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The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
JUND (JunD Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUND include Multiple Endocrine Neoplasia, Type I and Adult T-Cell Leukemia. Among its related pathways are Signal transduction_JNK pathway and IL-1 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enzyme binding. An important paralog of this gene is JUN.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003690 | double-stranded DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | TAS | 1903194 |
GO:0000790 | nuclear chromatin | IBA | 21873635 |
GO:0005634 | nucleus | IDA,IEA | -- |
GO:0005654 | nucleoplasm | IBA,TAS | -- |
GO:0005667 | transcription factor complex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0002076 | osteoblast development | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS,IEA | 1903194 |
GO:0006366 | transcription by RNA polymerase II | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
platypus (Ornithorhynchus anatinus) |
Mammalia | JUND 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | JUND 32 |
|
||
dog (Canis familiaris) |
Mammalia | JUND 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Jund 32 |
|
||
mouse (Mus musculus) |
Mammalia | Jund 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | JUND 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | JUND 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | jund 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | jund 33 32 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | Jra 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000078578 | -- | 18,282,019(-) | GGTGCCGGCCTCCGGGG/GG | upstream_transcript_variant | |
rs1000101088 | -- | 18,280,874(-) | G/A | coding_sequence_variant, missense_variant | |
rs1000352178 | -- | 18,280,387(-) | C/T | 3_prime_UTR_variant | |
rs1000403598 | -- | 18,281,897(-) | C/T | upstream_transcript_variant | |
rs1000753295 | -- | 18,282,059(-) | A/G | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv6293n54 | CNV | gain+loss | 21841781 |
dgv6294n54 | CNV | gain | 21841781 |
dgv6295n54 | CNV | gain | 21841781 |
dgv6296n54 | CNV | loss | 21841781 |
esv29755 | CNV | loss | 19812545 |
nsv1126517 | CNV | deletion | 24896259 |
nsv578744 | CNV | gain | 21841781 |
nsv828472 | CNV | loss | 20364138 |
nsv952420 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
multiple endocrine neoplasia, type i |
|
|
adult t-cell leukemia |
|
|
t-cell leukemia |
|
|
familial isolated hyperparathyroidism |
|
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lipodystrophy, congenital generalized, type 3 |
|
|