The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or tra... See more...

Aliases for KAT7 Gene

Aliases for KAT7 Gene

  • Lysine Acetyltransferase 7 2 3 4 5
  • Histone Acetyltransferase Binding To ORC1 2 3 4
  • MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 2 3 4
  • MYST Histone Acetyltransferase 2 2 3
  • Histone Acetyltransferase KAT7 3 4
  • K(Lysine) Acetyltransferase 7 2 3
  • MYST2 3 4
  • HBO1 3 4
  • Histone Acetyltransferase MYST2 3
  • EC 2.3.1.48 4
  • ZC2HC7 3
  • MYST-2 4
  • HBOA 3
  • HBOa 4

External Ids for KAT7 Gene

Previous HGNC Symbols for KAT7 Gene

  • MYST2

Previous GeneCards Identifiers for KAT7 Gene

  • GC17P047867

Summaries for KAT7 Gene

Entrez Gene Summary for KAT7 Gene

  • The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

GeneCards Summary for KAT7 Gene

KAT7 (Lysine Acetyltransferase 7) is a Protein Coding gene. Diseases associated with KAT7 include Ovarian Endodermal Sinus Tumor and Ovarian Primitive Germ Cell Tumor. Among its related pathways are Chromatin organization and Regulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is KAT6B.

UniProtKB/Swiss-Prot Summary for KAT7 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.

Gene Wiki entry for KAT7 Gene

Additional gene information for KAT7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KAT7 Gene

Genomics for KAT7 Gene

GeneHancer (GH) Regulatory Elements for KAT7 Gene

Promoters and enhancers for KAT7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KAT7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KAT7

Genomic Locations for KAT7 Gene

Genomic Locations for KAT7 Gene
chr17:49,788,619-49,835,026
(GRCh38/hg38)
Size:
46,408 bases
Orientation:
Plus strand
chr17:47,865,917-47,906,458
(GRCh37/hg19)
Size:
40,542 bases
Orientation:
Plus strand

Genomic View for KAT7 Gene

Genes around KAT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT7 Gene

Proteins for KAT7 Gene

  • Protein details for KAT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95251-KAT7_HUMAN
    Recommended name:
    Histone acetyltransferase KAT7
    Protein Accession:
    O95251
    Secondary Accessions:
    • B3KN74
    • B4DF85
    • B4DFB4
    • B4DFE0
    • B4DGY4
    • E7ER15
    • G5E9K7

    Protein attributes for KAT7 Gene

    Size:
    611 amino acids
    Molecular mass:
    70642 Da
    Quaternary structure:
    • Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone (PubMed:10930412). Interacts with CDT1 (PubMed:18832067). Interacts with MAP2K1 and CUL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for KAT7 Gene

    Alternative splice isoforms for KAT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT7 Gene

Post-translational modifications for KAT7 Gene

  • Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1 (PubMed:18250300). Phosphorylated by MAP2K1, which accelerates its degradation (By similarity).
  • Autoacetylation at Lys-432 is required for proper function.
  • Ubiquitinated at Lys-338, leading to proteasomal degradation.
  • Ubiquitination at Lys338 and Lys537
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KAT7 Gene

Domains & Families for KAT7 Gene

Gene Families for KAT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KAT7 Gene

Suggested Antigen Peptide Sequences for KAT7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52588, highly similar to Mus musculus MYST histone acetyltransferase 2 (Myst2), mRNA (B4DFB4_HUMAN)
  • cDNA FLJ50465, highly similar to Histone acetyltransferase MYST2 (EC 2.3.1.48) (B4DFE0_HUMAN)
  • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 (MYST2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95251

UniProtKB/Swiss-Prot:

KAT7_HUMAN :
  • The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1.
  • Belongs to the MYST (SAS/MOZ) family.
Domain:
  • The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1.
  • The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
genes like me logo Genes that share domains with KAT7: view

Function for KAT7 Gene

Molecular function for KAT7 Gene

UniProtKB/Swiss-Prot Function:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=. ;.

Enzyme Numbers (IUBMB) for KAT7 Gene

Phenotypes From GWAS Catalog for KAT7 Gene

Gene Ontology (GO) - Molecular Function for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003688 DNA replication origin binding IMP 21856198
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0004402 histone acetyltransferase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 10930412
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with KAT7: view
genes like me logo Genes that share phenotypes with KAT7: view

Animal Models for KAT7 Gene

MGI Knock Outs for KAT7:
  • Kat7 Kat7<tm1.2Avo>

Animal Model Products

CRISPR Products

miRNA for KAT7 Gene

miRTarBase miRNAs that target KAT7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT7

Clone Products

  • Addgene plasmids for KAT7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT7 Gene

Localization for KAT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT7 Gene

Nucleus, nucleoplasm. Cytoplasm, cytosol. Nucleus. Note=Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067). {ECO:0000269 PubMed:18832067}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT7 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
GO:0000790 nuclear chromatin IBA 21873635
GO:0005634 nucleus IDA,IEA 24739512
GO:0005654 nucleoplasm TAS,IDA --
GO:0005730 NOT nucleolus IDA 16387653
genes like me logo Genes that share ontologies with KAT7: view

Pathways & Interactions for KAT7 Gene

genes like me logo Genes that share pathways with KAT7: view

Pathways by source for KAT7 Gene

1 Qiagen pathway for KAT7 Gene
  • Androgen Signaling
1 Cell Signaling Technology pathway for KAT7 Gene
1 GeneTex pathway for KAT7 Gene

SIGNOR curated interactions for KAT7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA,IDA 16387653
GO:0006325 chromatin organization IEA --
GO:0006355 regulation of transcription, DNA-templated TAS,IEA 10438470
GO:0016573 histone acetylation IEA --
GO:0018393 internal peptidyl-lysine acetylation IDA 26221039
genes like me logo Genes that share ontologies with KAT7: view

Drugs & Compounds for KAT7 Gene

(4) Drugs for KAT7 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0

(1) Additional Compounds for KAT7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9

(3) ApexBio Compounds for KAT7 Gene

Compound Action Cas Number
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT7: view

Drug Products

Transcripts for KAT7 Gene

mRNA/cDNA for KAT7 Gene

6 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT7

Clone Products

  • Addgene plasmids for KAT7

Alternative Splicing Database (ASD) splice patterns (SP) for KAT7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KAT7 Gene

GeneLoc Exon Structure for
KAT7

Expression for KAT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KAT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.7), CD8 Tcells (12.3), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KAT7 Gene



Protein tissue co-expression partners for KAT7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KAT7

SOURCE GeneReport for Unigene cluster for KAT7 Gene:

Hs.21907

mRNA Expression by UniProt/SwissProt for KAT7 Gene:

O95251-KAT7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in testis.

Evidence on tissue expression from TISSUES for KAT7 Gene

  • Nervous system(5)
  • Liver(4.2)
  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with KAT7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT7 Gene

Orthologs for KAT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYST2 31
  • 100 (a)
OneToOne
KAT7 30
  • 94.76 (n)
chimpanzee
(Pan troglodytes)
Mammalia MYST2 31 30
  • 99.45 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYST2 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT7 31 30
  • 93.94 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat7 30
  • 91.6 (n)
mouse
(Mus musculus)
Mammalia Kat7 17 31 30
  • 91.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 12 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MYST2 31 30
  • 83.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT7 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat7 30
  • 80.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68869 30
zebrafish
(Danio rerio)
Actinopterygii KAT7 (2 of 2) 31
  • 85 (a)
OneToMany
kat7 31 30
  • 76.11 (n)
OneToMany
Dr.6107 30
fruit fly
(Drosophila melanogaster)
Insecta chm 31 30
  • 56.17 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mys-4 31
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESA1 31
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 60 (a)
OneToOne
Species where no ortholog for KAT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT7 Gene

ENSEMBL:
Gene Tree for KAT7 (if available)
TreeFam:
Gene Tree for KAT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KAT7: view image

Paralogs for KAT7 Gene

Paralogs for KAT7 Gene

(7) SIMAP similar genes for KAT7 Gene using alignment to 4 proteins:

  • KAT7_HUMAN
  • D6RFZ5_HUMAN
  • E7EUP3_HUMAN
  • G3V125_HUMAN

Pseudogenes.org Pseudogenes for KAT7 Gene

genes like me logo Genes that share paralogs with KAT7: view

Variants for KAT7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KAT7 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
730718 Benign: not provided 49,821,751(+) G/A SYNONYMOUS_VARIANT
rs193921114 Uncertain Significance: Malignant tumor of prostate 49,826,752(+) C/T NONSENSE

Additional dbSNP identifiers (rs#s) for KAT7 Gene

Structural Variations from Database of Genomic Variants (DGV) for KAT7 Gene

Variant ID Type Subtype PubMed ID
nsv1134656 CNV deletion 24896259
nsv962340 CNV duplication 23825009

Variation tolerance for KAT7 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KAT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KAT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT7 Gene

Disorders for KAT7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KAT7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian endodermal sinus tumor
  • endodermal sinus tumor of ovary
ovarian primitive germ cell tumor
meier-gorlin syndrome 1
  • eps
- elite association - COSMIC cancer census association via MalaCards
Search KAT7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KAT7

genes like me logo Genes that share disorders with KAT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KAT7 Gene

Publications for KAT7 Gene

  1. Androgen receptor interacts with a novel MYST protein, HBO1. (PMID: 10930412) Sharma M … Sun Z (The Journal of biological chemistry 2000) 2 3 4 23 54
  2. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. (PMID: 10438470) Iizuka M … Stillman B (The Journal of biological chemistry 1999) 2 3 4 23 54
  3. SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. (PMID: 23319590) Zou C … Mallampalli RK (The Journal of biological chemistry 2013) 3 4 54
  4. Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. (PMID: 19393168) Iizuka M … Smith MM (Gene 2009) 3 23 54
  5. HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1. (PMID: 18832067) Miotto B … Struhl K (Genes & development 2008) 3 4 54

Products for KAT7 Gene