This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains... See more...

Aliases for JMJD7-PLA2G4B Gene

Aliases for JMJD7-PLA2G4B Gene

  • JMJD7-PLA2G4B Readthrough 2 3 5 13
  • Jumonji Domain Containing 7-Phospholipase A2, Group IVB (Cytosolic) Read-Through 3
  • JMJD7-PLA2G4B Protein 3
  • JMJD7-PLA2G4B 5
  • CPLA2-Beta 3
  • HsT16992 3

External Ids for JMJD7-PLA2G4B Gene

Previous GeneCards Identifiers for JMJD7-PLA2G4B Gene

  • GC15P039910
  • GC15P042122
  • GC15P018968

Summaries for JMJD7-PLA2G4B Gene

Entrez Gene Summary for JMJD7-PLA2G4B Gene

  • This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]

GeneCards Summary for JMJD7-PLA2G4B Gene

JMJD7-PLA2G4B (JMJD7-PLA2G4B Readthrough) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G4B.

Gene Wiki entry for JMJD7-PLA2G4B Gene

Additional gene information for JMJD7-PLA2G4B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JMJD7-PLA2G4B Gene

Genomics for JMJD7-PLA2G4B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for JMJD7-PLA2G4B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JMJD7-PLA2G4B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JMJD7-PLA2G4B

Genomic Locations for JMJD7-PLA2G4B Gene

Latest Assembly
chr15:41,828,092-41,848,155
(GRCh38/hg38)
Size:
20,064 bases
Orientation:
Plus strand

Previous Assembly
chr15:42,120,290-42,140,341
(GRCh37/hg19 by Entrez Gene)
Size:
20,052 bases
Orientation:
Plus strand

chr15:42,120,293-42,140,353
(GRCh37/hg19 by Ensembl)
Size:
20,061 bases
Orientation:
Plus strand

Genomic View for JMJD7-PLA2G4B Gene

Genes around JMJD7-PLA2G4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JMJD7-PLA2G4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JMJD7-PLA2G4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD7-PLA2G4B Gene

Proteins for JMJD7-PLA2G4B Gene

  • Protein details for JMJD7-PLA2G4B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0Y9G9-H0Y9G9_HUMAN
    Recommended name:
    JMJD7-PLA2G4B readthrough
    Protein Accession:
    H0Y9G9

    Protein attributes for JMJD7-PLA2G4B Gene

    Size:
    81 amino acids
    Molecular mass:
    9403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JMJD7-PLA2G4B Gene

Protein Expression for JMJD7-PLA2G4B Gene

Post-translational modifications for JMJD7-PLA2G4B Gene

No Post-translational modifications

Other Protein References for JMJD7-PLA2G4B Gene

No data available for DME Specific Peptides for JMJD7-PLA2G4B Gene

Domains & Families for JMJD7-PLA2G4B Gene

Gene Families for JMJD7-PLA2G4B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for JMJD7-PLA2G4B Gene

InterPro:
genes like me logo Genes that share domains with JMJD7-PLA2G4B: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene

Function for JMJD7-PLA2G4B Gene

Phenotypes From GWAS Catalog for JMJD7-PLA2G4B Gene

Gene Ontology (GO) - Molecular Function for JMJD7-PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IBA --
genes like me logo Genes that share ontologies with JMJD7-PLA2G4B: view
genes like me logo Genes that share phenotypes with JMJD7-PLA2G4B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JMJD7-PLA2G4B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JMJD7-PLA2G4B Gene

Localization for JMJD7-PLA2G4B Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for JMJD7-PLA2G4B Gene

Pathways & Interactions for JMJD7-PLA2G4B Gene

genes like me logo Genes that share pathways with JMJD7-PLA2G4B: view

Interacting Proteins for JMJD7-PLA2G4B Gene

Gene Ontology (GO) - Biological Process for JMJD7-PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009395 phospholipid catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with JMJD7-PLA2G4B: view

No data available for SIGNOR curated interactions for JMJD7-PLA2G4B Gene

Drugs & Compounds for JMJD7-PLA2G4B Gene

No Compound Related Data Available

Transcripts for JMJD7-PLA2G4B Gene

mRNA/cDNA for JMJD7-PLA2G4B Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JMJD7-PLA2G4B

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD7-PLA2G4B Gene

No ASD Table

Relevant External Links for JMJD7-PLA2G4B Gene

GeneLoc Exon Structure for
JMJD7-PLA2G4B

Expression for JMJD7-PLA2G4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JMJD7-PLA2G4B Gene

Protein differential expression in normal tissues from HIPED for JMJD7-PLA2G4B Gene

This gene is overexpressed in Cervix (33.0) and Urine (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for JMJD7-PLA2G4B Gene



Protein tissue co-expression partners for JMJD7-PLA2G4B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JMJD7-PLA2G4B

SOURCE GeneReport for Unigene cluster for JMJD7-PLA2G4B Gene:

Hs.198161
genes like me logo Genes that share expression patterns with JMJD7-PLA2G4B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for JMJD7-PLA2G4B Gene

Orthologs for JMJD7-PLA2G4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for JMJD7-PLA2G4B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 98 (a)
ManyToMany
-- 30
  • 97 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia PLA2G4B 30
  • 84 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Pla2g4b 30
  • 84 (a)
ManyToMany
PLA2G4B 30
  • 81 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia PLA2G4B 30
  • 81 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 69 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 46 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 46 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 23 (a)
ManyToMany
-- 30
  • 19 (a)
ManyToMany
Species where no ortholog for JMJD7-PLA2G4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for JMJD7-PLA2G4B Gene

ENSEMBL:
Gene Tree for JMJD7-PLA2G4B (if available)
TreeFam:
Gene Tree for JMJD7-PLA2G4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JMJD7-PLA2G4B: view image
Alliance of Genome Resources:
Additional Orthologs for JMJD7-PLA2G4B

Paralogs for JMJD7-PLA2G4B Gene

Paralogs for JMJD7-PLA2G4B Gene

(1) SIMAP similar genes for JMJD7-PLA2G4B Gene using alignment to 1 proteins:

  • H0Y9G9_HUMAN
genes like me logo Genes that share paralogs with JMJD7-PLA2G4B: view

Variants for JMJD7-PLA2G4B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JMJD7-PLA2G4B Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
983095 Uncertain Significance: Neurodevelopmental disorder 41,847,819(+) C/T
NM_001114633.2(PLA2G4B):c.2305C>T (p.Arg769Cys)
MISSENSE_VARIANT,THREE_PRIME_UTR
rs139694386 Benign: not provided 41,828,174(+) C/T
NM_001114632.2(JMJD7):c.50C>T (p.Pro17Leu)
MISSENSE
rs377316217 Benign: not provided 41,841,258(+) C/T
NM_001114633.1(PLA2G4B):c.420C>T (p.Ser140=)
SYNONYMOUS
rs7174710 Benign: not provided 41,834,758(+) C/G
NM_001114632.2(JMJD7):c.83C>G (p.Ala28Gly)
MISSENSE
rs75094146 Benign: not provided 41,835,222(+) G/T
NM_001114632.2(JMJD7):c.471G>T (p.Leu157=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for JMJD7-PLA2G4B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for JMJD7-PLA2G4B Gene

Variant ID Type Subtype PubMed ID
dgv2582n100 CNV gain 25217958
esv2760027 CNV loss 17122850
esv3636251 CNV loss 21293372
nsv1035998 CNV gain 25217958
nsv1038933 CNV gain 25217958
nsv1050892 CNV gain 25217958
nsv1506 CNV insertion 18451855
nsv517631 CNV loss 19592680
nsv9244 CNV gain 18304495
nsv952613 CNV deletion 24416366
nsv977704 CNV duplication 23825009

Variation tolerance for JMJD7-PLA2G4B Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JMJD7-PLA2G4B Gene

Human Gene Mutation Database (HGMD)
JMJD7-PLA2G4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JMJD7-PLA2G4B
Leiden Open Variation Database (LOVD)
JMJD7-PLA2G4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene

Disorders for JMJD7-PLA2G4B Gene

Additional Disease Information for JMJD7-PLA2G4B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for JMJD7-PLA2G4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD7-PLA2G4B Gene

Publications for JMJD7-PLA2G4B Gene

  1. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PMID: 16617059) Ghosh M … Leslie CC (The Journal of biological chemistry 2006) 3 22
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3

Products for JMJD7-PLA2G4B Gene

Sources for JMJD7-PLA2G4B Gene