Aliases for JCHAIN Gene

Aliases for JCHAIN Gene

  • Joining Chain Of Multimeric IgA And IgM 2 3 4 5
  • Immunoglobulin J Chain 2 3 4
  • Immunoglobulin J Polypeptide, Linker Protein For Immunoglobulin Alpha And Mu Polypeptides 2 3
  • IgJ Chain 2 3
  • J Chain 2 3
  • IGCJ 3 4
  • IGJ 3 4
  • JCH 3

External Ids for JCHAIN Gene

Previous HGNC Symbols for JCHAIN Gene

  • IGJ

Summaries for JCHAIN Gene

GeneCards Summary for JCHAIN Gene

JCHAIN (Joining Chain Of Multimeric IgA And IgM) is a Protein Coding gene. Diseases associated with JCHAIN include Climatic Droplet Keratopathy and Alpha Chain Disease. Among its related pathways are Cell surface interactions at the vascular wall and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and antigen binding.

UniProtKB/Swiss-Prot Summary for JCHAIN Gene

  • Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Gene Wiki entry for JCHAIN Gene

Additional gene information for JCHAIN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JCHAIN Gene

Genomics for JCHAIN Gene

GeneHancer (GH) Regulatory Elements for JCHAIN Gene

Promoters and enhancers for JCHAIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J070703 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 -23.6 -23553 4.4 HNRNPK ZBTB40 EP300 CTCF SIN3A NRF1 TCF12 MYC POLR2G USF1 RUFY3 ENSG00000272986 JCHAIN RF00017-4324
GH04J070687 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 -7.8 -7821 5.1 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 MYC TCF12 USF1 UTP3 lnc-JCHAIN-3 JCHAIN lnc-UTP3-1
GH04J070667 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 500.4 +15.3 15316 1 MEF2C POLR2A MEF2B TBP TBX21 NFATC1 NFIC TBL1XR1 EP300 MEF2A JCHAIN LOC101927297 HSALNG0035032 ENSG00000286848
GH04J070680 Enhancer 0.8 Ensembl dbSUPER 500.7 +0.6 636 2 MEF2C SRF MEF2B BCOR TAL1 ATF2 ZNF217 KDM1A ATF7 NFIC JCHAIN ENAM LOC101927297 ENSG00000286848 HSALNG0035032
GH04J070682 Enhancer 0.2 dbSUPER 500.7 -1.4 -1392 0.7 JCHAIN LOC101927297 lnc-JCHAIN-3 ENSG00000286848 HSALNG0035032
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JCHAIN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JCHAIN

Genomic Locations for JCHAIN Gene

Genomic Locations for JCHAIN Gene
chr4:70,655,541-70,681,817
(GRCh38/hg38)
Size:
26,277 bases
Orientation:
Minus strand
chr4:71,521,258-71,547,534
(GRCh37/hg19)
Size:
26,277 bases
Orientation:
Minus strand

Genomic View for JCHAIN Gene

Genes around JCHAIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JCHAIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JCHAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JCHAIN Gene

Proteins for JCHAIN Gene

  • Protein details for JCHAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01591-IGJ_HUMAN
    Recommended name:
    Immunoglobulin J chain
    Protein Accession:
    P01591

    Protein attributes for JCHAIN Gene

    Size:
    159 amino acids
    Molecular mass:
    18099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JCHAIN Gene

Post-translational modifications for JCHAIN Gene

  • Glycosylation at Asn71
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • IGJ_HUMAN (277)

Other Protein References for JCHAIN Gene

No data available for DME Specific Peptides for JCHAIN Gene

Domains & Families for JCHAIN Gene

Gene Families for JCHAIN Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for JCHAIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JCHAIN Gene

GenScript: Design optimal peptide antigens:
  • Immunoglobulin J chain (IGJ_HUMAN)
genes like me logo Genes that share domains with JCHAIN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for JCHAIN Gene

Function for JCHAIN Gene

Molecular function for JCHAIN Gene

UniProtKB/Swiss-Prot Function:
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Phenotypes From GWAS Catalog for JCHAIN Gene

Gene Ontology (GO) - Molecular Function for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 contributes_to single-stranded DNA binding IDA 21786026
GO:0003823 antigen binding NAS 2984306
GO:0019862 IgA binding IMP 17237408
GO:0030674 protein binding, bridging IEA --
GO:0031210 contributes_to phosphatidylcholine binding IDA 21786026
genes like me logo Genes that share ontologies with JCHAIN: view
genes like me logo Genes that share phenotypes with JCHAIN: view

Animal Models for JCHAIN Gene

MGI Knock Outs for JCHAIN:

Animal Model Products

miRNA for JCHAIN Gene

miRTarBase miRNAs that target JCHAIN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JCHAIN Gene

Localization for JCHAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for JCHAIN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JCHAIN gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 23398317
GO:0070062 extracellular exosome HDA 19199708
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
GO:0071750 dimeric IgA immunoglobulin complex IMP 17237408
genes like me logo Genes that share ontologies with JCHAIN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for JCHAIN Gene

Pathways & Interactions for JCHAIN Gene

genes like me logo Genes that share pathways with JCHAIN: view

Gene Ontology (GO) - Biological Process for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
GO:0002250 adaptive immune response IDA 21786026
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 2984306
genes like me logo Genes that share ontologies with JCHAIN: view

No data available for SIGNOR curated interactions for JCHAIN Gene

Drugs & Compounds for JCHAIN Gene

(3) Drugs for JCHAIN Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2822
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0
genes like me logo Genes that share compounds with JCHAIN: view

Transcripts for JCHAIN Gene

mRNA/cDNA for JCHAIN Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JCHAIN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2:
SP3: -

Relevant External Links for JCHAIN Gene

GeneLoc Exon Structure for
JCHAIN

Expression for JCHAIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JCHAIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JCHAIN Gene

This gene is overexpressed in Milk (23.4) and Saliva (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JCHAIN Gene



Protein tissue co-expression partners for JCHAIN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JCHAIN

Evidence on tissue expression from TISSUES for JCHAIN Gene

  • Intestine(5)
  • Bone marrow(4.6)
  • Liver(4.5)
  • Lung(4.3)
  • Saliva(4.3)
  • Stomach(3.9)
  • Lymph node(3.3)
  • Spleen(3.2)
  • Blood(3)
  • Gall bladder(2.4)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with JCHAIN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JCHAIN Gene

Orthologs for JCHAIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for JCHAIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGJ 31 30
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IGJ 31 30
  • 89.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IGJ 31 30
  • 84.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Igj 31 30
  • 82.49 (n)
OneToOne
Jchain 17
oppossum
(Monodelphis domestica)
Mammalia IGJ 31
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGJ 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGJ 31 30
  • 63.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGJ 31
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734759 30
  • 61.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.261 30
Species where no ortholog for JCHAIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JCHAIN Gene

ENSEMBL:
Gene Tree for JCHAIN (if available)
TreeFam:
Gene Tree for JCHAIN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JCHAIN: view image

Paralogs for JCHAIN Gene

Pseudogenes.org Pseudogenes for JCHAIN Gene

genes like me logo Genes that share paralogs with JCHAIN: view

No data available for Paralogs for JCHAIN Gene

Variants for JCHAIN Gene

Additional dbSNP identifiers (rs#s) for JCHAIN Gene

Structural Variations from Database of Genomic Variants (DGV) for JCHAIN Gene

Variant ID Type Subtype PubMed ID
nsv1012495 CNV gain 25217958
nsv1123807 CNV deletion 24896259
nsv829965 CNV gain 17160897

Variation tolerance for JCHAIN Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JCHAIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JCHAIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JCHAIN Gene

Disorders for JCHAIN Gene

MalaCards: The human disease database

(10) MalaCards diseases for JCHAIN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
climatic droplet keratopathy
  • honey-droplet corneal dystrophy
alpha chain disease
  • seligmann's disease
renal artery obstruction
mu chain disease
  • mu-chain disease
keratopathy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for JCHAIN

genes like me logo Genes that share disorders with JCHAIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JCHAIN Gene

Publications for JCHAIN Gene

  1. Human J chain gene. Structure and expression in B lymphoid cells. (PMID: 2984306) Max EE … Korsmeyer SJ (The Journal of experimental medicine 1985) 2 3 4 54
  2. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4 54
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 54
  4. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen TZ … Pandey A (Molecular & cellular proteomics : MCP 2004) 3 4 54
  5. Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. (PMID: 1472500) Frutiger S … Jaton JC (Biochemistry 1992) 3 4 54

Products for JCHAIN Gene

Sources for JCHAIN Gene