Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic retic... See more...

Aliases for JPH2 Gene

Aliases for JPH2 Gene

  • Junctophilin 2 2 3 5
  • Junctophilin Type 2 3 4
  • Junctophilin-2 3 4
  • JP-2 3 4
  • JP2 3 4
  • CMH17 3

External Ids for JPH2 Gene

Previous GeneCards Identifiers for JPH2 Gene

  • GC20M042533
  • GC20M042431
  • GC20M043378
  • GC20M043425
  • GC20M042173
  • GC20M042740
  • GC20M039477

Summaries for JPH2 Gene

Entrez Gene Summary for JPH2 Gene

  • Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008]

GeneCards Summary for JPH2 Gene

JPH2 (Junctophilin 2) is a Protein Coding gene. Diseases associated with JPH2 include Cardiomyopathy, Familial Hypertrophic, 17 and Hypertrophic Cardiomyopathy. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylinositol-3-phosphate binding. An important paralog of this gene is JPH1.

UniProtKB/Swiss-Prot Summary for JPH2 Gene

  • [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity).
  • [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.

Gene Wiki entry for JPH2 Gene

Additional gene information for JPH2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JPH2 Gene

Genomics for JPH2 Gene

GeneHancer (GH) Regulatory Elements for JPH2 Gene

Promoters and enhancers for JPH2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JPH2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JPH2

Top Transcription factor binding sites by QIAGEN in the JPH2 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • Nkx6-1
  • POU3F1
  • Spz1
  • SRF
  • SRF (504 AA)
  • TBP

Genomic Locations for JPH2 Gene

Genomic Locations for JPH2 Gene
chr20:44,111,695-44,187,578
(GRCh38/hg38)
Size:
75,884 bases
Orientation:
Minus strand
chr20:42,740,335-42,816,218
(GRCh37/hg19)
Size:
75,884 bases
Orientation:
Minus strand

Genomic View for JPH2 Gene

Genes around JPH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JPH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JPH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JPH2 Gene

Proteins for JPH2 Gene

  • Protein details for JPH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR39-JPH2_HUMAN
    Recommended name:
    Junctophilin-2
    Protein Accession:
    Q9BR39
    Secondary Accessions:
    • E1P5X1
    • O95913
    • Q5JY74
    • Q9UJN4

    Protein attributes for JPH2 Gene

    Size:
    696 amino acids
    Molecular mass:
    74222 Da
    Quaternary structure:
    • Interacts with TRPC3 (PubMed:20095964). Junctophilin-2 N-terminal fragment: Interacts with MEF2C (By similarity).

    Alternative splice isoforms for JPH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JPH2 Gene

Post-translational modifications for JPH2 Gene

  • Phosphorylation on Ser-165, probably by PKC, affects RYR1-mediated calcium ion release, interaction with TRPC3, and skeletal muscle myotubule development.
  • Proteolytically cleaved by calpain in response to cardiac stress. The major cleavage site takes place at the C-terminus and leads to the release of the Junctophilin-2 N-terminal fragment chain (JP2NT).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JPH2 Gene

No data available for DME Specific Peptides for JPH2 Gene

Domains & Families for JPH2 Gene

Gene Families for JPH2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for JPH2 Gene

Blocks:
  • MORN motif
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JPH2 Gene

GenScript: Design optimal peptide antigens:
  • Junctophilin type 2 (JPH2_HUMAN)
  • JPH2 protein (Q86VZ3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BR39

UniProtKB/Swiss-Prot:

JPH2_HUMAN :
  • The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, by interacting with phospholipids (PubMed:24001019). Has affinity for phosphatidylserine, and phosphorylated phosphatidylinositols including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P2 and PtdIns(3,4,5)P3 (PubMed:24001019).
  • Belongs to the junctophilin family.
Domain:
  • The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, by interacting with phospholipids (PubMed:24001019). Has affinity for phosphatidylserine, and phosphorylated phosphatidylinositols including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P2 and PtdIns(3,4,5)P3 (PubMed:24001019).
  • [Junctophilin-2 N-terminal fragment]: The bipartite nuclear localization signal (bNLS) and Ala-rich (alanine-rich; ARR) regions are involved in DNA-binding.
Family:
  • Belongs to the junctophilin family.
genes like me logo Genes that share domains with JPH2: view

Function for JPH2 Gene

Molecular function for JPH2 Gene

UniProtKB/Swiss-Prot Function:
[Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity).
UniProtKB/Swiss-Prot Function:
[Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.

Phenotypes From GWAS Catalog for JPH2 Gene

Gene Ontology (GO) - Molecular Function for JPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 24001019
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20095964
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 24001019
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 24001019
genes like me logo Genes that share ontologies with JPH2: view
genes like me logo Genes that share phenotypes with JPH2: view

Human Phenotype Ontology for JPH2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for JPH2 Gene

MGI Knock Outs for JPH2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JPH2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for JPH2 Gene

Localization for JPH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JPH2 Gene

[Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. {ECO:0000250 UniProtKB:Q9ET78}.
[Junctophilin-2 N-terminal fragment]: Nucleus. Note=Accumulates in the nucleus of stressed hearts. {ECO:0000250 UniProtKB:Q9ET78}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JPH2 gene
Compartment Confidence
nucleus 5
plasma membrane 4
endoplasmic reticulum 4
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for JPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane IBA 21873635
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with JPH2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for JPH2 Gene

Pathways & Interactions for JPH2 Gene

PathCards logo

SuperPathways for JPH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007275 multicellular organism development IEA --
GO:0051209 release of sequestered calcium ion into cytosol IEA --
GO:0055024 regulation of cardiac muscle tissue development IEA --
GO:0055074 calcium ion homeostasis IDA 20095964
genes like me logo Genes that share ontologies with JPH2: view

No data available for Pathways by source and SIGNOR curated interactions for JPH2 Gene

Drugs & Compounds for JPH2 Gene

(2) Drugs for JPH2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with JPH2: view

Transcripts for JPH2 Gene

mRNA/cDNA for JPH2 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JPH2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JPH2 Gene

No ASD Table

Relevant External Links for JPH2 Gene

GeneLoc Exon Structure for
JPH2

Expression for JPH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JPH2 Gene

mRNA differential expression in normal tissues according to GTEx for JPH2 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.6), Esophagus - Gastroesophageal Junction (x5.2), Esophagus - Muscularis (x5.2), Muscle - Skeletal (x4.4), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for JPH2 Gene

This gene is overexpressed in Colon muscle (16.3), Urinary Bladder (9.1), Rectum (6.5), and Colon (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JPH2 Gene



Protein tissue co-expression partners for JPH2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JPH2

SOURCE GeneReport for Unigene cluster for JPH2 Gene:

Hs.441737

mRNA Expression by UniProt/SwissProt for JPH2 Gene:

Q9BR39-JPH2_HUMAN
Tissue specificity: Specifically expressed in skeletal muscle and heart.

Evidence on tissue expression from TISSUES for JPH2 Gene

  • Liver(4)
  • Muscle(3.3)
  • Heart(2.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for JPH2 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • respiratory
Regions:
Head and neck:
  • ear
Thorax:
  • heart
  • heart valve
genes like me logo Genes that share expression patterns with JPH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for JPH2 Gene

Orthologs for JPH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for JPH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JPH2 30
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia JPH2 31 30
  • 89.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jph2 30
  • 85.42 (n)
mouse
(Mus musculus)
Mammalia Jph2 17 31 30
  • 84.65 (n)
oppossum
(Monodelphis domestica)
Mammalia JPH2 31
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JPH2 31
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves JPH2 31 30
  • 78.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JPH2 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jph2 30
  • 65.34 (n)
zebrafish
(Danio rerio)
Actinopterygii jph2 31 30
  • 62.7 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jp 31
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea jph-1 31
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 55 (a)
OneToMany
Species where no ortholog for JPH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JPH2 Gene

ENSEMBL:
Gene Tree for JPH2 (if available)
TreeFam:
Gene Tree for JPH2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JPH2: view image

Paralogs for JPH2 Gene

Paralogs for JPH2 Gene

(6) SIMAP similar genes for JPH2 Gene using alignment to 2 proteins:

  • JPH2_HUMAN
  • Q86VZ3_HUMAN
genes like me logo Genes that share paralogs with JPH2: view

Variants for JPH2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JPH2 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
30455 Pathogenic: Familial hypertrophic cardiomyopathy 17 44,186,405(-) T/G MISSENSE_VARIANT
636590 Uncertain Significance: not provided 44,160,176(-) A/C MISSENSE_VARIANT
636764 Uncertain Significance: not provided 44,160,375(-) G/T MISSENSE_VARIANT
636877 Uncertain Significance: not provided 44,160,245(-) GC/G FRAMESHIFT_VARIANT
636914 Uncertain Significance: not provided 44,116,186(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for JPH2 Gene

Structural Variations from Database of Genomic Variants (DGV) for JPH2 Gene

Variant ID Type Subtype PubMed ID
esv1288244 CNV deletion 17803354
esv1407305 CNV insertion 17803354
esv2660521 CNV deletion 23128226
esv2722442 CNV deletion 23290073
esv3575374 CNV gain 25503493
esv3645903 CNV gain 21293372
esv3645904 CNV loss 21293372
nsv1057847 CNV loss 25217958
nsv1072539 CNV deletion 25765185
nsv1122032 CNV deletion 24896259
nsv1123489 CNV deletion 24896259
nsv1133506 CNV deletion 24896259
nsv178769 CNV deletion 16902084
nsv179208 CNV deletion 16902084
nsv954043 CNV deletion 24416366
nsv954261 CNV deletion 24416366

Variation tolerance for JPH2 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.58; 91.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JPH2 Gene

Human Gene Mutation Database (HGMD)
JPH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JPH2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JPH2 Gene

Disorders for JPH2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for JPH2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cardiomyopathy, familial hypertrophic, 17
  • cmh17
hypertrophic cardiomyopathy
  • cardiomyopathy, hypertrophic, familial
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
left ventricular noncompaction
  • left ventricular hypertrabeculation
lung abscess
- elite association - COSMIC cancer census association via MalaCards
Search JPH2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

JPH2_HUMAN
  • Cardiomyopathy, familial hypertrophic 17 (CMH17) [MIM:613873]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269 PubMed:17509612, ECO:0000269 PubMed:24001019, ECO:0000269 PubMed:28393127, ECO:0000269 PubMed:30235249}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for JPH2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with JPH2: view

No data available for Genatlas for JPH2 Gene

Publications for JPH2 Gene

  1. Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy. (PMID: 17476457) Matsushita Y … Matsuoka R (Journal of human genetics 2007) 3 4 23 41 54
  2. Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. (PMID: 17509612) Landstrom AP … Ackerman MJ (Journal of molecular and cellular cardiology 2007) 3 4 23 41 54
  3. Characterization of human junctophilin subtype genes. (PMID: 10891348) Nishi M … Takeshima H (Biochemical and biophysical research communications 2000) 2 3 4 23 54
  4. S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle. (PMID: 20095964) Woo JS … Lee EH (The Biochemical journal 2010) 3 4 23 54
  5. Heterozygous junctophilin-2 (JPH2) p.(Thr161Lys) is a monogenic cause for HCM with heart failure. (PMID: 30235249) Vanninen SUM … Koskenvuo JW (PloS one 2018) 3 4 54

Products for JPH2 Gene

Sources for JPH2 Gene