This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provide... See more...

Aliases for JUN Gene

Aliases for JUN Gene

  • Jun Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • V-Jun Avian Sarcoma Virus 17 Oncogene Homolog 2 3 4
  • Transcription Factor AP-1 3 4
  • Proto-Oncogene C-Jun 3 4
  • Activator Protein 1 3 4
  • Jun Oncogene 2 3
  • C-Jun 2 3
  • AP-1 2 3
  • AP1 3 4
  • P39 3 4
  • V-Jun Sarcoma Virus 17 Oncogene Homolog 3
  • Jun Activation Domain Binding Protein 3
  • Enhancer-Binding Protein AP1 3
  • Proto-Oncogene CJun 3
  • CJUN 3
  • JUN 5

External Ids for JUN Gene

Previous GeneCards Identifiers for JUN Gene

  • GC01M059163
  • GC01M058161
  • GC01M058604
  • GC01M058616
  • GC01M058958
  • GC01M057356
  • GC01M059246

Summaries for JUN Gene

Entrez Gene Summary for JUN Gene

  • This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

CIViC Summary for JUN Gene

GeneCards Summary for JUN Gene

JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Pertussis and Sarcoma. Among its related pathways are ATM Pathway and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot Summary for JUN Gene

  • Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Gene Wiki entry for JUN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JUN Gene

Genomics for JUN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for JUN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JUN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JUN

Top Transcription factor binding sites by QIAGEN in the JUN gene promoter:
  • c-Myb
  • CP2
  • GATA-2
  • HEN1
  • MZF-1
  • POU2F1
  • POU2F1a
  • STAT5A
  • USF-1
  • USF1

Genomic Locations for JUN Gene

Genomic Locations for JUN Gene
chr1:58,780,791-58,784,047
(GRCh38/hg38)
Size:
3,257 bases
Orientation:
Minus strand
chr1:59,246,463-59,249,785
(GRCh37/hg19)
Size:
3,323 bases
Orientation:
Minus strand

Genomic View for JUN Gene

Genes around JUN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUN Gene

Proteins for JUN Gene

  • Protein details for JUN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05412-JUN_HUMAN
    Recommended name:
    Transcription factor AP-1
    Protein Accession:
    P05412
    Secondary Accessions:
    • Q6FHM7
    • Q96G93

    Protein attributes for JUN Gene

    Size:
    331 amino acids
    Molecular mass:
    35676 Da
    Quaternary structure:
    • Heterodimer with either FOS or BATF3 or ATF7 (PubMed:10376527, PubMed:12087103, PubMed:15467742). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity (PubMed:10376527). Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20 (PubMed:10196196, PubMed:16478997, PubMed:8663478). Interacts with COPS5; the interaction leads indirectly to its phosphorylation (PubMed:8837781). Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site (PubMed:10995748). The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (PubMed:9732876). Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (PubMed:10995748). Interacts with methylated RNF187 (PubMed:20852630, PubMed:23624934). Binds to HIPK3. Interacts (when phosphorylated) with FBXW7 (PubMed:14739463). Found in a complex with PRR7 and FBXW7 (PubMed:27458189). Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189). Interacts with RBM39 (By similarity). Interacts with PAGE4 (PubMed:24263171, PubMed:24559171, PubMed:26242913).

    Three dimensional structures from OCA and Proteopedia for JUN Gene

neXtProt entry for JUN Gene

Post-translational modifications for JUN Gene

  • Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).
  • Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
  • Acetylated at Lys-271 by EP300.
  • Ubiquitination at Lys50
  • Modification sites at PhosphoSitePlus

Other Protein References for JUN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for JUN

No data available for DME Specific Peptides for JUN Gene

Domains & Families for JUN Gene

Gene Families for JUN Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for JUN Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
  • Jun transcription factor signature
  • Jun-like transcription factor
ProtoNet:

Suggested Antigen Peptide Sequences for JUN Gene

GenScript: Design optimal peptide antigens:
  • p39 (JUN_HUMAN)
  • JUN protein (Q6FHK0_HUMAN)
  • JUN protein (Q6FHM7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05412

UniProtKB/Swiss-Prot:

JUN_HUMAN :
  • Belongs to the bZIP family. Jun subfamily.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUN: view

Function for JUN Gene

Molecular function for JUN Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
GENATLAS Biochemistry:
avian sarcoma virus 17 (v-jun) oncogene homolog,ligand induced,immediate (primary ) early response gene interacting with MYC to regulate AP1 genes

Phenotypes From GWAS Catalog for JUN Gene

Gene Ontology (GO) - Molecular Function for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 9732876
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 19861239
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,ISM 19274049
GO:0001102 RNA polymerase II activating transcription factor binding IPI 10508860
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA,IMP 19962668
genes like me logo Genes that share ontologies with JUN: view
genes like me logo Genes that share phenotypes with JUN: view

Animal Models for JUN Gene

MGI Knock Outs for JUN:
  • Jun Jun<tm1Wag>
  • Jun Jun<tm1Pa>
  • Jun Jun<tm3Wag>

Animal Model Products

CRISPR Products

Transcription Factor Targets for JUN Gene

Selected GeneGlobe predicted Target genes for JUN
Targeted motifs for JUN Gene
HOMER Transcription Factor Regulatory Elements motif JUN
  • Consensus sequence: GATGACTCATCN Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUN

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUN Gene

Localization for JUN Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUN Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JUN gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
extracellular 3
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 3
peroxisome 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome TAS 10918580
GO:0000790 nuclear chromatin IEA,ISA --
GO:0005634 nucleus IDA 21113145
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with JUN: view

Pathways & Interactions for JUN Gene

PathCards logo

SuperPathways for JUN Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
.59
.54
.51
.49
.48
.47
.44
.43
.36
.35
3 Development HGF signaling pathway
.44
.44
.37
4 Toll-Like receptor Signaling Pathways
.42
.41
5 TNFR1 Pathway
.56
.55
.52
.35
genes like me logo Genes that share pathways with JUN: view

Pathways by source for JUN Gene

54 GeneGo (Thomson Reuters) pathways for JUN Gene
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Apoptosis and survival TNFR1 signaling pathway
  • Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
  • Cell cycle ESR1 regulation of G1/S transition
95 Qiagen pathways for JUN Gene
  • 14-3-3 Induced Apoptosis
  • 14-3-3 Induced Intracellular Signaling
  • 4-1BB Pathway
  • Agrin Interactions at Neuromuscular Junction
  • Androgen Signaling
1 Cell Signaling Technology pathway for JUN Gene

Gene Ontology (GO) - Biological Process for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0001525 angiogenesis IEA --
GO:0001774 microglial cell activation IEA --
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with JUN: view

Drugs & Compounds for JUN Gene

(73) Drugs for JUN Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma Target, inducer, inhibitor 131
Vinblastine Approved Pharma Target, other/unknown 189
Adapalene Approved Pharma Target, antagonist RAR尾 and RAR纬 agonist 90
Irbesartan Approved, Investigational Pharma Antagonist, Target, other/unknown Angiotensin II inhibitor 110
Pseudoephedrine Approved Pharma Target, inhibitor 426

(61) Additional Compounds for JUN Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 49498
SR 11302
160162-42-5

(1) Tocris Compounds for JUN Gene

Compound Action Cas Number
SR 11302 AP-1 inhibitor; antitumor agent 160162-42-5
genes like me logo Genes that share compounds with JUN: view

Transcripts for JUN Gene

mRNA/cDNA for JUN Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JUN

Alternative Splicing Database (ASD) splice patterns (SP) for JUN Gene

No ASD Table

Relevant External Links for JUN Gene

GeneLoc Exon Structure for
JUN

Expression for JUN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JUN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JUN Gene

This gene is overexpressed in Bone (60.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JUN Gene



Protein tissue co-expression partners for JUN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JUN

SOURCE GeneReport for Unigene cluster for JUN Gene:

Hs.696684

mRNA Expression by UniProt/SwissProt for JUN Gene:

P05412-JUN_HUMAN
Tissue specificity: Expressed in the developing and adult prostate and prostate cancer cells.

Evidence on tissue expression from TISSUES for JUN Gene

  • Nervous system(4.7)
  • Pancreas(4.6)
  • Lung(4.5)
  • Intestine(4.2)
  • Muscle(4.2)
  • Heart(4)
  • Kidney(3.9)
  • Liver(3.9)
  • Stomach(3.8)
  • Skin(3.7)
  • Eye(3.6)
  • Blood(3.6)
  • Bone marrow(3.5)
  • Spleen(3.5)
  • Adrenal gland(3.4)
  • Thyroid gland(3.4)
  • Lymph node(3.4)
  • Bone(2.9)
  • Gall bladder(2.8)
  • Urine(2.1)
genes like me logo Genes that share expression patterns with JUN: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for JUN Gene

Orthologs for JUN Gene

This gene was present in the common ancestor of animals.

Orthologs for JUN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia JUN 30 31
  • 99.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia JUN 30 31
  • 94.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia JUN 30 31
  • 92.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Jun 30 17 31
  • 91.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Jun 30
  • 90.94 (n)
Oppossum
(Monodelphis domestica)
Mammalia JUN 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves JUN 30 31
  • 79.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia JUN 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia jun 30
  • 70.65 (n)
Zebrafish
(Danio rerio)
Actinopterygii jun 30 31
  • 74.57 (n)
OneToOne
wufj36h07 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006386 30
  • 60.09 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Jra 31
  • 32 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3347 30
Species where no ortholog for JUN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for JUN Gene

ENSEMBL:
Gene Tree for JUN (if available)
TreeFam:
Gene Tree for JUN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JUN: view image

Paralogs for JUN Gene

Paralogs for JUN Gene

(2) SIMAP similar genes for JUN Gene using alignment to 3 proteins:

  • JUN_HUMAN
  • Q6FHK0_HUMAN
  • Q6FHM7_HUMAN
genes like me logo Genes that share paralogs with JUN: view

Variants for JUN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JUN Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
720254 Benign: not provided 58,782,852(-) C/A SYNONYMOUS_VARIANT
737246 Likely Benign: not provided 58,782,606(-) G/A SYNONYMOUS_VARIANT
rs377289876 Not Provided: not provided 58,782,413(-) G/C MISSENSE_VARIANT
rs9989 - p.Thr297Met

Additional dbSNP identifiers (rs#s) for JUN Gene

Structural Variations from Database of Genomic Variants (DGV) for JUN Gene

Variant ID Type Subtype PubMed ID
esv26947 CNV loss 19812545
nsv546315 CNV loss 21841781

Variation tolerance for JUN Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JUN Gene

Human Gene Mutation Database (HGMD)
JUN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JUN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUN Gene

Disorders for JUN Gene

MalaCards: The human disease database

(94) MalaCards diseases for JUN Gene - From: DISEASES, Novoseek, and GeneCards