This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining t... See more...

Aliases for JMJD7 Gene

Aliases for JMJD7 Gene

  • Jumonji Domain Containing 7 2 3 5
  • Bifunctional Peptidase And (3S)-Lysyl Hydroxylase JMJD7 3 4
  • Jumonji Domain-Containing Protein 7 3 4
  • JmjC Domain-Containing Protein 7 3 4
  • L-Lysine (3S)-Hydroxylase JMJD7 3 4
  • EC 1.14.11.63 4
  • EC 3.4.-.- 4

External Ids for JMJD7 Gene

Previous GeneCards Identifiers for JMJD7 Gene

  • GC15U900840
  • GC15P039909
  • GC15P042121
  • GC15P018969

Summaries for JMJD7 Gene

Entrez Gene Summary for JMJD7 Gene

  • This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for JMJD7 Gene

JMJD7 (Jumonji Domain Containing 7) is a Protein Coding gene. An important paralog of this gene is KDM8.

UniProtKB/Swiss-Prot Summary for JMJD7 Gene

  • Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed:28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed:29915238). Acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed:29915238).

Additional gene information for JMJD7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JMJD7 Gene

Genomics for JMJD7 Gene

GeneHancer (GH) Regulatory Elements for JMJD7 Gene

Promoters and enhancers for JMJD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J041827 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 533.8 +0.0 16 2.6 HNRNPK ZBTB40 EP300 SIN3A NRF1 POLR2G BCLAF1 PHF8 CTCF ZIC2 JMJD7 ENSG00000250379 JMJD7-PLA2G4B NDUFAF1 EHD4 PLA2G4B MAPKBP1
GH15J041834 Promoter/Enhancer 0.5 EPDnew dbSUPER 500.4 +6.9 6943 0.1 JMJD7 PLA2G4B JMJD7-PLA2G4B
GH15J041826 Enhancer 0.3 ENCODE dbSUPER 500.7 -1.6 -1627 0.2 ENSG00000250379 JMJD7 JMJD7-PLA2G4B LRRC57 NONHSAG016658.2 MAPKBP1
GH15J041772 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 43.3 -52.1 -52087 6.4 RXRA EP300 ZBTB40 ZNF217 CTCF SIN3A NRF1 MYC POLR2G SP1 MAPKBP1 JMJD7 SPTBN5 VPS39 ENSG00000250379 JMJD7-PLA2G4B CDAN1 ENSG00000174171 MGA INO80
GH15J041786 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 44.2 -35.7 -35654 15.3 FOS ZNF623 RELA MEF2A HDAC3 NR2F2 NCOR1 MBD2 ZNF316 NFIC JMJD7 TYRO3 SPTBN5 JMJD7-PLA2G4B ENSG00000250379 PLA2G4B LTK RPAP1 PPP1R14D MAPKBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JMJD7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JMJD7

Top Transcription factor binding sites by QIAGEN in the JMJD7 gene promoter:
  • AP-2gamma
  • c-Ets-1
  • c-Myb
  • GATA-1
  • Msx-1
  • NRSF form 1
  • NRSF form 2
  • SEF-1 (1)
  • STAT3

Genomic Locations for JMJD7 Gene

Genomic Locations for JMJD7 Gene
chr15:41,828,085-41,837,587
(GRCh38/hg38)
Size:
9,503 bases
Orientation:
Plus strand
chr15:42,120,283-42,129,785
(GRCh37/hg19)
Size:
9,503 bases
Orientation:
Plus strand

Genomic View for JMJD7 Gene

Genes around JMJD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JMJD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JMJD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD7 Gene

Proteins for JMJD7 Gene

  • Protein details for JMJD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C870-JMJD7_HUMAN
    Recommended name:
    Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
    Protein Accession:
    P0C870
    Secondary Accessions:
    • A5D6V5
    • O95712
    • Q59GF9
    • Q8TB10
    • Q9UKV7

    Protein attributes for JMJD7 Gene

    Size:
    316 amino acids
    Molecular mass:
    35932 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with DRG1 and DRG2.

    Three dimensional structures from OCA and Proteopedia for JMJD7 Gene

neXtProt entry for JMJD7 Gene

Post-translational modifications for JMJD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JMJD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for JMJD7

No data available for DME Specific Peptides for JMJD7 Gene

Domains & Families for JMJD7 Gene

Gene Families for JMJD7 Gene

Protein Domains for JMJD7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JMJD7 Gene

GenScript: Design optimal peptide antigens:
  • Jumonji domain-containing protein 7 (JMJD7_HUMAN)
genes like me logo Genes that share domains with JMJD7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for JMJD7 Gene

Function for JMJD7 Gene

Molecular function for JMJD7 Gene

UniProtKB/Swiss-Prot Function:
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed:28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed:29915238). Acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed:29915238).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate; Xref=Rhea:RHEA:57152, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15133, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:141492; EC=1.14.11.63; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57153; Evidence=. ;.

Enzyme Numbers (IUBMB) for JMJD7 Gene

Phenotypes From GWAS Catalog for JMJD7 Gene

Gene Ontology (GO) - Molecular Function for JMJD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 28847961
GO:0004177 aminopeptidase activity IDA,IEA 28847961
GO:0004497 monooxygenase activity IEA,IDA 29915238
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with JMJD7: view

Phenotypes for JMJD7 Gene

genes like me logo Genes that share phenotypes with JMJD7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for JMJD7

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JMJD7 Gene

Localization for JMJD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JMJD7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JMJD7 gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for JMJD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 29915238
GO:0005737 cytoplasm IEA,IDA 29915238
genes like me logo Genes that share ontologies with JMJD7: view

Pathways & Interactions for JMJD7 Gene

PathCards logo

SuperPathways for JMJD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JMJD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0018126 protein hydroxylation IDA 29915238
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with JMJD7: view

No data available for Pathways by source and SIGNOR curated interactions for JMJD7 Gene

Drugs & Compounds for JMJD7 Gene

No Compound Related Data Available

Transcripts for JMJD7 Gene

mRNA/cDNA for JMJD7 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD7 Gene

No ASD Table

Relevant External Links for JMJD7 Gene

GeneLoc Exon Structure for
JMJD7

Expression for JMJD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JMJD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JMJD7 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for JMJD7 Gene

This gene is overexpressed in Heart (13.5), Cervix (9.8), Salivary gland (8.8), and Retina (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JMJD7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JMJD7

Evidence on tissue expression from TISSUES for JMJD7 Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with JMJD7: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JMJD7 Gene

Orthologs for JMJD7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for JMJD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JMJD7 30
  • 98.84 (n)
-- 31
  • 98 (a)
OneToMany
-- 31
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia JMJD7 31 30
  • 89.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia JMJD7 31 30
  • 88.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jmjd7 30
  • 85.44 (n)
mouse
(Mus musculus)
Mammalia Jmjd7 17 31 30
  • 85.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia JMJD7 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves JMJD7 31 30
  • 65.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JMJD7 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jmjd7 30
  • 65.38 (n)
zebrafish
(Danio rerio)
Actinopterygii jmjd7 31 30
  • 66.67 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10133 31 30
  • 53.79 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007766 30
  • 52.51 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45880 30
  • 49.51 (n)
rice
(Oryza sativa)
Liliopsida Os09g0483600 30
  • 56.82 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03670 30
  • 45.5 (n)
Species where no ortholog for JMJD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JMJD7 Gene

ENSEMBL:
Gene Tree for JMJD7 (if available)
TreeFam:
Gene Tree for JMJD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JMJD7: view image

Paralogs for JMJD7 Gene

Paralogs for JMJD7 Gene

(1) SIMAP similar genes for JMJD7 Gene using alignment to 3 proteins:

  • JMJD7_HUMAN
  • B5MC20_HUMAN
  • C9K0I3_HUMAN
genes like me logo Genes that share paralogs with JMJD7: view

Variants for JMJD7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JMJD7 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
711107 Benign: not provided 41,834,758(+) C/G MISSENSE_VARIANT
731633 Benign: not provided 41,828,174(+) C/T MISSENSE_VARIANT
787425 Benign: not provided 41,835,222(+) G/T SYNONYMOUS_VARIANT
rs7174710 - p.Ala28Gly
VAR_069392 - p.Met160Val

Additional dbSNP identifiers (rs#s) for JMJD7 Gene

Structural Variations from Database of Genomic Variants (DGV) for JMJD7 Gene

Variant ID Type Subtype PubMed ID
dgv2582n100 CNV gain 25217958
esv2760027 CNV loss 17122850
esv3636251 CNV loss 21293372
nsv1035998 CNV gain 25217958
nsv1050892 CNV gain 25217958
nsv1506 CNV insertion 18451855
nsv517631 CNV loss 19592680
nsv9244 CNV gain 18304495
nsv952613 CNV deletion 24416366
nsv977704 CNV duplication 23825009

Variation tolerance for JMJD7 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JMJD7 Gene

Human Gene Mutation Database (HGMD)
JMJD7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JMJD7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD7 Gene

Disorders for JMJD7 Gene

Additional Disease Information for JMJD7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for JMJD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD7 Gene

Publications for JMJD7 Gene

  1. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. (PMID: 29915238) Markolovic S … Schofield CJ (Nature chemical biology 2018) 3 4 54
  2. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. (PMID: 28847961) Liu H … Zhang G (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 4 54
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival. (PMID: 28030848) Cheng Y … Wang CY (Oncotarget 2017) 3 54

Products for JMJD7 Gene

Sources for JMJD7 Gene