Aliases for JDP2 Gene
External Ids for JDP2 Gene
Previous HGNC Symbols for JDP2 Gene
Previous GeneCards Identifiers for JDP2 Gene
GeneCards Summary for JDP2 Gene
JDP2 (Jun Dimerization Protein 2) is a Protein Coding gene. Diseases associated with JDP2 include Granulomatous Amebic Encephalitis and Skeletal Muscle Neoplasm. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and ATF-2 transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ATF3.
UniProtKB/Swiss-Prot Summary for JDP2 Gene
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.