Aliases for KAT8 Gene
External Ids for KAT8 Gene
Previous HGNC Symbols for KAT8 Gene
Previous GeneCards Identifiers for KAT8 Gene
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for KAT8 Gene
KAT8 (Lysine Acetyltransferase 8) is a Protein Coding gene. Among its related pathways are Chromatin organization and p53 pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and histone acetyltransferase activity. An important paralog of this gene is KAT7.
UniProtKB/Swiss-Prot for KAT8 Gene
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at Lys-120.