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This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains... See more...
Aliases for JMJD7-PLA2G4B Gene
Aliases for JMJD7-PLA2G4B Gene
External Ids for JMJD7-PLA2G4B Gene
- HGNC: 34449
- NCBI Entrez Gene: 8681
- Ensembl: ENSG00000168970
- UniProtKB/TrEMBL: H0Y9G9
Previous GeneCards Identifiers for JMJD7-PLA2G4B Gene
- GC15P039910
- GC15P042122
- GC15P018968
Summaries for JMJD7-PLA2G4B Gene
-
This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]
GeneCards Summary for JMJD7-PLA2G4B Gene
JMJD7-PLA2G4B (JMJD7-PLA2G4B Readthrough) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G4B.
Additional gene information for JMJD7-PLA2G4B Gene
- HGNC (34449)
- NCBI Entrez Gene (8681)
- Ensembl (ENSG00000168970)
- UniProtKB/TrEMBL (H0Y9G9)
- Open Targets Platform(ENSG00000168970)
- Alliance of Genome Resources
- Search for JMJD7-PLA2G4B at DataMed
- Search for JMJD7-PLA2G4B at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JMJD7-PLA2G4B Gene
Genomics for JMJD7-PLA2G4B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for JMJD7-PLA2G4B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around JMJD7-PLA2G4B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JMJD7-PLA2G4B
Genomic Locations for JMJD7-PLA2G4B Gene
Latest Assembly
- chr15:41,828,092-41,848,155
- (GRCh38/hg38)
- Size:
- 20,064 bases
- Orientation:
- Plus strand
Previous Assembly
- chr15:42,120,290-42,140,341
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 20,052 bases
- Orientation:
- Plus strand
Genomic View for JMJD7-PLA2G4B Gene
Genes around JMJD7-PLA2G4B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by HGNC
- 15q15.1 by Entrez Gene
- 15q15.1 by Ensembl
JMJD7-PLA2G4B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for JMJD7-PLA2G4B Gene
Proteins for JMJD7-PLA2G4B Gene
-
Protein details for JMJD7-PLA2G4B Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H0Y9G9-H0Y9G9_HUMAN
- Recommended name:
- JMJD7-PLA2G4B readthrough
- Protein Accession:
- H0Y9G9
Protein attributes for JMJD7-PLA2G4B Gene
- Size:
- 81 amino acids
- Molecular mass:
- 9403 Da
- Quaternary structure:
- No Data Available
Protein Expression for JMJD7-PLA2G4B Gene
Post-translational modifications for JMJD7-PLA2G4B Gene
No Post-translational modifications
Other Protein References for JMJD7-PLA2G4B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
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-
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-
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Assay products for research
No data available for DME Specific Peptides for JMJD7-PLA2G4B Gene
Domains & Families for JMJD7-PLA2G4B Gene
Gene Families for JMJD7-PLA2G4B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene
Function for JMJD7-PLA2G4B Gene
Phenotypes From GWAS Catalog for JMJD7-PLA2G4B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004620 | phospholipase activity | IEA | -- |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | IBA | -- |
Phenotypes for JMJD7-PLA2G4B Gene
- GenomeRNAi human phenotypes for JMJD7-PLA2G4B:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with vaccinia virus (VACV) infection
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased shRNA abundance (Z-score > 2)
- Increased Nanog expression
- Decreased shRNA abundance (Z-score < -2)
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for JMJD7-PLA2G4B - Starting at $85 >
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Inhibitory RNAs for research
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Clone products for research
- Applied Biological Materials (abm): Clones for JMJD7-PLA2G4B - Starting at $45 >
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Cell Lines for research
-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JMJD7-PLA2G4B Gene
Localization for JMJD7-PLA2G4B Gene
- Cytosol (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for JMJD7-PLA2G4B Gene
Pathways & Interactions for JMJD7-PLA2G4B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Linoleic acid metabolism | ||
| 2 | Phospholipase D signaling pathway | ||
| 3 | Immune response Fc epsilon RI pathway | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
| 5 | Oxytocin signaling pathway | ||
Pathways by source for JMJD7-PLA2G4B Gene
23 KEGG pathways for JMJD7-PLA2G4B Gene
Interacting Proteins for JMJD7-PLA2G4B Gene
GPS-Prot Interaction Network for JMJD7-PLA2G4B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009395 | phospholipid catabolic process | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for JMJD7-PLA2G4B Gene
Transcripts for JMJD7-PLA2G4B Gene
mRNA/cDNA for JMJD7-PLA2G4B Gene
- 2 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000342159 2966 nts (view in UCSC)
- ENST00000382448 3331 nts (view in UCSC)
- ENST00000476036 577 nts (view in UCSC)
- ENST00000487292 3178 nts (view in UCSC)
- ENST00000490848 7218 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for JMJD7-PLA2G4B - Starting at $85 >
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-
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-
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miRNA products for research
Inhibitory RNAs for research
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Clone products for research
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Relevant External Links for JMJD7-PLA2G4B Gene
- GeneLoc Exon Structure for
- JMJD7-PLA2G4B
Expression for JMJD7-PLA2G4B Gene
This gene is overexpressed in Cervix (33.0) and Urine (32.0).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JMJD7-PLA2G4B
SOURCE GeneReport for Unigene cluster for JMJD7-PLA2G4B Gene:
Hs.198161Primer products for research
-
OriGene qPCR primer pairs for JMJD7-PLA2G4B
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for JMJD7-PLA2G4B Gene
Orthologs for JMJD7-PLA2G4B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | PLA2G4B 30 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Pla2g4b 30 |
|
ManyToMany | |
| PLA2G4B 30 |
|
ManyToMany | |||
| Dog (Canis familiaris) |
Mammalia | PLA2G4B 30 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany |
- Species where no ortholog for JMJD7-PLA2G4B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for JMJD7-PLA2G4B Gene
- ENSEMBL:
- Gene Tree for JMJD7-PLA2G4B (if available)
- TreeFam:
- Gene Tree for JMJD7-PLA2G4B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for JMJD7-PLA2G4B: view image
- Alliance of Genome Resources:
- Additional Orthologs for JMJD7-PLA2G4B
Paralogs for JMJD7-PLA2G4B Gene
Variants for JMJD7-PLA2G4B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JMJD7-PLA2G4B Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 983095 | Uncertain Significance: Neurodevelopmental disorder | 41,847,819(+) |
C/T NM_001114633.2(PLA2G4B):c.2305C>T (p.Arg769Cys) |
MISSENSE_VARIANT,THREE_PRIME_UTR | |
| rs139694386 | Benign: not provided | 41,828,174(+) |
C/T NM_001114632.2(JMJD7):c.50C>T (p.Pro17Leu) |
MISSENSE | |
| rs377316217 | Benign: not provided | 41,841,258(+) |
C/T NM_001114633.1(PLA2G4B):c.420C>T (p.Ser140=) |
SYNONYMOUS | |
| rs7174710 | Benign: not provided | 41,834,758(+) |
C/G NM_001114632.2(JMJD7):c.83C>G (p.Ala28Gly) |
MISSENSE | |
| rs75094146 | Benign: not provided | 41,835,222(+) |
G/T NM_001114632.2(JMJD7):c.471G>T (p.Leu157=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2582n100 | CNV | gain | 25217958 |
| esv2760027 | CNV | loss | 17122850 |
| esv3636251 | CNV | loss | 21293372 |
| nsv1035998 | CNV | gain | 25217958 |
| nsv1038933 | CNV | gain | 25217958 |
| nsv1050892 | CNV | gain | 25217958 |
| nsv1506 | CNV | insertion | 18451855 |
| nsv517631 | CNV | loss | 19592680 |
| nsv9244 | CNV | gain | 18304495 |
| nsv952613 | CNV | deletion | 24416366 |
| nsv977704 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
95.9% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for JMJD7-PLA2G4B Gene
- Human Gene Mutation Database (HGMD)
- JMJD7-PLA2G4B
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- JMJD7-PLA2G4B
- Leiden Open Variation Database (LOVD)
- JMJD7-PLA2G4B
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene
Disorders for JMJD7-PLA2G4B Gene
Additional Disease Information for JMJD7-PLA2G4B
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for JMJD7-PLA2G4B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD7-PLA2G4B Gene
Publications for JMJD7-PLA2G4B Gene
- Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PMID: 16617059) Ghosh M … Leslie CC (The Journal of biological chemistry 2006) 3 22
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
- The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3
Products for JMJD7-PLA2G4B Gene
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Sources for JMJD7-PLA2G4B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources