | 21873635 |
GO:0005634 | nucleus | IBA,IDA | 11742995 |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chromatin organization | ||
2 | Chromatin Regulation / Acetylation | ||
3 | p53 pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0010506 | regulation of autophagy | IDA | 23863932 |
GO:0016573 | histone acetylation | IDA | 11742995 |
GO:0030099 | myeloid cell differentiation | IDA | 11742995 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
acetyl-coa |
|
72-89-9 |
|
Compound | Action | Cas Number |
---|---|---|
Donepezil HCl | AChE inhibitor | 120011-70-3 |
MG 149 | HAT inhibitor | 1243583-85-8 |
Remodelin | 1622921-15-6 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KAT8 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | KAT8 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MYST1 31 |
|
OneToOne | |
KAT8 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | KAT8 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | KAT8 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Kat8 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Kat8 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | KAT8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kat8 30 |
|
||
Str.14579 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.19273 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | kat8 30 31 |
|
OneToOne | |
wufb22g02 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012229 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | mof 30 31 |
|
OneToMany | |
CG1894 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | mys-2 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ESA1 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | HAM1 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3525 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os07g0626600 30 |
|
||
Os.9844 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.4361 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.5414 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.4004 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.901 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
capgras syndrome |
|
|
gummatous syphilis |
|
|
optic nerve astrocytoma |
|
|
sphenoid sinusitis |
|
|
beta-lactam allergy |
|
|