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Aliases for KANSL3 Gene
Aliases for KANSL3 Gene
External Ids for KANSL3 Gene
- HGNC: 25473
- NCBI Entrez Gene: 55683
- Ensembl: ENSG00000114982
- OMIM®: 617742
- UniProtKB/Swiss-Prot: Q9P2N6
Previous HGNC Symbols for KANSL3 Gene
- KIAA1310
Previous GeneCards Identifiers for KANSL3 Gene
- GC02M097259
Summaries for KANSL3 Gene
GeneCards Summary for KANSL3 Gene
KANSL3 (KAT8 Regulatory NSL Complex Subunit 3) is a Protein Coding gene. Diseases associated with KANSL3 include Osteogenesis Imperfecta, Type I and Osteogenesis Imperfecta, Type Iv. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific). An important paralog of this gene is TEX30.
UniProtKB/Swiss-Prot Summary for KANSL3 Gene
-
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Additional gene information for KANSL3 Gene
- HGNC (25473)
- NCBI Entrez Gene (55683)
- Ensembl (ENSG00000114982)
- OMIM® (617742)
- UniProtKB/Swiss-Prot (Q9P2N6)
- Open Targets Platform(ENSG00000114982)
- Search for KANSL3 at DataMed
- Search for KANSL3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KANSL3 Gene
Genomics for KANSL3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KANSL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KANSL3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KANSL3
Genomic Locations for KANSL3 Gene
Latest Assembly
- chr2:96,593,170-96,642,787
- (GRCh38/hg38)
- Size:
- 49,618 bases
- Orientation:
- Minus strand
Previous Assembly
- chr2:97,258,909-97,304,049
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 45,141 bases
- Orientation:
- Minus strand
- chr2:97,258,907-97,308,524
- (GRCh37/hg19 by Ensembl)
- Size:
- 49,618 bases
- Orientation:
- Minus strand
Genomic View for KANSL3 Gene
Genes around KANSL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by HGNC
- 2q11.2 by Entrez Gene
- 2q11.2 by Ensembl
KANSL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KANSL3 Gene
Proteins for KANSL3 Gene
-
Protein details for KANSL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P2N6-KANL3_HUMAN
- Recommended name:
- KAT8 regulatory NSL complex subunit 3
- Protein Accession:
- Q9P2N6
- A1L184
- D3DXH3
- D3DXH4
- Q05BU4
- Q6P3X2
- Q6PJH6
- Q86T19
- Q96L64
- Q9H0C9
- Q9H8C9
- Q9HAP8
- Q9NWE5
Protein attributes for KANSL3 Gene
- Size:
- 904 amino acids
- Molecular mass:
- 95992 Da
- Quaternary structure:
-
- Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
- SequenceCaution:
-
- Sequence=AAH15469.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI27821.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=BAA92548.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for KANSL3 Gene
Post-translational modifications for KANSL3 Gene
Other Protein References for KANSL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005264044.1
- XP_011509756.1
- XP_011509757.1
- XP_011509758.1
- XP_011509759.1
- XP_011509760.1
- XP_011509761.1
- XP_011509762.1
- XP_011509763.1
- XP_011509764.1
- XP_011509765.1
- XP_011509766.1
- XP_011509768.1
- XP_011509769.1
- XP_016859961.1
- NP_001108488.1
- NP_001336185.1
- NP_001336186.1
- NP_001336187.1
- NP_001336188.1
- NP_001336189.1
- NP_001336190.1
- NP_001336191.1
Antibodies for research
- LifeSpan BioSciences KANSL3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for KANSL3
- Novus Biologicals Antibodies for KANSL3
- Invitrogen Antibodies for KANSL3 (AFLGC-KANSL3)
-
Boster Bio Antibodies for KANSL3
-
Custom Antibody ServicesProSci Antibodies for KANSL3
Protein products for research
-
OriGene Purified Proteins for KANSL3
- Search Origene for MassSpec and Protein Over-expression Lysates for KANSL3
- Origene Custom Protein Services for KANSL3
- Novus Biologicals proteins for KANSL3
- antibodies-online: Show 3 available KANSL3 Proteins ranked by validation data
- Compare Top KANSL3 Proteins
-
Quality Products:
Assay products for research
No data available for DME Specific Peptides for KANSL3 Gene
Domains & Families for KANSL3 Gene
Gene Families for KANSL3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KANSL3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KANSL3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55383 (B4E1W4_HUMAN)
- Testis development protein PRTD (K1310_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KANSL3 Gene
Function for KANSL3 Gene
Molecular function for KANSL3 Gene
- UniProtKB/Swiss-Prot Function:
- As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Phenotypes From GWAS Catalog for KANSL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043995 | histone acetyltransferase activity (H4-K5 specific) | IBA | -- |
| GO:0043996 | histone acetyltransferase activity (H4-K8 specific) | IBA | -- |
| GO:0046972 | histone acetyltransferase activity (H4-K16 specific) | IBA | -- |
Phenotypes for KANSL3 Gene
- MGI mutant phenotypes for KANSL3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KANSL3:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KANSL3 - Starting at $85 >
- * KANSL3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KANSL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for KANSL3
miRNA for KANSL3 Gene
- miRTarBase miRNAs that target KANSL3
-
- mmu-miR-24-3p (MIRT013879)
- mmu-miR-149-5p (MIRT014715)
- hsa-miR-26b-5p (MIRT030314)
- hsa-miR-877-3p (MIRT036963)
- hsa-miR-93-3p (MIRT038818)
- hsa-miR-484 (MIRT041753)
- hsa-miR-92a-3p (MIRT049440)
- hsa-miR-16-5p (MIRT051184)
- hsa-miR-3156-3p (MIRT643607)
- hsa-miR-1260b (MIRT643608)
- hsa-miR-1260a (MIRT643609)
- hsa-miR-188-3p (MIRT643610)
- hsa-miR-4301 (MIRT643611)
- hsa-miR-4705 (MIRT643612)
- hsa-miR-6500-3p (MIRT643613)
- hsa-miR-141-5p (MIRT643614)
- hsa-miR-196a-3p (MIRT712971)
- hsa-miR-7106-3p (MIRT712972)
- hsa-miR-3128 (MIRT712973)
- hsa-miR-150-5p (MIRT712974)
- hsa-miR-8073 (MIRT712975)
- hsa-miR-221-5p (MIRT712976)
- hsa-miR-1273g-3p (MIRT712977)
- hsa-miR-21-5p (MIRT763857)
- hsa-miR-3200-5p (MIRT765515)
- hsa-miR-4539 (MIRT770232)
- hsa-miR-4754 (MIRT771942)
- hsa-miR-590-5p (MIRT775360)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KANSL3
- Browse OriGene Inhibitory RNA Products For KANSL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KANSL3
Clone products for research
- Applied Biological Materials (abm): Clones for KANSL3 - Starting at $45 >
- * KANSL3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for KANSL3
- Addgene plasmids for KANSL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KANSL3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KANSL3 Gene
Localization for KANSL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KANSL3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000123 | histone acetyltransferase complex | IDA | 20018852 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
| GO:0044545 | NSL complex | IBA | 21873635 |
Pathways & Interactions for KANSL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
Pathways by source for KANSL3 Gene
3 Reactome pathways for KANSL3 Gene
Interacting Proteins for KANSL3 Gene
GPS-Prot Interaction Network for KANSL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0043981 | histone H4-K5 acetylation | IBA,IDA | 20018852 |
| GO:0043982 | histone H4-K8 acetylation | IBA,IDA | 20018852 |
| GO:0043984 | histone H4-K16 acetylation | IBA,IDA | 20018852 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
No data available for SIGNOR curated interactions for KANSL3 Gene
Drugs & Compounds for KANSL3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Naringenin | Experimental | Pharma | Target | 5 |
Transcripts for KANSL3 Gene
mRNA/cDNA for KANSL3 Gene
- 9 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354204 5253 nts (view in UCSC)
- ENST00000416138 552 nts (view in UCSC)
- ENST00000418735 594 nts (view in UCSC)
- ENST00000420155 5028 nts (view in UCSC)
- ENST00000425656 1526 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for KANSL3 - Starting at $85 >
- * KANSL3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KANSL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for KANSL3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KANSL3
- Browse OriGene Inhibitory RNA Products For KANSL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KANSL3
Clone products for research
- Applied Biological Materials (abm): Clones for KANSL3 - Starting at $45 >
- * KANSL3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for KANSL3
- Addgene plasmids for KANSL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KANSL3
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: |
| ExUns: | 11c | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: |
Relevant External Links for KANSL3 Gene
- GeneLoc Exon Structure for
- KANSL3
Expression for KANSL3 Gene
This gene is overexpressed in Liver, secretome (27.6), Peripheral blood mononuclear cells (19.3), and CD8 Tcells (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KANSL3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KANSL3
SOURCE GeneReport for Unigene cluster for KANSL3 Gene:
Hs.516341Evidence on tissue expression from TISSUES for KANSL3 Gene
- Nervous system(4.9)
- Intestine(4.4)
- Lung(4)
- Skin(2.5)
- Kidney(2.2)
- Muscle(2.1)
- Liver(2)
Primer products for research
-
OriGene qPCR primer pairs for KANSL3
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KANSL3 Gene
Orthologs for KANSL3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KANSL3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KANSL3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KANSL3 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Kansl3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Kansl3 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | KANSL3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | KANSL3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | KANSL3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100158552 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | kansl3 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rcd1 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | F54D11.2 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for KANSL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for KANSL3 Gene
- ENSEMBL:
- Gene Tree for KANSL3 (if available)
- TreeFam:
- Gene Tree for KANSL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KANSL3: view image
Paralogs for KANSL3 Gene
Variants for KANSL3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KANSL3 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34406082 | - |
p.Val707Ile |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv607e201 | CNV | deletion | 23290073 |
| esv2660856 | CNV | deletion | 23128226 |
| esv2720413 | CNV | deletion | 23290073 |
| esv3425717 | CNV | duplication | 20981092 |
| esv5003 | OTHER | complex | 18987735 |
| nsv1135873 | CNV | deletion | 24896259 |
| nsv1138819 | CNV | deletion | 24896259 |
| nsv469775 | CNV | loss | 16826518 |
| nsv819818 | CNV | loss | 19587683 |
| nsv834306 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.17;
61.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KANSL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KANSL3
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANSL3 Gene
Disorders for KANSL3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| osteogenesis imperfecta, type i |
|
|
| osteogenesis imperfecta, type iv |
|
|
| osteogenesis imperfecta, type iii |
|
|
| noonan syndrome 1 |
|
|
Search KANSL3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KANSL3
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KANSL3 Gene
Publications for KANSL3 Gene
- Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y … Conaway RC (The Journal of biological chemistry 2010) 3 4
- Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PMID: 16543150) Mendjan S … Akhtar A (Molecular cell 2006) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
ExternalLinks
Products for KANSL3 Gene
- Custom Antibody ServicesOriGene Antibodies for KANSL3
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- Custom Assay Services
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for KANSL3
- Novus Biologicals proteins for KANSL3
- Browse Antibodies
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- Invitrogen Antibodies for KANSL3 (AFLGC-KANSL3)
- VectorBuilder Custom and pre-made DNA vectors for KANSL3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for KANSL3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for KANSL3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for KANSL3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for KANSL3
- Addgene plasmids for KANSL3
- antibodies-online: Show 10 available KANSL3 Antibodies ranked by validation data
- Compare Top KANSL3 Antibodies
- antibodies-online: Search results for available KANSL3 related products ranked by validation data
- antibodies-online: Show 3 available KANSL3 Proteins ranked by validation data
- Compare Top KANSL3 Proteins
- Quality Products:
- Custom Antibody ServicesProSci Antibodies for KANSL3
- Search for KANSL3 Proteins at ProSci
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KANSL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KANSL3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KANSL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KANSL3
- Boster Bio Antibodies for KANSL3
- Browse Boster Bio ELISA Kits
Sources for KANSL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB