Aliases for JAML Gene

Aliases for JAML Gene

  • Junction Adhesion Molecule Like 2 3 5
  • Adhesion Molecule Interacting With CXADR Antigen 1 3 4
  • Adhesion Molecule, Interacts With CXADR Antigen 1 2 3
  • Junctional Adhesion Molecule-Like 3 4
  • AMICA1 3 4
  • Dendritic-Cell Specific Protein CREA7-1 3
  • Dendritic-Cell Specific Protein CREA7-4 3
  • Dendritic Cell-Specific Protein CREA7-1 4
  • Adhesion Molecule AMICA 3
  • CREA7-1 3
  • CREA7-4 3
  • AMICA 3
  • Gm638 3

External Ids for JAML Gene

Previous HGNC Symbols for JAML Gene

  • AMICA1

Summaries for JAML Gene

GeneCards Summary for JAML Gene

JAML (Junction Adhesion Molecule Like) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is SCN4B.

UniProtKB/Swiss-Prot Summary for JAML Gene

  • Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Gene Wiki entry for JAML Gene

Additional gene information for JAML Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JAML Gene

Genomics for JAML Gene

GeneHancer (GH) Regulatory Elements for JAML Gene

Promoters and enhancers for JAML Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J118210 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 765.8 +11.1 11122 7.2 ZNF24 FOXA1 MLX RBPJ NR2F6 ATF1 CREB1 MIXL1 ETV6 RELA JAML MPZL3 CD3D CD3G CD3E MPZL2 HSPE1P18 lnc-MPZL3-4
GH11J118223 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 750.6 -1.5 -1505 7.6 ZNF24 SP1 MYC ETV6 RELA MAX NKRF CTCF CBFA2T2 MLLT1 JAML piR-53430 MPZL3 SCN2B MPZL2 lnc-JAML-1 piR-33689
GH11J118906 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 23.9 -694.0 -694047 25.3 PPP1R10 E2F8 SIN3A ZNF24 SP1 CTCF SREBF1 SIX5 ZBTB6 FOXA1 BCL9L UPK2 ARCN1 RNF26 DPAGT1 ENSG00000245869 VPS11 ENSG00000254909 UBE4A HINFP
GH11J118238 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 32.3 -15.7 -15705 4.6 GTF3C2 ZNF24 ZBTB40 FOXA1 SMARCE1 ZNF217 RUNX1 CC2D1A ETV6 ELF1 ENSG00000254909 UBE4A JAML RPL23AP64 ENSG00000254428 BCL9L MPZL3 ARCN1 DPAGT1 CD3E
GH11J118603 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.9 -383.5 -383504 10 ZBTB40 CTCF ZBTB6 RBPJ SMARCE1 POLR2A NR2F6 ZNF133 MYC CC2D1A PHLDB1 lnc-IFT46-2 IFT46 KMT2A HINFP RPL5P30 TREHP1 VPS11 CCDC84 ENSG00000255422
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JAML on UCSC Golden Path with GeneCards custom track

Genomic Locations for JAML Gene

Genomic Locations for JAML Gene
chr11:118,193,727-118,225,094
(GRCh38/hg38)
Size:
31,368 bases
Orientation:
Minus strand
chr11:118,064,442-118,095,809
(GRCh37/hg19)
Size:
31,368 bases
Orientation:
Minus strand

Genomic View for JAML Gene

Genes around JAML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAML Gene

Proteins for JAML Gene

  • Protein details for JAML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YT9-JAML_HUMAN
    Recommended name:
    Junctional adhesion molecule-like
    Protein Accession:
    Q86YT9
    Secondary Accessions:
    • B0YIV1
    • B0YIV2
    • Q496M1
    • Q5DTC6
    • Q7Z499
    • Q8N9I7
    • Q8NF70

    Protein attributes for JAML Gene

    Size:
    394 amino acids
    Molecular mass:
    44339 Da
    Quaternary structure:
    • Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.
    SequenceCaution:
    • Sequence=BAC03390.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for JAML Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAML Gene

Post-translational modifications for JAML Gene

  • Glycosylation at Asn76 and Asn231
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for JAML Gene

Domains & Families for JAML Gene

Gene Families for JAML Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for JAML Gene

Suggested Antigen Peptide Sequences for JAML Gene

GenScript: Design optimal peptide antigens:
  • Dendritic cell-specific protein CREA7-1 (JAML1_HUMAN)
  • AMICA1 protein (Q496M2_HUMAN)
  • AMICA1 protein (Q496M3_HUMAN)
  • cDNA FLJ58210, highly similar to Junctional adhesion molecule-like (Q496M4_HUMAN)
  • Dendritic-cell specific protein CREA7-4 (Q5DTC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86YT9

UniProtKB/Swiss-Prot:

JAML_HUMAN :
  • The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
  • Belongs to the immunoglobulin superfamily.
Domain:
  • The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with JAML: view

Function for JAML Gene

Molecular function for JAML Gene

UniProtKB/Swiss-Prot Function:
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells.

Phenotypes From GWAS Catalog for JAML Gene

Gene Ontology (GO) - Molecular Function for JAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 12869515
GO:0042803 protein homodimerization activity IDA 12869515
GO:0050839 cell adhesion molecule binding IPI 12869515
genes like me logo Genes that share ontologies with JAML: view
genes like me logo Genes that share phenotypes with JAML: view

Animal Model Products

  • Taconic Biosciences Mouse Models for JAML

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JAML Gene

Localization for JAML Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAML Gene

Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JAML gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1
mitochondrion 0
peroxisome 0
nucleus 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for JAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IDA 15800062
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with JAML: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for JAML Gene

Pathways & Interactions for JAML Gene

genes like me logo Genes that share pathways with JAML: view

Interacting Proteins for JAML Gene

Gene Ontology (GO) - Biological Process for JAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 18948633
GO:0030593 neutrophil chemotaxis IMP 15800062
GO:0035696 monocyte extravasation IMP 18948633
GO:0046629 gamma-delta T cell activation IEA,ISS --
genes like me logo Genes that share ontologies with JAML: view

No data available for SIGNOR curated interactions for JAML Gene

Drugs & Compounds for JAML Gene

No Compound Related Data Available

Transcripts for JAML Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JAML Gene

No ASD Table

Relevant External Links for JAML Gene

GeneLoc Exon Structure for
JAML
ECgene alternative splicing isoforms for
JAML

Expression for JAML Gene

NURSA nuclear receptor signaling pathways regulating expression of JAML Gene:

JAML

mRNA Expression by UniProt/SwissProt for JAML Gene:

Q86YT9-JAML_HUMAN
Tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).

Evidence on tissue expression from TISSUES for JAML Gene

  • Blood(4.5)
  • Lymph node(4.4)
  • Spleen(4.4)
  • Bone marrow(4.2)
  • Nervous system(4.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JAML Gene

Orthologs for JAML Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAML Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMICA1 33 32
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AMICA1 33 32
  • 82.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AMICA1 33 32
  • 79.63 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amica1 32
  • 72.04 (n)
mouse
(Mus musculus)
Mammalia Amica1 33 32
  • 69.91 (n)
OneToOne
Jaml 17
chicken
(Gallus gallus)
Aves AMICA1 33
  • 26 (a)
OneToOne
Species where no ortholog for JAML was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JAML Gene

ENSEMBL:
Gene Tree for JAML (if available)
TreeFam:
Gene Tree for JAML (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JAML: view image

Paralogs for JAML Gene

Paralogs for JAML Gene

genes like me logo Genes that share paralogs with JAML: view

Variants for JAML Gene

Sequence variations from dbSNP and Humsavar for JAML Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000033150 -- 118,213,787(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000104794 -- 118,214,136(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000145497 -- 118,221,245(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000352345 -- 118,217,503(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000390697 -- 118,220,607(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for JAML Gene

Variant ID Type Subtype PubMed ID
esv3579923 CNV loss 25503493
esv3627867 CNV loss 21293372
nsv511 CNV insertion 18451855
nsv952742 CNV duplication 24416366

Variation tolerance for JAML Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.56; 77.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JAML Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JAML

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAML Gene

Disorders for JAML Gene

Additional Disease Information for JAML

No disorders were found for JAML Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JAML Gene

Publications for JAML Gene

  1. Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. (PMID: 18948633) Guo YL … Zen K (Arteriosclerosis, thrombosis, and vascular biology 2009) 3 4 23 56
  2. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. (PMID: 15800062) Zen K … Parkos CA (Molecular biology of the cell 2005) 3 4 23 56
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 56
  4. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. (PMID: 12869515) Moog-Lutz C … Lutz PG (Blood 2003) 3 4 23 56
  5. JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. (PMID: 19064666) Luissint AC … Bourdoulous S (The Journal of cell biology 2008) 3 4 56

Products for JAML Gene

Sources for JAML Gene