Aliases for KANK3 Gene

Aliases for KANK3 Gene

  • KN Motif And Ankyrin Repeat Domains 3 2 3 5
  • KN Motif And Ankyrin Repeat Domain-Containing Protein 3 3 4
  • Ankyrin Repeat Domain-Containing Protein 47 3 4
  • Ankyrin Repeat Domain 47 2 3
  • ANKRD47 3 4
  • Kidney Ankyrin Repeat-Containing Protein 3 3
  • FLJ46061 2
  • KANK3 5

External Ids for KANK3 Gene

Previous HGNC Symbols for KANK3 Gene

  • ANKRD47

Previous GeneCards Identifiers for KANK3 Gene

  • GC19M008297
  • GC19M008041
  • GC19M008387

Summaries for KANK3 Gene

GeneCards Summary for KANK3 Gene

KANK3 (KN Motif And Ankyrin Repeat Domains 3) is a Protein Coding gene. Diseases associated with KANK3 include Fuchs' Endothelial Dystrophy. An important paralog of this gene is KANK1.

UniProtKB/Swiss-Prot Summary for KANK3 Gene

  • May be involved in the control of cytoskeleton formation by regulating actin polymerization.

Additional gene information for KANK3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KANK3 Gene

Genomics for KANK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KANK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008340 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 605.5 +1.1 1143 3.6 SP1 GATAD2A TEAD4 PRDM10 IKZF1 KDM1A FOS LARP7 DDX20 PKNOX1 KANK3 RPS28 ELAVL1 HNRNPM ZNF558 ZNF699 XAB2 ENSG00000269300 MAP2K7 ZNF317
GH19J008334 Promoter/Enhancer 1 Ensembl ENCODE 5.2 +8.0 7961 1.8 CTCF ZNF692 PHF21A POLR2A EZH2 ZFX NRF1 KLF9 UBTF ZNF10 RPS28 KANK3 NDUFA7 piR-58171 lnc-KANK3-3
GH19J008139 Enhancer 0.6 Ensembl ENCODE 5.6 +203.5 203479 0.8 ESR1 ZNF580 NFIA CBFA2T3 KANK3 FBN3 RF00017-2791 CCL25 lnc-KANK3-3
GH19J008319 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 +21.5 21534 4.1 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 ATF7 TEAD4 PRDM10 ZNF629 TFE3 RPS28 ENSG00000167774 NDUFA7 lnc-NDUFA7-1 piR-53910-003 HNRNPM XAB2 ZNF699 ZNF317 ZNF558
GH19J008354 Enhancer 1.2 ENCODE dbSUPER 0.4 -13.1 -13064 3.1 GATAD2A ATF7 TFE3 LEF1 SOX13 IKZF1 NFKBIZ RCOR2 JUND MTA2 RAB11B HNRNPM ZNF559 ELAVL1 XAB2 ZNF699 MARCHF2 RPS28 lnc-KANK3-1 ANGPTL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KANK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KANK3

Top Transcription factor binding sites by QIAGEN in the KANK3 gene promoter:
  • aMEF-2
  • c-Myb
  • CP2
  • CREB
  • deltaCREB
  • GATA-2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KANK3 Gene

Genomic Locations for KANK3 Gene
chr19:8,322,584-8,343,262
(GRCh38/hg38)
Size:
20,679 bases
Orientation:
Minus strand
chr19:8,387,468-8,408,146
(GRCh37/hg19)
Size:
20,679 bases
Orientation:
Minus strand

Genomic View for KANK3 Gene

Genes around KANK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANK3 Gene

Proteins for KANK3 Gene

  • Protein details for KANK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NY19-KANK3_HUMAN
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 3
    Protein Accession:
    Q6NY19
    Secondary Accessions:
    • Q6NZI1
    • Q6ZQR3
    • Q8IUV2

    Protein attributes for KANK3 Gene

    Size:
    840 amino acids
    Molecular mass:
    88425 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KANK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANK3 Gene

Post-translational modifications for KANK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KANK3 Gene

No data available for DME Specific Peptides for KANK3 Gene

Domains & Families for KANK3 Gene

Gene Families for KANK3 Gene

Protein Domains for KANK3 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for KANK3 Gene

GenScript: Design optimal peptide antigens:
  • Kidney ankyrin repeat-containing protein 3 (B0I1P5_HUMAN)
  • Ankyrin repeat domain-containing protein 47 (KANK3_HUMAN)
genes like me logo Genes that share domains with KANK3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KANK3 Gene

Function for KANK3 Gene

Molecular function for KANK3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the control of cytoskeleton formation by regulating actin polymerization.

Phenotypes From GWAS Catalog for KANK3 Gene

Gene Ontology (GO) - Molecular Function for KANK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with KANK3: view
genes like me logo Genes that share phenotypes with KANK3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KANK3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KANK3 Gene

Localization for KANK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KANK3 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KANK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005856 cytoskeleton IBA 21873635
genes like me logo Genes that share ontologies with KANK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KANK3 Gene

Pathways & Interactions for KANK3 Gene

PathCards logo

SuperPathways for KANK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KANK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030837 negative regulation of actin filament polymerization IBA 21873635
genes like me logo Genes that share ontologies with KANK3: view

No data available for Pathways by source and SIGNOR curated interactions for KANK3 Gene

Drugs & Compounds for KANK3 Gene

No Compound Related Data Available

Transcripts for KANK3 Gene

mRNA/cDNA for KANK3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KANK3

Alternative Splicing Database (ASD) splice patterns (SP) for KANK3 Gene

No ASD Table

Relevant External Links for KANK3 Gene

GeneLoc Exon Structure for
KANK3

Expression for KANK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KANK3 Gene

mRNA differential expression in normal tissues according to GTEx for KANK3 Gene

This gene is overexpressed in Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for KANK3 Gene

This gene is overexpressed in Lung (15.2), Placenta (8.6), and Esophagus (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KANK3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KANK3

SOURCE GeneReport for Unigene cluster for KANK3 Gene:

Hs.745036

mRNA Expression by UniProt/SwissProt for KANK3 Gene:

Q6NY19-KANK3_HUMAN
Tissue specificity: Strongly expressed in breast, liver, lung, skeletal muscle and kidney.

Evidence on tissue expression from TISSUES for KANK3 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with KANK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KANK3 Gene

Orthologs for KANK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KANK3 30 31
  • 99.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KANK3 30 31
  • 83.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KANK3 30 31
  • 83.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kank3 30
  • 78.24 (n)
Mouse
(Mus musculus)
Mammalia Kank3 30 17 31
  • 76.5 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KANK3 31
  • 56 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KANK3 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KANK3 31
  • 40 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 38 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii kank3 31
  • 34 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG10249 31
  • 16 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea vab-19 31
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
ManyToMany
CSA.3164 31
  • 23 (a)
ManyToMany
Species where no ortholog for KANK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for KANK3 Gene

ENSEMBL:
Gene Tree for KANK3 (if available)
TreeFam:
Gene Tree for KANK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KANK3: view image

Paralogs for KANK3 Gene

Paralogs for KANK3 Gene

(10) SIMAP similar genes for KANK3 Gene using alignment to 2 proteins:

  • KANK3_HUMAN
  • M0QZJ3_HUMAN
genes like me logo Genes that share paralogs with KANK3: view

Variants for KANK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KANK3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2913955 - p.Ala485Thr
rs890850 - p.Asp288Tyr
rs890853 - p.Arg359His

Additional dbSNP identifiers (rs#s) for KANK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for KANK3 Gene

Variant ID Type Subtype PubMed ID
esv2718120 CNV deletion 23290073
esv2718121 CNV deletion 23290073
esv2718122 CNV deletion 23290073
esv3643614 CNV gain 21293372

Variation tolerance for KANK3 Gene

Gene Damage Index Score: 24.59; 99.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KANK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KANK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANK3 Gene

Disorders for KANK3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KANK3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search KANK3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with KANK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KANK3 Gene

Publications for KANK3 Gene

  1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PMID: 17996375) Zhu Y … Kiyama R (Biochimica et biophysica acta 2008) 2 3 4
  2. Kank proteins: structure, functions and diseases. (PMID: 19554261) Kakinuma N … Kiyama R (Cellular and molecular life sciences : CMLS 2009) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A novel HIF1AN substrate KANK3 plays a tumor-suppressive role in hepatocellular carcinoma. (PMID: 29047187) Kim I … Park JW (Cell biology international 2018) 3

Products for KANK3 Gene

Sources for KANK3 Gene