Aliases for JMJD7-PLA2G4B Gene
Aliases for JMJD7-PLA2G4B Gene
External Ids for JMJD7-PLA2G4B Gene
- HGNC: 34449
- Entrez Gene: 8681
- Ensembl: ENSG00000168970
- UniProtKB: H0Y9G9
Previous GeneCards Identifiers for JMJD7-PLA2G4B Gene
- GC15P039910
- GC15P042122
- GC15P018968
Summaries for JMJD7-PLA2G4B Gene
-
This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]
GeneCards Summary for JMJD7-PLA2G4B Gene
JMJD7-PLA2G4B (JMJD7-PLA2G4B Readthrough) is a Protein Coding gene. Among its related pathways are Ovarian steroidogenesis and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G4B.
Additional gene information for JMJD7-PLA2G4B Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD7-PLA2G4B Gene
Genomics for JMJD7-PLA2G4B Gene
GeneHancer (GH) Regulatory Elements for JMJD7-PLA2G4B Gene
Promoters and enhancers for JMJD7-PLA2G4B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around JMJD7-PLA2G4B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for JMJD7-PLA2G4B Gene
Genomic Locations for JMJD7-PLA2G4B Gene
- chr15:41,828,085-41,848,155
- (GRCh38/hg38)
- Size:
- 20,071 bases
- Orientation:
- Plus strand
- chr15:42,120,283-42,140,353
- (GRCh37/hg19)
- Size:
- 20,071 bases
- Orientation:
- Plus strand
Genomic View for JMJD7-PLA2G4B Gene
Genes around JMJD7-PLA2G4B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by Entrez Gene
- 15q15.1 by HGNC
- 15q15.1 by Ensembl
JMJD7-PLA2G4B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for JMJD7-PLA2G4B Gene
Proteins for JMJD7-PLA2G4B Gene
-
Protein details for JMJD7-PLA2G4B Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H0Y9G9-H0Y9G9_HUMAN
- Recommended name:
- JMJD7-PLA2G4B readthrough
- Protein Accession:
- H0Y9G9
Protein attributes for JMJD7-PLA2G4B Gene
- Size:
- 81 amino acids
- Molecular mass:
- 9403 Da
- Quaternary structure:
- No Data Available
Protein Expression for JMJD7-PLA2G4B Gene
Post-translational modifications for JMJD7-PLA2G4B Gene
No Post-translational modifications
Other Protein References for JMJD7-PLA2G4B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for JMJD7-PLA2G4B
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-
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Assay Products
No data available for DME Specific Peptides for JMJD7-PLA2G4B Gene
Domains & Families for JMJD7-PLA2G4B Gene
Gene Families for JMJD7-PLA2G4B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene
Function for JMJD7-PLA2G4B Gene
Phenotypes From GWAS Catalog for JMJD7-PLA2G4B Gene
Phenotypes for JMJD7-PLA2G4B Gene
- GenomeRNAi human phenotypes for JMJD7-PLA2G4B:
-
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased Nanog expression
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
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-
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for JMJD7-PLA2G4B
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JMJD7-PLA2G4B Gene
Localization for JMJD7-PLA2G4B Gene
- Cytosol (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for JMJD7-PLA2G4B Gene
Pathways & Interactions for JMJD7-PLA2G4B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Linoleic acid metabolism | ||
| 2 | Phospholipase D signaling pathway | ||
| 3 | Immune response Fc epsilon RI pathway | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
| 5 | Vascular smooth muscle contraction | ||
Pathways by source for JMJD7-PLA2G4B Gene
22 KEGG pathways for JMJD7-PLA2G4B Gene
Interacting Proteins for JMJD7-PLA2G4B Gene
GPS-Prot Interaction Network for JMJD7-PLA2G4B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008152 | metabolic process | IEA | -- |
| GO:0009395 | phospholipid catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for JMJD7-PLA2G4B Gene
Transcripts for JMJD7-PLA2G4B Gene
mRNA/cDNA for JMJD7-PLA2G4B Gene
- (2) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (147) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000490848 7218 bps (uc059ias.1)
- ENST00000382448 3331 bps (uc001zoo.5)
- ENST00000491746 7227 bps (uc059iav.1)
- ENST00000342159 2966 bps (uc010bcn.4)
- ENST00000476036 577 bps (uc059iax.1)
Unigene Clusters for JMJD7-PLA2G4B Gene
CRISPR Products
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- Applied Biological Materials CRISPR for JMJD7-PLA2G4B
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Vectors and viruses for KO, Activation, Repression, and more
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Clone Products
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Relevant External Links for JMJD7-PLA2G4B Gene
- GeneLoc Exon Structure for
- JMJD7-PLA2G4B
- ECgene alternative splicing isoforms for
- JMJD7-PLA2G4B
Expression for JMJD7-PLA2G4B Gene
This gene is overexpressed in Cervix (33.0) and Urine (32.0).
SOURCE GeneReport for Unigene cluster for JMJD7-PLA2G4B Gene:
Hs.198161Primer Products
-
OriGene qPCR primer pairs for JMJD7-PLA2G4B
- genomics-online: primer clones - Search results for 20 available JMJD7-PLA2G4B gene related products
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for JMJD7-PLA2G4B Gene
Orthologs for JMJD7-PLA2G4B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | PLA2G4B 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Pla2g4b 34 |
|
ManyToMany | |
| PLA2G4B 34 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | PLA2G4B 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for JMJD7-PLA2G4B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for JMJD7-PLA2G4B Gene
- ENSEMBL:
- Gene Tree for JMJD7-PLA2G4B (if available)
- TreeFam:
- Gene Tree for JMJD7-PLA2G4B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for JMJD7-PLA2G4B: view image
Paralogs for JMJD7-PLA2G4B Gene
Variants for JMJD7-PLA2G4B Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000072675 | -- | 41,829,698(+) | A/G | intron_variant | |
| rs1000127284 | -- | 41,833,547(+) | C/T | intron_variant | |
| rs1000139128 | -- | 41,846,914(+) | G/A | intron_variant | |
| rs1000200930 | -- | 41,841,488(+) | G/A | intron_variant | |
| rs1000379775 | -- | 41,846,602(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2582n100 | CNV | gain | 25217958 |
| esv2760027 | CNV | loss | 17122850 |
| esv3636251 | CNV | loss | 21293372 |
| nsv1035998 | CNV | gain | 25217958 |
| nsv1038933 | CNV | gain | 25217958 |
| nsv1050892 | CNV | gain | 25217958 |
| nsv1506 | CNV | insertion | 18451855 |
| nsv517631 | CNV | loss | 19592680 |
| nsv9244 | CNV | gain | 18304495 |
| nsv952613 | CNV | deletion | 24416366 |
| nsv977704 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
95.9% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for JMJD7-PLA2G4B Gene
- Human Gene Mutation Database (HGMD)
- JMJD7-PLA2G4B
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- JMJD7-PLA2G4B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene
Disorders for JMJD7-PLA2G4B Gene
Additional Disease Information for JMJD7-PLA2G4B
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for JMJD7-PLA2G4B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD7-PLA2G4B Gene
Publications for JMJD7-PLA2G4B Gene
- Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PMID: 16617059) Ghosh M … Leslie CC (The Journal of biological chemistry 2006) 3 22 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 58
Products for JMJD7-PLA2G4B Gene
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Sources for JMJD7-PLA2G4B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
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