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Aliases for JPT2 Gene

Aliases for JPT2 Gene

  • Jupiter Microtubule Associated Homolog 2 2 3 3 5
  • Hematological And Neurological Expressed 1-Like Protein 3 4
  • Hematological And Neurological Expressed 1 Like 2 3
  • HN1-Like Protein 3 4
  • C16orf34 3 4
  • HN1L 3 4
  • Hematological And Neurological Expressed 1-Like 2
  • Chromosome 16 Open Reading Frame 34 2
  • CRAMP_1 Like 3
  • HN1 Like 3
  • L11 3

External Ids for JPT2 Gene

Previous HGNC Symbols for JPT2 Gene

  • C16orf34
  • HN1L

Summaries for JPT2 Gene

GeneCards Summary for JPT2 Gene

JPT2 (Jupiter Microtubule Associated Homolog 2) is a Protein Coding gene.

Gene Wiki entry for JPT2 Gene

Additional gene information for JPT2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JPT2 Gene

Genomics for JPT2 Gene

GeneHancer (GH) Regulatory Elements for JPT2 Gene

Promoters and enhancers for JPT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J001677 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 670.4 +1.4 1360 4.3 HDGF PKNOX1 ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 ZNF207 ZNF143 JPT2 GC16M001677 PIR31117 TELO2 TBL3 CRAMP1 ENSG00000260051 CLCN7 ERVK13-1 TSC2
GH16J001645 Enhancer 1.3 FANTOM5 Ensembl ENCODE 32.4 -30.8 -30844 4 HDGF PKNOX1 ATF1 FOXA2 SIN3A ZNF121 ZNF766 FOS ATF7 ZNF592 JPT2 ENSG00000226890 IFT140 CRAMP1 MAPK8IP3 TMEM204 CCDC154 TELO2 CLCN7 GC16P001635
GH16J001540 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.9 -132.1 -132139 10.2 MLX FEZF1 SLC30A9 RXRA KAT8 NFIL3 MEF2D GMEB1 RCOR2 ETV4 TMEM204 IFT140 TELO2 JPT2 EME2 CRAMP1 ENSG00000226890 PTX4 CCDC154 ENSG00000261505
GH16J001769 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.3 +94.3 94295 6.4 HDGF PKNOX1 CLOCK ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 EME2 NME3 MRPS34 CRAMP1 ENSG00000260051 ENSG00000261505 TELO2 UNKL UBE2I E4F1
GH16J001479 Enhancer 0.9 Ensembl ENCODE dbSUPER 15.1 -197.5 -197487 1.6 SMARCA5 ZNF217 NR2F1 EBF1 MEF2B CCDC154 JPT2 TMEM204 IFT140 CRAMP1 ENSG00000226890 BAIAP3 CLCN7 ENSG00000260095 UBE2I
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JPT2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for JPT2 Gene

Genomic Locations for JPT2 Gene
chr16:1,678,256-1,702,280
(GRCh38/hg38)
Size:
24,025 bases
Orientation:
Plus strand
chr16:1,728,257-1,752,281
(GRCh37/hg19)
Size:
24,025 bases
Orientation:
Plus strand

Genomic View for JPT2 Gene

Genes around JPT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JPT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JPT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JPT2 Gene

Proteins for JPT2 Gene

  • Protein details for JPT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H910-JUPI2_HUMAN
    Recommended name:
    Jupiter microtubule associated homolog 2
    Protein Accession:
    Q9H910
    Secondary Accessions:
    • B1AJY2
    • B4DLH4
    • Q6EIC7

    Protein attributes for JPT2 Gene

    Size:
    190 amino acids
    Molecular mass:
    20063 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for JPT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JPT2 Gene

Post-translational modifications for JPT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for JPT2 Gene

Domains & Families for JPT2 Gene

Gene Families for JPT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for JPT2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H910

UniProtKB/Swiss-Prot:

JUPI2_HUMAN :
  • Belongs to the JUPITER family.
Family:
  • Belongs to the JUPITER family.
genes like me logo Genes that share domains with JPT2: view

Function for JPT2 Gene

Molecular function for JPT2 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC), bronchioalveolar carcinoma (BAC), breast and uterus tumors.

Phenotypes From GWAS Catalog for JPT2 Gene

Phenotypes for JPT2 Gene

genes like me logo Genes that share phenotypes with JPT2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JPT2 Gene

Localization for JPT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JPT2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JPT2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for JPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with JPT2: view

Pathways & Interactions for JPT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JPT2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for JPT2 Gene

Drugs & Compounds for JPT2 Gene

No Compound Related Data Available

Transcripts for JPT2 Gene

mRNA/cDNA for JPT2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JPT2 Gene

No ASD Table

Relevant External Links for JPT2 Gene

GeneLoc Exon Structure for
JPT2
ECgene alternative splicing isoforms for
JPT2

Expression for JPT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of JPT2 Gene:

JPT2

mRNA Expression by UniProt/SwissProt for JPT2 Gene:

Q9H910-JUPI2_HUMAN
Tissue specificity: Expressed in liver, kidney, prostate, testis and uterus.

Evidence on tissue expression from TISSUES for JPT2 Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with JPT2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JPT2 Gene

Orthologs for JPT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JPT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HN1L 34 33
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HN1L 34 33
  • 82.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hn1l 34 33
  • 80.88 (n)
OneToOne
Jpt2 16
rat
(Rattus norvegicus)
Mammalia Hn1l 33
  • 80.7 (n)
cow
(Bos Taurus)
Mammalia HN1L 34 33
  • 78.57 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HN1L 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves HN1L 34 33
  • 67.55 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HN1L 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hn1l 33
  • 57.58 (n)
zebrafish
(Danio rerio)
Actinopterygii hn1l 34 33
  • 54.72 (n)
OneToOne
wufb37f03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.297 33
Species where no ortholog for JPT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JPT2 Gene

ENSEMBL:
Gene Tree for JPT2 (if available)
TreeFam:
Gene Tree for JPT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JPT2: view image

Paralogs for JPT2 Gene

No data available for Paralogs for JPT2 Gene

Variants for JPT2 Gene

Sequence variations from dbSNP and Humsavar for JPT2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000181694 -- 1,696,015(+) G/C intron_variant
rs1000247915 -- 1,689,977(+) G/A intron_variant
rs1000339537 -- 1,702,369(+) A/T downstream_transcript_variant
rs1000392638 -- 1,676,682(+) G/C upstream_transcript_variant
rs1000484758 -- 1,695,602(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for JPT2 Gene

Variant ID Type Subtype PubMed ID
dgv4855n54 CNV loss 21841781
dgv4856n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1051692 CNV loss 25217958
nsv428317 CNV gain 18775914
nsv478955 CNV novel sequence insertion 20440878
nsv518641 CNV loss 19592680
nsv833118 CNV loss 17160897

Variation tolerance for JPT2 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JPT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JPT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JPT2 Gene

Disorders for JPT2 Gene

No disorders were found for JPT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JPT2 Gene

Publications for JPT2 Gene

  1. Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PMID: 15094197) Zhou G … Zhao S (Gene 2004) 2 3 4 22 58
  2. Jupiter, a new Drosophila protein associated with microtubules. (PMID: 16518797) Karpova N … Debec A (Cell motility and the cytoskeleton 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4 58

Products for JPT2 Gene

Sources for JPT2 Gene

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