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Aliases for JUND Gene

Aliases for JUND Gene

  • JunD Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • Transcription Factor Jun-D 2 3
  • Activator Protein 1 2 3
  • JunD-FL Isoform 2 3
  • Jun D Proto-Oncogene 3
  • AP-1 3

External Ids for JUND Gene

Previous GeneCards Identifiers for JUND Gene

  • GC19M018884
  • GC19M018782
  • GC19M018235
  • GC19M018252
  • GC19M018253
  • GC19M018254
  • GC19M018391
  • GC19M017954

Summaries for JUND Gene

Entrez Gene Summary for JUND Gene

  • The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

GeneCards Summary for JUND Gene

JUND (JunD Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUND include T-Cell Leukemia and Adult T-Cell Leukemia. Among its related pathways are ERK Signaling and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is JUN.

UniProtKB/Swiss-Prot for JUND Gene

  • Transcription factor binding AP-1 sites.

Gene Wiki entry for JUND Gene

Additional gene information for JUND Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUND Gene

Genomics for JUND Gene

GeneHancer (GH) Regulatory Elements for JUND Gene

Promoters and enhancers for JUND Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J018277 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 655 +1.0 1028 6.4 MLX FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC JUND MIR3188 GC19P020561 PIR55689 IQCN ENSG00000268030 UPF1 ENSG00000268938 NR2C2AP ENSG00000269191
GH19J018300 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.2 -22.8 -22849 8.2 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PPARGC1A GLIS1 RCOR2 ENSG00000268030 UPF1 ENSG00000268938 IQCN NR2C2AP ENSG00000269191 COLGALT1 MEF2B MVB12A ELL
GH19J018289 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -10.6 -10580 6.1 YBX1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 MEF2D ENSG00000268030 NR2C2AP IQCN UPF1 SUGP2 ENSG00000268938 MVB12A COLGALT1 GTPBP3 ENSG00000269439
GH19J017336 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 +944.3 944300 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTPBP3 ANO8 CHERP ENSG00000269578 IQCN ENSG00000268743 COLGALT1 C19orf44 HAUS8 SIN3B
GH19J018512 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.7 -236.2 -236155 10.5 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC SSRP1 ELL SSBP4 FKBP8 LRRC25 PGPEP1 IL12RB1 JUND KXD1 UPF1 IFI30
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JUND on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JUND gene promoter:
  • CREB
  • deltaCREB
  • C/EBPbeta
  • Sp1
  • NF-kappaB1
  • Pax-3
  • NRSF form 2

Genomic Locations for JUND Gene

Genomic Locations for JUND Gene
chr19:18,279,694-18,281,656
(GRCh38/hg38)
Size:
1,963 bases
Orientation:
Minus strand
chr19:18,390,563-18,392,432
(GRCh37/hg19)
Size:
1,870 bases
Orientation:
Minus strand

Genomic View for JUND Gene

Genes around JUND on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUND Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUND Gene

Proteins for JUND Gene

  • Protein details for JUND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17535-JUND_HUMAN
    Recommended name:
    Transcription factor jun-D
    Protein Accession:
    P17535
    Secondary Accessions:
    • Q53EK9

    Protein attributes for JUND Gene

    Size:
    347 amino acids
    Molecular mass:
    35174 Da
    Quaternary structure:
    • Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional activation.
    SequenceCaution:
    • Sequence=CAA40010.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for JUND Gene

neXtProt entry for JUND Gene

Post-translational modifications for JUND Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JUND Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JUND Gene

Domains & Families for JUND Gene

Gene Families for JUND Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for JUND Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17535

UniProtKB/Swiss-Prot:

JUND_HUMAN :
  • Belongs to the bZIP family. Jun subfamily.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUND: view

Function for JUND Gene

Molecular function for JUND Gene

UniProtKB/Swiss-Prot Function:
Transcription factor binding AP-1 sites.
GENATLAS Biochemistry:
jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1

Phenotypes From GWAS Catalog for JUND Gene

Gene Ontology (GO) - Molecular Function for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA,IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA,NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with JUND: view
genes like me logo Genes that share phenotypes with JUND: view

Animal Models for JUND Gene

MGI Knock Outs for JUND:

Animal Model Products

CRISPR Products

Transcription Factor Targets for JUND Gene

Selected GeneGlobe predicted Target genes for JUND
Targeted motifs for JUND Gene
HOMER Transcription Factor Regulatory Elements motif JUND
  • Consensus sequence: ATGACGTCATCN Submotif: canonical Cell Type: K562

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUND

Clone Products

  • Addgene plasmids for JUND

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUND Gene

Localization for JUND Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUND Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JUND gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
golgi apparatus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin TAS 1903194
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IEA,IDA --
GO:0005654 nucleoplasm IBA --
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with JUND: view

Pathways & Interactions for JUND Gene

genes like me logo Genes that share pathways with JUND: view

SIGNOR curated interactions for JUND Gene

Is activated by:

Gene Ontology (GO) - Biological Process for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0002076 osteoblast development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,TAS 1903194
genes like me logo Genes that share ontologies with JUND: view

Drugs & Compounds for JUND Gene

(20) Drugs for JUND Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for JUND Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with JUND: view

Transcripts for JUND Gene

mRNA/cDNA for JUND Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(343) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JUND Gene

Jun D proto-oncogene:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUND

Clone Products

  • Addgene plasmids for JUND

Alternative Splicing Database (ASD) splice patterns (SP) for JUND Gene

No ASD Table

Relevant External Links for JUND Gene

GeneLoc Exon Structure for
JUND
ECgene alternative splicing isoforms for
JUND

Expression for JUND Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JUND Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JUND Gene

This gene is overexpressed in Blymphocyte (17.6), Placenta (10.2), Peripheral blood mononuclear cells (6.6), and Monocytes (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JUND Gene



Protein tissue co-expression partners for JUND Gene

NURSA nuclear receptor signaling pathways regulating expression of JUND Gene:

JUND

SOURCE GeneReport for Unigene cluster for JUND Gene:

Hs.2780

Evidence on tissue expression from TISSUES for JUND Gene

  • Spleen(4.4)
  • Nervous system(3.2)
  • Adrenal gland(3)
  • Blood(2.9)
  • Lung(2.8)
  • Eye(2.7)
  • Kidney(2.7)
  • Muscle(2.7)
  • Liver(2.6)
  • Thyroid gland(2.6)
  • Bone marrow(2.5)
  • Intestine(2.5)
  • Skin(2.5)
  • Heart(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with JUND: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JUND Gene

Orthologs for JUND Gene

This gene was present in the common ancestor of animals.

Orthologs for JUND Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia JUND 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JUND 33
  • 91.3 (n)
dog
(Canis familiaris)
Mammalia JUND 34 33
  • 90.63 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jund 33
  • 80.65 (n)
mouse
(Mus musculus)
Mammalia Jund 16 34 33
  • 80.45 (n)
oppossum
(Monodelphis domestica)
Mammalia JUND 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JUND 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jund 33
  • 63.87 (n)
zebrafish
(Danio rerio)
Actinopterygii jund 34 33
  • 69.95 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Jra 34
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for JUND was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUND Gene

ENSEMBL:
Gene Tree for JUND (if available)
TreeFam:
Gene Tree for JUND (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JUND: view image

Paralogs for JUND Gene

Paralogs for JUND Gene

(2) SIMAP similar genes for JUND Gene using alignment to 2 proteins:

  • JUND_HUMAN
  • U3KPR5_HUMAN
genes like me logo Genes that share paralogs with JUND: view

Variants for JUND Gene

Sequence variations from dbSNP and Humsavar for JUND Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000078578 -- 18,282,019(-) GGTGCCGGCCTCCGGGG/GG upstream_transcript_variant
rs1000101088 -- 18,280,874(-) G/A coding_sequence_variant, missense_variant
rs1000352178 -- 18,280,387(-) C/T 3_prime_UTR_variant
rs1000403598 -- 18,281,897(-) C/T upstream_transcript_variant
rs1000753295 -- 18,282,059(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for JUND Gene

Variant ID Type Subtype PubMed ID
dgv6293n54 CNV gain+loss 21841781
dgv6294n54 CNV gain 21841781
dgv6295n54 CNV gain 21841781
dgv6296n54 CNV loss 21841781
esv29755 CNV loss 19812545
nsv1126517 CNV deletion 24896259
nsv578744 CNV gain 21841781
nsv828472 CNV loss 20364138
nsv952420 CNV deletion 24416366

Variation tolerance for JUND Gene

Gene Damage Index Score: 1.10; 22.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JUND Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JUND

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUND Gene

Disorders for JUND Gene

MalaCards: The human disease database

(3) MalaCards diseases for JUND Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
adult t-cell leukemia
  • adult t-cell leukemia/lymphoma
multiple endocrine neoplasia, type i
  • men1
- elite association - COSMIC cancer census association via MalaCards
Search JUND in MalaCards View complete list of genes associated with diseases

Additional Disease Information for JUND

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with JUND: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JUND Gene

Publications for JUND Gene

  1. Structure and function of human jun-D. (PMID: 1903194) Berger I … Shaul Y (Oncogene 1991) 2 3 4 22 58
  2. Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. (PMID: 2112242) Nomura N … Ishizaki R (Nucleic acids research 1990) 2 3 4 58
  3. JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts. (PMID: 19211927) Abdul-Hafez A … Uhal BD (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 3 22 58
  4. Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. (PMID: 18071306) Nakayama T … Yoshie O (Oncogene 2008) 3 22 58
  5. JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. (PMID: 18386285) Mehraein-Ghomi F … Wilding G (The Prostate 2008) 3 22 58

Products for JUND Gene

  • Addgene plasmids for JUND

Sources for JUND Gene