Aliases for KAAG1 Gene
Aliases for KAAG1 Gene
External Ids for KAAG1 Gene
- HGNC: 21031
- Entrez Gene: 353219
- Ensembl: ENSG00000146049
- OMIM: 608211
- UniProtKB: Q9UBP8
Previous GeneCards Identifiers for KAAG1 Gene
- GC06P024419
- GC06P024465
- GC06P024357
Summaries for KAAG1 Gene
GeneCards Summary for KAAG1 Gene
KAAG1 (Kidney Associated Antigen 1) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KAAG1 Gene
Genomics for KAAG1 Gene
GeneHancer (GH) Regulatory Elements for KAAG1 Gene
Promoters and enhancers for KAAG1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06I024357 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE | 550.8 | +0.9 | 936 | 1.6 | MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 PAF1 SP3 NFYC MXD4 | DCDC2 KAAG1 GC06P024361 | |
| GH06I024312 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 7.1 | -43.3 | -43304 | 2.1 | FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ETS1 SP5 NFYC MIER2 | DCDC2 KAAG1 ENSG00000251830 | |
| GH06I024341 | Enhancer | 1.2 | FANTOM5 ENCODE | 6.2 | -15.5 | -15535 | 0.2 | FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 TCF12 RXRA SP5 | KAAG1 DCDC2 ENSG00000251830 | |
| GH06I024321 | Enhancer | 1.1 | FANTOM5 ENCODE | 5.4 | -33.7 | -33729 | 3.3 | ELF3 FOXA2 ARID4B FEZF1 THRB RARA ZNF366 SCRT2 CREM MIXL1 | DCDC2 RNU6-391P MRS2 KAAG1 ENSG00000251830 | |
| GH06I024359 | Enhancer | 1.2 | Ensembl ENCODE | 0.8 | +3.4 | 3371 | 1.4 | CLOCK ARNT SIN3A ZNF2 ZNF121 GLIS2 ZNF213 ZNF207 ZNF143 KLF7 | GC06P024361 MRS2 KAAG1 DCDC2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KAAG1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for KAAG1 Gene
Genomic Locations for KAAG1 Gene
- chr6:24,356,903-24,358,284
- (GRCh38/hg38)
- Size:
- 1,382 bases
- Orientation:
- Plus strand
- chr6:24,357,131-24,358,512
- (GRCh37/hg19)
Genomic View for KAAG1 Gene
Genes around KAAG1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.3 by Ensembl
- 6p22.3 by Entrez Gene
- 6p22.3 by HGNC
KAAG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KAAG1 Gene
Proteins for KAAG1 Gene
-
Protein details for KAAG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBP8-KAAG1_HUMAN
- Recommended name:
- Kidney-associated antigen 1
- Protein Accession:
- Q9UBP8
Protein attributes for KAAG1 Gene
- Size:
- 84 amino acids
- Molecular mass:
- 8969 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for KAAG1 Gene
No Post-translational modifications
Other Protein References for KAAG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KAAG1
-
Abcam antibodies for KAAG1
- Invitrogen Antibodies for KAAG1
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Protein Products
-
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-
Abcam proteins for KAAG1
Assay Products
No data available for DME Specific Peptides for KAAG1 Gene
Domains & Families for KAAG1 Gene
Gene Families for KAAG1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for KAAG1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for KAAG1 Gene
Function for KAAG1 Gene
Phenotypes for KAAG1 Gene
- GenomeRNAi human phenotypes for KAAG1:
Animal Model Products
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-
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CRISPR Products
-
OriGene CRISPR knockouts for KAAG1
- genomics-online: gRNA clones - Search results for 22 available KAAG1 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KAAG1
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miRNA for KAAG1 Gene
- miRTarBase miRNAs that target KAAG1
miRNA Products
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Inhibitory RNA Products
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Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for KAAG1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for KAAG1
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ViGene Biosciences adenoviral particle packaged cDNA for KAAG1 gene
-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KAAG1 Gene
Localization for KAAG1 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| extracellular | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KAAG1 Gene
Pathways & Interactions for KAAG1 Gene
No Data Available
Interacting Proteins for KAAG1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | NAS | 10601354 |
No data available for Pathways by source and SIGNOR curated interactions for KAAG1 Gene
Transcripts for KAAG1 Gene
mRNA/cDNA for KAAG1 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (6) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KAAG1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KAAG1
- genomics-online: gRNA clones - Search results for 22 available KAAG1 gene related products
- Overview of 22 available KAAG1 gene related products
- Applied Biological Materials CRISPR for KAAG1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KAAG1
- GenScript: Design CRISPR guide RNA sequences for KAAG1
miRNA Products
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KAAG1
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- genomics-online: shRNA clones - Search results for 22 available KAAG1 gene related products
- Overview of 22 available KAAG1 gene related products
- Search ViGene Biosciences for KAAG1
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KAAG1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KAAG1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for KAAG1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KAAG1 Gene
NURSA nuclear receptor signaling pathways regulating expression of KAAG1 Gene:
KAAG1SOURCE GeneReport for Unigene cluster for KAAG1 Gene:
Hs.697888mRNA Expression by UniProt/SwissProt for KAAG1 Gene:
Q9UBP8-KAAG1_HUMAN
Tissue specificity:
Expressed in testis and kidney, and, at lower levels, in urinary bladder and liver. Expressed by a high proportion of tumors of various histologic origin, including melanomas, sarcomas and colorectal carcinomas.
Primer Products
-
OriGene qPCR primer pairs for KAAG1
- genomics-online: primer clones - Search results for 22 available KAAG1 gene related products
- Overview of 22 available KAAG1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KAAG1 Gene
Orthologs for KAAG1 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KAAG1 33 34 |
|
- Species where no ortholog for KAAG1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for KAAG1 Gene
No data available for Paralogs for KAAG1 Gene
Variants for KAAG1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1042640142 | pathogenic, Sclerosing cholangitis, neonatal | 24,357,700(+) | C/G/T | coding_sequence_variant, missense_variant | |
| rs33943110 | benign, Deafness, autosomal recessive 66, Sclerosing cholangitis, neonatal | 24,357,568(+) | G/A/C | 5_prime_UTR_variant | |
| rs757704417 | pathogenic, Nephronophthisis 19, Sclerosing cholangitis, neonatal | 24,357,627(+) | ACAC/AC | 5_prime_UTR_variant | |
| rs1000059221 | -- | 24,355,173(+) | A/G | upstream_transcript_variant | |
| rs1000829594 | -- | 24,357,225(+) | T/C | 5_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1026638 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.22;
4.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KAAG1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KAAG1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KAAG1 Gene
Disorders for KAAG1 Gene
Additional Disease Information for KAAG1
No disorders were found for KAAG1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KAAG1 Gene
Publications for KAAG1 Gene
- A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription. (PMID: 10601354) Van Den Eynde BJ … Boon T (The Journal of experimental medicine 1999) 2 3 4 58
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
- PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for KAAG1 Gene
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- Invitrogen Antibodies for KAAG1
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KAAG1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available KAAG1 related products ranked by validation data
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- Overview of 22 available KAAG1 gene related products
Sources for KAAG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew