Aliases for JKAMP Gene

Aliases for JKAMP Gene

  • JNK1/MAPK8 Associated Membrane Protein 2 3 5
  • Jun N-Terminal Kinase 1-Associated Membrane Protein 2 3
  • JNK1/MAPK8-Associated Membrane Protein 3 4
  • Medulloblastoma Antigen MU-MB-50.4 3 4
  • C14orf100 3 4
  • JAMP 3 4
  • Chromosome 14 Open Reading Frame 100 2
  • JNK1-Associated Membrane Protein 4
  • JNK-Associated Membrane Protein 3
  • C24orf100 3
  • HSPC213 3
  • HSPC327 3
  • CDA06 3

External Ids for JKAMP Gene

Previous HGNC Symbols for JKAMP Gene

  • C14orf100

Previous GeneCards Identifiers for JKAMP Gene

  • GC14P059020
  • GC14P059952
  • GC14P040115

Summaries for JKAMP Gene

GeneCards Summary for JKAMP Gene

JKAMP (JNK1/MAPK8 Associated Membrane Protein) is a Protein Coding gene. Diseases associated with JKAMP include Medulloblastoma and Large Cell Medulloblastoma. Among its related pathways are Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot Summary for JKAMP Gene

  • May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).

Gene Wiki entry for JKAMP Gene

Additional gene information for JKAMP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JKAMP Gene

Genomics for JKAMP Gene

GeneHancer (GH) Regulatory Elements for JKAMP Gene

Promoters and enhancers for JKAMP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J059481 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 509.8 -0.4 -406 5.5 ZBTB40 CTCF NRF1 TCF12 MYC POLR2G USF1 SP1 NCOR1 PHF8 L3HYPDH JKAMP SCOCP1 GPR135 PCNX4 RBM8B lnc-L3HYPDH-1 ENSG00000258782
GH14J059563 Enhancer 0.8 Ensembl ENCODE 20.3 +81.2 81215 3.5 ZIC2 ZNF341 OSR2 ZBTB17 MAFF MAFK FOXP2 PRDM6 FEZF1 ATF4 lnc-RTN1-2 L3HYPDH JKAMP RTN1 DAAM1 DHRS7 KR153240-004 CCDC175
GH14J059301 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -179.3 -179343 12.6 NCOR1 FOS TCF7 HES1 RUNX1 EP300 SKI TEAD1 TBX3 CTBP1 DAAM1 L3HYPDH JKAMP RTN1 lnc-GPR135-2 piR-38352-173
GH14J059405 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.7 -77.2 -77242 2.8 NCOR1 FOS MAFF MAFK JUND CREM FOXP1 TCF12 RAD21 GATA2 piR-48222-125 L3HYPDH JKAMP RTN1 DAAM1 RBM8B RF00017-1571
GH14J059507 Enhancer 0.9 Ensembl ENCODE 11.5 +23.2 23243 1.2 CTCF REST RAD21 TRIM22 ZBTB26 SMC3 ESRRA MYNN CEBPG ZNF205 L3HYPDH CCDC175 JKAMP NONHSAG015131.2 piR-48553-110 ENSG00000258782
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JKAMP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JKAMP

Genomic Locations for JKAMP Gene

Genomic Locations for JKAMP Gene
chr14:59,484,443-59,505,410
(GRCh38/hg38)
Size:
20,968 bases
Orientation:
Plus strand
chr14:59,951,161-59,972,128
(GRCh37/hg19)
Size:
20,968 bases
Orientation:
Plus strand

Genomic View for JKAMP Gene

Genes around JKAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JKAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JKAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JKAMP Gene

Proteins for JKAMP Gene

  • Protein details for JKAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P055-JKAMP_HUMAN
    Recommended name:
    JNK1/MAPK8-associated membrane protein
    Protein Accession:
    Q9P055
    Secondary Accessions:
    • B4DP67
    • Q6FIB6
    • Q6IAJ2
    • Q7Z5D4
    • Q86SY6
    • Q9H0Q6
    • Q9H2W0
    • Q9HAH5
    • Q9P0R3

    Protein attributes for JKAMP Gene

    Size:
    319 amino acids
    Molecular mass:
    36169 Da
    Quaternary structure:
    • Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1 (By similarity).
    Miscellaneous:
    • Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen.
    SequenceCaution:
    • Sequence=AAF29005.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF36133.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for JKAMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JKAMP Gene

Post-translational modifications for JKAMP Gene

  • Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for JKAMP Gene

Domains & Families for JKAMP Gene

Gene Families for JKAMP Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Protein Domains for JKAMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JKAMP Gene

GenScript: Design optimal peptide antigens:
  • Medulloblastoma antigen MU-MB-50.4 (JKAMP_HUMAN)
genes like me logo Genes that share domains with JKAMP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for JKAMP Gene

Function for JKAMP Gene

Molecular function for JKAMP Gene

UniProtKB/Swiss-Prot Function:
May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).

Phenotypes From GWAS Catalog for JKAMP Gene

Gene Ontology (GO) - Molecular Function for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 19269966
genes like me logo Genes that share ontologies with JKAMP: view
genes like me logo Genes that share phenotypes with JKAMP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JKAMP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JKAMP Gene

Localization for JKAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for JKAMP Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JKAMP gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
cytoskeleton 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with JKAMP: view

Pathways & Interactions for JKAMP Gene

genes like me logo Genes that share pathways with JKAMP: view

Pathways by source for JKAMP Gene

Gene Ontology (GO) - Biological Process for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0030433 ubiquitin-dependent ERAD pathway IDA 19269966
genes like me logo Genes that share ontologies with JKAMP: view

No data available for SIGNOR curated interactions for JKAMP Gene

Drugs & Compounds for JKAMP Gene

No Compound Related Data Available

Transcripts for JKAMP Gene

mRNA/cDNA for JKAMP Gene

6 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JKAMP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JKAMP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10:

Relevant External Links for JKAMP Gene

GeneLoc Exon Structure for
JKAMP

Expression for JKAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JKAMP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JKAMP Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JKAMP

SOURCE GeneReport for Unigene cluster for JKAMP Gene:

Hs.446850

Evidence on tissue expression from TISSUES for JKAMP Gene

  • Nervous system(4.8)
  • Bone marrow(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with JKAMP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JKAMP Gene

Orthologs for JKAMP Gene

This gene was present in the common ancestor of animals.

Orthologs for JKAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JKAMP 31 30
  • 99.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia JAMP 31
  • 98 (a)
OneToOne
JKAMP 30
  • 92.98 (n)
dog
(Canis familiaris)
Mammalia JKAMP 31 30
  • 93.89 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JKAMP 31
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JKAMP 31
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jkamp 30
  • 87.78 (n)
mouse
(Mus musculus)
Mammalia Jkamp 17 31 30
  • 87.57 (n)
4931417E11Rik 31
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves JKAMP 31 30
  • 76.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JKAMP 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jkamp 30
  • 72.67 (n)
Str.15301 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.22554 30
zebrafish
(Danio rerio)
Actinopterygii jkamp 31 30
  • 71.74 (n)
OneToOne
zgc63678 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001461 30
  • 54.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2126 31 30
  • 50.88 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea jamp-1 31 30
  • 44.82 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToOne
Species where no ortholog for JKAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JKAMP Gene

ENSEMBL:
Gene Tree for JKAMP (if available)
TreeFam:
Gene Tree for JKAMP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JKAMP: view image

Paralogs for JKAMP Gene

Pseudogenes.org Pseudogenes for JKAMP Gene

genes like me logo Genes that share paralogs with JKAMP: view

No data available for Paralogs for JKAMP Gene

Variants for JKAMP Gene

Additional dbSNP identifiers (rs#s) for JKAMP Gene

Variation tolerance for JKAMP Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JKAMP Gene

Human Gene Mutation Database (HGMD)
JKAMP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JKAMP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for JKAMP Gene

Disorders for JKAMP Gene

MalaCards: The human disease database

(2) MalaCards diseases for JKAMP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • mdb
large cell medulloblastoma
- elite association - COSMIC cancer census association via MalaCards
Search JKAMP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for JKAMP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with JKAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JKAMP Gene

Publications for JKAMP Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). (PMID: 19269966) Tcherpakov M … Ronai ZA (The Journal of biological chemistry 2009) 2 3 54
  3. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. (PMID: 16166642) Kadoya T … Ronai Z (Molecular and cellular biology 2005) 2 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for JKAMP Gene

Sources for JKAMP Gene