Aliases for KAT2A Gene
Aliases for KAT2A Gene
External Ids for KAT2A Gene
- HGNC: 4201
- Entrez Gene: 2648
- Ensembl: ENSG00000108773
- OMIM: 602301
- UniProtKB: Q92830
Previous HGNC Symbols for KAT2A Gene
- GCN5L2
Previous GeneCards Identifiers for KAT2A Gene
- GC17M037519
- GC17M040265
- GC17M036030
Summaries for KAT2A Gene
-
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
GeneCards Summary for KAT2A Gene
KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B.
UniProtKB/Swiss-Prot for KAT2A Gene
-
Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on Lys-79 (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
-
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT2A Gene
Genomics for KAT2A Gene
GeneHancer (GH) Regulatory Elements for KAT2A Gene
Promoters and enhancers for KAT2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KAT2A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KAT2A gene promoter:
-
- STAT1alpha
- STAT1
- Egr-4
- STAT1beta
- STAT2
- STAT3
- STAT4
- STAT5A
- STAT5B
- STAT6
Regulatory Element Products
Genomic Locations for KAT2A Gene
Genomic Locations for KAT2A Gene
- chr17:42,113,108-42,121,393
- (GRCh38/hg38)
- Size:
- 8,286 bases
- Orientation:
- Minus strand
- chr17:40,265,126-40,273,382
- (GRCh37/hg19)
- Size:
- 8,257 bases
- Orientation:
- Minus strand
Genomic View for KAT2A Gene
Genes around KAT2A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by Entrez Gene
- 17q21.2 by HGNC
- 17q21.2 by Ensembl
KAT2A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KAT2A Gene
Proteins for KAT2A Gene
-
Protein details for KAT2A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92830-KAT2A_HUMAN
- Recommended name:
- Histone acetyltransferase KAT2A
- Protein Accession:
- Q92830
- Q8N1A2
- Q9UCW1
Protein attributes for KAT2A Gene
- Size:
- 837 amino acids
- Molecular mass:
- 93926 Da
- Quaternary structure:
-
- Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP (PubMed:10373431, PubMed:10611234, PubMed:11438666). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (PubMed:18206972). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT14, MBIP and WDR5 (PubMed:19103755). Interacts with PML (By similarity). Interacts with CEBPB (PubMed:17301242). Interacts with TACC1, TACC2 and TACC3 (PubMed:14767476). Interacts with RELA (By similarity). Interacts with NFATC2 (By similarity). Interacts with TBX5 (PubMed:29174768). Interacts with PLK4 (PubMed:27796307). Associates with the 2-oxoglutarate dehydrogenase complex (PubMed:29211711).
- (Microbial infection) Interacts with and acetylates HIV-1 Tat.
Three dimensional structures from OCA and Proteopedia for KAT2A Gene
Protein Expression for KAT2A Gene
Post-translational modifications for KAT2A Gene
Other Protein References for KAT2A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KAT2A
- Novus Biologicals Antibodies for KAT2A
-
Abcam antibodies for KAT2A
- Invitrogen Antibodies for KAT2A (AFLGC-KAT2A)
- GeneTex KAT2A Antibody for KAT2A
-
Santa Cruz Biotechnology (SCBT) Antibodies for KAT2A
Protein Products
-
OriGene Purified Proteins for KAT2A
- Search Origene for MassSpec and Protein Over-expression Lysates for KAT2A
- Origene Custom Protein Services for KAT2A
- ProSpec Recombinant Proteins for KAT2A
- Search GeneTex for Proteins for KAT2A
-
ProSci Proteins for KAT2A
-
Abcam proteins for KAT2A
Assay Products
No data available for DME Specific Peptides for KAT2A Gene
Domains & Families for KAT2A Gene
Gene Families for KAT2A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for KAT2A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KAT2A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92830UniProtKB/Swiss-Prot:
KAT2A_HUMAN :- Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.
- Belongs to the acetyltransferase family. GCN5 subfamily.
- Domain:
-
- Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.
- Family:
-
- Belongs to the acetyltransferase family. GCN5 subfamily.
Function for KAT2A Gene
Molecular function for KAT2A Gene
- UniProtKB/Swiss-Prot Function:
- Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on Lys-79 (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Succinyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-succinyl-L-lysine.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.83 uM for acetyl-CoA {ECO:0000269 PubMed:29211711}; KM=0.36 uM for succinyl-CoA {ECO:0000269 PubMed:29211711};
Enzyme Numbers (IUBMB) for KAT2A Gene
Phenotypes From GWAS Catalog for KAT2A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IDA,IEA | 29211711 |
| GO:0003713 | transcription coactivator activity | IDA | 11564863 |
| GO:0004402 | histone acetyltransferase activity | TAS,IEA | -- |
| GO:0005515 | protein binding | IPI | 17664281 |
| GO:0008080 | N-acetyltransferase activity | IEA | -- |
Phenotypes for KAT2A Gene
- MGI mutant phenotypes for KAT2A:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for KAT2A:
-
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased TP53 mRNA expression
- Decreased ionizing radiation sensitivity
- Increased Nanog expression
- Decreased p24 protein expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- shRNA abundance <= 50%
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for KAT2A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KAT2A
-
CRISPR Products
-
OriGene CRISPR knockouts for KAT2A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KAT2A
- genomics-online: gRNA clones - Search results for available KAT2A gene related products
- Applied Biological Materials CRISPR for KAT2A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KAT2A
- GenScript: Design CRISPR guide RNA sequences for KAT2A
miRNA for KAT2A Gene
- miRTarBase miRNAs that target KAT2A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KAT2A
- Browse OriGene Inhibitory RNA Products For KAT2A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT2A
- genomics-online: shRNA clones - Search results for available KAT2A gene related products
Clone Products
- Sino Biological Human cDNA Clone for KAT2A
- Addgene plasmids for KAT2A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KAT2A
- genomics-online: cdna clones - Search results for available KAT2A gene related products
- orf clones - Search results for available KAT2A gene related products
- Applied Biological Materials Clones for KAT2A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KAT2A
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT2A Gene
Localization for KAT2A Gene
Subcellular locations from UniProtKB/Swiss-Prot for KAT2A Gene
- Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. {ECO:0000269 PubMed:27796307}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IEA | -- |
| GO:0005615 | extracellular space | HDA | 22664934 |
| GO:0005634 | nucleus | IEA,IDA | 11564863 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA,IEA | 18838386 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KAT2A Gene
Pathways & Interactions for KAT2A Gene
Pathways by source for KAT2A Gene
1 GeneTex pathway for KAT2A Gene
5 BioSystems pathways for KAT2A Gene
30 Reactome pathways for KAT2A Gene
4 KEGG pathways for KAT2A Gene
1 GeneGo (Thomson Reuters) pathway for KAT2A Gene
1 R&D Systems pathway for KAT2A Gene
1 Cell Signaling Technology pathway for KAT2A Gene
Interacting Proteins for KAT2A Gene
Selected Interacting proteins:
Q92830-KAT2A_HUMAN
ENSP00000225916
for KAT2A Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for KAT2A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001756 | somitogenesis | IEA | -- |
| GO:0001816 | cytokine production | ISS,IEA | -- |
| GO:0001843 | neural tube closure | IEA | -- |
| GO:0006338 | chromatin remodeling | TAS | 8552087 |
Drugs & Compounds for KAT2A Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| acetyl-coa |
|
72-89-9 |
|
Drug Products
Transcripts for KAT2A Gene
mRNA/cDNA for KAT2A Gene
- (4) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (939) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000225916 3109 bps (uc002hyx.3)
- ENST00000465682 2990 bps (uc060fgu.1)
- ENST00000586972 852 bps (uc060fgv.1)
- ENST00000588759 404 bps (uc060fgw.1)
- ENST00000592310 596 bps (uc060fgx.1)
Unigene Clusters for KAT2A Gene
CRISPR Products
-
OriGene CRISPR knockouts for KAT2A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KAT2A
- genomics-online: gRNA clones - Search results for available KAT2A gene related products
- Applied Biological Materials CRISPR for KAT2A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KAT2A
- GenScript: Design CRISPR guide RNA sequences for KAT2A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KAT2A
- Browse OriGene Inhibitory RNA Products For KAT2A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT2A
- genomics-online: shRNA clones - Search results for available KAT2A gene related products
Clone Products
- Sino Biological Human cDNA Clone for KAT2A
- Addgene plasmids for KAT2A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KAT2A
- genomics-online: cdna clones - Search results for available KAT2A gene related products
- orf clones - Search results for available KAT2A gene related products
- Applied Biological Materials Clones for KAT2A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for KAT2A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Skeletal Muscle (Muscoskeletal System)
-
Eye (Sensory Organs)
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
-
Epithelial Cells
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
This gene is overexpressed in Liver (66.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KAT2A Gene
NURSA nuclear receptor signaling pathways regulating expression of KAT2A Gene:
KAT2ASOURCE GeneReport for Unigene cluster for KAT2A Gene:
Hs.463045mRNA Expression by UniProt/SwissProt for KAT2A Gene:
Q92830-KAT2A_HUMAN
Tissue specificity:
Expressed in all tissues tested, with most abundant expression in ovary.
Evidence on tissue expression from TISSUES for KAT2A Gene
- Nervous system(4.7)
- Liver(4.4)
- Skin(4.3)
- Eye(4.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for KAT2A
-
OriGene qPCR primer pairs and template standards for KAT2A
- genomics-online: primer clones - Search results for available KAT2A gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT2A Gene
Orthologs for KAT2A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KAT2A 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KAT2A 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Kat2a 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Kat2a 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | KAT2A 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KAT2A 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | KAT2A 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KAT2A 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KAT2A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kat2a 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21330 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kat2a 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Pcaf 34 33 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004434 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pcaf-1 34 |
|
ManyToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GCN5 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5837 34 |
|
OneToMany |
- Species where no ortholog for KAT2A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for KAT2A Gene
- ENSEMBL:
- Gene Tree for KAT2A (if available)
- TreeFam:
- Gene Tree for KAT2A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KAT2A: view image
Paralogs for KAT2A Gene
Variants for KAT2A Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001558565 | -- | 42,120,961(-) | C/T | intron_variant | |
| rs1001757855 | -- | 42,120,609(-) | T/C | intron_variant | |
| rs1002003211 | -- | 42,113,525(-) | G/A | 3_prime_UTR_variant | |
| rs1002580833 | -- | 42,122,337(-) | C/G | upstream_transcript_variant | |
| rs1002779150 | -- | 42,122,036(-) | C/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2715947 | CNV | deletion | 23290073 |
| nsv1056904 | CNV | gain | 25217958 |
| nsv1071384 | CNV | deletion | 25765185 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv953898 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.16;
23.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KAT2A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KAT2A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT2A Gene
Disorders for KAT2A Gene
Additional Disease Information for KAT2A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for KAT2A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KAT2A Gene
Publications for KAT2A Gene
- The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PMID: 11384967) Col E … Khochbin S (The Journal of biological chemistry 2001) 3 4 22 58
- Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PMID: 9611240) Smith ER … Allis CD (Nucleic acids research 1998) 3 4 22 58
- Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R … Berger SL (Molecular and cellular biology 1996) 2 3 4 58
- Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. (PMID: 29174768) Ghosh TK … Brook JD (Journal of molecular and cellular cardiology 2018) 3 4 58
- KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase. (PMID: 29211711) Wang Y … Lu Z (Nature 2017) 3 4 58
Products for KAT2A Gene
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Sources for KAT2A Gene
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