JPT1 Gene (Protein Coding)

Jupiter Microtubule Associated Homolog 1

GC17M075136
GIFtS:
29

Aliases for JPT1 Gene

Aliases for JPT1 Gene

  • Jupiter Microtubule Associated Homolog 1 2 3 3 4 5
  • Androgen-Regulated Protein 2 2 3 4
  • Hematological And Neurological Expressed 1 Protein 3 4
  • ARM2 3 4
  • HN1 3 4
  • Hematological And Neurological Expressed 1 2
  • HN1A 3

External Ids for JPT1 Gene

Previous HGNC Symbols for JPT1 Gene

  • HN1

Summaries for JPT1 Gene

GeneCards Summary for JPT1 Gene

JPT1 (Jupiter Microtubule Associated Homolog 1) is a Protein Coding gene. Diseases associated with JPT1 include Testicular Leukemia. Among its related pathways are Apoptosis Modulation and Signaling.

UniProtKB/Swiss-Prot Summary for JPT1 Gene

  • Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).

Gene Wiki entry for JPT1 Gene

Additional gene information for JPT1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JPT1 Gene

Genomics for JPT1 Gene

GeneHancer (GH) Regulatory Elements for JPT1 Gene

Promoters and enhancers for JPT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J075169 Enhancer 0.4 Ensembl 750.6 -0.9 -920 0.4 ZNF362 ZNF384 NFE2 JPT1 RF00876-007 lnc-SUMO2-1 lnc-SUMO2-3 SUMO2
GH17J075168 Promoter 0.3 EPDnew 750.6 +0.1 101 0.1 JPT1 RF00876-007 lnc-SUMO2-1 lnc-SUMO2-3 SUMO2
GH17J075109 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.4 +57.7 57680 3.6 GTF3C2 ZBTB40 SREBF1 ZBTB6 MLX POLR2A ELF1 L3MBTL2 MNT ZBTB33 ARMC7 NUP85 GGA3 UNK NT5C ENSG00000266980 JPT1 SRP68 ATP5PD KCTD2
GH17J075113 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.4 +53.8 53811 1.6 SIN3A ZBTB40 CTCF RBPJ MIXL1 RUNX1 CC2D1A ELF1 RELA L3MBTL2 NUP85 JPT1 ATP5PD KCTD2 SLC16A5 ARMC7 NONHSAG022730.2 ENSG00000279035
GH17J075123 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +43.2 43180 6.6 ZBTB40 SREBF1 SMARCE1 POLR2A ZNF362 L3MBTL2 ZNF121 MNT TEAD4 ZNF148 NUP85 JPT1 TMEM94 NT5C ATP5PD KCTD2 HID1-AS1 ENSG00000267801 MRPL58 MRPS7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JPT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for JPT1 Gene

Genomic Locations for JPT1 Gene
chr17:75,135,243-75,168,281
(GRCh38/hg38)
Size:
33,039 bases
Orientation:
Minus strand
chr17:73,131,343-73,164,376
(GRCh37/hg19)
Size:
33,034 bases
Orientation:
Minus strand

Genomic View for JPT1 Gene

Genes around JPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JPT1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for JPT1 Gene

Proteins for JPT1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for JPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK76-JUPI1_HUMAN
    Recommended name:
    Jupiter microtubule associated homolog 1
    Protein Accession:
    Q9UK76
    Secondary Accessions:
    • B2R6K3
    • Q53FG7
    • Q7Z2D2
    • Q7Z2F0

    Protein attributes for JPT1 Gene

    Size:
    154 amino acids
    Molecular mass:
    16015 Da
    Quaternary structure:
    • Interacts with the complex composed, at least, of APC, CTNNB1 and GSK3B; the interaction takes place with the inactive form of GSK3B (phosphorylated at 'Ser-9').

    Alternative splice isoforms for JPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JPT1 Gene

Post-translational modifications for JPT1 Gene

  • Ubiquitination at Lys8, Lys64, Lys69, and Lys46
  • Modification sites at PhosphoSitePlus

Other Protein References for JPT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JPT1 Gene

Domains & Families for JPT1 Gene

Gene Families for JPT1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for JPT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JPT1 Gene

GenScript: Design optimal peptide antigens:
  • Androgen-regulated protein 2 (HN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UK76

UniProtKB/Swiss-Prot:

JUPI1_HUMAN :
  • Belongs to the JUPITER family.
Family:
  • Belongs to the JUPITER family.
genes like me logo Genes that share domains with JPT1: view

Function for JPT1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for JPT1 Gene

UniProtKB/Swiss-Prot Function:
Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).
UniProtKB/Swiss-Prot Induction:
Induced by EGF growth factor at mRNA and protein levels (PubMed:21323578). Induced by androgens (PubMed:22155408). Negatively regulated by the microRNA miR-132 (PubMed:25450365).

Phenotypes From GWAS Catalog for JPT1 Gene

genes like me logo Genes that share phenotypes with JPT1: view

Animal Model Products

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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JPT1 Gene

Localization for JPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JPT1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JPT1 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for JPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with JPT1: view

Pathways & Interactions for JPT1 Gene

PathCards logo

SuperPathways for JPT1 Gene

genes like me logo Genes that share pathways with JPT1: view

Pathways by source for JPT1 Gene

1 BioSystems pathway for JPT1 Gene

Gene Ontology (GO) - Biological Process for JPT1 Gene

None

No data available for SIGNOR curated interactions for JPT1 Gene

Drugs & Compounds for JPT1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for JPT1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for JPT1 Gene

(6) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(1667) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JPT1 Gene

No ASD Table

Relevant External Links for JPT1 Gene

GeneLoc Exon Structure for
JPT1
ECgene alternative splicing isoforms for
JPT1

Expression for JPT1 Gene

Products:

  1. Primer

NURSA nuclear receptor signaling pathways regulating expression of JPT1 Gene:

JPT1

mRNA Expression by UniProt/SwissProt for JPT1 Gene:

Q9UK76-JUPI1_HUMAN
Tissue specificity: Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.

Evidence on tissue expression from TISSUES for JPT1 Gene

  • Nervous system(4.9)
  • Blood(4.5)
  • Liver(4.3)
  • Lung(3.5)
  • Intestine(2.5)
  • Lymph node(2.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JPT1 Gene

Orthologs for JPT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HN1 33 32
  • 99.78 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia HN1 33 32
  • 89.61 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia HN1 33 32
  • 89.39 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Hn1 32
  • 88.37 (n)
mouse
(Mus musculus)
 Mammalia Hn1 33 32
  • 88.1 (n)
 OneToOne
Jpt1 17
oppossum
(Monodelphis domestica)
 Mammalia HN1 33
  • 55 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HN1 33 32
  • 73.42 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia HN1 33
  • 44 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia hn1 32
  • 53.43 (n)
zebrafish
(Danio rerio)
 Actinopterygii hn1a 33 32
  • 51.54 (n)
 OneToMany
hn1b 33
  • 31 (a)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.7331 32
Species where no ortholog for JPT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JPT1 Gene

ENSEMBL:
Gene Tree for JPT1 (if available)
TreeFam:
Gene Tree for JPT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JPT1: view image

Paralogs for JPT1 Gene

Pseudogenes.org Pseudogenes for JPT1 Gene

genes like me logo Genes that share paralogs with JPT1: view

No data available for Paralogs for JPT1 Gene

Variants for JPT1 Gene

Sequence variations from dbSNP and Humsavar for JPT1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000108112 -- 75,144,526(-) A/T intron_variant
rs1000299 -- 75,152,458(-) G/A intron_variant
rs1000449394 -- 75,155,847(-) G/T upstream_transcript_variant
rs1000872486 -- 75,151,707(-) C/T intron_variant
rs1000944120 -- 75,151,416(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for JPT1 Gene

Variant ID Type Subtype PubMed ID
nsv470602 CNV loss 18288195

Variation tolerance for JPT1 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JPT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JPT1 Gene

Disorders for JPT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for JPT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testicular leukemia
- elite association - COSMIC cancer census association via MalaCards
Search JPT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for JPT1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with JPT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JPT1 Gene

Publications for JPT1 Gene

  1. Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PMID: 15094197) Zhou G … Zhao S (Gene 2004) 2 3 4 56
  2. HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells. (PMID: 25169422) Varisli L … Korkmaz KS (Journal of cellular biochemistry 2015) 3 4 56
  3. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1. (PMID: 25450365) Zhang ZG … Zhang BX (Biochemical and biophysical research communications 2014) 3 4 56
  4. Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells. (PMID: 22155408) Varisli L … Korkmaz KS (Molecular and cellular endocrinology 2012) 3 4 56
  5. Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3β signaling, and its knockdown results in deregulated G2/M transition in prostate cells. (PMID: 21323578) Varisli L … Korkmaz KS (DNA and cell biology 2011) 3 4 56

ExternalLinks

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