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Aliases for JRKL Gene

Aliases for JRKL Gene

  • JRK Like 2 3 5
  • Human Homolog Of Mouse Jerky Gene Protein 3 4
  • HHMJG 3 4
  • Jerky (Mouse) Homolog-Like 2
  • Jerky Homolog-Like (Mouse) 2
  • Jerky Protein Homolog-Like 3

External Ids for JRKL Gene

Previous GeneCards Identifiers for JRKL Gene

  • GC11P098454
  • GC11P097631
  • GC11P096308
  • GC11P095811
  • GC11P095763
  • GC11P096123
  • GC11P092189

Summaries for JRKL Gene

Entrez Gene Summary for JRKL Gene

  • The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for JRKL Gene

JRKL (JRK Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD2.

Additional gene information for JRKL Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JRKL Gene

Genomics for JRKL Gene

GeneHancer (GH) Regulatory Elements for JRKL Gene

Promoters and enhancers for JRKL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I096388 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.1 -138 2.5 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CCDC82 JRKL FAM76B MAML2
GH11I096391 Enhancer 0.2 Ensembl 550.8 +1.7 1712 0.2 CCDC82 JRKL GC11M096475 RNA5SP346
GH11I095788 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.4 -599.6 -599573 4.4 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 CEP57 FAM76B FGFR3P2 MAML2 JRKL LOC101929295 MTMR2 GC11M095802
GH11I096328 Enhancer 1.4 Ensembl ENCODE dbSUPER 14.6 -58.8 -58772 5.8 PKNOX1 FOXA2 ARNT FEZF1 TCF12 ZNF766 ZNF213 CAVIN1 ZNF592 MEF2D FGFR3P2 FAM76B CCDC82 CEP57 JRKL MAML2 GC11M096338 GC11P096202
GH11I096153 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -233.9 -233900 5.8 HDGF PKNOX1 ATF1 SMAD1 ZFP64 SIN3A IRF4 ZNF766 ZNF213 FOS FAM76B CEP57 FGFR3P2 CCDC82 JRKL MAML2 GC11P096202 GC11M095989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around JRKL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JRKL gene promoter:

Genomic Locations for JRKL Gene

Genomic Locations for JRKL Gene
chr11:96,389,989-96,507,574
(GRCh38/hg38)
Size:
117,586 bases
Orientation:
Plus strand
chr11:96,123,153-96,240,738
(GRCh37/hg19)

Genomic View for JRKL Gene

Genes around JRKL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JRKL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JRKL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JRKL Gene

Proteins for JRKL Gene

  • Protein details for JRKL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4A0-JERKL_HUMAN
    Recommended name:
    Jerky protein homolog-like
    Protein Accession:
    Q9Y4A0
    Secondary Accessions:
    • A8K3G4
    • B2RAJ3
    • Q32MC2

    Protein attributes for JRKL Gene

    Size:
    524 amino acids
    Molecular mass:
    59912 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB65833.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for JRKL Gene

Post-translational modifications for JRKL Gene

No Post-translational modifications

Other Protein References for JRKL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JRKL Gene

Domains & Families for JRKL Gene

Gene Families for JRKL Gene

Protein Domains for JRKL Gene

Suggested Antigen Peptide Sequences for JRKL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4A0

UniProtKB/Swiss-Prot:

JERKL_HUMAN :
  • Belongs to the tigger transposable element derived protein family.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with JRKL: view

Function for JRKL Gene

Molecular function for JRKL Gene

GENATLAS Biochemistry:
murine jerky homolog-like,involved in epileptic syndromes in mice,expressed in many tissues,with two alternatively forms in testis

Phenotypes From GWAS Catalog for JRKL Gene

Gene Ontology (GO) - Molecular Function for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with JRKL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JRKL Gene

Localization for JRKL Gene

Subcellular locations from UniProtKB/Swiss-Prot for JRKL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JRKL gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
genes like me logo Genes that share ontologies with JRKL: view

Pathways & Interactions for JRKL Gene

No Data Available

Gene Ontology (GO) - Biological Process for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development TAS 9240447
genes like me logo Genes that share ontologies with JRKL: view

No data available for Pathways by source and SIGNOR curated interactions for JRKL Gene

Drugs & Compounds for JRKL Gene

No Compound Related Data Available

Transcripts for JRKL Gene

mRNA/cDNA for JRKL Gene

Unigene Clusters for JRKL Gene

Jerky homolog-like (mouse):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for JRKL Gene

No ASD Table

Relevant External Links for JRKL Gene

GeneLoc Exon Structure for
JRKL
ECgene alternative splicing isoforms for
JRKL

Expression for JRKL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JRKL Gene

Protein differential expression in normal tissues from HIPED for JRKL Gene

This gene is overexpressed in Heart (58.1) and Retina (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JRKL Gene



Protein tissue co-expression partners for JRKL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JRKL Gene:

JRKL

SOURCE GeneReport for Unigene cluster for JRKL Gene:

Hs.105940

mRNA Expression by UniProt/SwissProt for JRKL Gene:

Q9Y4A0-JERKL_HUMAN
Tissue specificity: Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.
genes like me logo Genes that share expression patterns with JRKL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for JRKL Gene

Orthologs for JRKL Gene

This gene was present in the common ancestor of chordates.

Orthologs for JRKL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JRKL 33
  • 99.87 (n)
cow
(Bos Taurus)
Mammalia JRKL 33 34
  • 92.37 (n)
dog
(Canis familiaris)
Mammalia JRKL 33 34
  • 91.03 (n)
mouse
(Mus musculus)
Mammalia Jrkl 33 16 34
  • 89.8 (n)
rat
(Rattus norvegicus)
Mammalia Jrkl 33
  • 88.93 (n)
oppossum
(Monodelphis domestica)
Mammalia JRKL 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
ManyToMany
Species where no ortholog for JRKL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JRKL Gene

ENSEMBL:
Gene Tree for JRKL (if available)
TreeFam:
Gene Tree for JRKL (if available)

Paralogs for JRKL Gene

Paralogs for JRKL Gene

(4) SIMAP similar genes for JRKL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JRKL: view

Variants for JRKL Gene

Sequence variations from dbSNP and Humsavar for JRKL Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000987155 -- 96,393,093(+) G/C 3_prime_UTR_variant
rs1001598465 -- 96,389,717(+) C/G upstream_transcript_variant
rs1001650782 -- 96,389,823(+) G/A/C upstream_transcript_variant
rs1002149379 -- 96,389,940(+) G/A upstream_transcript_variant
rs1002420048 -- 96,389,886(+) C/T upstream_transcript_variant

Variation tolerance for JRKL Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JRKL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JRKL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JRKL Gene

Disorders for JRKL Gene

Additional Disease Information for JRKL

No disorders were found for JRKL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JRKL Gene

Publications for JRKL Gene

  1. Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product. (PMID: 9240447) Zeng Z … Li Y (Biochemical and biophysical research communications 1997) 2 3 4 58
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  3. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L … Cho JH (Nature 2012) 3 58
  4. PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies. (PMID: 22648509) Wang KS … Zeng M (Journal of molecular neuroscience : MN 2012) 3 58
  5. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M … Deary IJ (Biological psychology 2011) 44 58

Products for JRKL Gene

Sources for JRKL Gene

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