KAT2A Gene (Protein Coding)

Lysine Acetyltransferase 2A

GCID:: GC17M042113

GIFtS:: 47

Genes Participants

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] See more...

Aliases for KAT2A Gene

Lysine Acetyltransferase 2A ² ³ ⁴ ⁵
GCN5 ² ³ ⁴
General Control Of Amino Acid Synthesis Protein 5-Like 2 ³ ⁴
Histone Glutaryltransferase KAT2A ³ ⁴
Histone Succinyltransferase KAT2A ³ ⁴
Histone Acetyltransferase KAT2A ³ ⁴
K(Lysine) Acetyltransferase 2A ² ³
Histone Acetyltransferase GCN5 ³ ⁴
EC 2.3.1.48 ⁴ ⁵¹

GCN5L2 ³ ⁴
PCAF-B ² ³
STAF97 ³ ⁴
HGCN5 ³ ⁴
GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 2 ³
General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 2 ³
GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast) ²
EC 2.3.1.- ⁴
HsGCN5 ³
KAT2A ⁵

External Ids for KAT2A Gene

HGNC: 4201
Entrez Gene: 2648
Ensembl: ENSG00000108773
OMIM: 602301
UniProtKB: Q92830

Previous HGNC Symbols for KAT2A Gene

GCN5L2

Previous GeneCards Identifiers for KAT2A Gene

GC17M037519
GC17M040265
GC17M036030

Search aliases for KAT2A gene in PubMed and other databases

Summaries for KAT2A Gene

Entrez Gene Summary for KAT2A Gene

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

GeneCards Summary for KAT2A Gene

KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Spinocerebellar Ataxia 7 and Chromosome 16P13.3 Deletion Syndrome, Proximal. Among its related pathways are Chromatin organization and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B.

UniProtKB/Swiss-Prot Summary for KAT2A Gene

Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297).
- KAT2A_HUMAN,Q92830
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
- KAT2A_HUMAN,Q92830

Gene Wiki entry for KAT2A Gene

Additional gene information for KAT2A Gene

Search for KAT2A at DataMed
Search for KAT2A at HumanCyc

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KAT2A Gene

Genomics for KAT2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data

Request up-to-date GeneHancer data

Promoters and enhancers for KAT2A Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH17J042120	Promoter/Enhancer	2.1	EPDnew Ensembl ENCODE CraniofacialAtlas	600.7	-0.5	-459	2.9	GATAD2A PRDM10 REST SIX5 IKZF1 POLR2A ZNF143 RBFOX2 PKNOX1 IRF2	HSPB9 KAT2A piR-30173 ZNF385C DHX58 KCNH4 HCRT ENSG00000267261
GH17J041687	Promoter/Enhancer	2.6	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	28	+431.0	430968	6.1	CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 REST ZNF629	EIF1 lnc-HAP1-1 lnc-GAST-2 ENSG00000267758 ENSG00000259623 CNTNAP1 HSD17B1 NT5C3B NAGLU KAT2A
GH17J042674	Promoter/Enhancer	2.4	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	20.7	-557.0	-557035	12	CEBPG SP1 CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 REST	CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 TUBG2 ENSG00000267340 ENSG00000267002 ENSG00000267681 DHX8 HSD17B1
GH17J042386	Promoter/Enhancer	2.3	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	20.7	-267.0	-267035	4.4	CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 REST ZNF629	STAT3 lnc-CAVIN1-1 lnc-ATP6V0A1-5 ENSG00000267681 ENSG00000267758 ENSG00000267340 ENSG00000266962 NBR2 ENSG00000267002 NAGLU
GH17J042179	Promoter/Enhancer	1.7	EPDnew Ensembl ENCODE	19.5	-61.4	-61434	5.6	SP1 HNRNPL GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 REST TFE3	KCNH4 lnc-HSPB9-3 lnc-HSPB9-4 ENSG00000267758 ENSG00000267681 ENSG00000267340 NBR2 RETREG3 ENSG00000266962 KAT2A

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KAT2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KAT2A

Top Transcription factor binding sites by QIAGEN in the KAT2A gene promoter:

Egr-4
STAT1
STAT1alpha
STAT1beta
STAT2
STAT3
STAT4
STAT5A
STAT5B
STAT6

Genomic Locations for KAT2A Gene

chr17:42,113,111-42,121,367: (GRCh38/hg38)

Size:: 8,257 bases
Orientation:: Minus strand

chr17:40,265,126-40,273,382: (GRCh37/hg19)

Size:: 8,257 bases
Orientation:: Minus strand

Genomic View for KAT2A Gene

Genes around KAT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

17q21.2 by HGNC
17q21.2 by Entrez Gene
17q21.2 by Ensembl

KAT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for KAT2A Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KAT2A Gene

NC_000017.11

Proteins for KAT2A Gene

Protein details for KAT2A Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q92830-KAT2A_HUMAN

Recommended name:

Histone acetyltransferase KAT2A

Protein Accession:

Q92830

Secondary Accessions:
- Q8N1A2
- Q9UCW1
Protein attributes for KAT2A Gene
Size:

837 amino acids

Molecular mass:

93926 Da
Quaternary structure:
Homooligomer; may form a tetramer of homodimers (PubMed:30109122). Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP (PubMed:10373431, PubMed:10611234, PubMed:11438666). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (PubMed:18206972). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT14, MBIP and WDR5 (PubMed:19103755). Interacts with PML (By similarity). Interacts with CEBPB (PubMed:17301242). Interacts with TACC1, TACC2 and TACC3 (PubMed:14767476). Interacts with RELA (By similarity). Interacts with NFATC2 (By similarity). Interacts with TBX5 (PubMed:29174768). Interacts with PLK4 (PubMed:27796307). Associates with the 2-oxoglutarate dehydrogenase complex (PubMed:29211711). Interacts with XPC; leading to KAT2A recruitment to promoters and subsequent acetylation of histones (PubMed:29973595, PubMed:31527837). Interacts with ERCC3/XPB; leading to KAT2A recruitment to promoters and subsequent acetylation of histones (PubMed:30894545).

(Microbial infection) Interacts with and acetylates HIV-1 Tat.
Three dimensional structures from OCA and Proteopedia for KAT2A Gene
- 1F68 (3D)
- 1Z4R (3D)
- 3D7C (3D)
- 5H84 (3D)
- 5H86 (3D)
- 5MLJ (3D)
Alternative splice isoforms for KAT2A Gene
UniProtKB/Swiss-Prot:
Q92830-1

Q92830-2

neXtProt entry for KAT2A Gene

Protein Expression for KAT2A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for KAT2A Gene

Q92830:

YAIGYFKKQGF
EQVKGYGT

Post-translational modifications for KAT2A Gene

Ubiquitination at Lys446 and Lys289
- NX_Q92830 (NX_Q92830-1)
Modification sites at PhosphoSitePlus
- Q92830

Other Protein References for KAT2A Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

LifeSpan BioSciences KAT2A / GCN5 Antibody

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GeneTex Anti-GCN5 antibody [C3], C-term and Anti-GCN5 antibody [C2C3], C-term

NSJ Bioreagents GCN5 Antibody

Creative Diagnostics Anti-KAT2A monoclonal antibody, clone 4G9

Creative Biolabs Recombinant Anti-Human GCN5 Antibody, Mouse Anti-KAT2A Recombinant Antibody (4D3), and Mouse Anti-KAT2A Recombinant Antibody (3G13)

OriGene Antibodies for KAT2A
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Novus Biologicals Antibodies for KAT2A

Abcam antibodies for KAT2A
- KAT2A / GCN5

Invitrogen Antibodies for KAT2A (AFLGC-KAT2A)

Biorbyt antibodies for KAT2A
- orb216116
- orb540067

Boster Bio Antibodies for KAT2A
- A07210
- A07210-1
- PB9713

Santa Cruz Biotechnology (SCBT) Antibodies for KAT2A
- GCN5 (A-11)
- GCN5 (A-11) X

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OriGene Purified Proteins for KAT2A
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Novus Biologicals proteins for KAT2A

ProSpec Recombinant Proteins for KAT2A

antibodies-online: Show 13 available KAT2A Proteins ranked by validation data
Compare Top KAT2A Proteins

ProSci Proteins for KAT2A
- K(lysine) acetyltransferase 2A

Abcam proteins for KAT2A
- KAT2A / GCN5

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Domains & Families for KAT2A Gene

Gene Families for KAT2A Gene

HGNC:

Human Protein Atlas (HPA):

Enzymes
Predicted intracellular proteins

Protein Domains for KAT2A Gene

InterPro:

Blocks:

Bromodomain signature
PCAF, N-terminal

ProtoNet:

Q92830

Suggested Antigen Peptide Sequences for KAT2A Gene

GenScript: Design optimal peptide antigens:

STAF97 (KAT2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92830

UniProtKB/Swiss-Prot:

KAT2A_HUMAN :

Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.
Belongs to the acetyltransferase family. GCN5 subfamily.

Domain:

Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.

Family:

Belongs to the acetyltransferase family. GCN5 subfamily.

Function for KAT2A Gene

Molecular function for KAT2A Gene

UniProtKB/Swiss-Prot Function:

Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297).

KAT2A_HUMAN,Q92830

UniProtKB/Swiss-Prot Function:

(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.

KAT2A_HUMAN,Q92830

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; Evidence={ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768};.

KAT2A_HUMAN,Q92830

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]; Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269|PubMed:27377381, ECO:0000269|PubMed:29211711, ECO:0000269|PubMed:31527837};.

KAT2A_HUMAN,Q92830

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:16261, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11877, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:87830; Evidence={ECO:0000269|PubMed:29211711};.

KAT2A_HUMAN,Q92830

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=glutaryl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]; Xref=Rhea:RHEA:18009, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11875, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57378, ChEBI:CHEBI:87828; Evidence={ECO:0000269|PubMed:31542297};.

KAT2A_HUMAN,Q92830

UniProtKB/Swiss-Prot BiophysicochemicalProperties:

Kinetic parameters: KM=0.83 uM for acetyl-CoA {ECO:0000269|PubMed:29211711}; KM=0.91 uM for acetyl-CoA {ECO:0000269|PubMed:27377381}; KM=0.36 uM for succinyl-CoA {ECO:0000269|PubMed:29211711};

KAT2A_HUMAN,Q92830

Enzyme Numbers (IUBMB) for KAT2A Gene

EC 2.3.1.48 ⁵¹ ⁴
EC 2.3.1.- ⁴

Phenotypes From GWAS Catalog for KAT2A Gene

Gene Ontology (GO) - Molecular Function for KAT2A Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA,IDA	29211711
GO:0003713	transcription coactivator activity	IDA	11564863
GO:0004402	histone acetyltransferase activity	IEA,TAS	--
GO:0005515	protein binding	IPI	17664281
GO:0008080	N-acetyltransferase activity	IEA	--

Phenotypes for KAT2A Gene

MGI mutant phenotypes for KAT2A:

inferred from 6 alleles

GenomeRNAi human phenotypes for KAT2A:

Animal Models for KAT2A Gene

MGI Knock Outs for KAT2A:

Kat2a ^{Kat2a<tm1Nkt>}
Kat2a ^{Kat2a<tm1Roth>}
Kat2a ^{Kat2a<tm3.1Roth>}

Animal Model Products

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CRISPR Products

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OriGene CRISPR knockouts for KAT2A
- GA101767
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Santa Cruz Biotechnology (SCBT) CRISPR for KAT2A

miRNA for KAT2A Gene

miRTarBase miRNAs that target KAT2A

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Clone Products

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OriGene clones in human,mouse,rat for KAT2A
- SC207419
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OriGene ORF clones in human,mouse,rat for KAT2A
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Sino Biological Human cDNA Clone for KAT2A

Addgene plasmids for KAT2A

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Horizon Cell Lines for KAT2A
- KAT2A knockout cell line
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No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT2A Gene

Localization for KAT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT2A Gene

Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307). {ECO:0000269 PubMed:27796307}.

Q92830-KAT2A_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
cytoskeleton	5
nucleus	5
extracellular	4
cytosol	3
plasma membrane	2
mitochondrion	2
peroxisome	1
endoplasmic reticulum	1
endosome	1
lysosome	1
golgi apparatus	1

Gene Ontology (GO) - Cellular Components for KAT2A Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000123	histone acetyltransferase complex	IEA,IDA	29973595
GO:0000790	nuclear chromatin	IEA	--
GO:0005615	extracellular space	HDA	22664934
GO:0005634	nucleus	IEA,IDA	11564863
GO:0005654	nucleoplasm	TAS	--

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KAT2A Gene

Pathways & Interactions for KAT2A Gene

SuperPathways for KAT2A Gene

	SuperPathway	Contained pathways
1	Signaling by NOTCH1	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants .78 Constitutive Signaling by NOTCH1 PEST Domain Mutants .78 Signaling by NOTCH1 .78 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer .78	Signaling by NOTCH1 in Cancer .78 Signaling by NOTCH1 PEST Domain Mutants in Cancer .78 NOTCH1 Intracellular Domain Regulates Transcription .68 Signaling by NOTCH .65
2	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	B-WICH complex positively regulates rRNA expression .86 Positive epigenetic regulation of rRNA expression .86 RNA Polymerase I Transcription .81	RNA Polymerase I Promoter Clearance .81 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription .75 Epigenetic regulation of gene expression .73
3	Notch Signaling Pathway (WikiPathways)	Notch signaling pathway .75 Notch Signaling Pathway .75	Notch Signaling Pathways .31
4	Chromatin organization	Chromatin modifying enzymes .51 Chromatin organization .51	HATs acetylate histones .51
5	Pre-NOTCH Expression and Processing	Pre-NOTCH Expression and Processing .64 Pre-NOTCH Transcription and Translation .64	Notch-HLH transcription pathway .01

Pathways by source for KAT2A Gene

5 BioSystems pathways for KAT2A Gene

30 Reactome pathways for KAT2A Gene

4 KEGG pathways for KAT2A Gene

1 GeneGo (Thomson Reuters) pathway for KAT2A Gene

Development Notch Signaling Pathway

Interacting Proteins for KAT2A Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: Q92830-KAT2A_HUMAN ENSP00000225916 for KAT2A Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
ZZZ3	Q8IYH5 ⁴ ²⁰ ¹²⁶ ENSP00000359837 ²¹	EBI-477622, EBI-2795524 MINT-8012388 STRING: ENSP00000359837 IID: # exp=2 # pred=1
CDK8	P49336 ²⁰ ¹²⁶ ENSP00000370938 ²¹	MINT-6744730 STRING: ENSP00000370938 IID: # exp=1 # pred=1
E2F1	Q01094 ⁴ ¹²⁶ ENSP00000345571 ²¹	EBI-477622, EBI-448924 STRING: ENSP00000345571 IID: # exp=2 # pred=2
E2F3	O00716 ²⁰ ¹²⁶ ENSP00000262904 ²¹	MINT-8376041 STRING: ENSP00000262904 IID: # exp=1
FUBP1	Q96AE4 ²⁰ ¹²⁶ ENSP00000359804 ²¹	MINT-8298193 STRING: ENSP00000359804 IID: # exp=1

GPS-Prot Interaction Network for KAT2A

SIGNOR curated interactions for KAT2A Gene

Activates:

Gene Ontology (GO) - Biological Process for KAT2A Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0001756	somitogenesis	IEA	--
GO:0001816	cytokine production	IEA,ISS	--
GO:0001843	neural tube closure	IEA	--
GO:0006338	chromatin remodeling	TAS	8552087

Drugs & Compounds for KAT2A Gene

(5) Drugs for KAT2A Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action
Coenzyme A	Investigational	MalaCards Medline Plus	Nutra	Target
Donepezil HCl		MalaCards Medline Plus	Pharma		AChE inhibitor
MG 149		MalaCards Medline Plus	Pharma		HAT inhibitor
Remodelin		MalaCards Medline Plus	Pharma

(1) Additional Compounds for KAT2A Gene - From: HMDB

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs
acetyl-coa	AcCoA Acetyl coenzyme A S-Acetyl-CoA S-Acetyl-coenzyme A Ac-CoA		MalaCards Medline Plus	72-89-9	444493

(3) ApexBio Compounds for KAT2A Gene

Compound	Action	Cas Number
Donepezil HCl	AChE inhibitor	120011-70-3
MG 149	HAT inhibitor	1243583-85-8
Remodelin		1622921-15-6

Drug Products

Browse Tocris compounds for KAT2A

ApexBio compounds for KAT2A

Transcripts for KAT2A Gene