Aliases for JMY Gene
External Ids for JMY Gene
Previous GeneCards Identifiers for JMY Gene
GeneCards Summary for JMY Gene
JMY (Junction Mediating And Regulatory Protein, P53 Cofactor) is a Protein Coding gene. Diseases associated with JMY include Phacolytic Glaucoma. Among its related pathways are Regulation of TP53 Activity and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include actin binding and transcription coactivator activity. An important paralog of this gene is WHAMM.
UniProtKB/Swiss-Prot Summary for JMY Gene
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).