Aliases for JUNB Gene

Aliases for JUNB Gene

  • JunB Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • Transcription Factor Jun-B 3 4
  • Jun B Proto-Oncogene 3
  • Activator Protein 1 3
  • AP-1 3
  • JUNB 5

External Ids for JUNB Gene

Previous GeneCards Identifiers for JUNB Gene

  • GC19P013033
  • GC19P013125
  • GC19P012747
  • GC19P012763
  • GC19P012902
  • GC19P012474

Summaries for JUNB Gene

GeneCards Summary for JUNB Gene

JUNB (JunB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUNB include Primary Cutaneous T-Cell Lymphoma and Anaplastic Large Cell Lymphoma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and G-protein signaling Ras family GTPases in kinase cascades (scheme). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is JUN.

UniProtKB/Swiss-Prot Summary for JUNB Gene

  • Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Gene Wiki entry for JUNB Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JUNB Gene

Genomics for JUNB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for JUNB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JUNB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JUNB

Top Transcription factor binding sites by QIAGEN in the JUNB gene promoter:
  • AP-1
  • Egr-1
  • SRF
  • SRF (504 AA)

Genomic Locations for JUNB Gene

Genomic Locations for JUNB Gene
chr19:12,791,486-12,793,315
(GRCh38/hg38)
Size:
1,830 bases
Orientation:
Plus strand
chr19:12,902,310-12,904,125
(GRCh37/hg19)
Size:
1,816 bases
Orientation:
Plus strand

Genomic View for JUNB Gene

Genes around JUNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUNB Gene

Proteins for JUNB Gene

  • Protein details for JUNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17275-JUNB_HUMAN
    Recommended name:
    Transcription factor jun-B
    Protein Accession:
    P17275
    Secondary Accessions:
    • Q96GH3

    Protein attributes for JUNB Gene

    Size:
    347 amino acids
    Molecular mass:
    35879 Da
    Quaternary structure:
    • Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).

neXtProt entry for JUNB Gene

Post-translational modifications for JUNB Gene

Other Protein References for JUNB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for JUNB

No data available for DME Specific Peptides for JUNB Gene

Domains & Families for JUNB Gene

Gene Families for JUNB Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for JUNB Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
  • Jun transcription factor signature
  • Jun-like transcription factor
ProtoNet:

Suggested Antigen Peptide Sequences for JUNB Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor jun-B (JUNB_HUMAN)
  • cDNA, FLJ94337, Homo sapiens jun B proto-oncogene (JUNB), mRNA (Q5U079_HUMAN)
  • Ribonuclease (Q6IBG3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17275

UniProtKB/Swiss-Prot:

JUNB_HUMAN :
  • Belongs to the bZIP family. Jun subfamily.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUNB: view

Function for JUNB Gene

Molecular function for JUNB Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.
UniProtKB/Swiss-Prot Induction:
By growth factors.
GENATLAS Biochemistry:
jun protooncogene homolog B,ligand induced,immediate (primary) early response gene

Phenotypes From GWAS Catalog for JUNB Gene

Gene Ontology (GO) - Molecular Function for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding TAS 10764760
genes like me logo Genes that share ontologies with JUNB: view
genes like me logo Genes that share phenotypes with JUNB: view

Animal Models for JUNB Gene

MGI Knock Outs for JUNB:
  • Junb Junb<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Transcription Factor Targets for JUNB Gene

Selected GeneGlobe predicted Target genes for JUNB

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUNB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for JUNB Gene

Localization for JUNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUNB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JUNB gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin TAS 2513129
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with JUNB: view

Pathways & Interactions for JUNB Gene

genes like me logo Genes that share pathways with JUNB: view

Pathways by source for JUNB Gene

9 GeneGo (Thomson Reuters) pathways for JUNB Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Development Growth hormone signaling via PI3K/AKT and MAPK cascades
  • Immune response CD16 signaling in NK cells
  • Immune response IL-1 signaling pathway
  • Immune response IL-2 activation and signaling pathway
7 Qiagen pathways for JUNB Gene
  • Ceramide Pathway
  • Epithelial Tight Junctions
  • ILK Signaling
  • iNOS Signaling
  • ITK and TCR Signaling
3 Cell Signaling Technology pathways for JUNB Gene

SIGNOR curated interactions for JUNB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0001570 vasculogenesis IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001829 trophectodermal cell differentiation IEA --
genes like me logo Genes that share ontologies with JUNB: view

Drugs & Compounds for JUNB Gene

(36) Drugs for JUNB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(21) Additional Compounds for JUNB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with JUNB: view

Transcripts for JUNB Gene

mRNA/cDNA for JUNB Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUNB

Alternative Splicing Database (ASD) splice patterns (SP) for JUNB Gene

No ASD Table

Relevant External Links for JUNB Gene

GeneLoc Exon Structure for
JUNB

Expression for JUNB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JUNB Gene

mRNA differential expression in normal tissues according to GTEx for JUNB Gene

This gene is overexpressed in Fallopian Tube (x4.9).

Protein differential expression in normal tissues from HIPED for JUNB Gene

This gene is overexpressed in Placenta (19.9), Peripheral blood mononuclear cells (18.5), CD8 Tcells (13.7), and Monocytes (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JUNB Gene



Protein tissue co-expression partners for JUNB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JUNB

SOURCE GeneReport for Unigene cluster for JUNB Gene:

Hs.25292

Evidence on tissue expression from TISSUES for JUNB Gene

  • Pancreas(4.7)
  • Nervous system(4.1)
  • Intestine(3.7)
  • Lung(3.6)
  • Kidney(3.6)
  • Muscle(3.5)
  • Blood(3.3)
  • Skin(3.2)
  • Bone marrow(3.1)
  • Liver(3)
  • Heart(3)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Adrenal gland(2.6)
  • Stomach(2.6)
  • Bone(2.3)
  • Thyroid gland(2.3)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with JUNB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JUNB Gene

Orthologs for JUNB Gene

This gene was present in the common ancestor of animals.

Orthologs for JUNB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia JUNB 30 31
  • 99.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia JUNB 30 31
  • 92.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia JUNB 30 31
  • 92.7 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Junb 30 17 31
  • 88.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Junb 30
  • 88.47 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia JUNB 31
  • 74 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia JUNB 31
  • 47 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia junb 30
  • 60 (n)
Zebrafish
(Danio rerio)
Actinopterygii junba 31
  • 58 (a)
OneToMany
junbb 31
  • 55 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Jra 31
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for JUNB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for JUNB Gene

ENSEMBL:
Gene Tree for JUNB (if available)
TreeFam:
Gene Tree for JUNB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JUNB: view image

Paralogs for JUNB Gene

Paralogs for JUNB Gene

(3) SIMAP similar genes for JUNB Gene using alignment to 3 proteins:

  • JUNB_HUMAN
  • Q5U079_HUMAN
  • Q6IBG3_HUMAN
genes like me logo Genes that share paralogs with JUNB: view

Variants for JUNB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JUNB Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17880705 - p.Leu230Val

Additional dbSNP identifiers (rs#s) for JUNB Gene

Structural Variations from Database of Genomic Variants (DGV) for JUNB Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for JUNB Gene

Gene Damage Index Score: 0.72; 15.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JUNB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JUNB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUNB Gene

Disorders for JUNB Gene

MalaCards: The human disease database

(7) MalaCards diseases for JUNB Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search JUNB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for JUNB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with JUNB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JUNB Gene

Publications for JUNB Gene

  1. jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. (PMID: 2513129) Schütte J … Minna J (Cell 1989) 2 3 4
  2. Over-expression of JunB inhibits mitochondrial stress and cytotoxicity in human lymphoma cells exposed to chronic oxidative stress. (PMID: 20132737) Son YO … Lee JC (BMB reports 2010) 3 23
  3. [Methylation status of JunB and CDH13 gene promoter in CD34(+)CD38(-) chronic myelogenous leukemia cells]. (PMID: 20030915) Wang XJ … Huang SA (Zhongguo shi yan xue ye xue za zhi 2009) 3 23
  4. Expression and clinical significance of p53, JunB and KAI1/CD82 in human hepatocellular carcinoma. (PMID: 19666408) Guo C … Yang X (Hepatobiliary & pancreatic diseases international : HBPD INT 2009) 3 23
  5. Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma. (PMID: 17965727) Watanabe M … Horie R (Laboratory investigation; a journal of technical methods and pathology 2008) 3 23

Products for JUNB Gene