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Aliases for KAT5 Gene

Aliases for KAT5 Gene

  • Lysine Acetyltransferase 5 2 3 4 5
  • HIV-1 Tat Interactive Protein, 60kDa 2 3
  • Histone Acetyltransferase HTATIP 3 4
  • Tat Interacting Protein, 60kDa 2 3
  • 60 KDa Tat-Interactive Protein 3 4
  • K(Lysine) Acetyltransferase 5 2 3
  • CPLA(2)-Interacting Protein 3 4
  • K-Acetyltransferase 5 2 3
  • EC 2.3.1.48 4 56
  • HTATIP 3 4
  • TIP60 3 4
  • Histone Acetyltransferase KAT5 3
  • HIV-1 Tat Interactive Protein 4
  • CPLA2 Interacting Protein 3
  • HTATIP1 3
  • ZC2HC5 3
  • CPLA2 3
  • ESA1 3
  • PLIP 3
  • TIP 3

External Ids for KAT5 Gene

Previous HGNC Symbols for KAT5 Gene

  • HTATIP

Previous GeneCards Identifiers for KAT5 Gene

  • GC11P065237
  • GC11P065479
  • GC11P061806

Summaries for KAT5 Gene

Entrez Gene Summary for KAT5 Gene

  • The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for KAT5 Gene

KAT5 (Lysine Acetyltransferase 5) is a Protein Coding gene. Diseases associated with KAT5 include Human Immunodeficiency Virus Type 1. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Gene Expression. Gene Ontology (GO) annotations related to this gene include transcription factor binding and protein complex binding. An important paralog of this gene is KAT6A.

UniProtKB/Swiss-Prot for KAT5 Gene

  • Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Gene Wiki entry for KAT5 Gene

Additional gene information for KAT5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT5 Gene

Genomics for KAT5 Gene

GeneHancer (GH) Regulatory Elements for KAT5 Gene

Promoters and enhancers for KAT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065709 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 563.3 -0.5 -499 4.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 KAT5 RBM14 ENSG00000258297 SF1 ZFPL1 POLA2 LOC105369352 RBM4 MUS81 EIF1AD
GH11I065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 100.2 -221.9 -221912 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 PCNX3 POLA2 ZFPL1 EIF1AD SART1 MUS81 LOC105369352 KAT5
GH11I065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 78.5 -287.8 -287815 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278050 ENSG00000278144 GC11P065529 SF1 ZFPL1 EIF1AD POLA2 PCNX3
GH11I065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 60.1 +145.5 145488 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD POLA2 PCNX3 SART1 ENSG00000258297 ZFPL1 RBM14 RBM4
GH11I065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.2 +183.5 183462 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP CCDC85B SNX32 ENSG00000258297 EIF1AD RBM14 MUS81 SART1 POLA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KAT5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KAT5 gene promoter:

Genomic Locations for KAT5 Gene

Genomic Locations for KAT5 Gene
chr11:65,711,996-65,719,606
(GRCh38/hg38)
Size:
7,611 bases
Orientation:
Plus strand
chr11:65,479,467-65,487,077
(GRCh37/hg19)

Genomic View for KAT5 Gene

Genes around KAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT5 Gene

Proteins for KAT5 Gene

  • Protein details for KAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92993-KAT5_HUMAN
    Recommended name:
    Histone acetyltransferase KAT5
    Protein Accession:
    Q92993
    Secondary Accessions:
    • B4E3C7
    • C9JL99
    • O95624
    • Q13430
    • Q17RW5
    • Q561W3
    • Q6GSE8
    • Q9BWK7

    Protein attributes for KAT5 Gene

    Size:
    513 amino acids
    Molecular mass:
    58582 Da
    Quaternary structure:
    • Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with PLA2G4A/CPLA2, EDNRA and HDAC7. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Interacts with ATM. Interacts with JADE1. Interacts with HIV-1 Tat. Interacts with TRIM24 and TRIM68. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Identified in a complex with HINT1. Interacts with ATF2 and CUL3. Interacts with NR1D2 (via N-terminus). Component of a SWR1-like complex. Interacts with FOXP3. Interacts with ZBTB49 (PubMed:25245946).
    SequenceCaution:
    • Sequence=AAB02683.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KAT5 Gene

    Alternative splice isoforms for KAT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT5 Gene

Selected DME Specific Peptides for KAT5 Gene

Q92993:
  • FSYELSK
  • WYFSPYP
  • LLIEFSY
  • VGYFSKEK
  • PLSDLGL
  • PPYQRRG
  • FNKRLDEW
  • ACILTLP
  • SFFEIDGR

Post-translational modifications for KAT5 Gene

  • Autoacetylation at Lys-327 is required for proper function.
  • Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. The phosphorylated form has a higher HAT activity.
  • Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies.
  • Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.
  • Ubiquitination at posLast=230230
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for KAT5 Gene

Gene Families for KAT5 Gene

Suggested Antigen Peptide Sequences for KAT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q92993

UniProtKB/Swiss-Prot:

KAT5_HUMAN :
  • Belongs to the MYST (SAS/MOZ) family.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
genes like me logo Genes that share domains with KAT5: view

Function for KAT5 Gene

Molecular function for KAT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).

Enzyme Numbers (IUBMB) for KAT5 Gene

Phenotypes From GWAS Catalog for KAT5 Gene

Gene Ontology (GO) - Molecular Function for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 17360565
GO:0004402 histone acetyltransferase activity IEA,IMP 17996965
GO:0005515 protein binding IPI 10966108
GO:0016407 acetyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with KAT5: view
genes like me logo Genes that share phenotypes with KAT5: view

Animal Models for KAT5 Gene

MGI Knock Outs for KAT5:

Animal Model Products

  • Taconic Biosciences Mouse Models for KAT5

CRISPR Products

miRNA for KAT5 Gene

miRTarBase miRNAs that target KAT5

Clone Products

  • Addgene plasmids for KAT5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT5 Gene

Localization for KAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT5 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT5 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IDA,IEA 17996965
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA,IEA 16387653
genes like me logo Genes that share ontologies with KAT5: view

Pathways & Interactions for KAT5 Gene

genes like me logo Genes that share pathways with KAT5: view

Pathways by source for KAT5 Gene

SIGNOR curated interactions for KAT5 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 17360565
GO:0000729 DNA double-strand break processing TAS --
GO:0000731 DNA synthesis involved in DNA repair TAS --
GO:0000732 strand displacement TAS --
GO:0006260 DNA replication TAS --
genes like me logo Genes that share ontologies with KAT5: view

Drugs & Compounds for KAT5 Gene

(15) Drugs for KAT5 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Acetyl-Cysteine Experimental Pharma Target 0
Coenzyme A Investigational Nutra Target 0
Anacardic acid Pharma HAT inhibitor 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0

(6) Additional Compounds for KAT5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(5) ApexBio Compounds for KAT5 Gene

Compound Action Cas Number
Anacardic acid HAT inhibitor 16611-84-0
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
NU 9056 KAT5 (Tip60) HAT inhibitor
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT5: view

Drug Products

Transcripts for KAT5 Gene

Unigene Clusters for KAT5 Gene

K(lysine) acetyltransferase 5:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for KAT5

Alternative Splicing Database (ASD) splice patterns (SP) for KAT5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - -
SP12: -
SP13:
SP14:

ExUns: 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KAT5 Gene

GeneLoc Exon Structure for
KAT5
ECgene alternative splicing isoforms for
KAT5

Expression for KAT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.9) and NK cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KAT5 Gene



Protein tissue co-expression partners for KAT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KAT5 Gene:

KAT5

SOURCE GeneReport for Unigene cluster for KAT5 Gene:

Hs.397010

Evidence on tissue expression from TISSUES for KAT5 Gene

  • Blood(4.3)
  • Nervous system(4.3)
  • Liver(4.2)
  • Thyroid gland(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with KAT5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT5 Gene

Orthologs for KAT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT5 33 34
  • 99.03 (n)
oppossum
(Monodelphis domestica)
Mammalia KAT5 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KAT5 33 34
  • 94.81 (n)
cow
(Bos Taurus)
Mammalia KAT5 33 34
  • 93.11 (n)
mouse
(Mus musculus)
Mammalia Kat5 33 16 34
  • 91.29 (n)
rat
(Rattus norvegicus)
Mammalia Kat5 33
  • 90.97 (n)
chicken
(Gallus gallus)
Aves KAT5 34
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT5 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat5 33
  • 76.91 (n)
Str.10748 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14238 33
zebrafish
(Danio rerio)
Actinopterygii KAT5 (1 of 2)