Aliases for KASH5 Gene
External Ids for KASH5 Gene
Previous HGNC Symbols for KASH5 Gene
GeneCards Summary for KASH5 Gene
KASH5 (KASH Domain Containing 5) is a Protein Coding gene. Diseases associated with KASH5 include Spermatogenic Failure 16 and Emery-Dreifuss Muscular Dystrophy. An important paralog of this gene is SSH2.
UniProtKB/Swiss-Prot Summary for KASH5 Gene
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.