The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair... See more...

Aliases for KAT5 Gene

Aliases for KAT5 Gene

  • Lysine Acetyltransferase 5 2 3 4 5
  • TIP60 2 3 4
  • HIV-1 Tat Interactive Protein, 60kDa 2 3
  • Histone Acetyltransferase HTATIP 3 4
  • Tat Interacting Protein, 60kDa 2 3
  • Histone Acetyltransferase KAT5 3 4
  • 60 KDa Tat-Interactive Protein 3 4
  • K(Lysine) Acetyltransferase 5 2 3
  • CPLA(2)-Interacting Protein 3 4
  • K-Acetyltransferase 5 2 3
  • EC 2.3.1.48 4 51
  • HTATIP1 2 3
  • HTATIP 3 4
  • ZC2HC5 2 3
  • CPLA2 2 3
  • ESA1 2 3
  • PLIP 2 3
  • HIV-1 Tat Interactive Protein 4
  • CPLA2 Interacting Protein 3
  • NEDFASB 3
  • Tip60 4
  • KAT5 5
  • TIP 3

External Ids for KAT5 Gene

Previous HGNC Symbols for KAT5 Gene

  • HTATIP

Previous GeneCards Identifiers for KAT5 Gene

  • GC11P065237
  • GC11P065479
  • GC11P061806

Summaries for KAT5 Gene

Entrez Gene Summary for KAT5 Gene

  • The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for KAT5 Gene

KAT5 (Lysine Acetyltransferase 5) is a Protein Coding gene. Diseases associated with KAT5 include Neurodevelopmental Disorder With Dysmorphic Facies, Sleep Disturbance, And Brain Abnormalities and Aicardi-Goutieres Syndrome 3. Among its related pathways are Androgen receptor signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is KAT6A.

UniProtKB/Swiss-Prot Summary for KAT5 Gene

  • Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:16387653, PubMed:19909775, PubMed:15196461). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:15196461). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:15196461). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:15196461). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17360565, PubMed:17996965, PubMed:29040603, PubMed:30704899). Directly acetylates and activates ATM (PubMed:16141325). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899).

Gene Wiki entry for KAT5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KAT5 Gene

Genomics for KAT5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KAT5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KAT5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KAT5

Top Transcription factor binding sites by QIAGEN in the KAT5 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • STAT3

Genomic Locations for KAT5 Gene

Latest Assembly
chr11:65,711,996-65,719,604
(GRCh38/hg38)
Size:
7,609 bases
Orientation:
Plus strand

Previous Assembly
chr11:65,479,723-65,487,075
(GRCh37/hg19 by Entrez Gene)
Size:
7,353 bases
Orientation:
Plus strand

chr11:65,479,467-65,487,075
(GRCh37/hg19 by Ensembl)
Size:
7,609 bases
Orientation:
Plus strand

Genomic View for KAT5 Gene

Genes around KAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT5 Gene

Proteins for KAT5 Gene

  • Protein details for KAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92993-KAT5_HUMAN
    Recommended name:
    Histone acetyltransferase KAT5
    Protein Accession:
    Q92993
    Secondary Accessions:
    • B4E3C7
    • C9JL99
    • O95624
    • Q13430
    • Q17RW5
    • Q561W3
    • Q6GSE8
    • Q9BWK7

    Protein attributes for KAT5 Gene

    Size:
    513 amino acids
    Molecular mass:
    58582 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (PubMed:12963728, PubMed:10966108, PubMed:15196461, PubMed:14966270). HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. The NuA4 complex interacts with MYC. Interacts with ATM (PubMed:16141325). Interacts with JADE1 (PubMed:15502158). Interacts with PLA2G4A/CPLA2, EDNRA and HDAC7 (PubMed:11416127, PubMed:11262386, PubMed:12551922). Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with TRIM24 and TRIM68 (PubMed:18451177, PubMed:19909775). Forms a complex with SENP6 and UBE2I in response to UV irradiation. Identified in a complex with HINT1 (PubMed:16835243). Interacts with ATF2 and CUL3 (PubMed:18397884). Interacts with NR1D2 (via N-terminus) (PubMed:17996965). Component of a SWR1-like complex (PubMed:24463511). Interacts with FOXP3 (PubMed:17360565). Interacts with ZBTB49 (PubMed:25245946).
    • (Microbial infection) Interacts with HIV-1 TAT.
    SequenceCaution:
    • Sequence=AAB02683.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KAT5 Gene

    Alternative splice isoforms for KAT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT5 Gene

Selected DME Specific Peptides for KAT5 Gene

Q92993:
  • FSYELSK
  • WYFSPYP
  • LLIEFSY
  • VGYFSKEK
  • PLSDLGL
  • PPYQRRG
  • FNKRLDEW
  • ACILTLP
  • SFFEIDGR

Post-translational modifications for KAT5 Gene

  • (Microbial infection) In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
  • Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies.
  • Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.
  • Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase (PubMed:12468530). The phosphorylated form has a higher histone acetyltransferase activity (PubMed:12468530). Phosphorylation at Ser-86 by GSK3 (GSK3A or GSK3B) activates acetyltransferase activity (PubMed:30704899). Phosphorylation at Ser-90 is a prerequisite for phosphorylation at Ser-86 by GSK3 (PubMed:30704899).
  • Autoacetylation at Lys-327 is required for proper function.
  • Ubiquitination at Lys230
  • Modification sites at PhosphoSitePlus

Domains & Families for KAT5 Gene

Gene Families for KAT5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KAT5 Gene

Suggested Antigen Peptide Sequences for KAT5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56211, highly similar to Histone acetyltransferase HTATIP (EC 2.3.1.48) (B4E3C7_HUMAN)
  • cPLA(2)-interacting protein (KAT5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92993

UniProtKB/Swiss-Prot:

KAT5_HUMAN :
  • Belongs to the MYST (SAS/MOZ) family.
Family:
  • Belongs to the MYST (SAS/MOZ) family.
genes like me logo Genes that share domains with KAT5: view

Function for KAT5 Gene

Molecular function for KAT5 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:16387653, PubMed:19909775, PubMed:15196461). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:15196461). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:15196461). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:15196461). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17360565, PubMed:17996965, PubMed:29040603, PubMed:30704899). Directly acetylates and activates ATM (PubMed:16141325). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269|PubMed:10096020, ECO:0000269|PubMed:12468530, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:30704899};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Acetyltransferase activity is promoted by phosphorylation at Ser-86 by GSK3 (GSK3A or GSK3B).

Enzyme Numbers (IUBMB) for KAT5 Gene

Phenotypes From GWAS Catalog for KAT5 Gene

Gene Ontology (GO) - Molecular Function for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IBA 21873635
GO:0003713 transcription coactivator activity IEA,TAS 17360565
GO:0004402 histone acetyltransferase activity IEA,IMP 17996965
GO:0005515 protein binding IPI 10966108
GO:0016407 acetyltransferase activity TAS --
genes like me logo Genes that share ontologies with KAT5: view
genes like me logo Genes that share phenotypes with KAT5: view

Animal Models for KAT5 Gene

MGI Knock Outs for KAT5:
  • Kat5 Kat5<tm1Jwl>
  • Kat5 Kat5<tm1.1(KOMP)Vlcg>

Animal Models for research

  • Taconic Biosciences Mouse Models for KAT5

miRNA for KAT5 Gene

miRTarBase miRNAs that target KAT5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT5

Clone products for research

  • Addgene plasmids for KAT5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT5 Gene

Localization for KAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT5 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT5 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IEA,IDA 17996965
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with KAT5: view

Pathways & Interactions for KAT5 Gene

genes like me logo Genes that share pathways with KAT5: view

SIGNOR curated interactions for KAT5 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for KAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 17360565
GO:0000729 DNA double-strand break processing TAS --
GO:0006260 DNA replication TAS --
GO:0006302 double-strand break repair IMP 10966108
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
genes like me logo Genes that share ontologies with KAT5: view

Drugs & Compounds for KAT5 Gene

(15) Drugs for KAT5 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Acetyl-Cysteine Experimental Pharma Target 0
Coenzyme A Investigational Nutra Target 0
Anacardic acid Pharma HAT inhibitor 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0

(6) Additional Compounds for KAT5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9

(5) ApexBio Compounds for KAT5 Gene

Compound Action Cas Number
Anacardic acid HAT inhibitor 16611-84-0
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
NU 9056 KAT5 (Tip60) HAT inhibitor
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT5: view

Drug products for research

Transcripts for KAT5 Gene

mRNA/cDNA for KAT5 Gene

4 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT5