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Aliases for KAT7 Gene

Aliases for KAT7 Gene

  • Lysine Acetyltransferase 7 2 3 4 5
  • Histone Acetyltransferase Binding To ORC1 2 3 4
  • MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 2 3 4
  • MYST Histone Acetyltransferase 2 2 3
  • K(Lysine) Acetyltransferase 7 2 3
  • MYST2 3 4
  • HBOA 3 4
  • HBO1 3 4
  • Histone Acetyltransferase MYST2 3
  • Histone Acetyltransferase KAT7 3
  • EC 2.3.1.48 4
  • ZC2HC7 3
  • MYST-2 4

External Ids for KAT7 Gene

Previous HGNC Symbols for KAT7 Gene

  • MYST2

Previous GeneCards Identifiers for KAT7 Gene

  • GC17P047867

Summaries for KAT7 Gene

Entrez Gene Summary for KAT7 Gene

  • The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

GeneCards Summary for KAT7 Gene

KAT7 (Lysine Acetyltransferase 7) is a Protein Coding gene. Among its related pathways are CCR5 Pathway in Macrophages and Chromatin organization. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is KAT6B.

UniProtKB/Swiss-Prot for KAT7 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.

Gene Wiki entry for KAT7 Gene

Additional gene information for KAT7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT7 Gene

Genomics for KAT7 Gene

GeneHancer (GH) Regulatory Elements for KAT7 Gene

Promoters and enhancers for KAT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I049787 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.6 +0.2 162 2.8 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC FAM117A KAT7 ENSG00000262837 UBE2Z LUC7L3 FLJ45513 ITGA3 TAC4 COL1A1 ENSG00000250751
GH17I049706 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.9 -80.3 -80337 2.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SLC35B1 PIR42611 ENSG00000250751 KAT7 CALCOCO2 CACNA1G-AS1 ENSG00000230532 PICART1 NXPH3 UBE2Z
GH17I049190 Enhancer 1.7 FANTOM5 Ensembl ENCODE 30.7 -595.8 -595816 4 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 TRQ-TTG1-1 ENSG00000262837 UBE2Z FAM117A FLJ45513 ENSG00000230532 KAT7 TAC4 PICART1 CALCOCO2
GH17I049575 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.6 -212.1 -212115 1.7 ARNT ARID4B SIN3A ZNF2 ZNF121 GLIS2 CBX5 ELK1 ZNF416 ZNF207 NXPH3 ENSG00000250310 KAT7 ENSG00000262837 SUMO2P17 ENSG00000230532 UBE2Z EME1 CACNA1G-AS1 LOC105371824
GH17I050371 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.7 +584.1 584064 2.7 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 MRPL27 EME1 ENSG00000262837 LUC7L3 MBTD1 CACNA1G-AS1 KAT7 FLJ45513 FAM117A TAC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KAT7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KAT7 Gene

Genomic Locations for KAT7 Gene
chr17:49,788,555-49,835,030
(GRCh38/hg38)
Size:
46,476 bases
Orientation:
Plus strand
chr17:47,865,917-47,906,458
(GRCh37/hg19)

Genomic View for KAT7 Gene

Genes around KAT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT7 Gene

Proteins for KAT7 Gene

  • Protein details for KAT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95251-KAT7_HUMAN
    Recommended name:
    Histone acetyltransferase KAT7
    Protein Accession:
    O95251
    Secondary Accessions:
    • B3KN74
    • B4DF85
    • B4DFB4
    • B4DFE0
    • B4DGY4
    • E7ER15
    • G5E9K7

    Protein attributes for KAT7 Gene

    Size:
    611 amino acids
    Molecular mass:
    70642 Da
    Quaternary structure:
    • Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone (PubMed:10930412). Interacts with CDT1 (PubMed:18832067). Interacts with MAP2K1 and CUL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for KAT7 Gene

    Alternative splice isoforms for KAT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT7 Gene

Post-translational modifications for KAT7 Gene

  • Autoacetylation at Lys-432 is required for proper function.
  • Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1 (PubMed:18250300). Phosphorylated by MAP2K1, which accelerates its degradation (By similarity).
  • Ubiquitinated at Lys-338, leading to proteasomal degradation.
  • Ubiquitination at isoforms=2, 3, 4, 5338 and isoforms=2, 3, 4, 5537
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KAT7 Gene

Domains & Families for KAT7 Gene

Gene Families for KAT7 Gene

Protein Domains for KAT7 Gene

Graphical View of Domain Structure for InterPro Entry

O95251

UniProtKB/Swiss-Prot:

KAT7_HUMAN :
  • The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1.
  • Belongs to the MYST (SAS/MOZ) family.
Domain:
  • The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1.
  • The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
genes like me logo Genes that share domains with KAT7: view

Function for KAT7 Gene

Molecular function for KAT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
UniProtKB/Swiss-Prot Function:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.

Enzyme Numbers (IUBMB) for KAT7 Gene

Phenotypes From GWAS Catalog for KAT7 Gene

Gene Ontology (GO) - Molecular Function for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003688 DNA replication origin binding IMP 21856198
GO:0003700 DNA binding transcription factor activity IEA --
GO:0004402 histone acetyltransferase activity IEA --
GO:0005515 protein binding IPI 10930412
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with KAT7: view
genes like me logo Genes that share phenotypes with KAT7: view

Animal Models for KAT7 Gene

MGI Knock Outs for KAT7:

Animal Model Products

miRNA for KAT7 Gene

miRTarBase miRNAs that target KAT7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT7 Gene

Localization for KAT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT7 Gene

Nucleus, nucleoplasm. Cytoplasm, cytosol. Nucleus. Note=Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067). {ECO:0000269 PubMed:18832067}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT7 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
GO:0005634 nucleus IEA,IDA 24739512
GO:0005654 nucleoplasm TAS,IDA --
GO:0005730 NOT nucleolus IDA 16387653
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with KAT7: view

Pathways & Interactions for KAT7 Gene

genes like me logo Genes that share pathways with KAT7: view

Pathways by source for KAT7 Gene

1 GeneTex pathway for KAT7 Gene
1 Qiagen pathway for KAT7 Gene
1 Cell Signaling Technology pathway for KAT7 Gene

SIGNOR curated interactions for KAT7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA,IEA 16387653
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS,IEA 10438470
GO:0016569 covalent chromatin modification IEA --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with KAT7: view

Drugs & Compounds for KAT7 Gene

(4) Drugs for KAT7 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0

(1) Additional Compounds for KAT7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(3) ApexBio Compounds for KAT7 Gene

Compound Action Cas Number
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT7: view

Drug Products

Transcripts for KAT7 Gene

Unigene Clusters for KAT7 Gene

K(lysine) acetyltransferase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KAT7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KAT7 Gene

GeneLoc Exon Structure for
KAT7
ECgene alternative splicing isoforms for
KAT7

Expression for KAT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KAT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.7), CD8 Tcells (12.3), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KAT7 Gene



Protein tissue co-expression partners for KAT7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KAT7 Gene:

KAT7

SOURCE GeneReport for Unigene cluster for KAT7 Gene:

Hs.21907

mRNA Expression by UniProt/SwissProt for KAT7 Gene:

O95251-KAT7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in testis.

Evidence on tissue expression from TISSUES for KAT7 Gene

  • Nervous system(5)
  • Liver(4.2)
  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with KAT7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT7 Gene

Orthologs for KAT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYST2 34
  • 100 (a)
OneToOne
KAT7 33
  • 94.76 (n)
chimpanzee
(Pan troglodytes)
Mammalia MYST2 33 34
  • 99.45 (n)
oppossum
(Monodelphis domestica)
Mammalia MYST2 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT7 33 34
  • 93.94 (n)
rat
(Rattus norvegicus)
Mammalia Kat7 33
  • 91.6 (n)
mouse
(Mus musculus)
Mammalia Kat7 33 16 34
  • 91.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 12 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MYST2 33 34
  • 83.63 (n)
lizard
(Anolis carolinensis)
Reptilia KAT7 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat7 33
  • 80.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68869 33
zebrafish
(Danio rerio)
Actinopterygii KAT7 (2 of 2) 34
  • 85 (a)
OneToMany
kat7 33 34
  • 76.11 (n)
Dr.6107 33
fruit fly
(Drosophila melanogaster)
Insecta chm 33 34
  • 56.17 (n)
worm
(Caenorhabditis elegans)
Secernentea mys-4 34
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 34
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToOne
Species where no ortholog for KAT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT7 Gene

ENSEMBL:
Gene Tree for KAT7 (if available)
TreeFam:
Gene Tree for KAT7 (if available)

Paralogs for KAT7 Gene

Paralogs for KAT7 Gene

(7) SIMAP similar genes for KAT7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for KAT7 Gene

genes like me logo Genes that share paralogs with KAT7: view

Variants for KAT7 Gene

Sequence variations from dbSNP and Humsavar for KAT7 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs193921114 uncertain-significance, Malignant tumor of prostate 49,826,752(+) C/T coding_sequence_variant, stop_gained
rs1000080818 -- 49,811,498(+) G/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000179058 -- 49,824,216(+) C/T intron_variant
rs1000186183 -- 49,807,139(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000240913 -- 49,811,380(+) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KAT7 Gene

Variant ID Type Subtype PubMed ID
nsv1134656 CNV deletion 24896259
nsv962340 CNV duplication 23825009

Variation tolerance for KAT7 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KAT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KAT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT7 Gene

Disorders for KAT7 Gene

Additional Disease Information for KAT7

No disorders were found for KAT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KAT7 Gene

Publications for KAT7 Gene

  1. Androgen receptor interacts with a novel MYST protein, HBO1. (PMID: 10930412) Sharma M … Sun Z (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. (PMID: 10438470) Iizuka M … Stillman B (The Journal of biological chemistry 1999) 2 3 4 22 58
  3. SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. (PMID: 23319590) Zou C … Mallampalli RK (The Journal of biological chemistry 2013) 3 4 58
  4. Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. (PMID: 19393168) Iizuka M … Smith MM (Gene 2009) 3 22 58
  5. Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. (PMID: 18250300) Wu ZQ … Liu X (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 58

Products for KAT7 Gene

  • Addgene plasmids for KAT7

Sources for KAT7 Gene

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