Aliases for KANK1 Gene
Aliases for KANK1 Gene
External Ids for KANK1 Gene
- HGNC: 19309
- Entrez Gene: 23189
- Ensembl: ENSG00000107104
- OMIM: 607704
- UniProtKB: Q14678
Previous HGNC Symbols for KANK1 Gene
- ANKRD15
Previous GeneCards Identifiers for KANK1 Gene
- GC09P000461
Summaries for KANK1 Gene
-
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]
GeneCards Summary for KANK1 Gene
KANK1 (KN Motif And Ankyrin Repeat Domains 1) is a Protein Coding gene. Diseases associated with KANK1 include Cerebral Palsy, Spastic Quadriplegic, 2 and Inherited Congenital Spastic Tetraplegia. Gene Ontology (GO) annotations related to this gene include beta-catenin binding. An important paralog of this gene is KANK2.
UniProtKB/Swiss-Prot for KANK1 Gene
-
Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.
Additional gene information for KANK1 Gene
- Monarch Initiative
- Search for KANK1 at DataMed
- Search for KANK1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANK1 Gene
Genomics for KANK1 Gene
GeneHancer (GH) Regulatory Elements for KANK1 Gene
Promoters and enhancers for KANK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KANK1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KANK1 gene promoter:
-
- Lmo2
- GATA-2
- COMP1
- AREB6
- AhR
- FOXO1
- Pax-5
- FOXO1a
- E2F
- ATF-2
Genomic Locations for KANK1 Gene
Genomic Locations for KANK1 Gene
- chr9:470,291-746,106
- (GRCh38/hg38)
- Size:
- 275,816 bases
- Orientation:
- Plus strand
- chr9:470,291-746,105
- (GRCh37/hg19)
- Size:
- 275,815 bases
- Orientation:
- Plus strand
Genomic View for KANK1 Gene
Genes around KANK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p24.3 by Entrez Gene
- 9p24.3 by HGNC
- 9p24.3 by Ensembl
KANK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KANK1 Gene
Proteins for KANK1 Gene
-
Protein details for KANK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14678-KANK1_HUMAN
- Recommended name:
- KN motif and ankyrin repeat domain-containing protein 1
- Protein Accession:
- Q14678
- A2A2W8
- D3DRH3
- Q5W0W0
- Q8IY65
- Q8WX74
Protein attributes for KANK1 Gene
- Size:
- 1352 amino acids
- Molecular mass:
- 147289 Da
- Quaternary structure:
-
- Interacts with YWHAQ; the interaction requires KANK1 phosphorylation at Ser-325 and is enhanced by growth factor stimulation. Interacts with YWHAB, YWHAG, YWHAE, YWHAH, YWHAZ and SFN; the interaction requires KANK1 phosphorylation at Ser-325. Interacts with ARFGEF1; however, colocalization cannot be experimentally confirmed. Interacts with BAIAP2. Interacts (via ANK repeats 1-5) with KIF21A (via coiled coil region); KIF21A enhances translocation of KANK1 to the plasma membrane. Interacts with CTNNB1.
- SequenceCaution:
-
- Sequence=BAA11489.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for KANK1 Gene
Post-translational modifications for KANK1 Gene
Other Protein References for KANK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_024303230.1
- XP_024303233.1
- XP_016870011.1
- NP_001341262.1
- NP_001341272.1
- NP_001341267.1
- XP_024303235.1
- NP_001341264.1
- NP_001341269.1
- XP_016870006.1
- XP_024303232.1
- NP_055973.2
- XP_024303234.1
- NP_001341261.1
- NP_001341271.1
- XP_024303237.1
- NP_001341266.1
- XP_016870014.1
- XP_024303229.1
- XP_024303239.1
- NP_001341268.1
- NP_001243805.1
- NP_001243806.1
- XP_024303236.1
- NP_694856.1
- NP_001341263.1
- NP_001341273.1
- XP_024303231.1
- NP_001341260.1
- NP_001341270.1
- NP_001341265.1
- XP_024303228.1
- XP_024303238.1
Antibody Products
- Novus Biologicals Antibodies for KANK1
- Invitrogen Antibodies for KANK1 (AFLGC-KANK1)
- Search GeneTex for Antibodies for KANK1
-
Boster Bio Antibodies for KANK1
-
Custom Antibody ServicesProSci Antibodies for KANK1
Protein Products
-
OriGene Purified Proteins for KANK1
- Search Origene for MassSpec and Protein Over-expression Lysates for KANK1
- Origene Custom Protein Services for KANK1
- Search GeneTex for Proteins for KANK1
-
Abcam proteins for KANK1
Assay Products
No data available for DME Specific Peptides for KANK1 Gene
Domains & Families for KANK1 Gene
Gene Families for KANK1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for KANK1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KANK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for KANK1 Gene
Function for KANK1 Gene
Molecular function for KANK1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.
Phenotypes From GWAS Catalog for KANK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16968744 |
| GO:0008013 | beta-catenin binding | IDA | 16968744 |
Phenotypes for KANK1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KANK1
-
CRISPR Products
-
OriGene CRISPR knockouts for KANK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KANK1
- genomics-online: gRNA clones - Search results for 94 available ANKRD15 gene related products
- Overview of 94 available ANKRD15 gene related products
- Applied Biological Materials CRISPR for KANK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KANK1
miRNA for KANK1 Gene
- miRTarBase miRNAs that target KANK1
-
- hsa-mir-124-3p (MIRT004930)
- hsa-mir-335-5p (MIRT017826)
- hsa-mir-10a-5p (MIRT047719)
- hsa-mir-100-5p (MIRT048597)
- hsa-mir-374b-3p (MIRT556846)
- hsa-mir-4524b-5p (MIRT556847)
- hsa-mir-4524a-5p (MIRT556848)
- hsa-mir-633 (MIRT556849)
- hsa-mir-3622b-5p (MIRT556850)
- hsa-mir-873-5p (MIRT556851)
- hsa-mir-3677-5p (MIRT556852)
- hsa-mir-646 (MIRT556853)
- hsa-mir-195-5p (MIRT556854)
- hsa-mir-424-5p (MIRT556855)
- hsa-mir-16-5p (MIRT556856)
- hsa-mir-15b-5p (MIRT556857)
- hsa-mir-497-5p (MIRT556858)
- hsa-mir-6838-5p (MIRT556859)
- hsa-mir-503-5p (MIRT556860)
- hsa-mir-15a-5p (MIRT556861)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KANK1
- Browse OriGene Inhibitory RNA Products For KANK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KANK1
- genomics-online: shRNA clones - Search results for 94 available ANKRD15 gene related products
- Overview of 94 available ANKRD15 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for KANK1 in any vector
- NM_153186.5
- NM_015158.4
- XM_005251414.3
- XM_005251417.3
- XM_005251415.2
- NM_001256877.2
- NM_001256876.2
- XM_005251418.2
- XM_005251416.2
- XM_005251411.2
- XM_005251419.2
- XM_006716743.2
- XM_011517821.1
- XM_017014520.1
- XM_017014538.1
- XM_017014521.1
- XM_017014522.1
- XM_017014534.1
- XM_017014535.1
- XM_017014529.1
- XM_017014530.1
- XM_017014514.1
- XM_017014517.1
- XM_017014531.1
- XM_017014532.1
- XM_017014511.1
- XM_017014526.1
- XM_017014523.1
- XM_017014540.1
- XM_017014541.1
- NM_001354340.1
- XM_017014533.1
- XM_017014537.1
- XM_017014524.1
- XM_017014525.1
- XM_017014518.1
- XM_017014542.1
- NM_001354335.1
- XM_011517819.1
- XM_017014516.1
- XM_017014519.1
- XM_017014515.1
- XM_017014527.1
- XM_017014528.1
- NM_001354334.1
- NM_001354341.1
- NM_001354331.1
- NM_001354344.1
- NM_001354338.1
- NM_001354337.1
- NM_001354333.1
- XM_017014512.1
- XM_017014513.1
- XM_017014536.1
- XM_017014539.1
- XM_011517820.1
- NM_001354339.1
- NM_001354342.1
- Sino Biological Human cDNA Clone for KANK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KANK1
- Applied Biological Materials Clones for KANK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KANK1
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KANK1 Gene
Localization for KANK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KANK1 Gene
- Cell projection, ruffle membrane. Note=Colocalizes with KIF21A in membrane ruffles.
- Isoform 1: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.
- Isoform 2: Cytoplasm. Nucleus. Cell projection, ruffle membrane. Note=Shuttles between the cytoplasm and nucleus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytoskeleton | 2 |
| cytosol | 2 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IBA | -- |
| GO:0005886 | plasma membrane | IDA,IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for KANK1 Gene
No Data Available
Interacting Proteins for KANK1 Gene
Selected Interacting proteins:
Q14678-KANK1_HUMAN
ENSP00000371734
for KANK1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KANK1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0010977 | negative regulation of neuron projection development | IDA | 19171758 |
| GO:0030177 | positive regulation of Wnt signaling pathway | IDA | 16968744 |
| GO:0030336 | negative regulation of cell migration | IMP | 18458160 |
No data available for Pathways by source and SIGNOR curated interactions for KANK1 Gene
Transcripts for KANK1 Gene
mRNA/cDNA for KANK1 Gene
- (33) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (207) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000382303 5581 bps (uc003zgl.3)
- ENST00000467541 514 bps (uc064rvi.1)
- ENST00000475690 342 bps (uc064rvj.1)
- ENST00000489369 7193 bps (uc064rvl.1)
- ENST00000354485 6912 bps (uc064rvm.1)
Unigene Clusters for KANK1 Gene
- KN motif and ankyrin repeat domains 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for KANK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KANK1
- genomics-online: gRNA clones - Search results for 94 available ANKRD15 gene related products
- Overview of 94 available ANKRD15 gene related products
- Applied Biological Materials CRISPR for KANK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KANK1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KANK1
- Browse OriGene Inhibitory RNA Products For KANK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KANK1
- genomics-online: shRNA clones - Search results for 94 available ANKRD15 gene related products
- Overview of 94 available ANKRD15 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for KANK1 in any vector
- NM_153186.5
- NM_015158.4
- XM_005251414.3
- XM_005251417.3
- XM_005251415.2
- NM_001256877.2
- NM_001256876.2
- XM_005251418.2
- XM_005251416.2
- XM_005251411.2
- XM_005251419.2
- XM_006716743.2
- XM_011517821.1
- XM_017014520.1
- XM_017014538.1
- XM_017014521.1
- XM_017014522.1
- XM_017014534.1
- XM_017014535.1
- XM_017014529.1
- XM_017014530.1
- XM_017014514.1
- XM_017014517.1
- XM_017014531.1
- XM_017014532.1
- XM_017014511.1
- XM_017014526.1
- XM_017014523.1
- XM_017014540.1
- XM_017014541.1
- NM_001354340.1
- XM_017014533.1
- XM_017014537.1
- XM_017014524.1
- XM_017014525.1
- XM_017014518.1
- XM_017014542.1
- NM_001354335.1
- XM_011517819.1
- XM_017014516.1
- XM_017014519.1
- XM_017014515.1
- XM_017014527.1
- XM_017014528.1
- NM_001354334.1
- NM_001354341.1
- NM_001354331.1
- NM_001354344.1
- NM_001354338.1
- NM_001354337.1
- NM_001354333.1
- XM_017014512.1
- XM_017014513.1
- XM_017014536.1
- XM_017014539.1
- XM_011517820.1
- NM_001354339.1
- NM_001354342.1
- Sino Biological Human cDNA Clone for KANK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KANK1
- Applied Biological Materials Clones for KANK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: |
| ExUns: | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | · | 18d | · | 18e | · | 18f | · | 18g | · | 18h | · | 18i | · | 18j | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP21: |
Expression for KANK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Limb (Muscoskeletal System)
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Choroid Plexus
- Medulla Oblongata
- Bone (Muscoskeletal System)
-
Lung (Respiratory System)
- Chondrocytes Tracheal Cartilage
- Tracheal Cartilage
- Cartilage (Muscoskeletal System)
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Gut Tube (Gastrointestinal Tract)
- Heart (Cardiovascular System)
This gene is overexpressed in Placenta (15.2), Heart (14.1), and Pancreas (11.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KANK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of KANK1 Gene:
KANK1SOURCE GeneReport for Unigene cluster for KANK1 Gene:
Hs.306764mRNA Expression by UniProt/SwissProt for KANK1 Gene:
Q14678-KANK1_HUMAN
Tissue specificity:
Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.
Evidence on tissue expression from TISSUES for KANK1 Gene
- Liver(4.3)
- Bone marrow(4.1)
- Nervous system(4)
- Kidney(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for KANK1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- face
- head
- skull
Thorax:
- lung
- rib
- rib cage
Pelvis:
- pelvis
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for KANK1
-
OriGene qPCR primer pairs and template standards for KANK1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for KANK1 Gene
Orthologs for KANK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD15 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | KANK1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KANK1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Kank1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Kank1 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KANK1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KANK1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KANK1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KANK1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kank1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kank1 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG10249 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | vab-19 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3164 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for KANK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for KANK1 Gene
- ENSEMBL:
- Gene Tree for KANK1 (if available)
- TreeFam:
- Gene Tree for KANK1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KANK1: view image
Paralogs for KANK1 Gene
(9) SIMAP similar genes for KANK1 Gene using alignment to 6 proteins:
- KANK1_HUMAN
- Q5W0W1_HUMAN
- Q5W0W2_HUMAN
- Q5W0W3_HUMAN
- Q6PIB3_HUMAN
- Q8WUM7_HUMAN
Pseudogenes.org Pseudogenes for KANK1 Gene
Variants for KANK1 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs372628779 | likely-pathogenic, Abnormality of brain morphology | 732,609(+) | C/G | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs376262343 | benign, Abnormality of neuronal migration | 744,585(+) | C/G/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs753441206 | uncertain-significance, Cerebral palsy, spastic quadriplegic, 2 | 731,194(+) | T/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs761345356 | benign, Abnormality of neuronal migration | 676,977(+) | C/ | 5_prime_UTR_variant, coding_sequence_variant, frameshift, genic_upstream_transcript_variant, non_coding_transcript_variant | |
| rs113240136 | likely-benign, not provided | 730,266(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
16.03;
97.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KANK1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANK1 Gene
Disorders for KANK1 Gene
(10) MalaCards diseases for KANK1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cerebral palsy, spastic quadriplegic, 2 |
|
|
| inherited congenital spastic tetraplegia |
|
|
| cerebral palsy |
|
|
| metanephric adenoma |
|
|
| quadriplegia |
|
|
Search KANK1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
KANK1_HUMAN- Cerebral palsy, spastic quadriplegic 2 (CPSQ2) [MIM:612900]: A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly. {ECO:0000269 PubMed:16301218}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for KANK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for KANK1 Gene
Publications for KANK1 Gene
- A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma. (PMID: 12133830) Sarkar S … Kiyama R (The Journal of biological chemistry 2002) 2 3 4 22 58
- Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. (PMID: 19171758) Roy BC … Kiyama R (The Journal of cell biology 2009) 3 4 22 58
- Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M … Probst-Hensch NM (The Journal of allergy and clinical immunology 2012) 3 44 58
- Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing. (PMID: 22084092) Li CC … Vaughan M (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for KANK1 Gene
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- NM_153186.5
- NM_015158.4
- XM_005251414.3
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- NM_001256877.2
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- XM_011517821.1
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- XM_017014511.1
- XM_017014526.1
- XM_017014523.1
- XM_017014540.1
- XM_017014541.1
- NM_001354340.1
- XM_017014533.1
- XM_017014537.1
- XM_017014524.1
- XM_017014525.1
- XM_017014518.1
- XM_017014542.1
- NM_001354335.1
- XM_011517819.1
- XM_017014516.1
- XM_017014519.1
- XM_017014515.1
- XM_017014527.1
- XM_017014528.1
- NM_001354334.1
- NM_001354341.1
- NM_001354331.1
- NM_001354344.1
- NM_001354338.1
- NM_001354337.1
- NM_001354333.1
- XM_017014512.1
- XM_017014513.1
- XM_017014536.1
- XM_017014539.1
- XM_011517820.1
- NM_001354339.1
- NM_001354342.1
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- Sino Biological Human cDNA Clone for KANK1
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Invitrogen Antibodies for KANK1 (AFLGC-KANK1)
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- antibodies-online: Search results for 23 available ANKRD15 Antibodies ranked by validation data
- Compare Top ANKRD15 Antibodies
- antibodies-online: Search results for available ANKRD15 related products ranked by validation data
- antibodies-online: Search results for available ANKRD15 related products ranked by validation data
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- Custom Antibody ServicesProSci Antibodies for KANK1
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- Horizon Cell Lines for KANK1
- genomics-online: cdna clones - Search results for 94 available ANKRD15 gene related products
- Overview of 94 available ANKRD15 gene related products
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- Overview of 94 available ANKRD15 gene related products
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- Overview of 94 available ANKRD15 gene related products
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- Overview of 94 available ANKRD15 gene related products
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- Boster Bio Antibodies for KANK1
- Browse Boster Bio ELISA Kits
Sources for KANK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt