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Aliases for KANK3 Gene

Aliases for KANK3 Gene

  • KN Motif And Ankyrin Repeat Domains 3 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 47 3 4
  • Ankyrin Repeat Domain 47 2 3
  • ANKRD47 3 4
  • KN Motif And Ankyrin Repeat Domain-Containing Protein 3 3
  • Kidney Ankyrin Repeat-Containing Protein 3 3

External Ids for KANK3 Gene

Previous HGNC Symbols for KANK3 Gene

  • ANKRD47

Previous GeneCards Identifiers for KANK3 Gene

  • GC19M008297
  • GC19M008041
  • GC19M008387

Summaries for KANK3 Gene

GeneCards Summary for KANK3 Gene

KANK3 (KN Motif And Ankyrin Repeat Domains 3) is a Protein Coding gene. An important paralog of this gene is KANK1.

UniProtKB/Swiss-Prot for KANK3 Gene

  • May be involved in the control of cytoskeleton formation by regulating actin polymerization.

Additional gene information for KANK3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANK3 Gene

Genomics for KANK3 Gene

GeneHancer (GH) Regulatory Elements for KANK3 Gene

Promoters and enhancers for KANK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I008340 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 555.6 +1.1 1143 3.6 PKNOX1 ATF1 FOXA2 ZNF121 GLIS2 ATF7 FOS SP3 CEBPZ RXRA KANK3 RPS28 ELAVL1 HNRNPM ZNF558 XAB2 ZNF699 ENSG00000269300 MAP2K7 ZNF317
GH19I008139 Enhancer 0.6 Ensembl ENCODE 5.6 +203.5 203501 0.8 NFIA ZNF580 CBFA2T3 KANK3 GC19M008115 FBN3
GH19I008319 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.3 +21.8 21806 3.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RPS28 GC19P008321 NDUFA7 ENSG00000167774 HNRNPM XAB2 ZNF317 ZNF699 ZNF558 MAP2K7
GH19I008334 Promoter/Enhancer 1.2 Ensembl ENCODE 0.4 +7.9 7885 0.9 CTCF MXI1 ZNF146 MAX SIN3A BACH1 EBF1 E2F1 ZFHX2 POLR2A RPS28 KANK3 PIR52170
GH19I008323 Enhancer 0.7 ENCODE 0.4 +19.0 18985 0.7 HDGF HNRNPUL1 CTCF ZNF48 RAD21 HIC1 POLR2B GLIS2 POLR2A ZBTB20 PIR52170 RPS28 XAB2 HNRNPM ZNF699 ZNF317 ZNF558 MAP2K7 ZNF559 ZNF414
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KANK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KANK3 gene promoter:

Genomic Locations for KANK3 Gene

Genomic Locations for KANK3 Gene
chr19:8,322,582-8,343,262
(GRCh38/hg38)
Size:
20,681 bases
Orientation:
Minus strand
chr19:8,387,468-8,408,146
(GRCh37/hg19)

Genomic View for KANK3 Gene

Genes around KANK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANK3 Gene

Proteins for KANK3 Gene

  • Protein details for KANK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NY19-KANK3_HUMAN
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 3
    Protein Accession:
    Q6NY19
    Secondary Accessions:
    • Q6NZI1
    • Q6ZQR3
    • Q8IUV2

    Protein attributes for KANK3 Gene

    Size:
    840 amino acids
    Molecular mass:
    88425 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KANK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANK3 Gene

Post-translational modifications for KANK3 Gene

No Post-translational modifications

Other Protein References for KANK3 Gene

No data available for DME Specific Peptides for KANK3 Gene

Domains & Families for KANK3 Gene

Suggested Antigen Peptide Sequences for KANK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KANK3: view

No data available for UniProtKB/Swiss-Prot for KANK3 Gene

Function for KANK3 Gene

Molecular function for KANK3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
genes like me logo Genes that share phenotypes with KANK3: view

Animal Model Products

Clone Products

  • Addgene plasmids for KANK3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KANK3 Gene

Localization for KANK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KANK3 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KANK3 Gene

Pathways & Interactions for KANK3 Gene

SuperPathways for KANK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KANK3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KANK3 Gene

Drugs & Compounds for KANK3 Gene

No Compound Related Data Available

Transcripts for KANK3 Gene

Unigene Clusters for KANK3 Gene

KN motif and ankyrin repeat domains 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for KANK3

Alternative Splicing Database (ASD) splice patterns (SP) for KANK3 Gene

No ASD Table

Relevant External Links for KANK3 Gene

GeneLoc Exon Structure for
KANK3
ECgene alternative splicing isoforms for
KANK3

Expression for KANK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KANK3 Gene

mRNA differential expression in normal tissues according to GTEx for KANK3 Gene

This gene is overexpressed in Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for KANK3 Gene

This gene is overexpressed in Lung (15.2), Placenta (8.6), and Esophagus (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KANK3 Gene



NURSA nuclear receptor signaling pathways regulating expression of KANK3 Gene:

KANK3

SOURCE GeneReport for Unigene cluster for KANK3 Gene:

Hs.745036

mRNA Expression by UniProt/SwissProt for KANK3 Gene:

Q6NY19-KANK3_HUMAN
Tissue specificity: Strongly expressed in breast, liver, lung, skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with KANK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KANK3 Gene

Orthologs for KANK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KANK3 33 34
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia KANK3 33 34
  • 83.81 (n)
cow
(Bos Taurus)
Mammalia KANK3 33 34
  • 83.5 (n)
rat
(Rattus norvegicus)
Mammalia Kank3 33
  • 78.24 (n)
mouse
(Mus musculus)
Mammalia Kank3 33 16 34
  • 76.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KANK3 34
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KANK3 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves KANK3 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii kank3 34
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10249 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-19 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
ManyToMany
CSA.3164 34
  • 23 (a)
ManyToMany
Species where no ortholog for KANK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KANK3 Gene

ENSEMBL:
Gene Tree for KANK3 (if available)
TreeFam:
Gene Tree for KANK3 (if available)

Paralogs for KANK3 Gene

Paralogs for KANK3 Gene

(10) SIMAP similar genes for KANK3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KANK3: view

Variants for KANK3 Gene

Sequence variations from dbSNP and Humsavar for KANK3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000083916 -- 8,339,862(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000135896 -- 8,329,678(-) G/A intron_variant
rs1000418774 -- 8,329,039(-) C/T intron_variant
rs1000538845 -- 8,341,257(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000591301 -- 8,341,502(-) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KANK3 Gene

Variant ID Type Subtype PubMed ID
esv3643614 CNV gain 21293372
esv2718122 CNV deletion 23290073
esv2718121 CNV deletion 23290073
esv2718120 CNV deletion 23290073

Variation tolerance for KANK3 Gene

Gene Damage Index Score: 24.59; 99.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KANK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KANK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANK3 Gene

Disorders for KANK3 Gene

Additional Disease Information for KANK3

No disorders were found for KANK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KANK3 Gene

Publications for KANK3 Gene

  1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PMID: 17996375) Zhu Y … Kiyama R (Biochimica et biophysica acta 2008) 2 3 4 58
  2. Kank proteins: structure, functions and diseases. (PMID: 19554261) Kakinuma N … Kiyama R (Cellular and molecular life sciences : CMLS 2009) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for KANK3 Gene

  • Addgene plasmids for KANK3

Sources for KANK3 Gene

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