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Aliases for KAT2A Gene

Aliases for KAT2A Gene

  • Lysine Acetyltransferase 2A 2 3 4 5
  • General Control Of Amino Acid Synthesis Protein 5-Like 2 3 4
  • Histone Succinyltransferase KAT2A 3 4
  • Histone Acetyltransferase GCN5 3 4
  • K(Lysine) Acetyltransferase 2A 2 3
  • GCN5L2 3 4
  • STAF97 3 4
  • HGCN5 3 4
  • GCN5 3 4
  • GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 2 3
  • General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 2 3
  • GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast) 2
  • Histone Acetyltransferase KAT2A 3
  • EC 2.3.1.48 4
  • EC 2.3.1.- 4
  • PCAF-B 3
  • HsGCN5 3

External Ids for KAT2A Gene

Previous HGNC Symbols for KAT2A Gene

  • GCN5L2

Previous GeneCards Identifiers for KAT2A Gene

  • GC17M037519
  • GC17M040265
  • GC17M036030

Summaries for KAT2A Gene

Entrez Gene Summary for KAT2A Gene

  • KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

GeneCards Summary for KAT2A Gene

KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B.

UniProtKB/Swiss-Prot for KAT2A Gene

  • Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on Lys-79 (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).

  • (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.

Gene Wiki entry for KAT2A Gene

Additional gene information for KAT2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT2A Gene

Genomics for KAT2A Gene

GeneHancer (GH) Regulatory Elements for KAT2A Gene

Promoters and enhancers for KAT2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J042120 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 -0.6 -555 2.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 GLIS2 ZNF143 HSPB9 KAT2A PIR31172 NKIRAS2 DHX58 ENSG00000267261
GH17J041687 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 28 +431.0 430994 6.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC17P041692 GC17P041691 EIF1 ENSG00000267758 ENSG00000259623 KLHL10 CNTNAP1 HSD17B1 NT5C3B KAT2A
GH17J042672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.7 -557.3 -557305 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 DHX8 TUBG2 HMGN1P29 ENSG00000267758 ENSG00000267002 ENSG00000266962
GH17J042266 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -151.0 -151047 12.8 MLX FEZF1 DMAP1 YY1 E2F8 SP3 MEF2D GLIS1 RCOR2 NBN STAT5B ENSG00000236194 CNTNAP1 TUBG2 ENSG00000267002 ENSG00000259623 ENSG00000267340 HSD17B1 ENSG00000267765 EZH1
GH17J042386 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.3 -267.1 -267055 4.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 STAT3 GC17M042386 NBR1 ENSG00000267765 ENSG00000267002 KLHL10 HMGN1P29 ENSG00000267758 ENSG00000267340 TUBG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KAT2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KAT2A gene promoter:
  • STAT1alpha
  • STAT1
  • Egr-4
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for KAT2A Gene

Genomic Locations for KAT2A Gene
chr17:42,113,108-42,121,393
(GRCh38/hg38)
Size:
8,286 bases
Orientation:
Minus strand
chr17:40,265,126-40,273,382
(GRCh37/hg19)
Size:
8,257 bases
Orientation:
Minus strand

Genomic View for KAT2A Gene

Genes around KAT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT2A Gene

Proteins for KAT2A Gene

  • Protein details for KAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92830-KAT2A_HUMAN
    Recommended name:
    Histone acetyltransferase KAT2A
    Protein Accession:
    Q92830
    Secondary Accessions:
    • Q8N1A2
    • Q9UCW1

    Protein attributes for KAT2A Gene

    Size:
    837 amino acids
    Molecular mass:
    93926 Da
    Quaternary structure:
    • Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP (PubMed:10373431, PubMed:10611234, PubMed:11438666). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (PubMed:18206972). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT14, MBIP and WDR5 (PubMed:19103755). Interacts with PML (By similarity). Interacts with CEBPB (PubMed:17301242). Interacts with TACC1, TACC2 and TACC3 (PubMed:14767476). Interacts with RELA (By similarity). Interacts with NFATC2 (By similarity). Interacts with TBX5 (PubMed:29174768). Interacts with PLK4 (PubMed:27796307). Associates with the 2-oxoglutarate dehydrogenase complex (PubMed:29211711).
    • (Microbial infection) Interacts with and acetylates HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for KAT2A Gene

    Alternative splice isoforms for KAT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT2A Gene

Post-translational modifications for KAT2A Gene

  • Ubiquitination at Lys446 and isoforms=289
  • Modification sites at PhosphoSitePlus

Other Protein References for KAT2A Gene

No data available for DME Specific Peptides for KAT2A Gene

Domains & Families for KAT2A Gene

Suggested Antigen Peptide Sequences for KAT2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92830

UniProtKB/Swiss-Prot:

KAT2A_HUMAN :
  • Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.
  • Belongs to the acetyltransferase family. GCN5 subfamily.
Domain:
  • Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.
Family:
  • Belongs to the acetyltransferase family. GCN5 subfamily.
genes like me logo Genes that share domains with KAT2A: view

Function for KAT2A Gene

Molecular function for KAT2A Gene

UniProtKB/Swiss-Prot Function:
Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on Lys-79 (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
UniProtKB/Swiss-Prot CatalyticActivity:
Succinyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-succinyl-L-lysine.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.83 uM for acetyl-CoA {ECO:0000269 PubMed:29211711}; KM=0.36 uM for succinyl-CoA {ECO:0000269 PubMed:29211711};

Enzyme Numbers (IUBMB) for KAT2A Gene

Phenotypes From GWAS Catalog for KAT2A Gene

Gene Ontology (GO) - Molecular Function for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA,IEA 29211711
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 histone acetyltransferase activity TAS,IEA --
GO:0005515 protein binding IPI 17664281
GO:0008080 N-acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with KAT2A: view
genes like me logo Genes that share phenotypes with KAT2A: view

Animal Models for KAT2A Gene

MGI Knock Outs for KAT2A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT2A

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT2A Gene

Localization for KAT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT2A Gene

Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. {ECO:0000269 PubMed:27796307}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT2A gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005615 extracellular space HDA 22664934
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA,IEA 18838386
genes like me logo Genes that share ontologies with KAT2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KAT2A Gene

Pathways & Interactions for KAT2A Gene

genes like me logo Genes that share pathways with KAT2A: view

SIGNOR curated interactions for KAT2A Gene

Activates:

Gene Ontology (GO) - Biological Process for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001816 cytokine production ISS,IEA --
GO:0001843 neural tube closure IEA --
GO:0006338 chromatin remodeling TAS 8552087
genes like me logo Genes that share ontologies with KAT2A: view

Drugs & Compounds for KAT2A Gene

(5) Drugs for KAT2A Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra Target 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0

(1) Additional Compounds for KAT2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
genes like me logo Genes that share compounds with KAT2A: view

Transcripts for KAT2A Gene

mRNA/cDNA for KAT2A Gene

Unigene Clusters for KAT2A Gene

K(lysine) acetyltransferase 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT2A

Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for KAT2A Gene

GeneLoc Exon Structure for
KAT2A
ECgene alternative splicing isoforms for
KAT2A

Expression for KAT2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT2A Gene

This gene is overexpressed in Liver (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KAT2A Gene



Protein tissue co-expression partners for KAT2A Gene

NURSA nuclear receptor signaling pathways regulating expression of KAT2A Gene:

KAT2A

SOURCE GeneReport for Unigene cluster for KAT2A Gene:

Hs.463045

mRNA Expression by UniProt/SwissProt for KAT2A Gene:

Q92830-KAT2A_HUMAN
Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary.

Evidence on tissue expression from TISSUES for KAT2A Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Skin(4.3)
  • Eye(4.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with KAT2A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT2A Gene

Orthologs for KAT2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KAT2A 34 33
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KAT2A 34 33
  • 92.79 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat2a 33
  • 90.96 (n)
mouse
(Mus musculus)
Mammalia Kat2a 16 34 33
  • 90.66 (n)
cow
(Bos Taurus)
Mammalia KAT2A 34 33
  • 89.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KAT2A 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KAT2A 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves KAT2A 34 33
  • 83.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KAT2A 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kat2a 33
  • 76.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21330 33
zebrafish
(Danio rerio)
Actinopterygii kat2a 34 33
  • 77.41 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pcaf 34 33
  • 56.49 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004434 33
  • 55.73 (n)
worm
(Caenorhabditis elegans)
Secernentea pcaf-1 34
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN5 34
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5837 34
  • 56 (a)
OneToMany
Species where no ortholog for KAT2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KAT2A Gene

ENSEMBL:
Gene Tree for KAT2A (if available)
TreeFam:
Gene Tree for KAT2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KAT2A: view image

Paralogs for KAT2A Gene

Paralogs for KAT2A Gene

(2) SIMAP similar genes for KAT2A Gene using alignment to 3 proteins:

  • KAT2A_HUMAN
  • K7EPC4_HUMAN
  • K7ERS6_HUMAN
genes like me logo Genes that share paralogs with KAT2A: view

Variants for KAT2A Gene

Sequence variations from dbSNP and Humsavar for KAT2A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001558565 -- 42,120,961(-) C/T intron_variant
rs1001757855 -- 42,120,609(-) T/C intron_variant
rs1002003211 -- 42,113,525(-) G/A 3_prime_UTR_variant
rs1002580833 -- 42,122,337(-) C/G upstream_transcript_variant
rs1002779150 -- 42,122,036(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KAT2A Gene

Variant ID Type Subtype PubMed ID
esv2715947 CNV deletion 23290073
nsv1056904 CNV gain 25217958
nsv1071384 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv953898 CNV deletion 24416366

Variation tolerance for KAT2A Gene

Residual Variation Intolerance Score: 5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KAT2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KAT2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT2A Gene

Disorders for KAT2A Gene

Additional Disease Information for KAT2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KAT2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KAT2A Gene

Publications for KAT2A Gene

  1. The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PMID: 11384967) Col E … Khochbin S (The Journal of biological chemistry 2001) 3 4 22 58
  2. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PMID: 9611240) Smith ER … Allis CD (Nucleic acids research 1998) 3 4 22 58
  3. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R … Berger SL (Molecular and cellular biology 1996) 2 3 4 58
  4. Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. (PMID: 29174768) Ghosh TK … Brook JD (Journal of molecular and cellular cardiology 2018) 3 4 58
  5. KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase. (PMID: 29211711) Wang Y … Lu Z (Nature 2017) 3 4 58

Products for KAT2A Gene

Sources for KAT2A Gene

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