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The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013] See more...
Aliases for JUND Gene
Aliases for JUND Gene
External Ids for JUND Gene
- HGNC: 6206
- Entrez Gene: 3727
- Ensembl: ENSG00000130522
- OMIM: 165162
- UniProtKB: P17535
Previous GeneCards Identifiers for JUND Gene
- GC19M018884
- GC19M018782
- GC19M018235
- GC19M018252
- GC19M018253
- GC19M018254
- GC19M018391
- GC19M017954
Summaries for JUND Gene
-
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
GeneCards Summary for JUND Gene
JUND (JunD Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUND include Multiple Endocrine Neoplasia, Type I and T-Cell Lymphoblastic Leukemia/Lymphoma. Among its related pathways are Signal transduction_JNK pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enzyme binding. An important paralog of this gene is JUN.
UniProtKB/Swiss-Prot Summary for JUND Gene
-
Transcription factor binding AP-1 sites.
Additional gene information for JUND Gene
- HGNC(6206)
- Entrez Gene(3727)
- Ensembl(ENSG00000130522)
- OMIM(165162)
- UniProtKB(P17535)
- Open Targets Platform(ENSG00000130522)
- Monarch Initiative
- Search for JUND at DataMed
- Search for JUND at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JUND Gene
Genomics for JUND Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for JUND Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around JUND on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JUND
- Top Transcription factor binding sites by QIAGEN in the JUND gene promoter:
-
- C/EBPbeta
- CREB
- deltaCREB
- NF-kappaB1
- NRSF form 2
- Pax-3
- Sp1
Genomic Locations for JUND Gene
Genomic Locations for JUND Gene
- chr19:18,279,694-18,281,622
- (GRCh38/hg38)
- Size:
- 1,929 bases
- Orientation:
- Minus strand
- chr19:18,390,563-18,392,432
- (GRCh37/hg19)
- Size:
- 1,870 bases
- Orientation:
- Minus strand
Genomic View for JUND Gene
Genes around JUND on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by HGNC
- 19p13.11 by Entrez Gene
- 19p13.11 by Ensembl
JUND Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for JUND Gene
Proteins for JUND Gene
-
Protein details for JUND Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17535-JUND_HUMAN
- Recommended name:
- Transcription factor jun-D
- Protein Accession:
- P17535
- Q53EK9
Protein attributes for JUND Gene
- Size:
- 347 amino acids
- Molecular mass:
- 35174 Da
- Quaternary structure:
-
- Binds DNA as a dimer (By similarity). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (PubMed:9989505, PubMed:22327296). Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (PubMed:22327296).
- SequenceCaution:
-
- Sequence=CAA40010.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for JUND Gene
Post-translational modifications for JUND Gene
- Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for JUND Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences AP-1 / JUND Monoclonal Antibody
- G Biosciences Immunotag™ JunD Antibody and Immunotag™ Phospho-JunD (Ser255) Antibody
- Creative Diagnostics Rabbit Anti-Human JunD monoclonal antibody, clone TE1941
-
Creative Biolabs
- Hi-Affi™ Recombinant Rabbit Anti-JUND Monoclonal Antibody (DS1904AB)
- Rabbit Anti-JUND Recombinant Antibody (EPR17365)
- Rabbit Anti-JUND Polyclonal Antibody (PTM-CBPAB-0771YC)
- Rabbit Anti-JUND (Phosphorylated S73) Polyclonal Antibody (PTM-CBPAB-0779YC)
- Recombinant Rabbit Anti-JUND (phosphorylated Ser255) Monoclonal Antibody (CBACN-634)
- Novus Biologicals Antibodies for JUND
-
Abcam antibodies for JUND
- Invitrogen Antibodies for JUND (AFLGC-JUND)
-
Boster Bio Antibodies for JUND
-
Santa Cruz Biotechnology (SCBT) Antibodies for JUND
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for JUND
- Origene Custom Protein Services for JUND
- antibodies-online: Show 8 available JUND Proteins ranked by validation data
- Compare Top JUND Proteins
-
Quality Products:
-
Abcam proteins for JUND
Assay Products
- antibodies-online: Show 6 available JUND Elisa Kits ranked by validation data
- Compare Top JUND Elisa Kits
-
Quality Products:
-
Abcam assays for JUND
No data available for DME Specific Peptides for JUND Gene
Domains & Families for JUND Gene
Gene Families for JUND Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for JUND Gene
- InterPro:
- Blocks:
-
- bZIP transcription factor, bZIP_1
- Jun transcription factor signature
- Jun-like transcription factor
- ProtoNet:
Suggested Antigen Peptide Sequences for JUND Gene
- GenScript: Design optimal peptide antigens:
-
- Transcription factor jun-D (JUND_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P17535- Family:
-
- Belongs to the bZIP family. Jun subfamily.
Function for JUND Gene
Molecular function for JUND Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor binding AP-1 sites.
- GENATLAS Biochemistry:
- jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1
Phenotypes From GWAS Catalog for JUND Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 1903194 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for JUND Gene
- MGI mutant phenotypes for JUND:
-
inferred from 1 alleles
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- embryo phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for JUND:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Reduced mammosphere formation
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability in pancreas lineage
- Increased circadian period length
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased virus production
- Decreased Aire reporter expression
- Actin fiber cells
Animal Models for JUND Gene
- MGI Knock Outs for JUND:
-
- Jund Jund<tm1Mya>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for JUND - Select products 50% OFF >
- * JUND CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for JUND
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for JUND
-
Santa Cruz Biotechnology (SCBT) CRISPR for JUND
miRNA for JUND Gene
- miRTarBase miRNAs that target JUND
-
- hsa-miR-663a (MIRT005354)
- mmu-miR-125b-5p (MIRT006097)
- hsa-miR-335-5p (MIRT017287)
- hsa-miR-186-5p (MIRT045282)
- hsa-miR-6780b-5p (MIRT491183)
- hsa-miR-4725-3p (MIRT491185)
- hsa-miR-4271 (MIRT491186)
- hsa-miR-6787-5p (MIRT491187)
- hsa-miR-1908-5p (MIRT491188)
- hsa-miR-4755-3p (MIRT491189)
- hsa-miR-3185 (MIRT491190)
- hsa-miR-6891-5p (MIRT491191)
- hsa-miR-3173-3p (MIRT491193)
- hsa-miR-625-5p (MIRT570206)
- hsa-miR-4695-5p (MIRT570207)
- hsa-miR-4707-5p (MIRT570208)
- hsa-miR-6875-3p (MIRT650155)
- hsa-miR-4778-3p (MIRT650156)
- hsa-miR-29b-1-5p (MIRT733073)
- hsa-miR-1827 (MIRT738113)
- hsa-miR-2277-5p (MIRT739119)
- hsa-miR-3141 (MIRT740193)
- hsa-miR-3153 (MIRT740387)
- hsa-miR-583 (MIRT751526)
- hsa-miR-6733-5p (MIRT754111)
- hsa-miR-6739-5p (MIRT754308)
- hsa-miR-6869-3p (MIRT757958)
- hsa-miR-885-3p (MIRT760385)
Transcription Factor Targets for JUND Gene
Targeted motifs for JUND Gene
HOMER Transcription Factor Regulatory Elements motif JUND
- Consensus sequence: ATGACGTCATCN Submotif: canonical Cell Type: K562
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for JUND
- Browse OriGene Inhibitory RNA Products For JUND
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUND
Clone Products
- Applied Biological Materials (abm): Clones for JUND - Select products 50% OFF >
- * JUND as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for JUND
- Addgene plasmids for JUND
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for JUND
Cell Line Products
-
Horizon Cell Lines for JUND
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUND Gene
Localization for JUND Gene
Subcellular locations from UniProtKB/Swiss-Prot for JUND Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | TAS | 1903194 |
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IBA | 21873635 |
Pathways & Interactions for JUND Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
|
|
| 2 | IL-17 Family Signaling Pathways |
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
|
|
| 3 | MAPK signaling pathway | ||
| 4 | Immune response IL-2 activation and signaling pathway |
Immune response IL-2 activation and signaling pathway
.41
|
Immune response IL-3 activation and signaling pathway
.41
|
| 5 | G-protein signaling Ras family GTPases in kinase cascades (scheme) |
Immune response Oncostatin M signaling via MAPK in human cells
.39
|
|
Pathways by source for JUND Gene
11 BioSystems pathways for JUND Gene
1 PharmGKB pathway for JUND Gene
4 KEGG pathways for JUND Gene
9 GeneGo (Thomson Reuters) pathways for JUND Gene
- Immune response CD16 signaling in NK cells
- Immune response IL-1 signaling pathway
- Immune response IL-2 activation and signaling pathway
- Immune response IL-3 activation and signaling pathway
- Immune response Oncostatin M signaling via MAPK in human cells
11 R&D Systems pathways for JUND Gene
8 Qiagen pathways for JUND Gene
- Ceramide Pathway
- CRHR Pathway
- Epithelial Tight Junctions
- ILK Signaling
- iNOS Signaling
1 Cell Signaling Technology pathway for JUND Gene
Interacting Proteins for JUND Gene
Selected Interacting proteins:
P17535-JUND_HUMAN
ENSP00000252818
for JUND Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for JUND
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0002076 | osteoblast development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,TAS | 1903194 |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
Transcripts for JUND Gene
mRNA/cDNA for JUND Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000252818 1929 nts (view in UCSC)
- ENST00000600972 500 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for JUND - Select products 50% OFF >
- * JUND CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for JUND
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for JUND
-
Santa Cruz Biotechnology (SCBT) CRISPR for JUND
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for JUND
- Browse OriGene Inhibitory RNA Products For JUND
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUND
Clone Products
- Applied Biological Materials (abm): Clones for JUND - Select products 50% OFF >
- * JUND as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for JUND
- Addgene plasmids for JUND
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for JUND
Relevant External Links for JUND Gene
- GeneLoc Exon Structure for
- JUND
Expression for JUND Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
- Bone (Muscoskeletal System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Breast (Uncategorized)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Blymphocyte (17.6), Placenta (10.2), Peripheral blood mononuclear cells (6.6), and Monocytes (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JUND Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JUND
SOURCE GeneReport for Unigene cluster for JUND Gene:
Hs.2780Evidence on tissue expression from TISSUES for JUND Gene
- Spleen(4.6)
- Nervous system(3.4)
- Blood(3.4)
- Kidney(3.3)
- Adrenal gland(3.2)
- Muscle(3.2)
- Lung(3.2)
- Liver(3.1)
- Bone marrow(3.1)
- Skin(3)
- Thyroid gland(3)
- Intestine(3)
- Eye(2.9)
- Heart(2.9)
- Lymph node(2.9)
- Pancreas(2.6)
- Stomach(2.5)
Primer Products
-
OriGene qPCR primer pairs for JUND
-
OriGene qPCR primer pairs and template standards for JUND
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JUND Gene
Orthologs for JUND Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | JUND 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | JUND 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | JUND 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Jund 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Jund 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | JUND 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | JUND 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | jund 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | jund 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Jra 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for JUND was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for JUND Gene
- ENSEMBL:
- Gene Tree for JUND (if available)
- TreeFam:
- Gene Tree for JUND (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for JUND: view image
Paralogs for JUND Gene
Variants for JUND Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JUND Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 729823 | Benign: not provided | 18,280,660(-) | C/A | SYNONYMOUS_VARIANT | |
| 730275 | Likely Benign: not provided | 18,280,896(-) | G/A | SYNONYMOUS_VARIANT | |
| rs41478151 | - | p.Gly20Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv6293n54 | CNV | gain+loss | 21841781 |
| dgv6294n54 | CNV | gain | 21841781 |
| dgv6295n54 | CNV | gain | 21841781 |
| dgv6296n54 | CNV | loss | 21841781 |
| esv29755 | CNV | loss | 19812545 |
| nsv1126517 | CNV | deletion | 24896259 |
| nsv578744 | CNV | gain | 21841781 |
| nsv828472 | CNV | loss | 20364138 |
| nsv952420 | CNV | deletion | 24416366 |
Gene Damage Index Score:
1.10;
22.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for JUND Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- JUND
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUND Gene
Disorders for JUND Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| multiple endocrine neoplasia, type i |
|
|
| t-cell lymphoblastic leukemia/lymphoma |
|
|
| adult t-cell leukemia |
|
|
| human t-cell leukemia virus type 1 |
|
|
| ovarian cancer |
|
Search JUND in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for JUND
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for JUND Gene
Publications for JUND Gene
- Structure and function of human jun-D. (PMID: 1903194) Berger I … Shaul Y (Oncogene 1991) 2 3 4 23
- Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. (PMID: 2112242) Nomura N … Ishizaki R (Nucleic acids research 1990) 2 3 4
- The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. (PMID: 22327296) Huang J … Lei M (Nature 2012) 3 4
- JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts. (PMID: 19211927) Abdul-Hafez A … Uhal BD (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 3 23
- Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. (PMID: 18071306) Nakayama T … Yoshie O (Oncogene 2008) 3 23
ExternalLinks
Products for JUND Gene
- Custom Antibody ServicesOriGene Antibodies for JUND
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- Custom Assay Services
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- Origene Custom Protein Services for JUND
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- Browse OriGene Inhibitory RNA Products For JUND
- OriGene qPCR primer pairs for JUND
- OriGene qPCR primer pairs and template standards for JUND
- OriGene CRISPR knockouts for JUND
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For JUND
- Sino Biological Human cDNA Clone for JUND
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for JUND
- Novus Biologicals proteins and lysates for JUND
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for JUND
- Abcam proteins for JUND
- Abcam assays for JUND
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- Invitrogen Antibodies for JUND (AFLGC-JUND)
- VectorBuilder Custom and pre-made DNA vectors for JUND (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for JUND (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for JUND (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for JUND CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for JUND
- Addgene plasmids for JUND
- antibodies-online: Show 50 available JUND Antibodies ranked by validation data
- Compare Top JUND Antibodies
- antibodies-online: Show 6 available JUND Elisa Kits ranked by validation data
- Compare Top JUND Elisa Kits
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- antibodies-online: Show 8 available JUND Proteins ranked by validation data
- Compare Top JUND Proteins
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- Santa Cruz Biotechnology (SCBT) Antibodies for JUND
- Search Santa Cruz Biotechnology (SCBT) for JUND siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for JUND
- Horizon Cell Lines for JUND
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for JUND
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for JUND
- Search GeneCopoeia for miRNA 3'UTR Target clone products for JUND
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUND