KAT2A Gene (Protein Coding)

Lysine Acetyltransferase 2A

GC17M042113
GIFtS:
48
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] See more...

Aliases for KAT2A Gene

Aliases for KAT2A Gene

  • Lysine Acetyltransferase 2A 2 3 4 5
  • GCN5 2 3 4
  • General Control Of Amino Acid Synthesis Protein 5-Like 2 3 4
  • Histone Glutaryltransferase KAT2A 3 4
  • Histone Succinyltransferase KAT2A 3 4
  • Histone Acetyltransferase KAT2A 3 4
  • K(Lysine) Acetyltransferase 2A 2 3
  • Histone Acetyltransferase GCN5 3 4
  • EC 2.3.1.48 4 51
  • GCN5L2 3 4
  • PCAF-B 2 3
  • STAF97 3 4
  • HGCN5 3 4
  • GCN5 (General Control Of Amino-Acid Synthesis, Yeast, Homolog)-Like 2 3
  • General Control Of Amino Acid Synthesis, Yeast, Homolog-Like 2 3
  • GCN5 General Control Of Amino-Acid Synthesis 5-Like 2 (Yeast) 2
  • EC 2.3.1.- 4
  • HsGCN5 3
  • KAT2A 5

External Ids for KAT2A Gene

Previous HGNC Symbols for KAT2A Gene

  • GCN5L2

Previous GeneCards Identifiers for KAT2A Gene

  • GC17M037519
  • GC17M040265
  • GC17M036030

Summaries for KAT2A Gene

Entrez Gene Summary for KAT2A Gene

  • KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

GeneCards Summary for KAT2A Gene

KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Spinocerebellar Ataxia 7 and Chromosome 16P13.3 Deletion Syndrome, Proximal. Among its related pathways are RNA Polymerase I Promoter Escape and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is KAT2B.

UniProtKB/Swiss-Prot Summary for KAT2A Gene

  • Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297).
  • (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.

Gene Wiki entry for KAT2A Gene

Additional gene information for KAT2A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KAT2A Gene

Genomics for KAT2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for KAT2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KAT2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KAT2A

Top Transcription factor binding sites by QIAGEN in the KAT2A gene promoter:
  • Egr-4
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for KAT2A Gene

Latest Assembly
chr17:42,113,111-42,121,367
(GRCh38/hg38)
Size:
8,257 bases
Orientation:
Minus strand

Previous Assembly
chr17:40,265,129-40,273,385
(GRCh37/hg19 by Entrez Gene)
Size:
8,257 bases
Orientation:
Minus strand

chr17:40,265,126-40,273,376
(GRCh37/hg19 by Ensembl)
Size:
8,251 bases
Orientation:
Minus strand

Genomic View for KAT2A Gene

Genes around KAT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT2A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KAT2A Gene

Proteins for KAT2A Gene

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  • Protein details for KAT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92830-KAT2A_HUMAN
    Recommended name:
    Histone acetyltransferase KAT2A
    Protein Accession:
    Q92830
    Secondary Accessions:
    • Q8N1A2
    • Q9UCW1

    Protein attributes for KAT2A Gene

    Size:
    837 amino acids
    Molecular mass:
    93926 Da
    Quaternary structure:
    • Homooligomer; may form a tetramer of homodimers (PubMed:30109122). Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP (PubMed:10373431, PubMed:10611234, PubMed:11438666). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (PubMed:18206972). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT14, MBIP and WDR5 (PubMed:19103755). Interacts with PML (By similarity). Interacts with CEBPB (PubMed:17301242). Interacts with TACC1, TACC2 and TACC3 (PubMed:14767476). Interacts with RELA (By similarity). Interacts with NFATC2 (By similarity). Interacts with TBX5 (PubMed:29174768). Interacts with PLK4 (PubMed:27796307). Associates with the 2-oxoglutarate dehydrogenase complex (PubMed:29211711). Interacts with XPC; leading to KAT2A recruitment to promoters and subsequent acetylation of histones (PubMed:29973595, PubMed:31527837). Interacts with ERCC3/XPB; leading to KAT2A recruitment to promoters and subsequent acetylation of histones (PubMed:30894545).
    • (Microbial infection) Interacts with and acetylates HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for KAT2A Gene

    Alternative splice isoforms for KAT2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT2A Gene

Protein Expression for KAT2A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for KAT2A Gene

Q92830:
  • YAIGYFKKQGF
  • EQVKGYGT

Post-translational modifications for KAT2A Gene

  • Ubiquitination at Lys446 and Lys289
  • Modification sites at PhosphoSitePlus

Other Protein References for KAT2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for KAT2A Gene

Gene Families for KAT2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for KAT2A Gene

InterPro:
Blocks:
  • Bromodomain signature
  • PCAF, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for KAT2A Gene

GenScript: Design optimal peptide antigens:
  • STAF97 (KAT2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92830

UniProtKB/Swiss-Prot:

KAT2A_HUMAN :
  • Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.
  • Belongs to the acetyltransferase family. GCN5 subfamily.
Domain:
  • Loop3 is required for substrate specificity and adopts different structural conformations in succinyl-CoA-bound and acetyl-CoA-bound forms. Tyr-645 has an important role in the selective binding of succinyl-CoA over acetyl-CoA.
Family:
  • Belongs to the acetyltransferase family. GCN5 subfamily.
genes like me logo Genes that share domains with KAT2A: view

Function for KAT2A Gene

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Molecular function for KAT2A Gene

UniProtKB/Swiss-Prot Function:
Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; Evidence={ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]; Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269|PubMed:27377381, ECO:0000269|PubMed:29211711, ECO:0000269|PubMed:31527837};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:16261, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11877, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:87830; Evidence={ECO:0000269|PubMed:29211711};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutaryl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]; Xref=Rhea:RHEA:18009, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11875, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57378, ChEBI:CHEBI:87828; Evidence={ECO:0000269|PubMed:31542297};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.83 uM for acetyl-CoA {ECO:0000269|PubMed:29211711}; KM=0.91 uM for acetyl-CoA {ECO:0000269|PubMed:27377381}; KM=0.36 uM for succinyl-CoA {ECO:0000269|PubMed:29211711};

Enzyme Numbers (IUBMB) for KAT2A Gene

Phenotypes From GWAS Catalog for KAT2A Gene

Gene Ontology (GO) - Molecular Function for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA,IDA 29211711
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 histone acetyltransferase activity IEA,TAS --
GO:0005515 protein binding IPI 17664281
GO:0008080 N-acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with KAT2A: view
genes like me logo Genes that share phenotypes with KAT2A: view

Animal Models for KAT2A Gene

MGI Knock Outs for KAT2A:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT2A

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT2A Gene

Localization for KAT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT2A Gene

Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307). {ECO:0000269 PubMed:27796307}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT2A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4
cytosol 3
plasma membrane 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IEA,IDA 29973595
GO:0005615 extracellular space HDA 22664934
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA,IDA 18838386
genes like me logo Genes that share ontologies with KAT2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KAT2A Gene

Pathways & Interactions for KAT2A Gene

genes like me logo Genes that share pathways with KAT2A: view

SIGNOR curated interactions for KAT2A Gene

Activates:

Gene Ontology (GO) - Biological Process for KAT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001816 cytokine production ISS --
GO:0001843 neural tube closure IEA --
GO:0006338 chromatin remodeling TAS 8552087
genes like me logo Genes that share ontologies with KAT2A: view

Drugs & Compounds for KAT2A Gene

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(5) Drugs for KAT2A Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra Target 0
Donepezil HCl Pharma AChE inhibitor 0
MG 149 Pharma HAT inhibitor 0
Remodelin Pharma 0

(1) Additional Compounds for KAT2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
 72-89-9

(3) ApexBio Compounds for KAT2A Gene

Compound Action Cas Number
Donepezil HCl AChE inhibitor 120011-70-3
MG 149 HAT inhibitor 1243583-85-8
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with KAT2A: view

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Transcripts for KAT2A Gene

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mRNA/cDNA for KAT2A Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KAT2A

Alternative Splicing Database (ASD) splice patterns (SP) for KAT2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for KAT2A Gene

GeneLoc Exon Structure for
KAT2A

Expression for KAT2A Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KAT2A Gene

mRNA expression in normal human tissues for KAT2A Gene
mRNA expression by GTEx for KAT2A GenemRNA expression by BioGPS for KAT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KAT2A Gene

This gene is overexpressed in Liver (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KAT2A Gene



Protein tissue co-expression partners for KAT2A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KAT2A

SOURCE GeneReport for Unigene cluster for KAT2A Gene:

Hs.463045

mRNA Expression by UniProt/SwissProt for KAT2A Gene:

Q92830-KAT2A_HUMAN
Tissue specificity: Expressed in all tissues tested, with most abundant expression in ovary.

Evidence on tissue expression from TISSUES for KAT2A Gene

  • Nervous system(4.8)
  • Skin(4.6)
  • Liver(4.5)
  • Eye(4.3)
  • Muscle(2.6)
  • Intestine(2.5)
  • Kidney(2.5)
  • Heart(2.4)
  • Spleen(2.3)
  • Blood(2.3)
  • Thyroid gland(2.2)
  • Adrenal gland(2.2)
  • Lung(2.2)
  • Lymph node(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with KAT2A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT2A Gene

Orthologs for KAT2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KAT2A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia KAT2A 30 31
  • 99.52 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia KAT2A 30 31
  • 92.79 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Kat2a 30
  • 90.96 (n)
Mouse
(Mus musculus)
 Mammalia Kat2a 30 17 31
  • 90.66 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia KAT2A 30 31
  • 89.52 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia KAT2A 31
  • 84 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia KAT2A 31
  • 83 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves KAT2A 30 31
  • 83.84 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia KAT2A 31
  • 80 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia kat2a 30
  • 76.02 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.21330 30
Zebrafish
(Danio rerio)
 Actinopterygii kat2a 30 31
  • 77.41 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Pcaf 30 31
  • 56.49 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004434 30
  • 55.73 (n)
Worm
(Caenorhabditis elegans)
 Secernentea pcaf-1 31
  • 30 (a)
 ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GCN5 31
  • 43 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.5837 31
  • 56 (a)
 OneToMany
Species where no ortholog for KAT2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KAT2A Gene

ENSEMBL:
Gene Tree for KAT2A (if available)
TreeFam:
Gene Tree for KAT2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KAT2A: view image

Paralogs for KAT2A Gene

Paralogs for KAT2A Gene

(2) SIMAP similar genes for KAT2A Gene using alignment to 3 proteins:

  • KAT2A_HUMAN
  • K7EPC4_HUMAN
  • K7ERS6_HUMAN
genes like me logo Genes that share paralogs with KAT2A: view

Variants for KAT2A Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KAT2A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs147034250 Benign: not provided 42,114,040(-) C/T
NM_021078.3(KAT2A):c.2280G>A (p.Ser760=) 		SYNONYMOUS
rs781885483 Benign: not provided 42,118,011(-) ACTGAAGCTGAGGAGA
NM_021078.3(KAT2A):c.1181-33_1186del 		SPLICE_ACCEPTOR
rs782241423 Likely Benign: not provided 42,120,711(-) G/A
NM_021078.3(KAT2A):c.458C>T (p.Pro153Leu) 		MISSENSE
rs9303326 Benign: not provided 42,114,374(-) A/G
NM_021078.3(KAT2A):c.2155T>C (p.Leu719=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KAT2A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KAT2A Gene

Variant ID Type Subtype PubMed ID
esv2715947 CNV deletion 23290073
nsv1056904 CNV gain 25217958
nsv1071384 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv953898 CNV deletion 24416366

Variation tolerance for KAT2A Gene

Residual Variation Intolerance Score: 5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KAT2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KAT2A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT2A Gene

Disorders for KAT2A Gene

MalaCards: The human disease database

(3) MalaCards diseases for KAT2A Gene - From: COP

Disorder Aliases PubMed IDs
spinocerebellar ataxia 7
  • sca7
chromosome 16p13.3 deletion syndrome, proximal
  • rubinstein-taybi deletion syndrome
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search KAT2A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KAT2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KAT2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KAT2A Gene

Publications for KAT2A Gene

  1. The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. (PMID: 11384967) Col E … Khochbin S (The Journal of biological chemistry 2001) 3 4 23
  2. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. (PMID: 9611240) Smith ER … Allis CD (Nucleic acids research 1998) 3 4 23
  3. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R … Berger SL (Molecular and cellular biology 1996) 2 3 4
  4. DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription. (PMID: 31527837) Semer M … Le May N (Nature chemical biology 2019) 3 4
  5. Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. (PMID: 30894545) Sandoz J … Coin F (Nature communications 2019) 3 4

ExternalLinks

View latest publications for KAT2A gene in Mastermind

Products for KAT2A Gene

  • Addgene plasmids for KAT2A