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Aliases for JMJD7 Gene

Aliases for JMJD7 Gene

  • Jumonji Domain Containing 7 2 3 5
  • Jumonji Domain-Containing Protein 7 4

External Ids for JMJD7 Gene

Previous GeneCards Identifiers for JMJD7 Gene

  • GC15U900840
  • GC15P039909
  • GC15P042121
  • GC15P018969

Summaries for JMJD7 Gene

Entrez Gene Summary for JMJD7 Gene

  • This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for JMJD7 Gene

JMJD7 (Jumonji Domain Containing 7) is a Protein Coding gene.

Additional gene information for JMJD7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD7 Gene

Genomics for JMJD7 Gene

GeneHancer (GH) Regulatory Elements for JMJD7 Gene

Promoters and enhancers for JMJD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I041827 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 583.6 +0.2 229 2 HDGF ATF1 ARID4B SIN3A ZNF2 ZNF48 YY1 TCF12 POLR2B GLIS2 JMJD7 ENSG00000250379 JMJD7-PLA2G4B INO80 LRRC57 CDAN1 GANC LOC105370795 MGA EHD4
GH15I041826 Enhancer 0.4 ENCODE dbSUPER 550.8 -1.6 -1627 0.2 ENSG00000250379 JMJD7 JMJD7-PLA2G4B LRRC57 GC15P041819 MAPKBP1
GH15I041772 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 43.3 -52.1 -52087 6.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 POLR2B MAPKBP1 JMJD7 SPTBN5 VPS39 JMJD7-PLA2G4B ENSG00000250379 CDAN1 LOC105370792 MGA INO80
GH15I041659 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 29.3 -167.1 -167065 3.6 HDGF PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 MGA JMJD7 INO80 DNAJC17 LOC105370795 GANC LRRC57 PLA2G4B RPAP1 VPS39
GH15I041786 Enhancer 1.2 Ensembl ENCODE dbSUPER 44.2 -36.8 -36815 8.6 HDAC1 PKNOX1 TCF12 ZNF121 EGR1 FOS IKZF2 RUNX3 SMARCA5 ZNF623 JMJD7 TYRO3 SPTBN5 JMJD7-PLA2G4B ENSG00000250379 PLA2G4B LTK RPAP1 MAPKBP1 GC15P041819
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around JMJD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JMJD7 gene promoter:

Genomic Locations for JMJD7 Gene

Genomic Locations for JMJD7 Gene
chr15:41,828,085-41,837,587
(GRCh38/hg38)
Size:
9,503 bases
Orientation:
Plus strand
chr15:42,120,283-42,129,785
(GRCh37/hg19)

Genomic View for JMJD7 Gene

Genes around JMJD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JMJD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JMJD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD7 Gene

Proteins for JMJD7 Gene

  • Protein details for JMJD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C870-JMJD7_HUMAN
    Recommended name:
    JmjC domain-containing protein 7
    Protein Accession:
    P0C870
    Secondary Accessions:
    • A5D6V5
    • O95712
    • Q59GF9
    • Q8TB10
    • Q9UKV7

    Protein attributes for JMJD7 Gene

    Size:
    316 amino acids
    Molecular mass:
    35932 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JMJD7 Gene

Post-translational modifications for JMJD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JMJD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JMJD7 Gene

Domains & Families for JMJD7 Gene

Gene Families for JMJD7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for JMJD7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JMJD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JMJD7: view

No data available for UniProtKB/Swiss-Prot for JMJD7 Gene

Function for JMJD7 Gene

Phenotypes From GWAS Catalog for JMJD7 Gene

Gene Ontology (GO) - Molecular Function for JMJD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with JMJD7: view

Phenotypes for JMJD7 Gene

GenomeRNAi human phenotypes for JMJD7:
genes like me logo Genes that share phenotypes with JMJD7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for JMJD7

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JMJD7 Gene

Localization for JMJD7 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for JMJD7 Gene

Pathways & Interactions for JMJD7 Gene

SuperPathways for JMJD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JMJD7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for JMJD7 Gene

Drugs & Compounds for JMJD7 Gene

No Compound Related Data Available

Transcripts for JMJD7 Gene

mRNA/cDNA for JMJD7 Gene

(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD7 Gene

No ASD Table

Relevant External Links for JMJD7 Gene

GeneLoc Exon Structure for
JMJD7
ECgene alternative splicing isoforms for
JMJD7

Expression for JMJD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JMJD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JMJD7 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for JMJD7 Gene

This gene is overexpressed in Heart (13.5), Cervix (9.8), Salivary gland (8.8), and Retina (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JMJD7 Gene



NURSA nuclear receptor signaling pathways regulating expression of JMJD7 Gene:

JMJD7

Evidence on tissue expression from TISSUES for JMJD7 Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with JMJD7: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JMJD7 Gene

Orthologs for JMJD7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for JMJD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JMJD7 33
  • 98.84 (n)
-- 34
  • 98 (a)
OneToMany
-- 34
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia JMJD7 33 34
  • 89.03 (n)
dog
(Canis familiaris)
Mammalia JMJD7 33 34
  • 88.82 (n)
rat
(Rattus norvegicus)
Mammalia Jmjd7 33
  • 85.44 (n)
mouse
(Mus musculus)
Mammalia Jmjd7 33 16 34
  • 85.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia JMJD7 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves JMJD7 33 34
  • 65.92 (n)
lizard
(Anolis carolinensis)
Reptilia JMJD7 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jmjd7 33
  • 65.38 (n)
zebrafish
(Danio rerio)
Actinopterygii jmjd7 33 34
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10133 33 34
  • 53.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007766 33
  • 52.51 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45880 33
  • 49.51 (n)
rice
(Oryza sativa)
Liliopsida Os09g0483600 33
  • 56.82 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03670 33
  • 45.5 (n)
Species where no ortholog for JMJD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JMJD7 Gene

ENSEMBL:
Gene Tree for JMJD7 (if available)
TreeFam:
Gene Tree for JMJD7 (if available)

Paralogs for JMJD7 Gene

(1) SIMAP similar genes for JMJD7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JMJD7: view

No data available for Paralogs for JMJD7 Gene

Variants for JMJD7 Gene

Sequence variations from dbSNP and Humsavar for JMJD7 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000072675 -- 41,829,698(+) A/G intron_variant
rs1000127284 -- 41,833,547(+) C/T intron_variant
rs1000783038 -- 41,834,250(+) T/G intron_variant
rs1000880083 -- 41,830,687(+) C/T intron_variant
rs1000926219 -- 41,835,949(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for JMJD7 Gene

Variant ID Type Subtype PubMed ID
dgv2582n100 CNV gain 25217958
esv2760027 CNV loss 17122850
esv3636251 CNV loss 21293372
nsv1035998 CNV gain 25217958
nsv1050892 CNV gain 25217958
nsv1506 CNV insertion 18451855
nsv517631 CNV loss 19592680
nsv9244 CNV gain 18304495
nsv952613 CNV deletion 24416366
nsv977704 CNV duplication 23825009

Variation tolerance for JMJD7 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JMJD7 Gene

Human Gene Mutation Database (HGMD)
JMJD7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JMJD7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD7 Gene

Disorders for JMJD7 Gene

Additional Disease Information for JMJD7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for JMJD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD7 Gene

Publications for JMJD7 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J … Vissers LE (The New England journal of medicine 2012) 4 58
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58

Products for JMJD7 Gene

Sources for JMJD7 Gene

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