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Aliases for JPX Gene

Subcategory (RNA class) for JPX Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for JPX Gene

  • JPX Transcript, XIST Activator 2 3
  • JPX Transcript, XIST Activator (Non-Protein Coding) 2 3 5
  • Expressed Neighbor Of XIST 2 3
  • Just Proximal To XIST 2 3
  • Non-Protein Coding RNA 183 2
  • NCRNA00183 3
  • LINC00183 3
  • DCBALD06 3
  • ENOX 3

External Ids for JPX Gene

Previous HGNC Symbols for JPX Gene

  • NCRNA00183

Previous GeneCards Identifiers for JPX Gene

  • GC0XP073166
  • GC0XP073946
  • GC0XP073950
  • GC0XP073952
  • GC0XP073953
  • GC0XP073954
  • GC0XP073955
  • GC0XP073956
  • GC0XP073957

Summaries for JPX Gene

Entrez Gene Summary for JPX Gene

  • JPX is a nonprotein-coding RNA transcribed from a gene within the X-inactivation center (XIC; MIM 314670) that appears to participate in X chromosome inactivation (Tian et al., 2010 [PubMed 21029862]).[supplied by OMIM, Feb 2011]

GeneCards Summary for JPX Gene

JPX (JPX Transcript, XIST Activator) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with JPX include Hepatocellular Carcinoma.

Gene Wiki entry for JPX Gene

Additional gene information for JPX Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JPX Gene

Genomics for JPX Gene

GeneHancer (GH) Regulatory Elements for JPX Gene

Promoters and enhancers for JPX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ073943 Promoter/Enhancer 1.7 Ensembl ENCODE 722.2 +0.4 429 2.4 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 JPX ENSG00000274430 ENSG00000276784 FTX RAB11FIP1P1 DDX3P1 ENSG00000271199 ENSG00000271533 CHIC1 ENSG00000228906
GH0XJ073849 Promoter/Enhancer 1.6 Ensembl ENCODE 59.8 -93.2 -93166 3.6 PKNOX1 SMAD1 ARNT FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 GC0XM073852 XIST ENSG00000278039 RAB11FIP1P1 JPX FTX DDX3P1 RN7SL648P TOMM20P4 ENSG00000271199
GH0XJ073915 Enhancer 0.9 Ensembl ENCODE 35 -26.5 -26479 4 JUN FEZF1 RAD21 HIC1 ZNF324 ZNF335 POLR2A FOSL2 KLF8 ZNF362 JPX ENSG00000228906 PIR36096
GH0XJ073977 Enhancer 0.9 ENCODE dbSUPER 35 +33.5 33499 1.2 KLF1 EBF1 BMI1 ZIC2 ZSCAN5C IKZF2 RUNX3 CREM SRF RFX1 JPX ENSG00000228906 ENSG00000271199 GC0XP074017 FTX
GH0XJ073562 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 13 -380.8 -380804 2.5 HDGF SIN3A GLI4 ZNF2 YY1 ZNF207 SP3 YY2 SREBF1 GMEB1 CHIC1 MAP2K4P1 FAM236D ZCCHC13 JPX ENSG00000271533 RAB11FIP1P1 PIR39676 GC0XM073547
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JPX on UCSC Golden Path with GeneCards custom track

Genomic Locations for JPX Gene

Genomic Locations for JPX Gene
chrX:73,944,184-74,070,408
(GRCh38/hg38)
Size:
126,225 bases
Orientation:
Plus strand
chrX:73,164,159-73,290,243
(GRCh37/hg19)
Size:
126,085 bases
Orientation:
Plus strand

Genomic View for JPX Gene

Genes around JPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JPX Gene

Proteins for JPX Gene

Post-translational modifications for JPX Gene

No Post-translational modifications

No data available for DME Specific Peptides for JPX Gene

Domains & Families for JPX Gene

Gene Families for JPX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JPX: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for JPX Gene

Function for JPX Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JPX Gene

Localization for JPX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JPX gene
Compartment Confidence
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for JPX Gene

Pathways & Interactions for JPX Gene

No Data Available

Interacting Proteins for JPX Gene

Gene Ontology (GO) - Biological Process for JPX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for JPX Gene

Drugs & Compounds for JPX Gene

No Compound Related Data Available

Transcripts for JPX Gene

mRNA/cDNA for JPX Gene

(4) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(14) RNA Central transcripts :

Unigene Clusters for JPX Gene

JPX transcript, XIST activator (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JPX Gene

No ASD Table

Relevant External Links for JPX Gene

GeneLoc Exon Structure for
JPX
ECgene alternative splicing isoforms for
JPX

Expression for JPX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JPX Gene

NURSA nuclear receptor signaling pathways regulating expression of JPX Gene:

JPX

SOURCE GeneReport for Unigene cluster for JPX Gene:

Hs.648316
genes like me logo Genes that share expression patterns with JPX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for JPX Gene

Orthologs for JPX Gene

Evolution for JPX Gene

ENSEMBL:
Gene Tree for JPX (if available)
TreeFam:
Gene Tree for JPX (if available)

No data available for Orthologs for JPX Gene

Paralogs for JPX Gene

No data available for Paralogs for JPX Gene

Variants for JPX Gene

Sequence variations from dbSNP and Humsavar for JPX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000069943 -- 73,975,120(+) A/G intron_variant
rs1000093565 -- 74,018,003(+) G/A intron_variant
rs1000119576 -- 73,952,712(+) G/A intron_variant
rs1000157822 -- 73,960,838(+) A/C intron_variant
rs1000171241 -- 74,009,192(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for JPX Gene

Variant ID Type Subtype PubMed ID
dgv223n73 CNV deletion 24416366
esv1005511 CNV insertion 20482838
esv2067362 CNV deletion 18987734
esv2656629 CNV deletion 23128226
esv2656958 CNV deletion 23128226
esv2673779 CNV deletion 23128226
esv29793 CNV loss 19812545
esv3558978 CNV deletion 23714750
nsv6960 CNV insertion 18451855

Additional Variant Information for JPX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JPX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for JPX Gene

Disorders for JPX Gene

MalaCards: The human disease database

(1) MalaCards diseases for JPX Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search JPX in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with JPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JPX Gene

Publications for JPX Gene

  1. [Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]. (PMID: 21254562) Kolesnikov NN … Elisafenko EA (Genetika 2010) 2 3 58
  2. The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. (PMID: 21029862) Tian D … Lee JT (Cell 2010) 2 3 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes. (PMID: 28854954) Hezroni H … Ulitsky I (Genome biology 2017) 3 58
  5. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PMID: 17567985) Tsuritani K … Suzuki Y (Genome research 2007) 3 58

Products for JPX Gene

Sources for JPX Gene

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