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This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]
JMJD7-PLA2G4B (JMJD7-PLA2G4B Readthrough) is a Protein Coding gene. Among its related pathways are Phospholipase D signaling pathway and Linoleic acid metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G4B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004620 | phospholipase activity | IEA | -- |
GO:0005509 | calcium ion binding | IEA | -- |
GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Linoleic acid metabolism | ||
2 | Phospholipase D signaling pathway | ||
3 | Immune response Fc epsilon RI pathway | ||
4 | Development Endothelin-1/EDNRA signaling | ||
5 | Oxytocin signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009395 | phospholipid catabolic process | IEA | -- |
GO:0055114 | oxidation-reduction process | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | PLA2G4B 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Pla2g4b 31 |
|
ManyToMany | |
PLA2G4B 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | PLA2G4B 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711107 | Benign: not provided | 41,834,758(+) | C/G | MISSENSE_VARIANT | |
726643 | Benign: not provided | 41,841,258(+) | C/T | SYNONYMOUS_VARIANT | |
731633 | Benign: not provided | 41,828,174(+) | C/T | MISSENSE_VARIANT | |
787425 | Benign: not provided | 41,835,222(+) | G/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2582n100 | CNV | gain | 25217958 |
esv2760027 | CNV | loss | 17122850 |
esv3636251 | CNV | loss | 21293372 |
nsv1035998 | CNV | gain | 25217958 |
nsv1038933 | CNV | gain | 25217958 |
nsv1050892 | CNV | gain | 25217958 |
nsv1506 | CNV | insertion | 18451855 |
nsv517631 | CNV | loss | 19592680 |
nsv9244 | CNV | gain | 18304495 |
nsv952613 | CNV | deletion | 24416366 |
nsv977704 | CNV | duplication | 23825009 |
No disorders were found for JMJD7-PLA2G4B Gene.