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Aliases for KAT14 Gene

Aliases for KAT14 Gene

  • Lysine Acetyltransferase 14 2 3 4 5
  • ADA2A-Containing Complex Subunit 2 3 4
  • CSRP2-Binding Protein 3 4
  • CSRP2BP 3 4
  • CRP2BP 3 4
  • ATAC2 3 4
  • Cysteine-Rich Protein 2-Binding Protein 3
  • Cysteine Rich Protein 2 Binding Protein 2
  • ATAC Component 2 Homolog (Drosophila) 2
  • ATAC Component 2 Homolog 3
  • CSRP2 Binding Protein 2
  • CRP2 Binding Partner 3
  • CRP2 Binding Protein 3
  • CRP2-Binding Partner 4
  • DJ717M23.1 3
  • PRO1194 3

External Ids for KAT14 Gene

Previous HGNC Symbols for KAT14 Gene

  • CSRP2BP

Summaries for KAT14 Gene

Entrez Gene Summary for KAT14 Gene

  • CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

GeneCards Summary for KAT14 Gene

KAT14 (Lysine Acetyltransferase 14) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for KAT14 Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.

Gene Wiki entry for KAT14 Gene

Additional gene information for KAT14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAT14 Gene

Genomics for KAT14 Gene

GeneHancer (GH) Regulatory Elements for KAT14 Gene

Promoters and enhancers for KAT14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J018136 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 656.7 +0.5 500 3.7 CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B KAT14 PET117 ZNF133 LOC100270804 LOC100286962 GC20P018220 LOC100529052
GH20J018251 Enhancer 0.8 Ensembl ENCODE 5.1 +114.7 114728 2.6 MXI1 JUN MAX USF2 CEBPB EP300 JUND POLR2A ZFP36 FOS KAT14 RN7SL14P LOC100529052 GC20P018220
GH20J018143 Promoter/Enhancer 1.3 EPDnew ENCODE 0.4 +6.9 6916 2.5 FOXA2 ZNF48 ETS1 ZNF614 CREM SP5 CEBPB PPARG SREBF1 SP1 SNX5 KAT14 GC20P018220 LOC100529052
GH20J018142 Promoter 0.5 EPDnew 0.7 +4.6 4624 0.1 PET117 KAT14 LOC100529052 GC20P018220
GH20J018176 Enhancer 0.7 ENCODE 0.3 +38.3 38314 0.2 CTCF ATF1 SMAD1 CEBPG ZIC2 ZNF644 RAD21 THRB ZNF335 CTBP1 ZNF133 KAT14 GC20P018220 LOC100529052
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KAT14 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KAT14 Gene

Genomic Locations for KAT14 Gene
chr20:18,138,118-18,188,387
(GRCh38/hg38)
Size:
50,270 bases
Orientation:
Plus strand
chr20:18,118,762-18,169,031
(GRCh37/hg19)
Size:
50,270 bases
Orientation:
Plus strand

Genomic View for KAT14 Gene

Genes around KAT14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KAT14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KAT14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KAT14 Gene

Proteins for KAT14 Gene

  • Protein details for KAT14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8E8-CSR2B_HUMAN
    Recommended name:
    Cysteine-rich protein 2-binding protein
    Protein Accession:
    Q9H8E8
    Secondary Accessions:
    • A2A2I5
    • Q96GW6
    • Q96IH3
    • Q9HBF0
    • Q9UIY5

    Protein attributes for KAT14 Gene

    Size:
    782 amino acids
    Molecular mass:
    88844 Da
    Quaternary structure:
    • Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.
    SequenceCaution:
    • Sequence=CAB56651.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KAT14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KAT14 Gene

Post-translational modifications for KAT14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KAT14 Gene

No data available for DME Specific Peptides for KAT14 Gene

Domains & Families for KAT14 Gene

Gene Families for KAT14 Gene

Protein Domains for KAT14 Gene

Suggested Antigen Peptide Sequences for KAT14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KAT14: view

No data available for UniProtKB/Swiss-Prot for KAT14 Gene

Function for KAT14 Gene

Molecular function for KAT14 Gene

UniProtKB/Swiss-Prot Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.

Phenotypes From GWAS Catalog for KAT14 Gene

Gene Ontology (GO) - Molecular Function for KAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity IDA 19103755
GO:0005515 protein binding IPI 16189514
GO:0008080 N-acetyltransferase activity IEA --
GO:0030274 LIM domain binding NAS 10924333
genes like me logo Genes that share ontologies with KAT14: view
genes like me logo Genes that share phenotypes with KAT14: view

Animal Models for KAT14 Gene

MGI Knock Outs for KAT14:
  • Kat14 Kat14<tm1a(KOMP)Wtsi>
  • Kat14 Kat14<tm1d(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for KAT14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KAT14 Gene

Localization for KAT14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KAT14 Gene

Nucleus. Cytoplasm. Note=Mainly nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KAT14 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IPI 10924333
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KAT14: view

Pathways & Interactions for KAT14 Gene

genes like me logo Genes that share pathways with KAT14: view

Pathways by source for KAT14 Gene

Gene Ontology (GO) - Biological Process for KAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0016573 histone acetylation IEA,IBA --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with KAT14: view

No data available for SIGNOR curated interactions for KAT14 Gene

Drugs & Compounds for KAT14 Gene

No Compound Related Data Available

Transcripts for KAT14 Gene

mRNA/cDNA for KAT14 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KAT14 Gene

No ASD Table

Relevant External Links for KAT14 Gene

GeneLoc Exon Structure for
KAT14
ECgene alternative splicing isoforms for
KAT14

Expression for KAT14 Gene

NURSA nuclear receptor signaling pathways regulating expression of KAT14 Gene:

KAT14

mRNA Expression by UniProt/SwissProt for KAT14 Gene:

Q9H8E8-CSR2B_HUMAN
Tissue specificity: Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung.

Evidence on tissue expression from TISSUES for KAT14 Gene

  • Kidney(4.2)
  • Eye(4.1)
  • Nervous system(2.3)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAT14 Gene

Orthologs for KAT14 Gene

This gene was present in the common ancestor of animals.

Orthologs for KAT14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRP2BP 34 33
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CSRP2BP 34 33
  • 91.89 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSRP2BP 34
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSRP2BP 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrp2bp 33
  • 88.28 (n)
mouse
(Mus musculus)
Mammalia Csrp2bp 34 33
  • 87.55 (n)
OneToOne
Kat14 16
cow
(Bos Taurus)
Mammalia CSRP2BP 34 33
  • 85.29 (n)
OneToOne
chicken
(Gallus gallus)
Aves CSRP2BP 34 33
  • 79.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRP2BP 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp2bp 33
  • 70.03 (n)
Str.13779 33
zebrafish
(Danio rerio)
Actinopterygii csrp2bp 34 33
  • 68.41 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atac2 34
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5283 34
  • 42 (a)
OneToOne
Cin.13011 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13011 33
Species where no ortholog for KAT14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KAT14 Gene

ENSEMBL:
Gene Tree for KAT14 (if available)
TreeFam:
Gene Tree for KAT14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KAT14: view image

Paralogs for KAT14 Gene

Pseudogenes.org Pseudogenes for KAT14 Gene

genes like me logo Genes that share paralogs with KAT14: view

No data available for Paralogs for KAT14 Gene

Variants for KAT14 Gene

Sequence variations from dbSNP and Humsavar for KAT14 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs771882905 likely-pathogenic, Global developmental delay, Seizures 18,162,673(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000048126 -- 18,160,791(+) A/G intron_variant
rs1000079257 -- 18,148,966(+) A/G intron_variant
rs1000126740 -- 18,167,635(+) T/A intron_variant
rs1000150140 -- 18,177,897(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KAT14 Gene

Variant ID Type Subtype PubMed ID
nsv1062244 CNV gain 25217958
nsv585665 CNV gain 21841781
nsv833933 CNV gain 17160897

Variation tolerance for KAT14 Gene

Residual Variation Intolerance Score: 6.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KAT14 Gene

Human Gene Mutation Database (HGMD)
KAT14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KAT14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAT14 Gene

Disorders for KAT14 Gene

No disorders were found for KAT14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KAT14 Gene

Publications for KAT14 Gene

  1. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). (PMID: 10924333) Weiskirchen R … Gressner AM (Biochemical and biophysical research communications 2000) 2 3 4 22 58
  2. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. (PMID: 19103755) Guelman S … Zha J (Molecular and cellular biology 2009) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for KAT14 Gene

Sources for KAT14 Gene

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