The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013] See more...

Aliases for JUND Gene

Aliases for JUND Gene

  • JunD Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • Transcription Factor Jun-D 2 3 4
  • Activator Protein 1 2 3
  • JunD-FL Isoform 2 3
  • AP-1 2 3
  • Jun D Proto-Oncogene 3
  • JUND 5

External Ids for JUND Gene

Previous GeneCards Identifiers for JUND Gene

  • GC19M018884
  • GC19M018782
  • GC19M018235
  • GC19M018252
  • GC19M018253
  • GC19M018254
  • GC19M018391
  • GC19M017954

Summaries for JUND Gene

Entrez Gene Summary for JUND Gene

  • The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

GeneCards Summary for JUND Gene

JUND (JunD Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUND include Multiple Endocrine Neoplasia, Type I and T-Cell Lymphoblastic Leukemia/Lymphoma. Among its related pathways are Signal transduction_JNK pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enzyme binding. An important paralog of this gene is JUN.

UniProtKB/Swiss-Prot Summary for JUND Gene

Gene Wiki entry for JUND Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JUND Gene

Genomics for JUND Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for JUND Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JUND on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JUND

Top Transcription factor binding sites by QIAGEN in the JUND gene promoter:
  • C/EBPbeta
  • CREB
  • deltaCREB
  • NF-kappaB1
  • NRSF form 2
  • Pax-3
  • Sp1

Genomic Locations for JUND Gene

Genomic Locations for JUND Gene
chr19:18,279,694-18,281,622
(GRCh38/hg38)
Size:
1,929 bases
Orientation:
Minus strand
chr19:18,390,563-18,392,432
(GRCh37/hg19)
Size:
1,870 bases
Orientation:
Minus strand

Genomic View for JUND Gene

Genes around JUND on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUND Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUND Gene

Proteins for JUND Gene

  • Protein details for JUND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17535-JUND_HUMAN
    Recommended name:
    Transcription factor jun-D
    Protein Accession:
    P17535
    Secondary Accessions:
    • Q53EK9

    Protein attributes for JUND Gene

    Size:
    347 amino acids
    Molecular mass:
    35174 Da
    Quaternary structure:
    • Binds DNA as a dimer (By similarity). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (PubMed:9989505, PubMed:22327296). Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (PubMed:22327296).
    SequenceCaution:
    • Sequence=CAA40010.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for JUND Gene

neXtProt entry for JUND Gene

Post-translational modifications for JUND Gene

  • Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JUND Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for JUND

No data available for DME Specific Peptides for JUND Gene

Domains & Families for JUND Gene

Gene Families for JUND Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for JUND Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
  • Jun transcription factor signature
  • Jun-like transcription factor
ProtoNet:

Suggested Antigen Peptide Sequences for JUND Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor jun-D (JUND_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17535

UniProtKB/Swiss-Prot:

JUND_HUMAN :
  • Belongs to the bZIP family. Jun subfamily.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUND: view

Function for JUND Gene

Molecular function for JUND Gene

UniProtKB/Swiss-Prot Function:
Transcription factor binding AP-1 sites.
GENATLAS Biochemistry:
jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1

Phenotypes From GWAS Catalog for JUND Gene

Gene Ontology (GO) - Molecular Function for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 1903194
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with JUND: view
genes like me logo Genes that share phenotypes with JUND: view

Animal Models for JUND Gene

MGI Knock Outs for JUND:

Animal Model Products

CRISPR Products

Transcription Factor Targets for JUND Gene

Selected GeneGlobe predicted Target genes for JUND
Targeted motifs for JUND Gene
HOMER Transcription Factor Regulatory Elements motif JUND
  • Consensus sequence: ATGACGTCATCN Submotif: canonical Cell Type: K562

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUND

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUND Gene

Localization for JUND Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUND Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JUND gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin TAS 1903194
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with JUND: view

Pathways & Interactions for JUND Gene

PathCards logo

SuperPathways for JUND Gene

SuperPathway Contained pathways
1 Toll-Like receptor Signaling Pathways
.42
.41
2 IL-17 Family Signaling Pathways
.48
3 MAPK signaling pathway
4 Immune response IL-2 activation and signaling pathway
.41
.41
5 G-protein signaling Ras family GTPases in kinase cascades (scheme)
.39
genes like me logo Genes that share pathways with JUND: view

Pathways by source for JUND Gene

1 PharmGKB pathway for JUND Gene
9 GeneGo (Thomson Reuters) pathways for JUND Gene
  • Immune response CD16 signaling in NK cells
  • Immune response IL-1 signaling pathway
  • Immune response IL-2 activation and signaling pathway
  • Immune response IL-3 activation and signaling pathway
  • Immune response Oncostatin M signaling via MAPK in human cells
8 Qiagen pathways for JUND Gene
  • Ceramide Pathway
  • CRHR Pathway
  • Epithelial Tight Junctions
  • ILK Signaling
  • iNOS Signaling
1 Cell Signaling Technology pathway for JUND Gene

SIGNOR curated interactions for JUND Gene

Is activated by:

Gene Ontology (GO) - Biological Process for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0002076 osteoblast development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,TAS 1903194
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with JUND: view

Drugs & Compounds for JUND Gene

(20) Drugs for JUND Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for JUND Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with JUND: view

Transcripts for JUND Gene

mRNA/cDNA for JUND Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUND

Alternative Splicing Database (ASD) splice patterns (SP) for JUND Gene

No ASD Table

Relevant External Links for JUND Gene

GeneLoc Exon Structure for
JUND

Expression for JUND Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JUND Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JUND Gene

This gene is overexpressed in Blymphocyte (17.6), Placenta (10.2), Peripheral blood mononuclear cells (6.6), and Monocytes (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JUND Gene



Protein tissue co-expression partners for JUND Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JUND

SOURCE GeneReport for Unigene cluster for JUND Gene:

Hs.2780

Evidence on tissue expression from TISSUES for JUND Gene

  • Spleen(4.6)
  • Nervous system(3.4)
  • Blood(3.4)
  • Kidney(3.3)
  • Adrenal gland(3.2)
  • Muscle(3.2)
  • Lung(3.2)
  • Liver(3.1)
  • Bone marrow(3.1)
  • Skin(3)
  • Thyroid gland(3)
  • Intestine(3)
  • Eye(2.9)
  • Heart(2.9)
  • Lymph node(2.9)
  • Pancreas(2.6)
  • Stomach(2.5)
genes like me logo Genes that share expression patterns with JUND: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JUND Gene

Orthologs for JUND Gene

This gene was present in the common ancestor of animals.

Orthologs for JUND Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
Mammalia JUND 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia JUND 30
  • 91.3 (n)
Dog
(Canis familiaris)
Mammalia JUND 30 31
  • 90.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Jund 30
  • 80.65 (n)
Mouse
(Mus musculus)
Mammalia Jund 30 17 31
  • 80.45 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia JUND 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia JUND 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia jund 30
  • 63.87 (n)
Zebrafish
(Danio rerio)
Actinopterygii jund 30 31
  • 69.95 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Jra 31
  • 34 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for JUND was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for JUND Gene

ENSEMBL:
Gene Tree for JUND (if available)
TreeFam:
Gene Tree for JUND (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JUND: view image

Paralogs for JUND Gene

Paralogs for JUND Gene

(2) SIMAP similar genes for JUND Gene using alignment to 2 proteins:

  • JUND_HUMAN
  • U3KPR5_HUMAN
genes like me logo Genes that share paralogs with JUND: view

Variants for JUND Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JUND Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
729823 Benign: not provided 18,280,660(-) C/A SYNONYMOUS_VARIANT
730275 Likely Benign: not provided 18,280,896(-) G/A SYNONYMOUS_VARIANT
rs41478151 - p.Gly20Val

Additional dbSNP identifiers (rs#s) for JUND Gene

Structural Variations from Database of Genomic Variants (DGV) for JUND Gene

Variant ID Type Subtype PubMed ID
dgv6293n54 CNV gain+loss 21841781
dgv6294n54 CNV gain 21841781
dgv6295n54 CNV gain 21841781
dgv6296n54 CNV loss 21841781
esv29755 CNV loss 19812545
nsv1126517 CNV deletion 24896259
nsv578744 CNV gain 21841781
nsv828472 CNV loss 20364138
nsv952420 CNV deletion 24416366

Variation tolerance for JUND Gene

Gene Damage Index Score: 1.10; 22.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JUND Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JUND

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUND Gene

Disorders for JUND Gene

MalaCards: The human disease database

(6) MalaCards diseases for JUND Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
multiple endocrine neoplasia, type i
  • men1
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
adult t-cell leukemia
  • adult t-cell leukemia/lymphoma
human t-cell leukemia virus type 1
  • htlv-1
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search JUND in MalaCards View complete list of genes associated with diseases

Additional Disease Information for JUND

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with JUND: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JUND Gene

Publications for JUND Gene

  1. Structure and function of human jun-D. (PMID: 1903194) Berger I … Shaul Y (Oncogene 1991) 2 3 4 23
  2. Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. (PMID: 2112242) Nomura N … Ishizaki R (Nucleic acids research 1990) 2 3 4
  3. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. (PMID: 22327296) Huang J … Lei M (Nature 2012) 3 4
  4. JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts. (PMID: 19211927) Abdul-Hafez A … Uhal BD (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 3 23
  5. Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. (PMID: 18071306) Nakayama T … Yoshie O (Oncogene 2008) 3 23

Products for JUND Gene