This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provide... See more...

Aliases for JUN Gene

Aliases for JUN Gene

  • Jun Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • V-Jun Avian Sarcoma Virus 17 Oncogene Homolog 2 3 4
  • Transcription Factor AP-1 3 4
  • Proto-Oncogene C-Jun 3 4
  • Activator Protein 1 3 4
  • Jun Oncogene 2 3
  • AP1 3 4
  • P39 3 4
  • V-Jun Sarcoma Virus 17 Oncogene Homolog 3
  • Jun Activation Domain Binding Protein 3
  • Enhancer-Binding Protein AP1 3
  • Proto-Oncogene CJun 3
  • C-Jun 3
  • AP-1 3
  • CJUN 3

External Ids for JUN Gene

Previous GeneCards Identifiers for JUN Gene

  • GC01M059163
  • GC01M058161
  • GC01M058604
  • GC01M058616
  • GC01M058958
  • GC01M057356
  • GC01M059246

Summaries for JUN Gene

Entrez Gene Summary for JUN Gene

  • This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

CIViC Summary for JUN Gene

GeneCards Summary for JUN Gene

JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Sarcoma and Primary Cutaneous T-Cell Lymphoma. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot Summary for JUN Gene

  • Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Gene Wiki entry for JUN Gene

Additional gene information for JUN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JUN Gene

Genomics for JUN Gene

GeneHancer (GH) Regulatory Elements for JUN Gene

Promoters and enhancers for JUN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JUN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JUN gene promoter:
  • c-Myb
  • CP2
  • GATA-2
  • HEN1
  • MZF-1
  • POU2F1
  • POU2F1a
  • STAT5A
  • USF-1
  • USF1

Genomic Locations for JUN Gene

Genomic Locations for JUN Gene
chr1:58,780,788-58,784,327
(GRCh38/hg38)
Size:
3,540 bases
Orientation:
Minus strand
chr1:59,246,463-59,249,785
(GRCh37/hg19)
Size:
3,323 bases
Orientation:
Minus strand

Genomic View for JUN Gene

Genes around JUN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUN Gene

Proteins for JUN Gene

  • Protein details for JUN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05412-JUN_HUMAN
    Recommended name:
    Transcription factor AP-1
    Protein Accession:
    P05412
    Secondary Accessions:
    • Q6FHM7
    • Q96G93

    Protein attributes for JUN Gene

    Size:
    331 amino acids
    Molecular mass:
    35676 Da
    Quaternary structure:
    • Heterodimer with either FOS or BATF3 or ATF7 (PubMed:10376527, PubMed:12087103, PubMed:15467742). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity (PubMed:10376527). Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20 (PubMed:10196196, PubMed:16478997, PubMed:8663478). Interacts with COPS5; the interaction leads indirectly to its phosphorylation (PubMed:8837781). Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site (PubMed:10995748). The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (PubMed:9732876). Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (PubMed:10995748). Interacts with methylated RNF187 (PubMed:20852630, PubMed:23624934). Binds to HIPK3. Interacts (when phosphorylated) with FBXW7 (PubMed:14739463). Found in a complex with PRR7 and FBXW7 (PubMed:27458189). Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189). Interacts with RBM39 (By similarity).

    Three dimensional structures from OCA and Proteopedia for JUN Gene

neXtProt entry for JUN Gene

Post-translational modifications for JUN Gene

  • Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).
  • Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
  • Acetylated at Lys-271 by EP300.
  • Ubiquitination at Lys50
  • Modification sites at PhosphoSitePlus

Other Protein References for JUN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for JUN

No data available for DME Specific Peptides for JUN Gene

Domains & Families for JUN Gene

Gene Families for JUN Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for JUN Gene

GenScript: Design optimal peptide antigens:
  • p39 (JUN_HUMAN)
  • JUN protein (Q6FHK0_HUMAN)
  • JUN protein (Q6FHM7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05412

UniProtKB/Swiss-Prot:

JUN_HUMAN :
  • Belongs to the bZIP family. Jun subfamily.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUN: view

Function for JUN Gene

Molecular function for JUN Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
GENATLAS Biochemistry:
avian sarcoma virus 17 (v-jun) oncogene homolog,ligand induced,immediate (primary ) early response gene interacting with MYC to regulate AP1 genes

Phenotypes From GWAS Catalog for JUN Gene

Gene Ontology (GO) - Molecular Function for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 22083952
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 19861239
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,NAS 19274049
GO:0001102 RNA polymerase II activating transcription factor binding IPI 10508860
genes like me logo Genes that share ontologies with JUN: view
genes like me logo Genes that share phenotypes with JUN: view

Animal Models for JUN Gene

MGI Knock Outs for JUN:
  • Jun Jun<tm1Wag>
  • Jun Jun<tm3Wag>
  • Jun Jun<tm1Pa>

Animal Model Products

CRISPR Products

Transcription Factor Targets for JUN Gene

Selected GeneGlobe predicted Target genes for JUN
Targeted motifs for JUN Gene
HOMER Transcription Factor Regulatory Elements motif JUN
  • Consensus sequence: GATGACTCATCN Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Clone Products

  • Addgene plasmids for JUN

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUN Gene

Localization for JUN Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUN Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JUN gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome TAS 10918580
GO:0000790 nuclear chromatin IBA,IEA 21873635
GO:0005634 nucleus IDA 21113145
GO:0005654 nucleoplasm IBA,TAS --
GO:0005667 transcription factor complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with JUN: view

Pathways & Interactions for JUN Gene

PathCards logo

SuperPathways for JUN Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
.59
.54
.51
.49
.48
.47
.44
.43
.36
.35
3 Toll-like Receptor Signaling Pathway
4 Development HGF signaling pathway
5 TNFR1 Pathway
.56
.55
.35
genes like me logo Genes that share pathways with JUN: view

Pathways by source for JUN Gene

95 Qiagen pathways for JUN Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Agrin Interactions at Neuromuscular Junction
  • Androgen Signaling
1 Cell Signaling Technology pathway for JUN Gene

Gene Ontology (GO) - Biological Process for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0001525 angiogenesis IEA --
GO:0001774 microglial cell activation IEA --
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with JUN: view

Drugs & Compounds for JUN Gene

(72) Drugs for JUN Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma Target, inducer, inhibitor 129
Vinblastine Approved Pharma Target, other/unknown 215
Irbesartan Approved, Investigational Pharma Antagonist, Target, other/unknown Angiotensin II inhibitor 108
Pseudoephedrine Approved Pharma Target, inhibitor 450
LGD-1550 Investigational Pharma Target 0

(61) Additional Compounds for JUN Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 49498
SR 11302
160162-42-5

(1) Tocris Compounds for JUN Gene

Compound Action Cas Number
SR 11302 AP-1 inhibitor; antitumor agent 160162-42-5
genes like me logo Genes that share compounds with JUN: view

Transcripts for JUN Gene

mRNA/cDNA for JUN Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(886) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for JUN

Alternative Splicing Database (ASD) splice patterns (SP) for JUN Gene

No ASD Table

Relevant External Links for JUN Gene

GeneLoc Exon Structure for
JUN
ECgene alternative splicing isoforms for
JUN

Expression for JUN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JUN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JUN Gene

This gene is overexpressed in Bone (60.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JUN Gene



Protein tissue co-expression partners for JUN Gene

NURSA nuclear receptor signaling pathways regulating expression of JUN Gene:

JUN

SOURCE GeneReport for Unigene cluster for JUN Gene:

Hs.696684

Evidence on tissue expression from TISSUES for JUN Gene

  • Nervous system(4.7)
  • Pancreas(4.5)
  • Lung(4.4)
  • Intestine(4)
  • Muscle(4)
  • Heart(3.7)
  • Kidney(3.6)
  • Liver(3.6)
  • Stomach(3.4)
  • Eye(3.3)
  • Skin(3.3)
  • Adrenal gland(3.1)
  • Blood(3.1)
  • Bone marrow(3)
  • Thyroid gland(2.8)
  • Spleen(2.7)
  • Lymph node(2.5)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with JUN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JUN Gene

Orthologs for JUN Gene

This gene was present in the common ancestor of animals.

Orthologs for JUN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JUN 33 32
  • 99.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia JUN 33 32
  • 94.54 (n)
OneToOne