Aliases for JOSD2 Gene
External Ids for JOSD2 Gene
Previous GeneCards Identifiers for JOSD2 Gene
This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for JOSD2 Gene
JOSD2 (Josephin Domain Containing 2) is a Protein Coding gene. Among its related pathways are Josephin domain DUBs and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity and omega peptidase activity. An important paralog of this gene is JOSD1.
UniProtKB/Swiss-Prot for JOSD2 Gene
Cleaves Lys-63-linked poly-ubiquitin chains, and with lesser efficiency Lys-48-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.