Aliases for KANSL2 Gene

Aliases for KANSL2 Gene

  • KAT8 Regulatory NSL Complex Subunit 2 2 3 4 5
  • Non-Specific Lethal 2 Homolog 3 4
  • NSL Complex Protein NSL2 3 4
  • C12orf41 3 4
  • NSL2 3 4
  • Chromosome 12 Open Reading Frame 41 2

External Ids for KANSL2 Gene

Previous HGNC Symbols for KANSL2 Gene

  • C12orf41

Previous GeneCards Identifiers for KANSL2 Gene

  • GC12M049056
  • GC12M049062
  • GC12M049069
  • GC12M049080
  • GC12M049092

Summaries for KANSL2 Gene

GeneCards Summary for KANSL2 Gene

KANSL2 (KAT8 Regulatory NSL Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific).

UniProtKB/Swiss-Prot Summary for KANSL2 Gene

  • As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.

Gene Wiki entry for KANSL2 Gene

Additional gene information for KANSL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KANSL2 Gene

Genomics for KANSL2 Gene

GeneHancer (GH) Regulatory Elements for KANSL2 Gene

Promoters and enhancers for KANSL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KANSL2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KANSL2 Gene

Genomic Locations for KANSL2 Gene
chr12:48,653,211-48,682,252
(GRCh38/hg38)
Size:
29,042 bases
Orientation:
Minus strand
chr12:49,046,994-49,076,035
(GRCh37/hg19)
Size:
29,042 bases
Orientation:
Minus strand

Genomic View for KANSL2 Gene

Genes around KANSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANSL2 Gene

Proteins for KANSL2 Gene

  • Protein details for KANSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9L4-KANL2_HUMAN
    Recommended name:
    KAT8 regulatory NSL complex subunit 2
    Protein Accession:
    Q9H9L4
    Secondary Accessions:
    • Q8N3B5
    • Q96CV0
    • Q9NX51

    Protein attributes for KANSL2 Gene

    Size:
    492 amino acids
    Molecular mass:
    55042 Da
    Quaternary structure:
    • Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
    SequenceCaution:
    • Sequence=AAH09746.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH13900.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91169.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB14211.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD39126.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KANSL2 Gene

    Alternative splice isoforms for KANSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANSL2 Gene

Post-translational modifications for KANSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KANSL2 Gene

Domains & Families for KANSL2 Gene

Gene Families for KANSL2 Gene

Protein Domains for KANSL2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with KANSL2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KANSL2 Gene

Function for KANSL2 Gene

Molecular function for KANSL2 Gene

UniProtKB/Swiss-Prot Function:
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.

Phenotypes From GWAS Catalog for KANSL2 Gene

Gene Ontology (GO) - Molecular Function for KANSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24788516
GO:0043995 contributes_to histone acetyltransferase activity (H4-K5 specific) IDA 20018852
GO:0043996 contributes_to histone acetyltransferase activity (H4-K8 specific) IDA 20018852
GO:0046972 contributes_to histone acetyltransferase activity (H4-K16 specific) IDA 20018852
genes like me logo Genes that share ontologies with KANSL2: view

Phenotypes for KANSL2 Gene

genes like me logo Genes that share phenotypes with KANSL2: view

Animal Model Products

CRISPR Products

miRNA for KANSL2 Gene

miRTarBase miRNAs that target KANSL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KANSL2 Gene

Localization for KANSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KANSL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KANSL2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 4
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KANSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with KANSL2: view

Pathways & Interactions for KANSL2 Gene

PathCards logo

SuperPathways for KANSL2 Gene

genes like me logo Genes that share pathways with KANSL2: view

Pathways by source for KANSL2 Gene

Gene Ontology (GO) - Biological Process for KANSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0043981 histone H4-K5 acetylation IBA,IDA 20018852
GO:0043982 histone H4-K8 acetylation IBA,IDA 20018852
GO:0043984 histone H4-K16 acetylation IBA,IDA 20018852
genes like me logo Genes that share ontologies with KANSL2: view

No data available for SIGNOR curated interactions for KANSL2 Gene

Drugs & Compounds for KANSL2 Gene

No Compound Related Data Available

Transcripts for KANSL2 Gene

mRNA/cDNA for KANSL2 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KANSL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e ·
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - -
SP6:
SP7: - -
SP8: -
SP9: - - - -
SP10: -
SP11:

ExUns: 15f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KANSL2 Gene

GeneLoc Exon Structure for
KANSL2
ECgene alternative splicing isoforms for
KANSL2

Expression for KANSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KANSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KANSL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.2), CD8 Tcells (7.0), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KANSL2 Gene



Protein tissue co-expression partners for KANSL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KANSL2 Gene:

KANSL2

SOURCE GeneReport for Unigene cluster for KANSL2 Gene:

Hs.505412

Evidence on tissue expression from TISSUES for KANSL2 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with KANSL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KANSL2 Gene

Orthologs for KANSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KANSL2 33 32
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KANSL2 33 32
  • 94.44 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KANSL2 33
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KANSL2 33 32
  • 93.81 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kansl2 32
  • 89.89 (n)
mouse
(Mus musculus)
Mammalia Kansl2 17 33 32
  • 89.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KANSL2 33
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves KANSL2 33 32
  • 75.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KANSL2 33
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kansl2 32
  • 68.63 (n)
Str.15082 32
African clawed frog
(Xenopus laevis)
Amphibia flj20436-prov 32
zebrafish
(Danio rerio)
Actinopterygii kansl2 33 32
  • 68.47 (n)
OneToOne
wufb75c02 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9143 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006680 32
  • 48.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta dgt1 33 32
  • 47.57 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 31 (a)
OneToMany
Species where no ortholog for KANSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KANSL2 Gene

ENSEMBL:
Gene Tree for KANSL2 (if available)
TreeFam:
Gene Tree for KANSL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KANSL2: view image

Paralogs for KANSL2 Gene

Pseudogenes.org Pseudogenes for KANSL2 Gene

genes like me logo Genes that share paralogs with KANSL2: view

No data available for Paralogs for KANSL2 Gene

Variants for KANSL2 Gene

Sequence variations from dbSNP and Humsavar for KANSL2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000091379 -- 48,681,275(-) A/T intron_variant
rs1000107764 -- 48,677,644(-) G/A intron_variant
rs1000113522 -- 48,653,134(-) G/C downstream_transcript_variant
rs1000141125 -- 48,652,989(-) A/G downstream_transcript_variant
rs1000294553 -- 48,669,038(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KANSL2 Gene

Variant ID Type Subtype PubMed ID
dgv1496n100 CNV gain 25217958
esv3409205 CNV insertion 20981092
nsv438209 CNV loss 16468122
nsv519053 CNV loss 19592680

Variation tolerance for KANSL2 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KANSL2 Gene

Human Gene Mutation Database (HGMD)
KANSL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KANSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANSL2 Gene

Disorders for KANSL2 Gene

Additional Disease Information for KANSL2

No disorders were found for KANSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KANSL2 Gene

Publications for KANSL2 Gene

  1. Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. (PMID: 24788516) Dias J … Akhtar A (Genes & development 2014) 2 3 56
  2. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y … Conaway RC (The Journal of biological chemistry 2010) 3 4 56
  3. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PMID: 16543150) Mendjan S … Akhtar A (Molecular cell 2006) 3 4 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for KANSL2 Gene

Sources for KANSL2 Gene